Clinical trials: completed, sponsored by Duke University
Smoking, Smoking, Cigarette
Impact of New Standards for Tobacco Products Among Dual E-Cigarette/Combusted Cigarette Users - Project 2
The purpose of the study is to evaluate how limiting the nicotine content in regular cigarettes affects choices for regular cigarette and e-cigarette products.
- Conditions
- Smoking, Smoking, Cigarette, E-Cig Use, Nicotine Dependence
- Trial name
- NCT05473585
- Testing
- very low nicotine content cigarettes, normal nicotine content cigarettes, Study e-cigarette
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Duke University
Rheumatoid Arthritis, Healthy Controls
MusculRA: The Effects of Rheumatoid Arthritis on Skeletal Muscle Biomechanics
Persons with rheumatoid arthritis (RA) suffer from increased disability and mortality, in part resulting from skeletal muscle impairments.
- Trial name
- MusculRA (NCT04226131)
- Testing
- Blood Draw, Disease Activity (DAS-28) Assessment, Skeletal Muscle Mitochondrial Respiratory Capacity
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Duke University
Chemo-radiation Induced Nausea and Vomiting
Rolapitant as an Antiemetic in Malignant Glioma Patients Receiving Radiotherapy and Temozolomide
The purpose of this phase 2 study is to assess the efficacy and patient satisfaction of oral rolapitant plus ondansetron vs. oral ondansetron monotherapy in malignant glioma (MG) patients receiving standard of care radiation (RT)…
- Trial name
- NCT02991456
- Testing
- Rolapitant, Ondansetron
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Duke University
Colorectal Cancer
Virtual Reality for Improving Pain and Distress in Patients With Advanced Stage Colorectal Cancer
Patients with advanced colorectal cancer often experience high levels of debilitating pain and pain-related psychological distress. Pain in cancer patients is typically treated with analgesics.
- Trial name
- VR Blue (NCT04069702)
- Testing
- VR Blue
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Kidney Disease
Transplant Social Worker Support for Live Kidney Donation in African Americans
Talking About Live Kidney Donation Support (TALKS) will study the effectiveness of education, behavior, and financial support interventions to improve consideration of live kidney transplantation/live kidney donation among…
- Trial name
- TALKS (NCT02369354)
- Testing
- TALKS Social Worker Intervention, Financial Assistance Intervention
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Duke University
Multiple Myeloma, Chronic Lymphocytic Leukemia
Multiple Myeloma/Chronic Lymphocytic Leukemia Coach RCT
The purpose of this study is to test the effectiveness of evidence-informed mobile apps, Myeloma Coach and CLL Coach. These apps have been developed to help manage the physical and emotional symptoms experienced by multiple…
- Trial name
- NCT05928156
- Testing
- Myeloma Coach or CLL Coach Mobile App, Springboard Beyond Cancer informational website
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Duke University
Gastroenteropancreatic Neuroendocrine Tumors
Study of Pembrolizumab With Lanreotide Depot for Gastroenteropancreatic Neuroendocrine Tumors
This study is for patients with non-resectable, recurrent, or metastatic well or moderately differentiated gastroenteropancreatic neuroendocrine tumors (GEP-NETs).
- Trial name
- PLANET (NCT03043664)
- Testing
- Lanreotide, Pembrolizumab
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Duke University
Heart Failure, Congestive Heart Failure
Daxor - Blood Volume Analysis
The purpose of this study is to better understand blood volume status and whether knowledge of it can change and improve heart failure care.
- Trial name
- NCT04111185
- Testing
- Receive Blood Volume Analysis Guided Treatment
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Duke University
Pancreatic Cancer, Surgery
Immunologic Signatures Following Surgery for Pancreatic Cancer
The goal of this pilot study is to evaluate and describe the immunologic and overall outcomes of subjects who undergo routine pancreatectomy with or without irreversible electroporation (IRE) for pancreatic cancer.
- Trial name
- NCT03001518
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Duke University
Chronic Heart Failure
Splanchnic Nerve Block for Therapy of Chronic Heart Failure (Splanchnic III)
Splanchnic vasoconstriction may contribute to decompensation of chronic heart failure (HF) via volume redistribution from the splanchnic vascular bed to the central compartment.
- Trial name
- NCT04575428
- Testing
- Splanchnic nerve block
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Duke University
Pneumonia, Ventilator-Associated, Pneumonia, Bacterial
CTTI Risk Factors for HABP/VABP Study
The purpose of this study is to better define the intensive care unit population at highest risk for developing Hospital-Acquired and Ventilator-Associated Bacterial Pneumonia (HABP/VABP).
- Conditions
- Pneumonia, Ventilator-Associated, Pneumonia, Bacterial, Pneumonia, Hospital-Acquired
- Trial name
- PROPHETIC (NCT02689531)
- Where
- 15 sites in United States
- Volunteers
- 7,530 people
- Sponsor
- Duke University
Tricuspid Valve Insufficiency, Right Heart Failure
Treatment of Tricuspid Valve Regurgitation in Patients Undergoing Left Ventricular Assist Device Implantation Study
The purpose of this study is to determine the utility of tricuspid valve repair at the time of LVAD implantation for patients presenting with moderate or severe tricuspid regurgitation.
- Conditions
- Tricuspid Valve Insufficiency, Right Heart Failure, Heart Failure
- Trial name
- TVVAD (NCT03775759)
- Testing
- Tricuspid valve repair or replacement, Medical management of tricuspid regurgitation
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Duke University
Hematopoietic Neoplasms (Leukemia, Lymphoma, Multiple Myeloma)
In Person and Mobile Health Coping Skills Training for Improving Symptom Management and Daily Steps in Hematopoietic Stem Cell Transplant Patients
The purpose of the study is to assess the feasibility, acceptability, and efficacy of a novel mHealth behavioral intervention to enable HCT patients to effectively cope with symptoms to improve their ability to engage in physical…
- Trial name
- CST Step Up (NCT03960619)
- Testing
- coping skills training
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Duke University
Opioid Use, Opioid-use Disorder
Providing Suboxone and PrEP Using Telemedicine
The purpose of this study is to provide medication for opioid use disorder (MOUD) with buprenorphine and naloxone, or bup/nx, and pre-exposure prophylaxis (PrEP) for HIV prevention for persons who inject opioids accessing syringe…
- Conditions
- Opioid Use, Opioid-use Disorder, Risk Reduction, Hiv
- Trial name
- NCT04521920
- Testing
- Suboxone, PrEP
- Where
- 3 sites in United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Duke University
Malignant Glioma
Mindfulness Meditation in Glioma Patients
This pilot study is designed to determine the feasibility of providing a mindfulness meditation program to patients with newly diagnosed malignant glioma during standard of care chemoradiation.
- Trial name
- NCT03915912
- Testing
- Mindfulness meditation
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Duke University
COVID-19
You and Me COVID Free
Observational, study that distributes rapid at-home, self-administered, SARS-CoV-2 antigen testing kits to households within pre-selected communities.
- Trial name
- YMCF (NCT05212883)
- Testing
- Behavioral questionaires
- Where
- United States
- Volunteers
- 2,778 people, healthy volunteers welcome
- Sponsor
- Duke University
Pompe Disease
The Effects of Respiratory Muscle Strength Training (RMST) on Inspiratory and Expiratory Muscle Strength in Adults and Children With Pompe Disease
The purpose of the study is to determine if respiratory muscle strength training will be beneficial for inspiratory and expiratory muscle strength in adults and children with Pompe disease.
- Trial name
- NCT01701154
- Testing
- respiratory muscle strength training
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Duke University
COVID-19
Longitudinal Energy Expenditure and Metabolic Effects in Patients With COVID-19 (LEEP-COVID)
This current proposal evaluates the Longitudinal Energy Expenditure and Metabolic Effects in Patients with COVID-19 (LEEP-COVID) to understand, guide and optimize our metabolic and nutritional care of these high risk patients.
- Trial name
- NCT04350073
- Testing
- Q-NRG Metobolic Cart Device, MuscleSound Ultrasound, Multifrequency Bioimpedance Spectroscopy
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Duke University
Interstitial Lung Disease, Idiopathic Pulmonary Fibrosis
Palliative Care Planner (PCplanner)
The purpose of this research study is to determine the feasibility, acceptability, and evidence for clinical impact of a mobile app-based program called Palliative Care Planner (PCplanner) in addressing needs and promoting…
- Trial name
- NCT05095363
- Testing
- PCplanner
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Duke University
Anxiety
Surveillance Pelvic Examination Anxiety: Brief Coping Skills Intervention
The purpose of this study is to test the feasibility and acceptability of a brief coping skills training program addressing anxiety and pain related to surveillance pelvic examinations for female gynecologic cancer survivors.
- Trial name
- PEACE (NCT05285306)
- Testing
- PEACE Program
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Duke University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.