Clinical trials: completed, sponsored by Duke University
Nicotine Dependence
Adaptive Pharmacotherapy for Smoking Cessation
The purpose of this study is to assess an "adaptive" approach to smoking cessation pharmacotherapy. The protocol is designed to compare adaptive vs.
- Trial name
- NCT02501265
- Testing
- Varenicline Standard Protocol, Nicotine Patch Standard Protocol, Varenicline Adaptive Protocol
- Where
- United States
- Volunteers
- 188 people
- Sponsor
- Duke University
Ovarian Cancer, Ovarian Neoplasms
Atezolizumab With Neoadjuvant Chemotherapy for Patients With Newly-Diagnosed Advanced-Stage Ovarian Cancer
The main purpose of this study is to validate a safe dose of atezolizumab with dose-dense paclitaxel and carboplatin when utilized with neoadjuvant chemotherapy and interval cytoreductive surgery followed by maintenance…
- Trial name
- AdORN (NCT03394885)
- Testing
- Atezolizumab, Carboplatin, Paclitaxel
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- Duke University
Alcohol Use
Evaluating a Brief Negotiational Intervention for Alcohol Use Among Injury Patients in Tanzania
A brief negotiational interview (BNI), administered in an Emergency Department setting for both hazardous and harmful drinkers has been shown to cost-effectively reduce a patient's alcohol intake and re-injury rate up to 3 years…
- Trial name
- BNI (NCT02828267)
- Testing
- Brief Negotiational Intervention, Standard Booster, Personalized Booster
- Where
- Tanzania
- Volunteers
- 75 people
- Sponsor
- Duke University
Depression
Latina Adolescent Depression Treatment Study
Despite experiencing higher rates of depressive symptoms and similar rates of Major Depressive Disorder (MDD), Latina (female) adolescents in the U.S.
- Trial name
- NCT04164537
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Duke University
Early Stage Endometrial Cancer
Endometrial Cancer Diet and Exercise
This study will evaluate whether the use of the Jawbone wristband monitor, in connection with home-based exercise and nutritional counseling can be safely completed and improve cardiorespiratory fitness (heart and lung health) in…
- Trial name
- NCT02987881
- Testing
- Home-based aerobic exercise and nutritional counseling
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Duke University
Prostate Cancer
A Survivorship Care Plan and Embedded Navigation Tool
This is a parallel group, multisite prospective clinical study. The purpose of this study is to evaluate whether ASCENT enables patients to adhere to the survivorship guidelines and improves coordination of care to address…
- Trial name
- ASCENT (NCT03424837)
- Testing
- ASCENT
- Where
- 6 sites in United States
- Volunteers
- 77 people
- Sponsor
- Duke University
Opioid Use Disorder
Buprenorphine Physician-Pharmacist Collaboration in the Management of Patients With Opioid Use Disorder: CTN 0075
This pilot study examines the feasibility and acceptability of transitioning office-based buprenorphine treatment of opioid use disorder from physicians to pharmacists.
- Trial name
- Pharm-OUD-Care (NCT03248947)
- Testing
- buprenorphine/naloxone, Pharmacist-administered buprenorphine/naloxone maintenance care
- Where
- 6 sites in United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Duke University
Glycogen Storage Disease
Lingual Muscle Training in Late-Onset Pompe Disease (LOPD)
This study is being done to test the effects of Lingual Muscle Therapy (LMT) in patients with Late-Onset Pompe Disease (LOPD) who have tongue weakness.
- Trial name
- NCT03255213
- Testing
- Lingual Muscle Training
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Duke University
Acute Stroke, Intracranial Hemorrhages
IMPROVE Stroke Care- Developing and Optimizing Regional Systems of Stroke Care
The purpose of this program is to develop a regional integrated stroke system that identifies, classifies, and treats patients with acute ischemic stroke more rapidly and effectively with reperfusion therapy.
- Conditions
- Acute Stroke, Intracranial Hemorrhages, Subarachnoid Hemorrhage
- Trial name
- NCT04242784
- Where
- 9 sites in United States
- Volunteers
- 21,646 people
- Sponsor
- Duke University
E Coli Infection
Multi-Drug Resistant Organism (MDRO): Study of Highly Resistant Escherichia Coli
This is a prospective, observational, multicenter, case-control study.
- Trial name
- SHREC (NCT04574596)
- Testing
- no Intervention
- Where
- 13 sites in United States
- Volunteers
- 300 people
- Sponsor
- Duke University
Anxiety, Depression
Neuromodulation Enhanced Cognitive Restructuring: A Proof of Concept Study
Psychological treatments are effective, but take a long time and can be burdensome. Therefore, avenues to optimize behavioral treatments are needed.
- Conditions
- Anxiety, Depression, Personality Disorders, Trauma and Stress-related Disorders
- Trial name
- NCT02573246
- Testing
- Cognitive Restructuring, rTMS
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Duke University
Pregnancy Complications, Obesity
Acute Exercise Effects in Obese Pregnancy
Obesity before and during pregnancy is associated with a higher risk for a number of obstetric and metabolic complications in women and their offspring.
- Conditions
- Pregnancy Complications, Obesity, Pre-Eclampsia, Gestational Diabetes
- Trial name
- NCT03750695
- Testing
- Resistance exercise, Aerobic Exercise, Rest
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Duke University
Attention Deficit Hyperactivity Disorder
Sleep Dysfunction and Neurocognitive Outcomes in Adolescent ADHD
This study seeks to characterize sleep physiology in adolescents with and without Attention deficit hyperactivity disorder (ADHD) and its relationship to differential neurocognitive and clinical outcomes within these groups.
- Trial name
- NCT02897362
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Duke University
Snorkeling, Face Mask Squeeze
Evaluation of Full Face Snorkel Masks (FFSMs)
Recently, multiple models of Full Face Snorkel Mask (FFSM) have entered the retail market. However, several fatalities have been reported to the non-profit agency Divers Alert Network (DAN) for snorkelers who were using FFSMs…
- Conditions
- Snorkeling, Face Mask Squeeze, Underwater Physiology, Swimming Physiology
- Trial name
- NCT04783688
- Testing
- Full Face Snorkel Mask (FFSM)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Duke University
Myopathy, Neuropathy
Identification of Tongue Involvement in Late-Onset Pompe Disease
This purpose of this study is to determine if tongue strength and tongue ultrasound measurements differentiates patients with untreated late-onset Pompe Disease (LOPD) from patients with acquires/hereditary myopathies or…
- Conditions
- Myopathy, Neuropathy, Glycogen Storage Disease Type II (Late-onset Pompe Disease)
- Trial name
- NCT02765828
- Testing
- Observational study
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Duke University
Aging, Chronic Lymphocytic Leukemia
Exercise Training to Promote Resilience to Chronic Lymphocytic Leukemia
PURPOSE: The purpose of the study is to determine the effects of 12-weeks of exercise training on physical reserve, as measured by aerobic capacity, strength and physical function, in patients with CLL.
- Trial name
- HIIT-CLL (NCT04950452)
- Testing
- Exercise Training
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Atherosclerotic Cardiovascular Disease
Aspirin Dosing: A Patient-Centric Trial Assessing Benefits and Long-term
ADAPTABLE is a pragmatic clinical trial in which 15,000 patients who are at high risk for ischemic events will be randomly assigned in a 1:1 ratio to receive an aspirin dose of 81 mg/day vs. 325 mg/day.
- Trial name
- ADAPTABLE (NCT02697916)
- Testing
- aspirin
- Where
- 40 sites in United States
- Volunteers
- 15,076 people
- Sponsor
- Duke University
Atrial Fibrillation
Arterial Versus Venous Activated Clotting Time (ACT) Measurements During Atrial Fibrillation Ablations
Activated clotting times (ACTs) are routinely measured throughout atrial fibrillation ablations to monitor anticoagulation prior to and after heparin administration.
- Trial name
- NCT04285840
- Testing
- Venous ACT
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Duke University
Pediatric Obesity
Pediatric Metabolism and Microbiome Repository
The aim of this project is to establish a bio-repository of diverse specimen types to provide investigators access to specimens in order to further research related to metabolism and the microbiome in the pediatric population.
- Trial name
- PMMR (NCT02959034)
- Where
- United States
- Volunteers
- 486 people, healthy volunteers welcome
- Sponsor
- Duke University
Pediatric Obesity
Pediatric Obesity Observational Prospective Trial
Using an observational case-control cohort design, the investigator aims to define the mechanisms underlying microbiome regulation of metabolism in adolescence before and after medically indicated therapies for obesity.
- Trial name
- NCT03139877
- Where
- United States
- Volunteers
- 295 people, healthy volunteers welcome
- Sponsor
- Duke University