Clinical trials: completed, sponsored by Duke University
Burkitt Lymphoma, Retinoblastoma
Mobile Health Case Management System for Reducing Pediatric Treatment Abandonment
Digital case management systems have the potential to increase compliance with protocol-driven treatment, reduce treatment abandonment and ultimately help to close the discrepancy in pediatric cancer outcomes between Low and…
- Conditions
- Burkitt Lymphoma, Retinoblastoma, Diffuse Large B-cell Lymphoma
- Trial name
- NCT03677128
- Testing
- mNavigator
- Where
- Tanzania
- Volunteers
- 75 people
- Sponsor
- Duke University
Stress Reduction
DeStress for Health: Partnering With Granville and Vance Counties to Reduce Stress and Cancer Risk (Part 2)
The purpose of this research study is to determine whether a positive psychology intervention paired with a health behavior intervention is successful in decreasing perceived stress and increasing positive affect in residents of…
- Trial name
- NCT05469334
- Testing
- DeStress for Health Program Participants
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Duke University
Hypertension
Tailored to You (TTY) Pilot Study
The purpose of this research study is to use a test called impedance cardiography (ICG) to provide more information about how to improve the control of blood pressure.
- Trial name
- NCT05141175
- Testing
- Hypertension medication algorithm, Impedance Cardiography
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Coronary Heart Disease
An mHealth Intervention to Improve Medication Adherence and Health Outcomes
Investigators evaluated the efficacy of a pilot-tested mHealth intervention to improving medication adherence and health outcomes among patients with coronary heart disease.
- Trial name
- NCT04703439
- Testing
- Medication-taking reminders & educational materials, Educational materials
- Where
- China
- Volunteers
- 230 people
- Sponsor
- Duke University
Opioid Use, Opioid Use Disorder
Providing PrEP, Hepatitis C Treatment, and MOUD Through Telemedicine at Greensboro SSP
The purpose of this study is to provide medication for opioid use disorder (MOUD) with buprenorphine and naloxone, or bup/nx, pre-exposure prophylaxis (PrEP) for HIV prevention, and/or hepatitis C treatment for persons who inject…
- Conditions
- Opioid Use, Opioid Use Disorder, Risk Reduction, Hiv
- Trial name
- PARTNERUP (NCT05108935)
- Testing
- Suboxone, Truvada, Mavyret
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Duke University
Parkinson Disease
Quantification of Beta Activity in Routine EEG Recordings in Parkinson's Disease Patients
The investigators are studying the relationship between a certain oscillatory brain rhythm (13-30 cycles/sec) that emerges prominently in patients with Parkinson's disease and symptoms of slowness of movement.
- Trial name
- PD-EEG (NCT03103347)
- Volunteers
- 27 people
- Sponsor
- Duke University
Head and Neck Cancers, Lung and Esophagus Cancers
Adaptive Pet Study
The purpose of this study is to determine the benefit of using positron emission tomography (PET) in addition to the standard (computed tomography) CT to plan radiation therapy for cancer treatment.
- Conditions
- Head and Neck Cancers, Lung and Esophagus Cancers, Anal, Cervix, Vulvar, Vaginal, and Endometrium Cancers
- Trial name
- NCT01908504
- Testing
- PET-CT
- Where
- United States
- Volunteers
- 271 people
- Sponsor
- Duke University
Low Back Pain, Depression
Self System Therapy and Chronic Low Back Pain Trial
This study is for people with chronic low back pain who may also be feeling discouraged, frustrated, or depressed. This study is testing a new therapy that is designed to specifically help these patients foster a better…
- Trial name
- Low Back Pain (NCT00672880)
- Testing
- Self-System Therapy, Education, Standard Care
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Duke University
Breast Cancer, Melanoma
Ipsilateral Peripheral Intravenous Access Procedures (The iPIVAP Study)
This pilot study will examine facilitators and barriers that impact staff uptake for implementation of practice change involving ipsilateral IV insertion in patients with axillary lymphadenectomy/dissection in a single radiology…
- Conditions
- Breast Cancer, Melanoma, Thoracic Cancer, Lymphedema of Upper Arm
- Trial name
- iPIVAP (NCT04570722)
- Testing
- Ipsilateral peripheral IV insertion
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Duke University
Development, Child
Targeting Infant Development With Early Screening
The purpose of this study is to assess feasibility and acceptability of parent-completed screeners of child social/emotional development, social determinants of health, and adverse childhood experiences in the setting of a…
- Trial name
- TIDES (NCT04326179)
- Where
- United States
- Volunteers
- 7,720 people
- Sponsor
- Duke University
Eye Manifestations
Intraoperative OCT Guidance of Intraocular Surgery
The purpose of this study is to investigate the use of optical coherence tomography imaging integrated with an operating microscope (MIOCT) in ophthalmic surgeries.
- Trial name
- MIOCT (NCT01588041)
- Where
- 2 sites in United States
- Volunteers
- 269 people, healthy volunteers welcome
- Sponsor
- Duke University
Vaccine Refusal
Development and Testing of ADEPT: A Parent Decision Support for Childhood Vaccinations
The purpose of this study is to develop and evaluate a tool designed to help parents make decisions about childhood vaccines.
- Trial name
- ADEPT (NCT04496453)
- Testing
- Childhood vaccination decision support tool
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Duke University
Dementia
Implementation of Cognitive Stimulation Therapy
This project aims to examine the feasibility of implementing Cognitive Stimulation Therapy (CST) under real world circumstances in a more heterogenous population, with the ultimate goal of making the treatment broadly accessible.
- Trial name
- NCT04754932
- Testing
- Cognitive Stimulation Therapy
- Where
- 4 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Duke University
Alzheimers Disease, Postoperative Delirium
Markers of Alzheimers Disease and Cognitive Outcomes After Perioperative Care
This study will examine the hypothesis that changes in the cognition (i.e. thinking and memory) after anesthesia and surgery are correlated with changes in markers of Alzheimers Disease in the fluid around the brain and spinal…
- Conditions
- Alzheimers Disease, Postoperative Delirium, Post Operative Cognitive Dysfunction
- Trial name
- MADCO-PC (NCT01993836)
- Testing
- Total intravenous anesthesia with propofol, General anesthesia with isoflurane
- Where
- United States
- Volunteers
- 191 people
- Sponsor
- Duke University
Diabetes Mellitus
A Transition of Care Model From Hospital to Community for Hispanic/Latino Adult Patients With Diabetes.
This pilot study was designed to address the existing gap in the transition of care of Hispanic/Latino Adults with diabetes from hospital to community.
- Trial name
- TOC (NCT04864639)
- Testing
- Transition of Care Model
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Duke University
Stress Reduction
DeStress for Health: Partnering With Granville and Vance Counties to Reduce Stress and Cancer Risk
The purpose of this research study is to determine whether a positive psychology intervention paired with a health behavior intervention is successful in decreasing perceived stress and increasing positive affect in residents of…
- Trial name
- NCT03776890
- Testing
- DeStress for Health Program
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Duke University
Infections Resistant to Multiple Drugs, Bacterial Infections
Multi-Drug Resistant Organism Network
This study is specifically designed to provide observational data which can be used to help in the design of future randomized clinical trials on both therapeutics and diagnostics for MDRO infections.
- Trial name
- MDRO Network (NCT03646227)
- Testing
- Standard of Care
- Where
- 4 sites in United States, Australia and 2 more
- Volunteers
- 6,496 people
- Sponsor
- Duke University
Substance Use, Mental Health
Project Uplift: Substance Use and Mental Health Treatment for Young Sexual and Gender Minorities
This study provides substance use and mental health treatment for young sexual and gender minority adults in Durham and Charlotte, NC and seeks to provide intensive wraparound services that address factors that influence…
- Trial name
- NCT04546061
- Testing
- Project Uplift
- Where
- 2 sites in United States
- Volunteers
- 112 people
- Sponsor
- Duke University
Cognition Disorders
Cognitive Effects of Body Temperature During Hypothermic Circulatory Arrest
In this study the investigator will randomize 273 subjects to deep (<20°C), low (20.1°C-24°C), or moderate (24.1°C-28°C) hypothermia during aortic arch surgery with circulatory arrest.
- Trial name
- NCT02834065
- Testing
- Cardiopulmonary bypass machine
- Where
- 4 sites in United States
- Volunteers
- 273 people
- Sponsor
- Duke University
Asthma, Obesity
Pulmonary Inflammation and Microbiome Changes With Bariatric Surgery in Obese Asthma
The purpose of this study is to gain understanding of mechanisms whereby bariatric surgery modulates pulmonary inflammation and pulmonary microbiome composition and how these changes direct the pathobiology of human obese asthma.
- Trial name
- NCT04247971
- Testing
- Blood draw, Sputum collection, Pulmonary function test
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Duke University
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