Clinical trials: completed, sponsored by Duke University
Lactating Women on Select DOI, Breastmilk Fed Infants of Mothers on Select DOI
Pharmacokinetics of Antiretroviral Drugs in Lactating Women and Breastmilk Fed Infants Under 6 Months of Age in Botswana
The purpose of this study is to characterize the pharmacokinetics (PK) of understudied drugs administered to lactating women, receiving antiretroviral drugs per SOC as prescribed by their healthcare provider, and their…
- Conditions
- Lactating Women on Select DOI, Breastmilk Fed Infants of Mothers on Select DOI, HIV Infections
- Trial name
- BMS02 (NCT04862975)
- Testing
- Dolutegravir, Lamivudine, Emtricitabine
- Where
- 4 sites in South Africa
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Duke University
Cesarean Section Complications
ESP Block for Post Cesarean Analgesia
The purpose of this pilot study is to assess the analgesic efficacy of Erector Spinae Plane block (ESPB) with liposomal bupivacaine in women undergoing cesarean delivery and receiving a postoperative multimodal analgesic regimen…
- Trial name
- NCT05664958
- Testing
- Erector Spinae Plane (ESP) Block, bupivacaine liposome injectable suspension, bupivacaine
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Duke University
Multiple Myeloma
Real-World Analysis of Belantamab Mafodotin Care Patterns in Patients With Relapsed and/or Refractory Multiple Myeloma
The purpose of this study is to describe the real-world use of Belantamab Mafodotin - blmf (BLENREP) and associated patterns of care, including dosing and dose modification, eye care specialist visits, associated healthcare…
- Trial name
- NCT05986682
- Testing
- Blenrep
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Duke University
Kidney Failure, Chronic
Deprescribing for Older Dialysis Patients
Aim 1 of the study is to identify the elements of a deprescribing intervention that address contextual factors specific to dialysis.
- Trial name
- NCT03631290
- Testing
- Deprescribing Intervention
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Duke University
Acute Coronary Syndrome
Acute Coronary Syndrome KCMC
The purpose of this study is to develop a quality improvement intervention to address barriers to evidence-based acute coronary syndrome (ACS) care in northern Tanzania.
- Trial name
- NCT04563546
- Testing
- Quality Improvement
- Where
- United States
- Volunteers
- 641 people
- Sponsor
- Duke University
Cancer, Immune-related Adverse Event
Immune-Related Adverse Events and Associated Biomarkers in Patients Receiving Cancer Immunotherapy
The purpose of this project is to collect body samples like blood and tissue and health information from people receiving immune-based treatment for cancer.
- Trial name
- IMBARC (NCT06089967)
- Testing
- Medical chart review
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Duke University
Colorectal Cancer
An mHealth Symptom Management Intervention for Colorectal Cancer Patients (mCOPE)
The investigators have developed an innovative mobile health (mHealth) coping skills training protocol, mCOPE, that is adapted to meet the multiple symptom needs and stage-of-life challenges faced by young and middle-aged adults…
- Trial name
- NCT04763174
- Testing
- mHealth Coping Skills Training for Symptom Management (mCOPE)
- Where
- 2 sites in United States
- Volunteers
- 167 people
- Sponsor
- Duke University
Sleep Disorder, Insulin Resistance
Sleep and IR in Transgender Adolescents
Disordered sleep is a health issue with significant impacts on physical and psychological well-being that has increased in prevalence, but its impact on transgender adolescents has not been fully quantified.
- Conditions
- Sleep Disorder, Insulin Resistance, Gender Dysphoria
- Trial name
- ATP (NCT05489159)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Duke University
Chronic Kidney Diseases, High Blood Pressure
Diet and Hypertension Management in African Americans With Chronic Kidney Disease
The purpose of this study is to determine cultural and disease-related barriers and facilitators to following the Dietary Approaches to Stop Hypertension (DASH) dietary pattern among Black Americans with moderate chronic kidney…
- Trial name
- NCT04084574
- Testing
- DASH diet counseling
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Duke University
Healthy Volunteers
Modeling Organ Motion During Abdominal Imaging in Healthy Volunteers
In this study, we plan to systematically analyze the motion of organs and tissues in the abdomen, to understand the physical mechanisms of three-dimensional (3D) motion and interactions of abdominal organs and tissues.
- Trial name
- NCT05674851
- Testing
- MRI
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Duke University
Heart Failure With Reduced Ejection Fraction
Ketone Pharmacokinetic Study in HFrEF
The purpose of this study is to test whether an over-the-counter ketone ester drink is well tolerated in people with heart failure on, and not on, a heart failure medication class called SGLT2 inhibitors.
- Trial name
- NCT05757193
- Testing
- DeltaG (250 mg/kg), DeltaG (500 mg/kg)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
NAFLD, Diabetes Mellitus
Improving Detection and Evidence-based Care of NAFLD in Latinx and Black Patients With Type 2 Diabetes
The primary objective of this pilot study is to assess the feasibility and acceptability of an intervention for improved detection and evidence-based care of NAFLD in Latinx and Black patients with type 2 diabetes (T2D) in Duke…
- Trial name
- NAFLD-DM (NCT05844137)
- Testing
- NAFLD Education, diet/lifestyle support, T2D medication management
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Duke University
Sickle Cell Disease, COVID-19 Vaccine
COVID-19 Vaccination Hesitancy in Adults With Sickle Cell Disease
The goal of this clinical trial is to test an COVID-19 vaccination information video in adults with sickle cell disease. The main questions it aims to answer are why are some adults with sickle cell disease hesitant to receive…
- Conditions
- Sickle Cell Disease, COVID-19 Vaccine, Vaccine Hesitancy
- Trial name
- NCT05998824
- Testing
- SCD-specific COVID-19 vaccination information (SCVI) video
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Duke University
Cannabis, Cannabis Use
Impact of Reduced Cannabis Use on Functional Outcomes (R33 Phase)
Nearly 20 million Americans report use of cannabis in the past month, and heavy cannabis use has increased by nearly 60% in the U.S. since 2007.
- Trial name
- FOCUS (NCT04567238)
- Testing
- Mobile contingency management
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Asthma in Children
The Duke-Reinvestment Partners Community Collaborative (DRC)- Healthy Homes
The goal of this open-label, single arm home intervention feasibility study is to improve quality of life for children ages 4-16 years with asthma.
- Trial name
- DRC (NCT05934370)
- Testing
- Home-Based Environmental Interventions (HEI)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Duke University
Smokeless Tobacco Cessation
Smokeless Tobacco Cessation Intervention for Firefighters
The investigators are asking professional firefighters across North Carolina to take part in focus groups to discuss the specific needs of firefighters in smokeless tobacco cessation.
- Trial name
- NCT05111041
- Testing
- #EnufSnuff.TXT- First Responder, Enough Snuff Intervention
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Duke University
Health Behavior
Effect of Social Accountability on Improving Service Delivery and Outcomes in the Public Sector in Uttar Pradesh, India
In several low and middle-income countries, Social Accountability (SA) interventions have been introduced as an innovative approach to governance, aiming to improve delivery of public services.
- Trial name
- D0168 (NCT02879708)
- Testing
- Information Only, Information and Facilitation
- Where
- India
- Volunteers
- 105,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Pelvic Organ Prolapse
EVeRLAST 2-Year Follow-Up
This is a 2-year follow-up study from EVeRLAST which objective was to determine whether expedited resumption of postoperative activity levels is non-inferior to standard activity restrictions with respect to short-term anatomic…
- Trial name
- NCT05542836
- Testing
- Expedited postoperative activity instructions, Standard postoperative activity restructions
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Duke University
Hematologic Malignancy
Mindfulness and CBT for Sleep
Patients with hematologic cancer frequently report significant difficulties with sleep in the months after discharge from inpatient chemotherapy.
- Trial name
- NCT04736056
- Testing
- Mindfulness-Based Therapy for Insomnia with Cognitive-Behavioral Symptom Coping Skills
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Duke University
Hypertension
Food Is Medicine: Makin' Healthy Groceries
This is a minimal risk study focusing on food purchasing and consumption in 100 subjects in the greater New Orleans area. There is evidence showing that individually-targeted vouchers effectively increase category-level food…
- Trial name
- FIM (NCT06214806)
- Testing
- Grocery Vouchers
- Where
- 2 sites in United States
- Volunteers
- 97 people
- Sponsor
- Duke University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.