Clinical trials: sponsored by Changhai Hospital
Rectal Cancer
Short-course Radiotherapy Combined With Furoquintinib and PD-1 Monoclonal Antibody
The investigators conduct a single-arm, single-center, prospective clinical study enrolling patients diagnoses with pMMR / MSS type middle and low locally advanced rectal cancer who had not received systemic anti-tumor therapy to…
- Trial name
- PMMR/MSS (NCT06014944)
- Testing
- Short-course radiotherapy combined with furoquintinib and PD-1 monoclonal antibody
- Volunteers
- 30 people
- Sponsor
- Changhai Hospital
Pancreatic Cancer
SBRT Plus vNKT for Pancreatic Cancer
Owing to that the previous study of the investigators showed that SBRT plus pembrolizumab and trametinib provided favorable outcomes compared with SBRT plus gemcitabine for pancreatic cancer, therefore, the investigators aim to…
- Trial name
- NCT05783076
- Testing
- Stereotactic body radiation therapy, adoptive cell therapy with vNKT cells
- Where
- China
- Volunteers
- 29 people
- Sponsor
- Changhai Hospital
Diffuse Large B Cell Lymphoma
The Study of Anti-CD19 CAR NK Cells in the Treatment of Relapsed/Refractory Diffuse Large B Cell Lymphoma
A single arm, open-label pilot study is designed to determine the safety and effectiveness of anti-CD19 CAR NK cells in patients with B-cell Non Hodgkin Lymphoma.
- Trial name
- NCT05673447
- Testing
- anti-CD19 CAR NK cells
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Changhai Hospital
Chronic Pancreatitis, Pancreatic Exocrine Insufficiency
Establishment and Clinical Application of Pancreatic Endocrine and Exocrine Function Tests
The goal of this observational study is to improve the epidemiological data of pancreatic exocrine insufficiency in China, determine the FE-1 cut-off value for the classification of PEI, and explore the characteristic differences…
- Conditions
- Chronic Pancreatitis, Pancreatic Exocrine Insufficiency, Diabetes Mellitus, Community Populations
- Trial name
- NCT06006312
- Testing
- fecal elastase-1 test, 72-hour fecal fat quantification, blood sample test
- Where
- China
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Chronic Pancreatitis, Pancreatogenic Type 3C Diabetes Mellitus
Evaluation of OGTT in Patients With Post-pancreatitis Diabetes Mellitus for Diagnosis and Characterization
To evaluate the islet function and insulin secretion pattern of post-pancreatitis diabetes mellitus by oral glucose tolerance testing, and to explore the pathophysiological characteristics of PPDM-C which provide evidence for the…
- Conditions
- Chronic Pancreatitis, Pancreatogenic Type 3C Diabetes Mellitus, Diabetes Mellitus, Oral Glucose Tolerance Test
- Trial name
- NCT05989867
- Testing
- blood test, Continuous Glucose Monitor
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Changhai Hospital
CD70-positive Advanced Urologic Neoplasms
Anti-CD70 CAR-T Cell Injection in Patients With CD70-positive Advanced Urologic Neoplasms
This is a single-arm, open-label, exploratory clinical study to evaluate the safety, tolerability and preliminary efficacy of Anti-CD70 CAR-T cell injection in patients with CD70-positive Advanced Urologic Neoplasms.
- Trial name
- NCT05990621
- Testing
- Anti-CD70 CAR-T cells
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Changhai Hospital
Metastatic Pancreatic Cancer
Implantation of iodine125-Seeds Combined With Chemotherapy in the Treatment of Metastatic Pancreatic Carcinoma
The goal of this clinical trial is to evaluate the clinical efficacy and safety of endoscopic ultrasonography (EUS)-guided radioactive iodine 125 seeds in combination with AG regimen chemotherapy for the treatment of metastatic…
- Trial name
- NCT05869474
- Testing
- Iodine125-Seeds implantation, Gem/nab-P Chemotherapy
- Where
- China
- Volunteers
- 206 people
- Sponsor
- Changhai Hospital
ICAS - Intracranial Atherosclerosis
IntraCranial Angiography-derived Fraction Flow-guided Percutaneous Transluminal Angioplasty and Stenting Versus Medical Therapy (ICAS-MT)
A multicenter, open-label, blinded-endpoint, prospective, randomized controlled clinical trial with an "all comers" design.
- Trial name
- NCT05974033
- Testing
- Stenting plus medical therapy, Medical therapy alone
- Volunteers
- 536 people
- Sponsor
- Changhai Hospital
Liver Cirrhosis, Portal Hypertension
Accuracy of Magnetically Maneuvered Capsule Endoscopy for Detection of EGV in Patients With Cirrhosis
This is a diagnostic accuracy study. Eligible individuals will be enrolled and asked to undergo ds-MCE and EGD examinations. EGD is the reference standard against which ds-MCE is compared, and it will be performed within 48 hours…
- Conditions
- Liver Cirrhosis, Portal Hypertension, Esophageal Varices, Gastric Varix
- Trial name
- NCT03748563
- Testing
- ds-MCE and EGD
- Where
- 14 sites in China
- Volunteers
- 607 people
- Sponsor
- Changhai Hospital
Gastric Disease, Capsule Endoscopy
The Usage of Soda-Water in Gastric Preparation for Magnetically Controlled Capsule Endoscopy
Magnetically controlled capsule endoscopy (MCE) is a noninvasive technique (90.4% sensitivity, 94.7% specificity and 93.4% accuracy) without requiring sedation or air insufflation, which makes it welcomed by most of participants.
- Trial name
- NCT04479423
- Testing
- Soda-water instead of pure water to observe gastric filling
- Where
- China
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Obesity
MCE for Gastric Examination in Obese People
This retrospective study aimed to evaluate the feasibility and safety of MCE for the detection of gastric disease in obese people.
- Trial name
- NCT05909124
- Testing
- MCE
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Relapsed or Refractory B-cell Lymphoma
A Study of Secondary Infusion of Relmacabtagene Autoleucel Injection for Relapsed or Refractory B-cell Lymphoma
To evaluate the efficacy and safety of post-marketing Regiorense injection secondary infusion in the treatment of adult patients with relapsed or refractory B-cell lymphoma.
- Trial name
- NCT05814848
- Testing
- Relmacabtagene Autoleucel Injection
- Volunteers
- 13 people
- Sponsor
- Changhai Hospital
Bile Duct Stenosis
"eyeMax Insight" Cholangioscopy for Unexplained Bile Duct Stenosis
When clinical doctors cannot diagnose the cause of biliary stricture after comprehensive laboratory and imaging examinations, it is collectively referred to as unexplained bile duct stenosis.
- Trial name
- NCT05905744
- Testing
- cholangioscopy
- Volunteers
- 157 people
- Sponsor
- Changhai Hospital
Inflammatory Bowel Diseases
Clinical Study of Vitamin B5 in Adjuvant Treatment of IBD
Patients with IBD are randomized to oral administration of vitamin B5 and placebo based on the standard treatment, exploring whether Vitamin B5 can increase the clinical remission rate of IBD patients and improve the treatment…
- Trial name
- NCT05701501
- Testing
- Vitamin B5 Tablets
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Changhai Hospital
Hematuria, Urothelial Carcinoma
UroCAD for Hematuria Evaluation--A Prospective, Multi-center Study
Hematuria is recognized as an important sigh of potential urinary tract malignancy. Therefore, understanding the disease processes and discovering the potential urothelial carcinoma (UC) underlying this important sign is…
- Trial name
- NCT05893316
- Testing
- urine sample collection
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Changhai Hospital
Chronic Pancreatitis
Balloon Catheter vs. Basket Catheter in Pancreatic Duct Stone Clearance
The aim of the study is to compare the safety and efficacy of the basket catheter with that of the balloon catheter for endoscopic extraction of pancreatic stones.
- Trial name
- NCT05888012
- Testing
- basket catheter, balloon catheter
- Where
- China
- Volunteers
- 6,493 people
- Sponsor
- Changhai Hospital
Chronic Pancreatitis, Diabetes Mellitus
An Observational Study on Post-chronic Pancreatitis Diabetes Mellitus
To explore the risk factors influencing glycemic status, optimized treatment, and prognosis of post-chronic pancreatitis diabetes mellitus (PPDM-C).
- Trial name
- NCT05764629
- Testing
- blood test, pharmacologic approaches to glycemic treatment
- Where
- China
- Volunteers
- 324 people
- Sponsor
- Changhai Hospital
Pancreatic Cancer
Re-irradiation With Stereotactic Body Radiotherapy for Relapsed Pancreatic Cancer
The safety and efficacy of re-irradiation with stereotactic body radiotherapy for relapsed pancreatic cancer will be evaluated.
- Trial name
- NCT02745847
- Testing
- Re-irradiation with SBRT
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Changhai Hospital
Coronary Artery Disease, Carotid Plaque
Association Between Carotid Plaque Length and Cardiovascular Outcomes
This multicenter study involved 5 hospitals (Changhai Hospital; Yueyang Hospital of Shanghai University of Traditional Chinese Medicine; Gongli Hospital; Putuo Hospital of Shanghai University of Traditional Chinese Medicine; No.
- Trial name
- NCT05843487
- Where
- 5 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Changhai Hospital
Advanced Solid Tumor
A Study of IMC008 for Advanced Solid Tumors
An open label, multi-center, dose-escalating study to evaluate the safety and preliminary efficacy of IMC008 in CLDN18.2 positive advanced solid tumors.
- Trial name
- NCT05837299
- Testing
- IMC008
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Changhai Hospital