Clinical trials: completed, sponsored by Duke University
Pain, Postoperative, Atrial Fibrillation
BRS and Outcomes in Cardiothoracic Surgery
The purpose of this study is to determine whether baroreceptor sensitivity (the ability of your body to change your heart rate and/or blood pressure in response to a situation) has any effect on how likely you are to suffer…
- Conditions
- Pain, Postoperative, Atrial Fibrillation, Cognitive Dysfunction
- Trial name
- NCT03243279
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Duke University
Central Line-associated Bloodstream Infection (CLABSI)
Implementation Program to Improve CHG Bathing Compliance
This study will be a multicenter, cluster randomized, step-wedged design. The unit of randomization will be the inpatient units admitted critically ill patients, with the interventions being carried out over 4 months.
- Trial name
- NCT03898115
- Testing
- CHG Education
- Where
- 2 sites in United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Duke University
Healthy Diet
The Effects of Western Diet Patterns on Plasma Inflammatory and Cardio Metabolic Health Signatures in Middle-aged Adults
The Western diet pattern or standard American diet is a modern dietary pattern that is characterized by high intakes of meat, pre-packaged foods, fried foods, high-fat dairy products, eggs, refined grains etc.
- Trial name
- NCT04275843
- Testing
- Traditional Diet, Modern Diet
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Duke University
Health Behavior
Active Dads Healthy Families
The purpose of this study is to evaluate the feasibility of implementing a community-delivered physical activity program for fathers and their children ages 2-5 years.
- Trial name
- NCT04505085
- Testing
- Active Dads Healthy Families: Outdoor Education, Active Dads Healthy Families: Fitness
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Duke University
Pediatric Obesity, Asthma in Children
Steroid Metabolism in Obese and Non-Obese Pediatric Patients Hospitalized for Status Asthmaticus
Single center, open-label, non-randomized study to assess the pharmacokinetic profile of methylprednisolone in healthy children 2-20 years of age admitted for asthma exacerbation.
- Trial name
- NCT04874610
- Testing
- Methylprednisolone
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Duke University
Uveitis
OCT Technology Development to Assess Ocular Integrity and Characterize Ocular Integrity and Intraocular Scatterers
The purpose of this study is to develop and demonstrate new technologies that will enable a non-contact, compact eye imaging system based on OCT to assist an early responder in acute care settings (like an emergency room) to help…
- Trial name
- NCT03531853
- Testing
- hand-held swept source optical coherence tomography
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Duke University
Pain Measurement
COA-APTIC Caregiver Concept Elicitation Study
This is a concept elicitation study to identify important aspects of pain assessment, treatment, and response to treatment in children under than 3 years of age from a caregiver's perspective.
- Trial name
- NCT04392180
- Testing
- Qualitative Interview
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Duke University
Brain Metastases, Adult
SIMT Stereotactic Radiosurgery Outcomes Study
The purpose of this study is to determine the effectiveness and efficiency of Single Isocenter Multi-target Stereotactic Radiosurgery (SIMT SRS) in patients with four or more brain metastases
- Trial name
- SIMT (NCT02886572)
- Testing
- Stereotactic radiosurgery
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Duke University
Morbid Obesity, Labor Pain
DPE Technique in Labor Epidural for Morbidly Obese Women
The primary purpose of this study is to determine differences in block quality between the "dural-puncture epidural" (DPE) and standard epidural (EPL) techniques for labor analgesia in the morbidly obese patient.
- Trial name
- NCT03074695
- Testing
- Dural puncture epidural (DPE), Standard Epidural (EPL)
- Where
- United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Duke University
Stress, Acculturation
SER Hispano Longitudinal Study
Hispanic immigrants to the U.S. are more likely to experience negative health outcomes the longer they live in the U.S. For example, over time Hispanic immigrants engage in riskier behaviors such as substance abuse, violence, and…
- Conditions
- Stress, Acculturation, Health
- Trial name
- NCT03527654
- Testing
- Observational
- Where
- United States
- Volunteers
- 390 people
- Sponsor
- Duke University
Advance Care Planning
Quality Improvement Project for Advance Care Planning Tool in Hospital Medicine
Hospitalized patients and their families are often unprepared regarding end-of-life care. Even patients with high risk of mortality within the index admission or 30 days after admission often do not have clearly defined goals of…
- Trial name
- NCT04296136
- Testing
- Advance Care Planning Discussion
- Where
- United States
- Volunteers
- 743 people
- Sponsor
- Duke University
Spinal Fusion, Activities of Daily Living Following Complex Spinal Fusions
Impact of Body Habitus (Arm Span and Abdominal Girth) on Activities of Daily Living (ADL)
This study is being done to assess the impact of arm length and abdominal (belly) width on patient performance of daily self-care activities following multiple level spinal fusions.
- Trial name
- ADL (NCT04037059)
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Duke University
Advanced Solid Tumor, Pain
Meaning-Centered Pain Coping Skills Training
This study is a randomized clinical trial of a psychosocial pain management intervention called, Meaning-Centered Pain Coping Skills Training (MCPC).
- Trial name
- NCT04431830
- Testing
- Meaning-Centered Pain Coping Skills Training
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Healthy
Effect of Octreotide on Saliva
The purpose of this study is to determine the effect of Octreotide on saliva enzymes. The study team hypothesizes that Octreotide will decrease the levels of certain proteins, specifically the metalloproteinase family.
- Trial name
- NCT05340192
- Testing
- Octreotide 1 MG/ML
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Duke University
Multiple Sclerosis
MS Mosaic: A Longitudinal Research Study on Multiple Sclerosis
The purpose of this study is to better characterize the fluctuations in multiple sclerosis symptoms and their relationship to medications, to length/extent of disease, and to a variety of physiologic measures.
- Trial name
- NCT02845635
- Testing
- Personal history of multiple sclerosis
- Where
- United States
- Volunteers
- 2,200 people, healthy volunteers welcome
- Sponsor
- Duke University
Kidney Transplant; Complications, Patient Empowerment
Duke Transplant University
The purpose of this research study is to determine the effectiveness of educational videos for patients who have just had kidney transplant compared to usual patient education practices.
- Conditions
- Kidney Transplant; Complications, Patient Empowerment, Medication Adherence, Patient Satisfaction
- Trial name
- NCT04219839
- Testing
- SOC + Educational Videos Designed Especially for post-transplant patients
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Duke University
Pediatric Obesity
Childhood Obesity Microbiome Study
The purpose of this study is to measure the effectiveness of a microbiome diet using direct food provision on dietary quality and microbiome composition among children with obesity.
- Trial name
- CHOICE (NCT04770311)
- Testing
- Microbiome friendly diet
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Duke University
Test if Increased Chewing Will Increased Microbiota SCFA Production
Particle Size Project
This study is designed to test the effects of chewing efficiency on human gut microbiome composition and function.
- Trial name
- EPSOM (NCT05091801)
- Testing
- Intervention
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Duke University
Malignant Glioma, Glioblastoma
Avastin/Radiation (XRT)/Temozolomide (Temodar) Followed by Avastin/Temodar/Topotecan for Glioblastoma
This is a phase II study of the combination of radiation therapy, temozolomide and Avastin followed by Avastin, temozolomide, and topotecan in grade IV malignant glioma patients.
- Conditions
- Malignant Glioma, Glioblastoma, Gliosarcoma
- Trial name
- NCT01004874
- Testing
- Bevacizumab, Temozolomide, Radiation Therapy (XRT)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Duke University
Covid19
COVID-19 Surveillance and Exposure Testing in School Communities
This is a prospective, observational study of COVID-19 surveillance and exposure testing in school communities. Participating school communities are providing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) tests to…
- Trial name
- NCT04831866
- Where
- 2 sites in United States
- Volunteers
- 4,000 people
- Sponsor
- Duke University
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