Clinical trials: sponsored by Children's Hospital Los Angeles
Stem Cell Transplantation
Problem-Solving Skills Training for Parents of Children Undergoing Hematopoietic Stem Cell Transplantation: A Feasibility Study
The goal of this clinical trial is to test the feasibility and acceptability of the Bright IDEAS problem-solving skills training (PSST) intervention for parents of children undergoing hematopoietic stem cell transplantation…
- Trial name
- NCT07219524
- Testing
- Bright Ideas Problem-Solving Skills Training
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Children's Hospital Los Angeles
Low-Grade Gliomas, Malignant Neoplasms, Brain
Study of MEK162 for Children With Low-Grade Gliomas
The goal of this clinical trial is to study the drug MEK162 in children with a brain tumor call low-grade glioma, as well as in children with other tumors in which a specific growth signal is abnormally turned on.
- Conditions
- Low-Grade Gliomas, Malignant Neoplasms, Brain, Soft Tissue Neoplasms
- Trial name
- NCT02285439
- Testing
- MEK162
- Where
- 15 sites in United States
- Volunteers
- 105 people
- Sponsor
- Children's Hospital Los Angeles
Ventilation Therapy; Complications, Diaphragm Disease
Real-time Effort Driven VENTilator Management
This study is a Phase II controlled clinical trial that will obtain comprehensive, serial assessments of respiratory muscle strength and architecture to understand the evolution of ventilator-induced respiratory muscle weakness…
- Conditions
- Ventilation Therapy; Complications, Diaphragm Disease, Pediatric Respiratory Diseases
- Trial name
- REDvent (NCT03266016)
- Testing
- Computerized Ventilator Protocol, Esophageal Manometry, Respiratory Inductance Plethysmography (RIP)
- Where
- United States
- Volunteers
- 248 people
- Sponsor
- Children's Hospital Los Angeles
Congenital Heart Disease
Parent Navigator Program (PNP) to Improve Outcomes in Latino/x Children and Parents
The goal of this clinical trial is to see if a Parent Navigator Program (PNP) is helpful for Latino/x parents of babies with congenital heart disease (CHD) to get connected to developmental follow-up services.
- Trial name
- NCT07023367
- Testing
- Parent Navigator Program, Standard of Care
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Hospital Los Angeles
Obesity, Childhood
Group Telehealth Weight Management Visits for Adolescents With Obesity
Summary Description The goal of this intervention study is to test how well does a weight management curriculum work in virtual group-based medical visits (telehealth) for the treatment of adolescents with obesity.
- Trial name
- NCT03508622
- Testing
- Telehealth group sessions, Empower clinic
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Children's Hospital Los Angeles
Anesthesia; Reaction, Anesthesia
Individual Cerebral Hemodynamic Oxygenation Relationships - ICHOR 4
The goal of this clinical trial is to understand whether there are differences in the cerebral blood flow, and oxygen metabolism affected by two types of anesthesia: Propofol or Dexmedetomidine.
- Trial name
- ICHOR (NCT07103616)
- Testing
- Randomization of Propofol or Dexmedetomidine
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Leukemia
Effects of Using a Storybook, to Explain Leukemia to Children Versus the Standard Child Life Intervention, on Parental Stress.
The goal of this clinical trial is to measure the effects of using a storybook versus standard child life intervention with parents of children newly diagnosed with leukemia on parental stress.
- Trial name
- NCT06360718
- Testing
- "Who is Luke Eemia?" Storybook
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Medication Adherence
Adaptive Cell Phone Support (ACPS)
The goal of this pilot clinical trial is to test a mobile health intervention for promoting medication adherence in a population of adolescents and young adults with chronic health conditions.
- Trial name
- ACPS (NCT07064824)
- Testing
- Adaptive Cell Phone Support, Computer-Delivered Cell Phone Support, Automated Text Reminders
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Children's Hospital Los Angeles
Single-ventricle, Stenosis
Transcatheter Fontan Stenting: Impact on Hepatic Stiffness and Exercise Capacity
The goal of this observational study is to assess the clinical impact following Fontan stent placement for extracardiac Fontan conduit (EFC) stenosis in patients with single-ventricle Fontan-palliated patients ages 12-21 years…
- Trial name
- NCT07073612
- Testing
- Cardiopulmonary Exercise Testing (CPET), Shear Wave Elastography Scan
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's Hospital Los Angeles
Infant Development
Mobile Health Intervention to Promote Positive Infant Health Outcomes in Guatemala
Promoting optimal development for children at risk in low- and middle-income countries (LMICs) is an important global health priority.
- Trial name
- NCT05106894
- Testing
- smartphone application to promote nurturing care, printed caregiving materials
- Where
- Guatemala
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Chronic Conditions, Multiple
Perceptions of LARC Among AYA With Chronic Illness
The investigators aim to perform a qualitative study exploring attitudes and perceived barriers to Long Acting Reversible Contraception (LARC), both implants and IUDs, among adolescent and young adults (AYA) with chronic illness…
- Trial name
- LARC (NCT05000489)
- Testing
- No intervention being administered
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Children's Hospital Los Angeles
Respiratory Distress Syndrome, Adult, Ventilator-Induced Lung Injury
Long Term Follow up of Children Enrolled in the REDvent Study
This is a prospective observational follow-up study of children enrolled in a single center randomized controlled trial (REDvent).
- Conditions
- Respiratory Distress Syndrome, Adult, Ventilator-Induced Lung Injury, Neurocognitive Dysfunction, Quality of Life
- Trial name
- NCT03709199
- Testing
- Ventilation Inhomogeneity, Diaphragm Ultrasound, Respiratory Inductance Plethysmography
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- Children's Hospital Los Angeles
Anxiety Disorders
Fluoxetine vs CBT in Childhood Anxiety Disorders
Treatment of every child with anxiety disorder begins with the question of which treatment to start first. Both fluoxetine and CBT have strong empirical support, but few studies have compared their initial effectiveness…
- Trial name
- SMART (NCT04760275)
- Testing
- Fluoxetine, Cognitive Behavioral Therapy (CBT)
- Where
- United States
- Volunteers
- 316 people
- Sponsor
- Children's Hospital Los Angeles
Type 1 Diabetes
Team Clinic: Virtual Expansion of an Innovative Multi-Disciplinary Care Model for Adolescents and Young Adults With Type 1 Diabetes
Team Clinic is a new care approach for middle and high school aged patients living with T1D and their families. This study is a 15-month randomized control trial (RCT) that consists of Virtual Team Clinic Care appointments…
- Trial name
- NCT04190368
- Testing
- Team Clinic Care, Standard Care
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Children's Hospital Los Angeles
Pediatric Femur Fracture
Femur Fracture: Functional Bracing vs. Hip Spica Cast
Spica casting is the current standard of care when treating pediatric diaphyseal femur fractures in the 0-5 year age group. A study conducted by Kramer et al.
- Trial name
- NCT03948139
- Testing
- Functional Brace, Hip Spica Cast
- Where
- 2 sites in United States
- Volunteers
- 92 people
- Sponsor
- Children's Hospital Los Angeles
Neuromuscular Scoliosis, Adolescent Idiopathic Scoliosis
Postoperative Steroid Use in Adolescent Idiopathic Scoliosis and Neuromuscular Scoliosis Patients
The goal of this randomized clinical trial is to compare the immediate use of steroids after surgery for accelerated discharge in adolescent idiopathic scoliosis and neuromuscular scoliosis after a posterior spinal fusion.
- Trial name
- NCT06023043
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Children's Hospital Los Angeles
Cardiovascular Complication, Chemotherapeutic Toxicity
At-Home Cardiac Rehabilitation for Adolescents at Risk for Heart Failure
The goal of this clinical trial is to explore the impact that an at-home cardio-oncology rehabilitation (CORE) may have on short-term cardiovascular fitness and psychosocial wellness in pediatric cancer survivors.
- Trial name
- NCT06826534
- Testing
- Cardio-oncology rehabilitation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's Hospital Los Angeles
Congenital Upper Limb Differences
Adaptive Rock Climbing
The goal of this clinical trial is to assess changes in functional and psychosocial outcomes following a 12-week adaptive rock-climbing program for children with congenital upper limb differences.
- Trial name
- NCT06507072
- Testing
- Adaptive Rock Climbing Program
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's Hospital Los Angeles
Pediatric Acute Respiratory Distress Syndrome
Pediatric Positive End Expiratory Pressure (PEEP) Titration Using Electrical Impedence Tomography (EIT)
The goal of this clinical trial is to perform a PEEP titration protocol and use EIT to identify the optimal PEEP at which lung overdistention and collapse are most effectively balanced.
- Trial name
- NCT06684119
- Testing
- Electrical Impedance Tomography positive end-expiratory pressure titration
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Children's Hospital Los Angeles
Cerebral Palsy, Mobile Phone Use
Using Augmented Reality to Promote Physical Activity in Children With Cerebral Palsy
Children with cerebral palsy (CP), Gross Motor Functional Classification Scale (GMFCS) I-II will be recruited to participate in a home based physical activity intervention for 4 weeks.
- Conditions
- Cerebral Palsy, Mobile Phone Use, Pediatric ALL, Physical Disability
- Trial name
- NCT06096272
- Testing
- Augment Reality Exergames
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Children's Hospital Los Angeles