Clinical trials: sponsored by China National Center for Cardiovascular Diseases
LVAD (Left Ventricular Assist Device) Thrombosis, LVAD
STudy of Aspirin Removal in Patients Supported by the Fully Magnetically Levitated CH-VAD Pump
This multi-center, prospective, randomized, double-blinded, placebo-controlled study aims to investigate whether withdrawal of aspirin from the antithrombotic regimen in patients supported with the CH-VAD pump is non-inferior to…
- Conditions
- LVAD (Left Ventricular Assist Device) Thrombosis, LVAD, LVAD (Left Ventricular Assist Device), LVAD-related GI Bleed
- Trial name
- STAR (NCT07644247)
- Testing
- Warfarin (INR 2-3) with aspirin
- Volunteers
- 370 people
- Sponsor
- China National Center for Cardiovascular Diseases
Atrial Fibrillation (AF)
Discontinuation of Anticoagulations After Successful Catheter Ablation of Atrial Fibrillation
The DESTINATION Study investigates whether anticoagulation therapy is necessary after successful catheter ablation (CA) for atrial fibrillation (AF).
- Trial name
- DESTINATION (NCT06615596)
- Testing
- discontinue anticoagulation therapy, Anticoagulant drugs, Catheter Ablation
- Where
- 12 sites in United States, China
- Volunteers
- 3,160 people
- Sponsor
- China National Center for Cardiovascular Diseases
AKI - Acute Kidney Injury, Cardiac Surgical Procedures
rhBNP for Prevention of Cardiac Surgery-Associated Acute Kidney Injury (CSA-AKI)
Cardiac surgery-associated acute kidney injury (CSA-AKI) is a common and serious perioperative complication, independently associated with prolonged hospitalization, increased mortality, and progression to chronic kidney disease.
- Conditions
- AKI - Acute Kidney Injury, Cardiac Surgical Procedures, Cardiopulmonary Bypass
- Trial name
- PROTECT-CS (NCT07617675)
- Testing
- Recombinant Human Brain Natriuretic Peptide (rhBNP)
- Where
- China
- Volunteers
- 694 people
- Sponsor
- China National Center for Cardiovascular Diseases
Atrial Fibrillation (AF), Atrial Fibrillation Ablation
Pulsed Field Ablation Outcomes With Efficacy and Randomization in Atrial Fibrillation (POWER-AF)
Atrial fibrillation (AF) is one of the most common arrhythmias in clinical practice. As of 2019, there were approximately 59.7 million patients with AF worldwide, including atrial flutter (AF).
- Conditions
- Atrial Fibrillation (AF), Atrial Fibrillation Ablation, Atrial Fibrillation Recurrent, Pulsed Field Ablation
- Trial name
- POWER-AF (NCT07601763)
- Testing
- Pulsed field ablation, Radiofrequency ablation alone, Pulsed field ablation system
- Where
- China
- Volunteers
- 1,574 people
- Sponsor
- China National Center for Cardiovascular Diseases
Cardiomyopathies, Cost
Healthcare Utilization and Costs Among Hospitalized Patients With Cardiomyopathy
Cardiomyopathy is the most common inherited cardiovascular disease, showing family aggregation, and it has a huge psychological and economic burden on family members.
- Trial name
- NCT06893731
- Where
- China
- Volunteers
- 15,764 people
- Sponsor
- China National Center for Cardiovascular Diseases
Atrial Fibrillation
A Study of Using CARTO SOUND™ FAM to Guide Pulsed Field Ablation for Atrial Fibrillation
This study is being done to see if a new method for treating a heart rhythm problem called paroxysmal atrial fibrillation (AFib) is safe and works well.
- Trial name
- CSPFA (NCT07572253)
- Testing
- CARTO SOUND™ FAM System with Varipulse™ PFA Catheter
- Volunteers
- 70 people
- Sponsor
- China National Center for Cardiovascular Diseases
Heart Failure
Effect of Finerenone on Myocardial Fibrosis and Cardiac Function in HFmrEF/HFpEF Patients
FINE-FOCUS study is a multicenter, randomized, double-blind, placebo-controlled, parallel-group trial to evaluate the effect of Finerenone versus placebo on myocardial fibrosis and cardiac structure/function as assessed by…
- Trial name
- FINE-FOCUS (NCT07583173)
- Testing
- Oral finerenone
- Where
- China
- Volunteers
- 104 people
- Sponsor
- China National Center for Cardiovascular Diseases
Hypertension
Study of a Comprehensive Intelligent Hypertension managEment SyStem
This cluster randomized controlled trial aims to evaluate the efficacy of a comprehensive intelligent hypertension management system (CHESS) in blood pressure lowering in primary health care (PHC) settings of China.
- Trial name
- CHESS (NCT05605418)
- Testing
- CHESS intervention
- Where
- China
- Volunteers
- 1,666 people
- Sponsor
- China National Center for Cardiovascular Diseases
Coronary Artery Disease, Coronary Stenosis
Retrospective Algorithm Validation of IVUS-FFR in Patients
This is a retrospective, single-center study to develop and validate an updated algorithm for computing fractional flow reserve from intravascular ultrasound images (IvusFFR v2.0).
- Conditions
- Coronary Artery Disease, Coronary Stenosis, Algorithm Validation for Fractional Flow Reserve Derived From Intravascular Ultrasound
- Trial name
- V-IVUS_FFR (NCT07551518)
- Testing
- No Intervention (Retrospective Data Analysis)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- China National Center for Cardiovascular Diseases
Aortic Stenosis, TAVI
Echo-Guided vs Fluoroscopy-Guided Transcatheter Aortic Valve Replacement in Patients With Aortic Stenosis（ECHO-TAVR）
Aortic stenosis (AS) is a common valvular heart disease whose prevalence increases markedly with age-approximately 2-4% in individuals aged 65 years and older, and up to 3.4% for severe AS in those over 75.
- Conditions
- Aortic Stenosis, TAVI, TAVI(Transcatheter Aortic Valve Implantation)
- Trial name
- ECHO-TAVR (NCT07317804)
- Testing
- Echocardiographic guidance, Fluoroscopic guidance
- Where
- China
- Volunteers
- 212 people
- Sponsor
- China National Center for Cardiovascular Diseases
M-health, Metabolic Syndrome
Exercise-Targeted Smart Lifestyle Management
To investigate the effects of simple dietary management and diet combined with exercise capacity-targeted intelligent lifestyle management on improving metabolic indicators in patients with overweight/obesity and metabolic…
- Conditions
- M-health, Metabolic Syndrome, Lifestyle Alteration, Lifestyle (Sedentary Behavior and Physical Activity)
- Trial name
- NCT07535333
- Testing
- Dietary Prescription, Personalized Exercise Prescription, Metabolic Syndrome Prevention and Education
- Volunteers
- 435 people
- Sponsor
- China National Center for Cardiovascular Diseases
Coronary Artery Bypass Graft (CABG)
Aortic No-Touch vs Partial Aortic Clamping in Off-Pump CABG
To explore surgical strategies that reduce perioperative neurologic complications in cardiovascular surgery, with the aim of improving perioperative outcomes and quality of life while reducing the socioeconomic burden.
- Trial name
- PROTECT-CABG (NCT07302659)
- Testing
- Aortic no-touch coronary artery bypass grafting (RIMA-SVG), Conventional off-pump CABG with partial clamping of the ascending aorta (Ao-SVG)
- Where
- 4 sites in China
- Volunteers
- 380 people
- Sponsor
- China National Center for Cardiovascular Diseases
Congenital Heart Disease, Complex Congenital Heart Disease
A Chinese Multicenter Study on Surgical Techniques and Outcomes Across the Lifespan in Congenital Heart Disease
The goal of this observational study is to learn about recovery after heart surgery for people with Complex Congenital Heart Disease (CCHD), build a comprehensive data platform for CCHD care across a person's whole life, and…
- Conditions
- Congenital Heart Disease, Complex Congenital Heart Disease, Surgery (Cardiac), Perioperative Care
- Trial name
- NCT07524998
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- China National Center for Cardiovascular Diseases
Acute Coronary Syndromes (ACS)
Sirolimus-Coated vs Paclitaxel-Coated DCBs in ACS Treatment
This study aims to investigate and compare the local inflammatory responses and plaque healing characteristics between sirolimus-coated and paclitaxel-coated coronary drug-coated balloons in patients with acute coronary syndrome.
- Trial name
- NCT07514988
- Testing
- Sirolimus-coated DCB, Paclitaxel-coated DCB
- Where
- China
- Volunteers
- 60 people
- Sponsor
- China National Center for Cardiovascular Diseases
Coronary Heart Disease, Acute Coronary Syndrome
A Study Evaluating the Vascular Healing and Neointimal Transformation at 1 Month After Implantation of BioFreedom™ Drug-coated Stents and the Xience Drug-eluting Stent System in Patients With Acute Coronary Syndrome and High Bleeding Risk Using Optical Coherence Tomography
BioFreedom™ is the world's first polymer-free drug-coated stent (DCS), utilizing a proprietary microstructured surface technology.
- Trial name
- NCT07230847
- Testing
- BioFreedom™, Xience
- Where
- China
- Volunteers
- 60 people
- Sponsor
- China National Center for Cardiovascular Diseases
Coronary Artery Disease, Artificial Intelligence (AI)
Performance of an OCR-Prompt-LLM Integrated Workflow for Extracting Multi-dimensional Clinical Data in Ischemic Heart Disease
This research aims to evaluate a comprehensive AI-driven workflow for both clinical data extraction and diagnostic classification in coronary artery disease (CAD).
- Conditions
- Coronary Artery Disease, Artificial Intelligence (AI), Data Collection
- Trial name
- OPAL-CAD (NCT07499830)
- Testing
- OCR-Prompt-LLM Information Extraction Workflow, Manual Clinical Data Review
- Where
- China
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- China National Center for Cardiovascular Diseases
Non-Valvular Atrial Fibrillation
Population Pharmacokinetics of Edoxaban in Chinese Patients With Non-Valvular Atrial Fibrillation
Based on the population pharmacokinetic data of Chinese patients with atrial fibrillation, the study will evaluate the suitability of the ENGAGE Population Pharmacokinetics model of edoxaban in patients with atrial fibrillation…
- Trial name
- NCT05320627
- Testing
- Edoxaban
- Where
- China
- Volunteers
- 150 people
- Sponsor
- China National Center for Cardiovascular Diseases
Obstructive Hypertrophic Cardiomyopathy (oHCM)
Ademetionine in Obstructive Hypertrophic Cardiomyopathy
This study is a multicenter, double-blind, randomized controlled Phase 2 trial designed to evaluate the safety and efficacy of Ademetionine in patients with obstructive hypertrophic cardiomyopathy (oHCM).
- Trial name
- NCT07367724
- Testing
- Ademetionine 1,4-Butanedisulfonate
- Where
- 3 sites in China
- Volunteers
- 44 people
- Sponsor
- China National Center for Cardiovascular Diseases
Pulmonary Arterial Hypertension
A Study on the Efficacy and Safety of Empagliflozin in the Treatment of Pulmonary Arterial Hypertension
The goal of this clinical trial is to learn if empagliflozin works to treat patients with pulmonary arterial hypertension. It will also learn about the safety of empagliflozin.
- Trial name
- NCT06554301
- Testing
- empagliflozin in treatment pulmonary aerterial hypertension
- Where
- China
- Volunteers
- 72 people
- Sponsor
- China National Center for Cardiovascular Diseases
Acute Kidney Disease
Predicting Post-Cardiac Surgery Acute Kidney Disease: A Machine Learning Approach
Renal injury after cardiac surgery is one of the common complications with high incidence rate, high risk of death and progression to chronic kidney disease (CKD).
- Trial name
- NCT07482683
- Where
- China
- Volunteers
- 820 people
- Sponsor
- China National Center for Cardiovascular Diseases