Clinical trials: sponsored by Children's National Research Institute
Sickle Cell Disease
Sickle Cell Disease Transplant Using a Nonmyeloablative Approach for Patients With Anti-donor Red Cell Antibody
This multicenter prospective study seeks to determine if daratumumab given, prior to HLA-identical sibling donor transplantation using alemtuzumab, low dose total-body irradiation, and sirolimus, can prevent pure red blood cell…
- Trial name
- SUN-RAY (NCT06358638)
- Testing
- Daratumumab, Alemtuzumab, Sirolimus
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Children's National Research Institute
Infections, Pain
Augmented Reality For MRI-Guided Interventions
The purpose of this study is to determine feasibility and safety of using an augmented reality system in patients undergoing MRI-Guided needle procedures.
- Conditions
- Infections, Pain, Diagnosis
- Trial name
- NCT06224933
- Testing
- Augmented Reality System
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Gastroenterology Surgery, Tube Feeding
Efficacy of a Novel Prototype Gastrostomy Tube Anchor Dressing
This is a single-center prospective study evaluating the efficacy of a prototype gastrostomy anchor dressing for use with button gastrostomy tubes.
- Trial name
- Tube Anchor (NCT07115134)
- Testing
- Bearables Gastrostomy Tube Dressing
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Children's National Research Institute
Perinatal Depression, Perinatal Anxiety
The DC Mother-Infant Behavioral Wellness Program
This randomized controlled study will examine the effectiveness of patient navigation with culturally adapted cognitive-behavioral interventions and peer support groups for low-income Black/of African Descent pregnant women who…
- Conditions
- Perinatal Depression, Perinatal Anxiety, Prenatal Stress
- Trial name
- NCT05345834
- Testing
- Patient Navigation, Adapted Cognitive-Behavioral Therapy
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
New Daily Persistent Headache (NDPH)
Nerivio Device for Treatment of New Daily Headache Persistence (NDHP)
The goal of this study is to examine the effects of the Remote Electrical Neuromodulation (REN) device on adolescents ages 12-17 who have been diagnosed with New Daily Persistent Headache (NDPH).
- Trial name
- NCT05310227
- Testing
- Nerivio
- Where
- United States
- Sponsor
- Children's National Research Institute
Asthma in Children, Atopy
Omalizumab Before Onset of Exacerbations
OBOE is a prospective, pilot, parallel group RCT with the overall aim of examining the effect of a single dose of anti-IgE (omalizumab) vs.
- Conditions
- Asthma in Children, Atopy, Viral Upper Respiratory Infection
- Trial name
- OBOE (NCT05332067)
- Testing
- Omalizumab
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Children's National Research Institute
Food Allergy in Children
Evaluation of The Food Allergy Mastery Program
The proposed research project will evaluate a novel behavioral intervention that promotes early adolescent food allergy self-management and adjustment through 1) food allergy education, 2) problem-solving, communication…
- Trial name
- NCT06034678
- Testing
- Food Allergy Mastery Program
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Children's National Research Institute
Osteoid Osteoma
MR-HIFU Treatment of Painful Osteoid Osteoma
To determine treatment safety and efficacy of MR-HIFU ablation of painful Osteoid Osteoma (OO) in children and young adults.
- Trial name
- NCT04658771
- Testing
- MR-HIFU treatment
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Children's National Research Institute
Very Preterm Maturity of Infant, Very Low Birth Weight Infant
Individualized Nutrition to Optimize Preterm Infant Growth and Neurodevelopment
Human milk has several well-established benefits but does not adequately meet the increased nutritional demands of the growing preterm infant, necessitating additional nutrient supplementation in a process known as fortification.
- Trial name
- THRIVE (NCT06266455)
- Testing
- Standardized Fortification, Adjustable Fortification
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Children's National Research Institute
Celiac Disease
Behavioral Intervention for Celiac Disease
Celiac disease (CD) is a chronic autoimmune condition whose only currently available treatment is a strict, burdensome gluten-free diet (GFD).
- Trial name
- NCT05204446
- Testing
- GROW Project, GROW+ Project
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Children's National Research Institute
Type 1 Diabetes (T1D)
Pragmatic Clinic-Based Trial of a Mindfulness Based Intervention for Mood Concerns in Youth With Type 1 Diabetes
Type 1 diabetes (T1D) is a common chronic illness among children requiring a high degree of self-management for good glycemic control.
- Trial name
- BREATHE-T1D (NCT06618027)
- Testing
- BREATHE-T1D, HealthEd-T1D
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Children's National Research Institute
Rhabdomyolysis
Dexamethasone Use in Pediatric Rhabdomyolysis Patients in Addition to Standard Protocols
There is a significant unmet need for optimized treatment in rhabdomyolysis. There are few prospective interventional studies on treatment for rhabdomyolysis, a condition which affects diverse and underrepresented populations at…
- Trial name
- NCT06429982
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Children's National Research Institute
Zika Virus, Congenital Zika Syndrome
Neurodevelopmental Outcomes in ZIKV-Exposed Children
In this study the investigators will follow the neurodevelopmental outcome of children with in utero ZIKV exposure who do not have microcephaly or severe abnormalities consistent with Congenital Zika Syndrome.
- Conditions
- Zika Virus, Congenital Zika Syndrome, Congenital Infection, Child Development
- Trial name
- NCT04398901
- Testing
- Neurodevelopmental assessments
- Where
- 2 sites in United States, Colombia
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Growth Disorders
Growth Hormone in a Patient With a Dominant-Negative GHR Mutation
This is a prospective interventional study designed for a single patient with a dominant-negative mutation in the growth hormone receptor gene (GHR) which results in increased levels of growth hormone binding protein (GHBP).
- Trial name
- NCT05382637
- Testing
- Somatropin
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Children's National Research Institute
Rare Diseases
FACE for Children With Rare Diseases
Children with ultra-rare or complex rare diseases are routinely excluded from research studies because of their conditions, creating a health disparity.
- Trial name
- FACE-Rare (NCT04855734)
- Testing
- FAmily CEntered (FACE) pACP Intervention
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Children's National Research Institute
Sickle Cell Disease
Advancing Feasibility and Acceptability of Digital Cognitive Rehabilitation in Sickle Cell Disease
This is a single site nonrandomized pilot clinical trial of the feasibility, acceptability, and efficacy of a combination treatment involving digital Cogmed working memory skills training, social support components, and memory…
- Trial name
- ALL IN (NCT06770010)
- Testing
- Cogmed+
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Children's National Research Institute
Cerebral Palsy
PedBot Ankle Rehablitation
The primary objective of the study is to determine engagement with use and adherence to a home exercise program with our PedBotHome ankle rehabilitation device.
- Trial name
- NCT05825508
- Testing
- ankle robot
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's National Research Institute
type1diabetes
Feasibility Trial of a Mindfulness Based Intervention in Youth With Type 1 Diabetes
Type 1 diabetes (T1D) is one of the most common chronic illnesses of childhood. The involved treatment regimen, including daily insulin administration/pump management, frequent blood glucose checks, and careful track-ing of food…
- Trial name
- BREATHE-T1D (NCT05268393)
- Testing
- BREATHE-T1D
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Children's National Research Institute
Sickle Cell Disease, Attention Deficit
Feasibility and Efficacy of Attentional-Control Training in Sickle Cell Disease
Children with sickle cell disease (SCD) exhibit significantly reduced cognitive functioning (often difficulties with attention) compared to peers and siblings without SCD.
- Conditions
- Sickle Cell Disease, Attention Deficit, Cognitive Deficit in Attention
- Trial name
- ACT (NCT05099874)
- Testing
- EndeavorRx
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's National Research Institute
Pediatric Cancer, Pediatric ALL
Feasibility/Acceptability of Attentional-Control Training in Survivors
This is a multicenter pilot randomized controlled trial, with an active control condition, of the feasibility, acceptability, and preliminary efficacy of EndeavorRx in a cohort of survivors of acute lymphoblastic leukemia or…
- Conditions
- Pediatric Cancer, Pediatric ALL, Pediatric Brain Tumor, Attention Difficulties
- Trial name
- FAACTS (NCT05528939)
- Testing
- EndeavorRx, Control video game
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Children's National Research Institute