Clinical trials: completed, sponsored by Duke University
NAFLD
A Feasibility Trial of OCM Supplements for the Treatment of NAFLD
The purpose of the study is to assess the feasibility of a trial to test the effects of homocysteine (Hcy) lowering supplements in patients with NAFLD.
- Trial name
- NCT05720702
- Testing
- homocysteine (Hcy) lowering supplements
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Duke University
ARDS, Acute Respiratory Failure
Generating Evidence in ECMO Ventilation Strategies
The goal of this pilot clinical trial is to test if ICU level ventilator protocols are appropriate interventions to study differences in ventilator strategies for patients with acute respiratory failure supported by VV-ECMO.
- Trial name
- GENIE-Vent (NCT05708365)
- Testing
- Standard-Lung Protective Ventilation, Ultra-Lung Protective Ventilation
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Duke University
Mechanical Ventilation Complication, Weaning Failure
Preventing Failed Extubations
More than 300,00 people in the United States experience acute respiratory failure and require mechanical ventilation every year.
- Trial name
- PreFIX (NCT06301867)
- Testing
- Plateau Pressure
- Where
- United States
- Volunteers
- 248 people
- Sponsor
- Duke University
Children/Youth With Special Healthcare Needs, Adults With Multiple Chronic Conditions
Caremap: A Digital Personal Health Record for Complex Care Coordination
This study will implement a new mobile application ('app') called Caremap to improve care coordination for patients with complex health needs.
- Trial name
- NCT05056493
- Testing
- Caremap app
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Duke University
Diabetes Mellitus, Type 2, Cardiovascular Diseases
A 12 Month Site Randomized Trial in Adults With Type 2 Diabetes Mellitus and History of Cardiovascular Disease
COORDINATE-Diabetes is a cluster-randomized clinical trial to test the effectiveness of an innovative, clinic-level educational intervention to improve the management of patients with type 2 diabetes mellitus and cardiovascular…
- Trial name
- COORDINATE (NCT03936660)
- Testing
- Intense Education Intervention
- Where
- 44 sites in United States
- Volunteers
- 1,049 people
- Sponsor
- Duke University
Children, Only, Children and Youth With Special Healthcare Needs
Feasibility Study of a Mobile Digital Personal Health Record for Family-Centered Care Coordination for Children and Youth With Special Healthcare Needs
A Fast Healthcare Interoperability Resources (FHIR)-enabled digital personal health record mobile app has the potential to enhance care coordination for families of children and youth with special healthcare needs (CYSHCN) and to…
- Trial name
- NCT05513235
- Testing
- Digital personal health record
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Duke University
Environmental Exposure
Customized Approaches for Evaluating and Reducing Chemical Exposures From Home Building Materials
This project will evaluate new approaches to quantify and reduce chemical exposures from common building materials, with an emphasis on plastic additives, pesticides, flame retardants and lead in addition to other environmental…
- Trial name
- NCT05416281
- Testing
- Robotic Vacuum
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Duke University
Fever After Vaccination, Fever
Fever After Simultaneous Versus Sequential Vaccination in Young Children
A prospective, randomized open-label clinical trial that will be conducted during the 2017-2018 influenza season. During the 2017-2018 season, approximately 280 children will be enrolled at Duke University Medical Center and…
- Conditions
- Fever After Vaccination, Fever, Febrile Seizure
- Trial name
- NCT03165981
- Testing
- PCV13, DTaP, IIV
- Where
- 3 sites in United States
- Volunteers
- 221 people, healthy volunteers welcome
- Sponsor
- Duke University
Brain Injuries, Traumatic, Transitional Care
Enhancing the Transition From Hospital to Home for Patients With Traumatic Brain Injury and Families
Despite high risks of readmission and complex medical needs, there are no transitional care standards in the U.S. for patients with moderate-to-severe traumatic brain injury (TBI) discharged home from acute hospital care without…
- Conditions
- Brain Injuries, Traumatic, Transitional Care, Family Members, Patients
- Trial name
- R03 (NCT04584554)
- Testing
- BETTER Transitional Care Intervention
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Duke University
Mental Health Wellness 1, Burnout, Professional
ABC Mental Health: A Behavioral Study of K-12 Teachers and School Staff
This study looks at school employees' mental health, well-being, and effectiveness before and after completing a professional development workshop.
- Conditions
- Mental Health Wellness 1, Burnout, Professional, Self Efficacy
- Trial name
- NCT05574764
- Testing
- Cultivating Awareness and Resilience in Education (CARE)
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Duke University
Labor Pain
Comparing Effectiveness of CSE Versus DPE for Labor Analgesia
The primary purpose of this study is to determine if there are differences in block quality between the CSE and DPE techniques for labor analgesia in parturients in active labor.
- Trial name
- NCT05068661
- Testing
- Ropivacaine 0.1% Injectable Solution, Bupivacaine 0.25% Injectable Solution
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Duke University
Preterm Birth
EngagINg the COmmunity to Reduce Preterm Birth Via Adherence To an Individualized Prematurity Prevention Plan
The purpose of this study is to determine if INCORPorATe IP3 is feasible prior to a larger trial focused on determining efficacy.
- Trial name
- NCT04933812
- Testing
- Facebook discussions and Virtual group meetings
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Duke University
Advance Care Planning
Advance Care Planning Notifications in General Inpatient Medicine
This study will evaluate the impact of and response by physicians on Hospital Medicine/General Internal Medicine service to a notification identifying seriously ill patients at high risk of death within 30 days as well as within…
- Trial name
- NCT04756583
- Testing
- Notification system
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Duke University
Obstructive Sleep Apnea, Tonsillitis
Pediatric Pain Optimization After Tonsillectomy
The purpose of this study is to compare the use of short acting opioids (fentanyl/hydromorphone) with long acting opioids (methadone) for pain control following tonsillectomy surgery.
- Conditions
- Obstructive Sleep Apnea, Tonsillitis, Pain, Procedural
- Trial name
- NCT05244226
- Testing
- Fentanyl/Hydromorphone, Methadone
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Duke University
Insomnia Chronic
Sleep Device Testing to Promote Sleep in Infants
Infants often have sleep challenges. Most of these challenges in otherwise healthy children and due to behavioral insomnia. The goal for infants is to become independent sleepers by learning the process of self-soothing.
- Trial name
- NCT05078112
- Testing
- Sleep sensor technology
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Duke University
Carcinoma, Renal Cell
Alternative Schedule Sunitinib in Metastatic Renal Cell Carcinoma: Cardiopulmonary Exercise Testing
The purpose of this study is to determine the effect of a sunitinib administration schedule 2/1 (2 weeks of treatment followed by 1 week without) compared to a schedule 4/2 (4 weeks of treatment followed by 2 weeks without) on…
- Trial name
- ASSET (NCT03109015)
- Testing
- Sunitinib
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Duke University
Dysfunctional Voiding, Urinary Dysfunction
At-Home Diaphragmatic Interventions for Voiding Abnormalities (DIVA)
The goal of the DIVA trial is to test the effectiveness of at-home diaphragmatic breathing exercises with bladder hygiene education in female patients with symptoms of difficulty urinating (dysfunctional voiding).
- Trial name
- DIVA (NCT06165731)
- Testing
- Diaphragmatic Breathing Exercises, Bladder Hygiene Education
- Where
- 2 sites in United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Duke University
Cytomegalovirus Infections
Comparison of Oral Valganciclovir and Placebo for the Prevention of Cytomegalovirus (CMV) After Lung Transplantation
The study evaluated the efficacy and safety of a prolonged, continuous course of Valganciclovir (Valgan) in the prevention of CMV by comparing 3 months of Vaglanciclovir, the standard of care upon initiation of the study, to 12…
- Trial name
- Valgan (NCT00227370)
- Testing
- valganciclovir
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Duke University
Hematologic Malignancy
A Research Program Targeting Pre- and Peri-transplant Optimization Program (R-PPOP)
The purpose of this study is to evaluate the feasibility and outcomes of a research pre- and peri-transplant optimization program (R-PPOP) to improve multiple domains of health including physical function, cognitive function…
- Trial name
- NCT03823651
- Testing
- Interval training, Psychiatric consult, Nutrition/diet evaluation
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Duke University
Abdominal Site, Colostomy Site
LowCostomy: Dedicated Toward Creating a High-quality, Low-cost Colostomy Appliance for Those in Sub-Saharan Africa
The purpose of this study is to examine the safety of the LowCostomy appliance's peristomal adhesive interface composed of a mix of beeswax and pine resin.
- Trial name
- NCT05824351
- Testing
- Tanzanian beeswax-pine resin, Domestic beeswax-pine resin, Hollister's AdaptTM Barrier Rings
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Duke University
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