Clinical trials: sponsored by Changhai Hospital
Pancreatic Neuroendocrine Tumor
A Study of Surufatinib as Adjuvant Therapy for Pancreatic Neuroendocrine Tumors
pNENs still have a risk of recurrence after radical resection, and the overall recurrence and metastasis rate is as high as 13.7%-36.2% in China.
- Trial name
- NCT06158516
- Testing
- Surufatinib
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Changhai Hospital
Chronic Pancreatitis, Pancreatic Cancer
Immune Repertoire Decoding for Chronic Pancreatitis-to-Pancreatic Cancer Risk Stratification
This study will follow people with chronic pancreatitis, people with pancreatic cancer, and healthy volunteers. The goal is to better understand why some people with chronic pancreatitis may later develop pancreatic cancer.
- Trial name
- NCT07612566
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Sessile Serrated Lesion
Polyp Pretreatment Device for SSL Diagnosis
Colorectal cancer (CRC) is the third most common malignancy globally. Sessile serrated lesions (SSLs) account for 15-30% of CRC via the serrated pathway.
- Trial name
- NCT07601230
- Testing
- Polyp Pretreatment Device
- Volunteers
- 1,156 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Sessile Serrated Lesion
Impact of Acetic Acid-Indigo Carmine Chromocolonoscopy on Proximal Sessile Serrated Lesions
Chromocolonoscopy with acetic acid and indigo carmine has shown promise for improving the detection of sessile serrated lesions (SSLs), the precursor lesions responsible for a substantial proportion of interval colorectal…
- Trial name
- ACID-SSL (NCT07601217)
- Testing
- Acetic Acid-Indigo Carmine Chromocolonoscopy Group
- Where
- China
- Volunteers
- 2,689 people
- Sponsor
- Changhai Hospital
IBD (Inflammatory Bowel Disease), Colonoscopy
Analysis of Factors Influencing the Quality of Bowel Preparation Before Colonoscopy in IBD Patients
The primary objectives of this project are twofold. On the one hand, it aims to investigate the current status of bowel preparation protocols and their quality in IBD patients undergoing colonoscopy, particularly focusing on the…
- Conditions
- IBD (Inflammatory Bowel Disease), Colonoscopy, Colonoscopy: Bowel Preparation
- Trial name
- NCT07335705
- Testing
- Standard Pre-colonoscopy Bowel Preparation Protocol
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
IBD (Inflammatory Bowel Disease), Colonoscopy
Pre-packaged Low-residue Diet for Bowel Preparation in Patients With Inflammatory Bowel Disease
The primary objectives of this project are twofold: firstly, to evaluate the role of Maifu Changqing® Complete Nutrition Formula Powder in bowel preparation for colonoscopy in patients with IBD; and secondly, to enhance the…
- Conditions
- IBD (Inflammatory Bowel Disease), Colonoscopy, Colonoscopy: Bowel Preparation
- Trial name
- NCT07353853
- Testing
- pre-packaged low-residue diet for bowel preparation
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Changhai Hospital
Colonoscopy: Bowel Preparation, IBD - Inflammatory Bowel Disease
Pre-Packaged Low-Residue Diet Assisting Bowel Preparation in Patients With Inflammatory Bowel Disease
The primary objectives of this study are as follows: 1.To evaluate the efficacy of Maifu Changqing® Complete Nutritional Formula Powder in bowel preparation for colonoscopy among inflammatory bowel disease (IBD) patients;2.To…
- Trial name
- NCT07165470
- Testing
- pre-packaged low-residue diet for bowel preparation
- Where
- 2 sites in China
- Volunteers
- 500 people
- Sponsor
- Changhai Hospital
Metastatic Castration-Resistant Prostate Cancer Patients, Castration-Resistant Prostate Cancer (CRPC)
YS247 (Neoantigen-Pulsed DC Vaccine) for Metastatic Prostate Cancer
This phase I study tests a personalized cancer vaccine (Neo-DC) for men with advanced prostate cancer (metastatic castration-resistant prostate cancer, or mCRPC) that has continued to grow despite standard hormone therapies and…
- Conditions
- Metastatic Castration-Resistant Prostate Cancer Patients, Castration-Resistant Prostate Cancer (CRPC), Prostate Neoplasms
- Trial name
- YS247 (NCT07583160)
- Testing
- Autologous Neoantigen-Pulsed Dendritic Cell Vaccine
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Changhai Hospital
Stroke, Cerebrovascular Disorders
Comprehensive Management of High-risk PopuLatIon for Stroke Based on Social Network
The purpose of this study is to evaluate the effectiveness of social network in improving drug compliance and risk factors control rate of stroke high-risk population after discharge.
- Conditions
- Stroke, Cerebrovascular Disorders, Brain Diseases, Central Nervous System Diseases
- Trial name
- COMPLIANCE-MT (NCT05963828)
- Testing
- conventional care, Social network-based intervention
- Where
- China
- Volunteers
- 720 people
- Sponsor
- Changhai Hospital
Acute Pancreatitis
FMT for the Prevention of Infectious Complications in Patients With Moderately Severe and Severe Acute Pancreatitis
The goal of this clinical trial is to learn whether fecal microbiota transplantation (FMT) works to prevent infections complications in patients in the late phase of moderately severe or severe acute pancreatitis.
- Trial name
- NCT07464392
- Testing
- Fecal Microbiota Transplantation
- Where
- 12 sites in China
- Volunteers
- 150 people
- Sponsor
- Changhai Hospital
Pancreatitis, Chronic, Pancreatitis, Acute
Indometacin With or Without Aggressive Intravenous Hydration to Prevent Pancreatitis After Pancreatic Extracorporeal Shock Wave Lithotripsy
This study aims to determine whether combining aggressive intravenous hydration with indometacin is more effective at preventing pancreatitis after a Extracorporeal Shock Wave Lithotripsy (ESWL) than using indometacin alone.
- Conditions
- Pancreatitis, Chronic, Pancreatitis, Acute, Pancreatic Duct Stones
- Trial name
- NCT07202559
- Testing
- Indometacin suppository, Lactated ringers solution, Normal Saline
- Where
- 10 sites in China
- Volunteers
- 1,250 people
- Sponsor
- Changhai Hospital
Early Gastric Cancer
Comparison of the Sensitivity of pCLE and Pathological Biopsy for Gastric Mucosal Lesions
The pathological biopsy of gastric lesions, performed prior to endoscopic submucosal dissection (ESD), is crucial for differentiating the pathological nature of the lesions and guiding treatment decisions.
- Trial name
- pCLE (NCT07507071)
- Testing
- Probe-based Confocal Laser Endomicroscopy, Pathological biopsy
- Where
- China
- Volunteers
- 169 people
- Sponsor
- Changhai Hospital
Chemotherapy-induced Thrombocytopenia (CIT) in Patients With Gastrointestinal Tumors
Efficacy and Safety of Hetrombopag in Preventing Chemotherapy-induced Thrombocytopenia in Gastrointestinal Tumors
This trial is a single-arm, prospective clinical study aimed at evaluating the efficacy and safety of hetrombopag in preventing chemotherapy-induced thrombocytopenia (CIT) in patients with gastrointestinal tumors.
- Trial name
- NCT07492693
- Testing
- Hetrombopag
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Changhai Hospital
Neoadjuvant Therapy, Urothelial Carcinoma Ureter
Neoadjuvant Chemotherapy Before Surgery vs Surgery Alone for UTUC: A Randomized Trial
This clinical trial aims to compare the effectiveness and safety of two treatment options for patients with high-risk upper tract urothelial carcinoma (UTUC).
- Conditions
- Neoadjuvant Therapy, Urothelial Carcinoma Ureter, Upper Urinary Tract Urothelial Carcinoma
- Trial name
- NCT07492225
- Testing
- Neoadjuvant Gemcitabine + Cisplatin Chemotherapy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Changhai Hospital
Esophageal Squamous Carcinoma
Neoadjuvant Therapy With Iparomlimab and Tuvonralimab, Lenvatinib and Chemotherapy in Resectable ESCC
This is a single-arm, exploratory clinical study.
- Trial name
- NCT07490002
- Testing
- Iparomlimab and Tuvonralimab+Lenvatinib + Cisplatin/Carboplatin + Nab-paclitaxel
- Volunteers
- 33 people
- Sponsor
- Changhai Hospital
End Stage Renal Disease
Effects of Hemodialysis Plus Hemoperfusion in Maintenance Hemodialysis Patients: A Clinical Study
This multi-center, open-label, randomized, parallel controlled trial aims to investigate the efficacy of hemoperfusion (HP) in combination with hemodialysis (HD) by assessing blood β2-microglobulin (β2-MG), parathyroid hormone…
- Trial name
- NCT05639010
- Testing
- regular hemodialysis, hemoperfusion combined with hemodialysis
- Where
- China
- Volunteers
- 410 people
- Sponsor
- Changhai Hospital
Gastrointestinal Bleeding
Capsule Endoscopy in GI Bleeding: A Retrospective Study
The goal of this observational study is to evaluate the diagnostic value and safety of capsule endoscopy in patients with gastrointestinal bleeding.
- Trial name
- NCT07481591
- Testing
- capsule endoscopy
- Volunteers
- 350 people
- Sponsor
- Changhai Hospital
Upper Gastrointestinal Cancer, Upper Gastrointestinal Precancerous Lesions
Establishment of Image Database for Early Upper Gastrointestinal Cancer, Precancerous Lesions, and Precancerous Conditions
The study is designed to collect magnetically-controlled capsule endoscopy (MCE) images, esophagogastroduodenoscopy (EGD) images, CT images, and histopathology results to establish a database for early upper gastrointestinal…
- Conditions
- Upper Gastrointestinal Cancer, Upper Gastrointestinal Precancerous Lesions, Upper Gastrointestinal Precancerous Conditions
- Trial name
- NCT07462247
- Testing
- magnetically-controlled capsule endoscopy, esophagogastroduodenoscopy, CT scan, ESD, biopsy
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Changhai Hospital
Pancreatic Cancer, Diagnose Disease
AI-Powered Precision Decision-Making for Pancreatic Diseases
This multicenter clinical trial evaluates an artificial intelligence (AI) system designed to assist in the diagnosis and management of pancreatic diseases.
- Conditions
- Pancreatic Cancer, Diagnose Disease, IPMN, Pancreatic, Pancreatic Cystic Lesions
- Trial name
- NCT07439757
- Testing
- Diagnosis by Artificial Intelligence model
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Changhai Hospital
Atrial Fibrillation (AF)
Research on Post-Stroke Anticoagulation Strategies for Atrial Fibrillation Based on Left Atrial Appendage Flow Velocity Measured by Intracardiac Echocardiography (ICE)
1. Study Purpose The primary aim of this research was to systematically describe and characterize a novel, thrombus-mimicking artifact observed during Intracardiac Echocardiography (ICE), termed the "Floating Lotus" sign.
- Trial name
- NCT07439731
- Testing
- Intracardiac Echocardiography (ICE) for Differential Diagnosis
- Where
- 2 sites in China
- Volunteers
- 172 people
- Sponsor
- Changhai Hospital