Clinical trials: open to volunteers, sponsored by Changhai Hospital
Malignant Gastric Outlet Obstruction
Prophylactic PPI Use After EUS-GE Procedure
This study aims to compare the 6-month cumulative incidence of mucosal erosion or ulcer involving the anastomosis and LAMS flange in patients with and without 6-month prophylactic PPI treatment following EUS-GE, and to assess…
- Trial name
- NCT07896577
- Testing
- Esomeprazole
- Volunteers
- 273 people
- Sponsor
- Changhai Hospital
Aortic Arch Aneurysm, Aortic Arch Pseudoaneurysm
Triple Branched Stent Graft System for Aortic Arch Lesions
The goal of this clinical trial is to evaluate the safety and efficacy of the Triple Branched Covered Stent Graft System in treating aortic arch lesions.
- Conditions
- Aortic Arch Aneurysm, Aortic Arch Pseudoaneurysm, Aortic Arch Ulcer
- Trial name
- TRACE (NCT07067840)
- Testing
- Treated with the triple branched stent graft system
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Changhai Hospital
Health Adults
Sodium Bicarbonate Solution Enhances Lens Cleanliness in Magnetically Controlled Capsule Endoscopy
Magnetically controlled capsule endoscopy (MCE) is a noninvasive alternative to conventional gastroscopy with comparable diagnostic accuracy.
- Trial name
- NCT07877506
- Testing
- Sodium Bicarbonate Solution
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
MSS-type Low Rectal Cancer，Neoadjuvant Chemoradiotherapy, QL1706
Neoadjuvant Chemoradiotherapy Combined With QL1706 for MSS-Type Low-Rectal Cancer
he goal of this prospective, exploratory clinical trial is to learn if neoadjuvant chemoradiotherapy combined with QL1706 (a dual PD-1/CTLA-4 antibody) can effectively treat in patients with MSS-type low rectal cancer (tumor…
- Trial name
- NCT07866313
- Testing
- Neoadjuvant short-term radiotherapy and chemotherapy + iparomlimab and tuvonralimab, Neoadjuvant long-term radiotherapy and chemotherapy + iparomlimab and tuvonralimab
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Changhai Hospital
Painless Chronic Pancreatitis
Endotherapy and/or Extracorporeal Shockwave Lithotripsy for Painless Chronic Pancreatitis
Chronic pancreatitis (CP) is caused by factors such as genetics and the environment, leading to the destruction of pancreatic tissue, infiltration of inflammatory cells, and progressive fibrosis of the pancreas.
- Trial name
- PCP (NCT07074379)
- Testing
- Lifestyle modifications, Pancreatic enzyme replacement therapy (PERT) and glycemic control therapy, Endoscopic Retrograde Cholangiopancreatography (ERCP) and/or Extracorporeal Shockwave Lithotripsy (ESWL)
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Changhai Hospital
Acute Ischemic Stroke, Intracranial Arterial Stenosis
Post-Market Active Surveillance and Health Economic Evaluation of Cerebrovascular Diagnostic and Therapeutic Devices
The research focuses on "post-market active surveillance and health economic evaluation of non-pharmacological therapies and innovative cerebrovascular diagnostic and therapeutic devices".
- Conditions
- Acute Ischemic Stroke, Intracranial Arterial Stenosis, Extracranial Arterial Stenosis, Intracranial Aneurysms
- Trial name
- NCT07828379
- Testing
- Endovascular Treatment for Acute Ischemic Stroke
- Volunteers
- 2,000 people
- Sponsor
- Changhai Hospital
Crohn's Disease (CD), Ulcerative Colitis (UC)
Accurately Profiling the Changes and Functions of Key Microflora in the Whole Intestinal Microenvironment Based on the Visual Sampling Capsule Endoscopy in Patients With Inflammatory Bowel Disease
This is a prospective, single-center, observational cohort study that will enroll 250 participants: 50 with active Crohn's disease, 50 with Crohn's disease in remission, 50 with active ulcerative colitis, 50 with ulcerative…
- Trial name
- NCT07799506
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Acute Uncomplicated Appendicitis
Direct Visualization ERAT Versus Laparoscopic Appendectomy in Adults With Acute Uncomplicated Appendicitis
This study compares two ways of treating acute uncomplicated appendicitis, which is a mild form of appendicitis. In the Direct Visualization ERAT group, participants will receive Endoscopic Retrograde Appendicitis Therapy (ERAT).
- Trial name
- E-APPEND (NCT07230379)
- Testing
- Direct Visualization Endoscopic Retrograde Appendicitis Therapy, Laparoscopic appendectomy
- Where
- 14 sites in China
- Volunteers
- 376 people
- Sponsor
- Changhai Hospital
Chronic Pancreatitis, Pancreatic Cancer
Blood Biomarkers and Gut Microbiota for Pancreatic Cancer Risk in Chronic Pancreatitis
The goal of this observational study is to learn more about pancreatic cancer risk in people with chronic pancreatitis. Researchers will study blood markers and gut microorganisms, which are bacteria and other microbes living in…
- Trial name
- NCT07762950
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Carotid Artery Stenosis
A Cohort Study Comparing PCSK9 Inhibitor Plus Statin With Statin Monotherapy for Carotid Artery Stenosis
A multicenter cohort study
- Trial name
- TRIP-CAS (NCT07036991)
- Testing
- PCSK9 inhibitor (biweekly injections) + Rosuvastatin/Atorvastatin ± Ezetimibe, Rosuvastatin/Atorvastatin ± Ezetimibe
- Where
- China
- Volunteers
- 406 people
- Sponsor
- Changhai Hospital
Bladder Cancer
Toripalimab Combined With BCG Perfusion for the Treatment of HR-NMIBC After TURBT Surgery Exploration
This is a single-center, prospective, open-label, non-randomized clinical study initiated and conducted by the Department of Urology, Shanghai Changhai Hospital.
- Trial name
- MARINE-01 (NCT07307456)
- Testing
- Treatment with toripalimab combined with BCG perfusion following transurethral resection of bladder tumor (TURBT)
- Where
- China
- Volunteers
- 31 people
- Sponsor
- Changhai Hospital
Atrial Fibrillation (AF), Cardiac Events
Prevention of Atrial Fibrillation After Cardiac Surgery by Pericardiotomy
PRINCE-CH is a multicentre, randomized controlled trial which evaluates the effectiveness and safety of posterior pericardiotomy in preventing POAF after cardiac surgery in Chinese population.
- Conditions
- Atrial Fibrillation (AF), Cardiac Events, Pericardial Effusion
- Trial name
- PRINCE-CH (NCT06728826)
- Testing
- Posterior pericardiotomy
- Where
- China
- Volunteers
- 650 people
- Sponsor
- Changhai Hospital
Pancreatic Cancer
Neoadjuvant HRS-4642 Plus Chemotherapy With or Without Immunotherapy for Pancreatic Cancer
To evaluate the safety and efficacy of neoadjuvant HRS-4642 plus chemotherapy with or without adebrelimab in patients with pancreatic ductal adenocarcinoma.
- Trial name
- NCT07691593
- Testing
- HRS-4642+NALIRIFOX, HRS-4642+NALIRIFOX+Adebrelimab
- Volunteers
- 60 people
- Sponsor
- Changhai Hospital
Sessile Serrated Lesion, Serrated Polyp
Study on the Association Between Serrated Polyps and Metachronous Advanced Colorectal Neoplastic Lesions
This study aims to explore the risk factors associated with the development of ACN and same-site ACN in patients with SP, thereby informing the optimization of clinical surveillance strategies
- Trial name
- NCT07678788
- Volunteers
- 750 people
- Sponsor
- Changhai Hospital
Nephropathy
An Exploratory Clinical Study of Anti-CD19 CAR NK Cell (KN5501) in the Treatment of Relapsed/Refractory Immune Nephropathy
A single arm, open-label pilot study is designed to determine the safety and effectiveness of anti-CD19 CAR NK cell injection (KN5501) in patients with immune nephropathy.
- Trial name
- NCT06469190
- Testing
- anti-CD19 CAR NK cells
- Where
- China
- Volunteers
- 36 people
- Sponsor
- Changhai Hospital
Chronic Pancreatitis, Pancreatic Cancer
Immune Repertoire Decoding for Chronic Pancreatitis-to-Pancreatic Cancer Risk Stratification
This study will follow people with chronic pancreatitis, people with pancreatic cancer, and healthy volunteers. The goal is to better understand why some people with chronic pancreatitis may later develop pancreatic cancer.
- Trial name
- NCT07612566
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Sessile Serrated Lesion
Impact of Acetic Acid-Indigo Carmine Chromocolonoscopy on Proximal Sessile Serrated Lesions
Chromocolonoscopy with acetic acid and indigo carmine has shown promise for improving the detection of sessile serrated lesions (SSLs), the precursor lesions responsible for a substantial proportion of interval colorectal…
- Trial name
- ACID-SSL (NCT07601217)
- Testing
- Acetic Acid-Indigo Carmine Chromocolonoscopy Group
- Where
- China
- Volunteers
- 2,689 people
- Sponsor
- Changhai Hospital
Sessile Serrated Lesion
Polyp Pretreatment Device for SSL Diagnosis
Colorectal cancer (CRC) is the third most common malignancy globally. Sessile serrated lesions (SSLs) account for 15-30% of CRC via the serrated pathway.
- Trial name
- NCT07601230
- Testing
- Polyp Pretreatment Device
- Volunteers
- 1,156 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Colonoscopy: Bowel Preparation, IBD - Inflammatory Bowel Disease
Pre-Packaged Low-Residue Diet Assisting Bowel Preparation in Patients With Inflammatory Bowel Disease
The primary objectives of this study are as follows: 1.To evaluate the efficacy of Maifu Changqing® Complete Nutritional Formula Powder in bowel preparation for colonoscopy among inflammatory bowel disease (IBD) patients;2.To…
- Trial name
- NCT07165470
- Testing
- pre-packaged low-residue diet for bowel preparation
- Where
- 2 sites in China
- Volunteers
- 500 people
- Sponsor
- Changhai Hospital
IBD (Inflammatory Bowel Disease), Colonoscopy
Analysis of Factors Influencing the Quality of Bowel Preparation Before Colonoscopy in IBD Patients
The primary objectives of this project are twofold. On the one hand, it aims to investigate the current status of bowel preparation protocols and their quality in IBD patients undergoing colonoscopy, particularly focusing on the…
- Conditions
- IBD (Inflammatory Bowel Disease), Colonoscopy, Colonoscopy: Bowel Preparation
- Trial name
- NCT07335705
- Testing
- Standard Pre-colonoscopy Bowel Preparation Protocol
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital