Clinical trials: completed, sponsored by Duke University
Neisseria Gonorrheae Infection
Master Protocol for Evaluating Multiple Infection Diagnostics for Ciprofloxacin-Resistant Neisseria Gonorrhoeae
The goal of this study is to learn if a few investigational tests can correctly find the gene mutation (mutant allele gyrA 91F) that predicts ciprofloxacin resistance in clinical specimens that harbor Neisseria gonorrhoeae.
- Trial name
- MASTERMINDRING (NCT06815536)
- Testing
- Investigational Reflex Test 1, Investigational Reflex Test 2, Investigational Reflex Test 3
- Where
- 8 sites in United States
- Volunteers
- 2,627 people
- Sponsor
- Duke University
Metabolic Profiling Muscle
HIP: Hip Imaging Protocol
Objective measures of skeletal muscle features have previously been used to assess skeletal muscle quality. In certain clinical populations, such as intensive care (ICU) patients, specific features of the psoas muscle measured by…
- Trial name
- NCT04126161
- Testing
- CT, Ultrasound
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Duke University
Atherosclerosis, Wounds and Injuries
Machine Learning for Handheld Vascular Studies
The use of handheld arterial 'stethoscopes' (continuous wave Doppler devices) are ubiquitous in clinical practice. However, most users have received no formal training in their use or the interpretation of the returned data.
- Trial name
- DopplerZAM (NCT02932176)
- Testing
- Non-invasive vascular testing, machine-learning algorithm
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Duke University
Systemic Lupus Erythematosus, Contraception
The HOP-STEP Intervention: Improving Maternal Health in Women With Lupus sIRB
While the HOP-STEP (Healthy Outcomes in Pregnancy with SLE Through Education of Providers) program has been demonstrated to be effective in improving provider confidence, increasing contraception documentation, and facilitating…
- Trial name
- HOP-STEPsIRB (NCT05818254)
- Testing
- HOP-STEP (Healthy Outcomes in Pregnancy with SLE Through Education of Providers) Intervention, Routine Care
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Duke University
Smoking Cessation, Pain
Project HOPES: Healthy Options for Pain and Ending Smoking. A Program for Cancer Survivors.
The proposed pilot study will develop and test feasibility, acceptability, and signal for efficacy of a smoking cessation and pain management intervention for 20 cancer survivors.
- Trial name
- NCT06029907
- Testing
- Smoking cessation and pain management intervention, Varenicline
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Duke University
Idiopathic Pulmonary Fibrosis
Genentech Xenon MRI Idiopathic Pulmonary Fibrosis
The purpose of this study is being done to determine whether magnetic resonance imaging (MRI) using inhaled hyper-polarized 129 Xenon gas can help visualize impaired lung function to detect changes over time in Idiopathic…
- Trial name
- NCT04071769
- Testing
- Hyperpolarized 129 Xenon Gas Comparing Idiopathic Pulmonary Fibrosis (IPF) Treatment
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Duke University
Suicide
Comprehensive Adaptive Multisite Prevention of University Student Suicide
Suicide is the 2nd leading cause of death among college students and suicidal ideation and suicide-related behaviors are a frequent presenting problem at college counseling centers (CCCs), which are overburdened.
- Trial name
- CAMPUS (NCT04707066)
- Testing
- Treatment As Usual (TAU), Collaborative Assessment and Management of Suicidality (CAMS) - Phase 1, Dialectical Behavior Therapy (DBT) - Phase 2
- Where
- 4 sites in United States
- Volunteers
- 253 people
- Sponsor
- Duke University
Pediatric Obesity, Implementation
Parks & Pediatrics Fit Together
The proposed project will test an implementation strategy (the "TrailGuide") for delivering an existing model of pediatric obesity treatment ("Fit Together") that has demonstrated ability to meet published recommendations for…
- Trial name
- NCT05455190
- Testing
- Fit Together, Educational materials
- Where
- 3 sites in United States
- Volunteers
- 209 people
- Sponsor
- Duke University
Chronic Rheumatic Diseases
Medication Adherence in Rheumatic Diseases
The investigators will pilot test a clinician-led intervention to improve medication adherence in general rheumatology clinic across a spectrum of rheumatic diseases.
- Trial name
- NCT06018350
- Testing
- Clinician-led adherence intervention
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Duke University
Single-ventricle, Infant Conditions
PK/PD of Digoxin in Infants With SVHD
The primary participant will be an infant with single ventricle heart disease. This is a research study to learn more about how the medication digoxin, which is routinely prescribed to infants and children with heart disease in…
- Conditions
- Single-ventricle, Infant Conditions, Infant, Newborn, Diseases, Infant, Premature, Diseases
- Trial name
- Digoxin R01 (NCT06613477)
- Testing
- PK/PD Model Based Dosing of Digoxin in Infants with Single Ventricle Heart Disease
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Duke University
Musculoskeletal Pain
Multimodal Management of Neck and Back Pain in the Emergency Department (Multi-ED)
The purpose of this study is to assess the feasibility and acceptability of psychologically-informed physical therapy (PIPT) in the ED in a pilot study of ED patients with neck or back pain.
- Trial name
- NCT05221125
- Testing
- Psychologically-Informed Physical Therapy (PIPT)
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Duke University
Long COVID, Long Covid19
RECOVER-NEURO: Platform Protocol, Appendix_A to Measure the Effects of BrainHQ, PASC CoRE and tDCS Interventions on Long COVID Symptoms
This platform protocol is designed to be flexible so that it is suitable for a wide range of settings within health care systems, for remote settings, and in community settings where it can be integrated into COVID-19 programs…
- Conditions
- Long COVID, Long Covid19, Long Covid-19
- Trial name
- NCT05965739
- Testing
- BrainHQ/Active Comparator Activity, BrainHQ, PASC CoRE
- Where
- United States
- Volunteers
- 328 people
- Sponsor
- Duke University
Stroke
Optimizing Parameters of Low-Intensity Focused Ultrasound for Cortical Modulation in Stroke Patients
The purpose of this research study is to find out the optimal intensity and frequency of Low Intensity Focused Ultrasound (LIFU) that is safe and tolerable in people who have had a stroke.
- Trial name
- LIFU (NCT05016531)
- Testing
- Low Intensity Focused Ultrasonic Stimulation, Low Intensity Focused Ultrasonic Stimulation Frequency
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Duke University
Physical Activity, Cardiometabolic Risk Factors
Going Places: A Multi-level Intervention to Improve Youth Transportation Efficacy and Physical Activity
Going Places is a community driven intervention to increase transportation self-efficacy among low-income youth, enabling access to community-based programs that promote physical activity and improve long term cardiometabolic…
- Conditions
- Physical Activity, Cardiometabolic Risk Factors, Cardiometabolic Health Indicators, Self-Efficacy
- Trial name
- Going Places (NCT07044375)
- Testing
- Going Places
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Duke University
HIV
PrEP (Pre-exposure Prophylaxis) Stigma and Women Ethnodrama Pilot Phase
The investigators will pilot test an ethnodrama intervention designed to transform community member beliefs about and foster support of young cisgender women (YCW) using Pre-exposure Prophylaxis (PrEP).
- Trial name
- NCT07225894
- Testing
- Ethnodrama Intervention
- Where
- Kenya
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Duke University
HIV
PrEP (Pre-exposure Prophylaxis) Stigma and Women Ethnodrama Pre-Test Phase
The investigators will develop and pre-test an ethnodrama intervention designed to transform community member beliefs about and foster support of young cisgender women (YCW) using PrEP.
- Trial name
- NCT06501885
- Testing
- Ethnodrama Intervention
- Where
- Kenya
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Duke University
HIV-1-infection, Mental Health Issue
SYV: A Mental Health Intervention to Improve HIV Outcomes in Tanzanian Youth
The overall objectives of this proposal are to support positive coping strategies that bolster mental health and lead to improved HIV outcomes among Young People Living with HIV (YPLWH).
- Conditions
- HIV-1-infection, Mental Health Issue, Adherence, Medication
- Trial name
- NCT05374109
- Testing
- SYV: Sauti ya Vijana (The Voice of Youth intervention)
- Where
- 6 sites in Tanzania
- Volunteers
- 690 people
- Sponsor
- Duke University
Gram-negative Bacteremia, Bloodstream Infection
Fast Antibiotic Susceptibility Testing for Gram Negative Bacteremia Trial
This study is a 2-arm, multicenter, multinational, prospective, randomized, controlled clinical trial. Hospitalized subjects with blood cultures growing Gram negative bacilli (GNB) will be randomized 1:1 to have the positive…
- Trial name
- FAST (NCT06174649)
- Testing
- Reveal
- Where
- 7 sites in Greece, India and 2 more
- Volunteers
- 899 people
- Sponsor
- Duke University
Influenza
Immunogenicity of Influenza Vaccinations
This study is a randomized immunogenicity study in an enrolled cohort with active surveillance for influenza-like illness (ILI).
- Trial name
- NCT06518577
- Testing
- Flucelvax® (ccIIV3), Flublok® (RIV3)
- Where
- 7 sites in United States
- Volunteers
- 606 people, healthy volunteers welcome
- Sponsor
- Duke University
Deep Brain Stimulation
Evaluation of Advanced Imaging and Visualization for Clinical Deep Brain Stimulation
The objective of this project is to evaluate next generation visualization tools and surgical targeting models for clinical deep brain stimulation (DBS).
- Trial name
- NCT06191874
- Testing
- Standard-of-care (SOC) surgery plan, HoloDBS hypothetical surgery plan
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Duke University