Clinical trials: completed, sponsored by Duke University
Systemic Lupus Erythematosus
Individual Patient Exposure and Response in Pediatric Lupus
The purpose of this research study is to see if an electronic pill bottle cap can help children and teens with systemic lupus better remember to take their medicine.
- Trial name
- iPERSONAL (NCT04358302)
- Testing
- Pillsy
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Duke University
Pain, Quality of Life
Simultaneous RZV and aIIV4 Vaccination
The overall aim of the study is to compare the safety of simultaneous Zoster Vaccine Recombinant, Adjuvanted (RZV) (SHINGRIX®) and Quadrivalent Influenza Vaccine, Adjuvanted (FLUAD®) versus simultaneous Zoster Vaccine…
- Conditions
- Pain, Quality of Life, Injection Site Reaction, Adverse Drug Event
- Trial name
- NCT05007041
- Testing
- FLUAD® Quadrivalent, Fluzone® High-Dose Quadrivalent, SHINGRIX®
- Where
- 2 sites in United States
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- Duke University
Percutaneous Coronary Intervention
Adenosine Contrast CorrELations in Evaluating RevAscularizaTION
The purpose of this study is to compare FFR measurements done with adenosine to FFR measurements done with contrast, where the contrast is injected using the ACIST CVi automated contrast injector.
- Trial name
- ACCELERATION (NCT03557385)
- Testing
- Iopamidol, adenosine, Navvus® Catheter
- Where
- 5 sites in United States
- Volunteers
- 201 people
- Sponsor
- Duke University
Covid19
Protecting With ARNI Against Cardiac Consequences of Coronavirus Disease 2019
The purpose of this study is to determine the effect of sacubitril/valsartan versus placebo on markers of cardiac injury, structure, and function among patients who recovered from acute COVID-19 infection.
- Trial name
- PARACOR-19 (NCT04883528)
- Testing
- Sacubitril / Valsartan Oral Tablet [Entresto]
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Duke University
COVID-19 Respiratory Infection, Respiratory Syncytial Virus Infections
Infection Watch Study
This study will reach out to patients who have undergone diagnostic testing for the following respiratory illnesses from January 1st, 2018 to July 9th, 2023: COVID-19, Influenza, Rhinovirus, and Respiratory Syncytial Virus.
- Conditions
- COVID-19 Respiratory Infection, Respiratory Syncytial Virus Infections, Rhinoviral Infections, Influenza Viral Infections
- Trial name
- NCT04623047
- Where
- United States
- Volunteers
- 10,034 people, healthy volunteers welcome
- Sponsor
- Duke University
Contraception Behavior
A Pilot Study to Estimate the Impact of a Screening and Referral Service on Contraceptive Use
The specific aim of this pilot study is to estimate the impact of a new digital health service on the uptake of family planning among Kenyan women with an unmet need for contraception.
- Trial name
- E0108 (NCT03224390)
- Testing
- digital family planning screening and referral service
- Where
- Kenya
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Duke University
Malignant Glioma, Glioblastoma
The PCSK9i Inhibitor Evolocumab - a Surgical Trial of Pharamcodynamics and Kinetics Evaluation
This Phase 0 surgical window of opportunity trial seeks to evaluate the pharmacokinetic (PK) and pharmacodynamic (PD) properties of an FDA-approved proprotein convertase/ kexin type 9 serine protease inhibitor (PCSK9i) in…
- Trial name
- NCT04937413
- Testing
- Evolocumab
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Duke University
Mental Health, Family Relations
An Evaluation of a Family Counseling Intervention ("Tuko Pamoja") in Kenya: a Single Case Series Design
The purpose of this study is to evaluate a family counseling intervention, entitled "Tuko Pamoja" (Translation "We are Together" in Kiswahili).
- Conditions
- Mental Health, Family Relations, Family Conflict, Child Mental Disorder
- Trial name
- C0058 (4A) (NCT03360201)
- Testing
- Tuko Pamoja, "We are Together" in Kiswahili
- Where
- Kenya
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Duke University
Respiratory Muscles
Diaphragm Function and Diver Endurance
This project will test the following hypotheses: 1. Training of the inspiratory muscles increases underwater endurance and reduces hypercapnia in divers. 2.
- Trial name
- NCT04679402
- Testing
- Carbon monoxide 200 ppm in air
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Duke University
COVID-19, SARS-CoV 2
Network-Targeted Strategies for Efficient Community SARS-CoV-2 (COVID-19) Sampling
The primary objective is to use "network targeted sampling design" to detect active and/or undiagnosed cases of COVID-19 in the community and determine the spread or distribution of 1) active infection, and 2) past exposure.
- Trial name
- Snowball (NCT04437706)
- Where
- United States
- Volunteers
- 602 people, healthy volunteers welcome
- Sponsor
- Duke University
Obesity, Osteoarthritis
Reducing Obesity and Cartilage Compression in Knees
OA is a degenerative joint disease that involves the degradation of articular cartilage and underlying subchondral bone. Obesity is identified as a critical and potentially modifiable risk factor for the development and…
- Conditions
- Obesity, Osteoarthritis, Knee Osteoarthritis
- Trial name
- ROCCK (NCT04730557)
- Testing
- Weight Loss
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Duke University
Spina Bifida, Neurogenic Bladder
CIC Behavioral Economics in Children With Spina Bifida
The purpose of the study is to develop a comprehensive program to increase early initiation of self-catheterization in children with Spina Bifida. This will be a prospective open label randomized control trial.
- Trial name
- NCT05562713
- Testing
- Present Bias without Loss Aversion, Present Bias with Loss Aversion
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Duke University
Improved Communication Between Clinician and Patient
Communication Coaching to Improve Patient and Clinician Satisfaction in Cardiology Encounters
The purpose of this study is to determine the effect of a clinician communication coaching intervention versus control on an objective measure of the quality of communication (primary outcome) and patients' perceptions of the…
- Trial name
- NCT03464110
- Testing
- Communication Intervention
- Where
- 2 sites in United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Duke University
Pain
Patient-Empowered Mobile Technology in Hospitalized Patients (TRU-PAIN)
The purpose of this study is to learn more about the ways in which mobile technology can be integrated into inpatient care to help better track pain levels using mobile technology of patients with sickle cell disease, oncology…
- Trial name
- NCT02895841
- Testing
- SMART app wearable
- Where
- United States
- Volunteers
- 174 people
- Sponsor
- Duke University
Primary Progressive Multiple Sclerosis
Serial Collection of Primary Progressive Multiple Sclerosis Participants in the MURDOCK Study
The goal of this study is to enroll 100 participants with Primary Progressive Multiple Sclerosis (PPMS) that have joined the MURDOCK Study Horizon 1.5 (Duke IRB Pro00011196) and the Multiple Sclerosis cohort (Duke IRB…
- Trial name
- NCT01776060
- Testing
- generation of 'omic markers of disease progression
- Where
- 3 sites in United States
- Volunteers
- 28 people
- Sponsor
- Duke University
Appendicitis, Evidence of Cholecystectomy
Point of Care 3D Ultrasound for Various Applications: A Pilot Study
Summary 1. Purpose and Objective: The purpose of this study is to test the feasibility of rapid acquisition of point of care 3D ultrasound in obtaining abdominal and/or pelvic images.
- Conditions
- Appendicitis, Evidence of Cholecystectomy, Gallstones, Pregnancy, Ectopic
- Trial name
- NCT02831556
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Duke University
Metastatic Cancer, Congestive Heart Failure
Reducing Disparities in the Quality of Advance Care Planning for Older Adults
This study compares the effectiveness of two different approaches to advance care planning among older African Americans and older Whites living in the community.
- Conditions
- Metastatic Cancer, Congestive Heart Failure, Chronic Obstructive Pulmonary Disease, Parkinson Disease
- Trial name
- EQUALACP (NCT03516994)
- Testing
- Respecting Choices First Steps, Five Wishes Form
- Where
- 4 sites in United States
- Volunteers
- 790 people
- Sponsor
- Duke University
Breast Cancer, Estrogen Receptor-positive Breast Cancer
Evaluation of Endocrine Therapy Effects of Host Immunity in Early Stage Breast Cancer
The purpose of this research study is to learn about the effects that standard of care endocrine therapies have on the immune system's response to cancer by looking at the number and types of immune cells present and how they…
- Conditions
- Breast Cancer, Estrogen Receptor-positive Breast Cancer, Healthy
- Trial name
- NCT03719495
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Duke University
Malaria, Febrile Illness
Malaria Diagnostic Testing and Conditional Subsidies to Target ACTs in the Retail Sector: TESTsmART Aim 2 - Nigeria
Highly subsidized first-line antimalarials (artemisinin combination therapy or ACT) are available over the counter in the private retail sector in most malaria-endemic countries.
- Trial name
- NCT04428385
- Testing
- Testing incentive, Conditional artemisinin combination therapy subsidy
- Where
- Nigeria
- Volunteers
- 2,205 people
- Sponsor
- Duke University
Healthy
Improving Physician Vaccine Recommendation Using Social Norms, Trust, and Presumptive Language
This research examines vaccination recommendation perceptions and behaviors of physicians and advanced practice providers.
- Trial name
- NCT05957393
- Testing
- Quantity of vaccination recommendations, Quality of vaccination recommendations, Control
- Where
- 3 sites in United States, Brazil
- Volunteers
- 447 people, healthy volunteers welcome
- Sponsor
- Duke University
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