Clinical trials: sponsored by Columbia University
Syncope, Presyncope
Practical Approaches to Care in Emergency Syncope
Syncope, or transient loss of consciousness, is a common reason for visit to the Emergency Department and often leads to extensive testing and hospitalization.
- Trial name
- PACES (NCT04533425)
- Where
- 5 sites in United States
- Volunteers
- 1,297 people
- Sponsor
- Columbia University
Carpal Tunnel Syndrome
Lipografting Versus Steroid Injections for Treatment of Carpal Tunnel Syndrome
This study applies the regenerative properties of autologous fat transfer to treat mild to moderate carpal tunnel syndrome in comparison to the current standard of care, corticosteroid treatment.
- Trial name
- NCT03722303
- Testing
- Fat Injection, Steroid Injection
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Columbia University
CMV Viremia, Heart Transplant Infection
Valganciclovir vs. Letermovir for CMV Prophylaxis in Heart Transplant
The purpose of this study is to compare the safety and efficacy of letermovir with valganciclovir for prevention of Cytomegalovirus (CMV) viremia in moderate to high risk serostatus heart transplant recipients.
- Conditions
- CMV Viremia, Heart Transplant Infection, Heart Transplant Failure and Rejection
- Trial name
- VALET-CMV (NCT07079735)
- Testing
- Letermovir, Valganciclovir
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Columbia University
Osteoarthritis, Unicompartmental Knee Arthroplasty
Post-op Prednisone and Glucose Monitoring in TKA
This study compares the efficacy of a 5-day post-operative oral prednisone regimen (40 mg daily) with the standard intraoperative steroid regimen, focusing on pain, swelling, range of motion, opioid use, and glucose levels…
- Conditions
- Osteoarthritis, Unicompartmental Knee Arthroplasty, Total Hip Arthroplasty (THA)
- Trial name
- NCT07630896
- Testing
- Prednisone, Continuous Glucose Monitor, InkWell Health Tattoos
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Columbia University
Disc Herniation
Discogen for Low Back Pain
This study will be a double-blinded, two-arm, prospective, randomized controlled pilot feasibility study in 40 evaluable subjects (20 in each arm) at one study site within the United States.
- Trial name
- NCT06611397
- Testing
- Discogen Low pulsed ultrasound treatment
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Columbia University
Tuberculosis (TB), Tuberculosis Infection, Latent
Screening With Portable X-rays for Rapid Recognition of TB
SPOT-TB (Screening with Portable X-rays for rapid recOgniTion of TB) is a prospective study evaluating a community-based tuberculosis (TB) screening strategy for migrant populations in New York City.
- Conditions
- Tuberculosis (TB), Tuberculosis Infection, Latent, HIV (Human Immunodeficiency Virus)
- Trial name
- SPOT-TB (NCT07737275)
- Testing
- Mobile chest radiography for tuberculosis screening
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Columbia University
Human Papillomavirus Vaccination
HPV Vaccine Reminders - SEARCH II Study
This RCT will take place at health centres and their affiliated schools and community immunization centers overseen by the Kampala Capital City Authority (KCCA) as well as at the Makerere/Mulago/Columbia Adolescent Health Clinic…
- Trial name
- NCT06161831
- Testing
- Text Message/automated phone reminder
- Where
- 2 sites in United States, Uganda
- Volunteers
- 396 people
- Sponsor
- Columbia University
Hyperinsulinemia, Insulin Resistance
Glycemic Effect of Diazoxide in NAFLD
The goal of this clinical trial is to compare a two-week course of diazoxide (at two different doses) and placebo in people with overweight/obesity and insulin resistance (IR) with, or at high risk for, non-alcoholic fatty liver…
- Conditions
- Hyperinsulinemia, Insulin Resistance, Non-Alcoholic Fatty Liver Disease, Prediabetic State
- Trial name
- NCT05729282
- Testing
- Diazoxide oral suspension, 1 mg per kg per dose, Diazoxide oral suspension, 2 mg per kg per dose, FreeStyle Libre Pro
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Columbia University
Polycystic Ovary Syndrome, Non-Alcoholic Fatty Liver Disease
NAFLD in Adolescents and Young Adults With PCOS
This project focuses on an at-risk adolescent and young adult population who may gain long-term health benefits from detection of risk factors at a young age.
- Conditions
- Polycystic Ovary Syndrome, Non-Alcoholic Fatty Liver Disease, Metabolic Syndrome
- Trial name
- NCT02506946
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Columbia University
Anxiety, Osteoarthritis
Preoperative Music Intervention for Anxiety in Hip and Knee Arthroplasty
Many patients feel anxious before joint replacement surgery. This anxiety is common - affecting roughly 1 in 3 patients - and research has shown that patients who are more anxious before surgery tend to have more pain afterward…
- Trial name
- NCT07845695
- Testing
- Music via Headphones
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Columbia University
Growth Hormone Deficiency
The AgRP and GH/IGF-1 Axis in Children
Recent data support the existence of a GH-Agouti-related peptide (AgRP) axis. The neuropeptide AgRP promotes food intake and has important effects on energy homeostasis.
- Trial name
- NCT05645211
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Columbia University
Prematurity, Very Preterm Maturity of Infant
Sleep in SNOO Smart Sleeper Bassinet in Preterm Infants
The goal of this clinical trial is to compare sleeping in a SNOO Smart Sleeper bassinet (SNOO) with sleeping in traditional bassinet conditions in premature infants. The main questions it aims to answer are: 1.
- Trial name
- NCT05711927
- Testing
- SNOO Smart Sleeper, Traditional bassinet
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Columbia University
Mammography, Medical Overuse
A Multi-Level Strategy for De-implementing Mammography Overuse Among Older Women
This project aims to advance methodological and theoretical approaches for developing, selecting, refining, and piloting a multilevel de-implementation strategy to reduce the overuse of screening mammography in women aged ≥75…
- Conditions
- Mammography, Medical Overuse, Evidence-based Practice, Older Adults
- Trial name
- NCT07511621
- Testing
- Enhanced Usual Care (EUC), Multilevel De-Implementation Strategy
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Columbia University
Vasectomy, NSAIDs
Post-Vasectomy Pain Study
This is a prospective four-armed unblinded randomized controlled trial to assess four different potential post-operative treatment options for men who undergo a vasectomy.
- Conditions
- Vasectomy, NSAIDs, Post-operative Care
- Trial name
- NCT07824258
- Testing
- Acetaminophen, ibuprofen, oxycodone
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Columbia University
Obsessive-Compulsive Symptoms, Cognitive Control
Brain Function and Cognitive Control Training in Children With Obsessive-Compulsive Symptoms
The goal of this clinical trial is to learn about brain function and cognition in children ages 8-12 who have subclinical obsessive-compulsive symptoms (OCS), such as unwanted thoughts or repetitive behaviors.
- Trial name
- AKILI - OCS (NCT07839013)
- Testing
- Cognitive Control Training
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Columbia University
Shoulder Dislocation
Conservative Versus Operative - First Time Shoulder Dislocations
There is no consensus regarding whether rehabilitation or surgical stabilization leads to optimized outcomes for treatment of primary anterior shoulder dislocations.
- Trial name
- NCT05532150
- Testing
- Arthroscopic Bankart repair, Physical therapy
- Volunteers
- healthy volunteers welcome
- Sponsor
- Columbia University
Obesity
Circadian Misalignment and Energy Balance
Preliminary findings from the investigators' lab suggest that circadian misalignment, occurring when meals and sleep are mistimed from one another, alters resting state neuronal processing in areas relevant to food reward and…
- Trial name
- CM (NCT03663530)
- Testing
- Meal times
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Columbia University
Pancreatic Cancer, Adenocarcinoma of the Pancreas
Chemo4METPANC Combination Chemokine Inhibitor, Immunotherapy, and Chemotherapy in Pancreatic Adenocarcinoma
The purpose of this study is to determine if combination treatment with cemiplimab, motixafortide, gemcitabine, and nab-paclitaxel is effective in decreasing the size of the tumor(s), if it will prolong life in patients, and if…
- Conditions
- Pancreatic Cancer, Adenocarcinoma of the Pancreas, Adenocarcinoma
- Trial name
- NCT04543071
- Testing
- Motixafortide, Cemiplimab, Gemcitabine
- Where
- 5 sites in United States
- Volunteers
- 118 people
- Sponsor
- Columbia University
Patella Dislocation
Conservative Versus Operative - First Time Patella Dislocations
There is no consensus regarding whether rehabilitation or surgical management is best for the management of a primary patellar dislocation.
- Trial name
- NCT05533671
- Testing
- medial patellofemoral reconstruction, Non-operative group
- Volunteers
- healthy volunteers welcome
- Sponsor
- Columbia University
Early Onset Genetic Conditions With Near Complete Penetrance
Genomic Uniformed-Screening Against Rare Disease In All Newborns
The goal of this study is to learn how genomic sequencing technology can be used to effectively expand the conditions screened on newborn screening.
- Trial name
- GUARDIAN (NCT05990179)
- Testing
- Genome sequencing-based newborn screening
- Where
- United States
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Columbia University