Clinical trials: completed, sponsored by Duke University
HIV Infection
MAPS PrEP Van Study
For this study the investigators aim to see if giving participants an oral HIV prevention medication on a medical van, is a good option of care for individuals who inject drugs and/or are sexually active and therefore at a higher…
- Trial name
- MAPS PrEP (NCT06908252)
- Testing
- Pre-Exposure Prophylaxis (PrEP)
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Duke University
Sickle Cell Disease, Chronic Kidney Diseases
Peer i-Coaching for Activated Self-Management Optimization in Adolescents and Young Adults With Chronic Conditions
The purpose of this study is to test the efficacy of a peer support coaching intervention to improve activated chronic illness self-management versus an attention control group in 225 adolescents and young adults with childhood…
- Conditions
- Sickle Cell Disease, Chronic Kidney Diseases, Systemic Lupus Erythematosus, Childhood Cancer
- Trial name
- PiCASO (NCT03938324)
- Testing
- PiCASO Intervention Group
- Where
- United States
- Volunteers
- 222 people
- Sponsor
- Duke University
Misophonia, Emotion Dysregulation
Using Neurostimulation to Accelerate Change in Misophonia: a Pilot Study
Misophonia, the inability to tolerate certain repetitive distressing sounds that are common, is gaining, recognition as an impairing condition. It is not a well-understood condition and there are no known treatments.
- Conditions
- Misophonia, Emotion Dysregulation, Sensory Processing Disorder, Auditory Over Responsivity
- Trial name
- MISO-STIM (NCT06333925)
- Testing
- High Frequency Repetitive Transcranial Magnetic Stimulation (HF rTMS), Cognitive Restructuring
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Duke University
Arthropathy of Knee, Antibiotic Prophylaxis
Antibiotic Prophylaxis in Patients Undergoing Elective Total Knee Arthroplasty- Multi-center Trial
The Antibiotic Prophylaxis in Patients Undergoing Elective Total Knee Arthroplasty (TKA): Multi-Center Trial is a study that will compare the effectiveness of various perioperative strategies for antibiotic delivery as…
- Trial name
- NCT03283878
- Testing
- Cefazolin
- Where
- 14 sites in United States
- Volunteers
- 1,770 people
- Sponsor
- Duke University
Systemic Lupus Erythematosus
Reducing Disparities in Medication Adherence in SLE
This is a pilot study to assess the feasibility of using Surescripts refill data during the clinical encounter to improve medication adherence in patients with systemic lupus erythematosus
- Trial name
- NCT03738826
- Testing
- Behavioral Intervention
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- Duke University
Hematologic Malignancy
VitalTraq for the Detection of CRS
The purpose of this study is to evaluate two vital sign monitoring devices, TempTraq and VitalTraq, in patients with hematologic malignancies undergoing therapy with Chimeric antigen receptor T-cell therapy (CAR-T) or Bispecific…
- Trial name
- NCT06415656
- Testing
- TempTraq, VitalTraq
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Duke University
Prediabetic State, Cardiovascular Diseases
Role of Aging and Individual Variation in Exercise Training Responsiveness
The primary purpose of this study is to assess the effects of aging on markers of physical reserve and exercise-induced adaptations in resilience in older adults who completed a structured exercise program within the last 15…
- Conditions
- Prediabetic State, Cardiovascular Diseases, Insulin Resistance, Obesity
- Trial name
- STRRIDE IV (NCT06471569)
- Testing
- Low/Mod, High/Mod, High/Vig
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Duke University
Preexposure Prophylaxis, HIV Infections
Start the Conversation: Evaluating Implementation of a Multi-level PrEP Initiative for Black Cisgender Women in Nola
The study objectives are to: Evaluate implementation outcomes from piloting the Start the Conversation Initiative Assess initial indicators of clinical effectiveness among patients engaged in the Start the Conversation Initiative…
- Trial name
- NCT05909176
- Testing
- GYN Residency Training, Social Media Campaign
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Duke University
Sleep, Psychiatric Health
Sustainable Habits for Encouraging Even Teen Sleep
This study will examine the feasibility, acceptability, and effectiveness of two digital sleep interventions in improving sleep regularity and psychiatric health during a critical period of adolescence.
- Trial name
- SHEETS (NCT05378373)
- Testing
- Garmin, Pattern Health App
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Duke University
Pediatric Obesity, Weight Gain Trajectory
Assessing Better Bottles for Babies
This study will use a 2 x 2 factorial design to test impact of two intervention strategies (bottle size and bottle opacity) on infant weight gain.
- Conditions
- Pediatric Obesity, Weight Gain Trajectory, Infant Obesity
- Trial name
- AB3 (NCT06357299)
- Testing
- Small Bottle Size, Standard Bottle Size, Clear Bottle
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Duke University
Long COVID, Long COVID-19
RECOVER-SLEEP: Platform Protocol, Appendix_B (CPSD)
The platform protocol is designed to be flexible so that it is suitable for a range of study settings and intervention types. Therefore, the platform protocol provides a general protocol structure that can be shared by multiple…
- Conditions
- Long COVID, Long COVID-19, Sleep Disturbance
- Trial name
- NCT06404112
- Testing
- Melatonin, Tailored lighting (TL) Active
- Where
- United States
- Volunteers
- 469 people
- Sponsor
- Duke University
Breast Cancer
Adaptation and Pilot Testing of a Mindfulness-Based Insomnia and Symptom Management Intervention for Women With Breast Cancer Receiving Treatment in Rural Medically Underserved Areas
Women with breast cancer often experience multiple difficult symptoms, for example insomnia, fatigue, stress, and pain. This study is being done to test a mindfulness-based insomnia and symptom management intervention for women…
- Trial name
- NCT06529120
- Testing
- Mindfulness-Based Therapy for Insomnia with Cognitive-Behavioral Symptom Coping Skills
- Where
- 4 sites in United States
- Volunteers
- 15 people
- Sponsor
- Duke University
Long COVID, Long Covid19
RECOVER-ENERGIZE Platform Protocol_Appendix A (Exercise Intolerance)
This is a platform protocol designed to be flexible so that it is suitable for a range of interventions and settings within diverse health care systems and community settings with incorporation into clinical COVID-19 management…
- Conditions
- Long COVID, Long Covid19, Long Covid-19
- Trial name
- NCT06404060
- Testing
- Personalized Cardiopulmonary Rehabilitation, Education
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Duke University
Alcohol Drinking, Veterans
Cost Effectiveness of Combined Contingency Management and Cognitive Behavioral Therapy for Alcohol Use Disorder
Alcohol contributes to 88,000 deaths and costs an estimated $223 billion annually in the United States. Alcohol use disorder (AUD) is highly prevalent in veterans.
- Trial name
- NCT03987581
- Testing
- Cognitive Behavioral Therapy (CBT), Mobile Contingency Management (mCM), Long-term incentive
- Where
- United States
- Volunteers
- 151 people
- Sponsor
- Duke University
Pain, Injection Site Reaction
Safety of Pediatric COVID-19 Vaccination
This is a prospective, observational study. During the study, children and adolescents (ages ≥ 5 to < 16) will be followed post administration of mRNA COVID-19 vaccines.
- Conditions
- Pain, Injection Site Reaction, Adverse Drug Event
- Trial name
- NCT05157191
- Testing
- Observational
- Where
- 5 sites in United States
- Volunteers
- 299 people, healthy volunteers welcome
- Sponsor
- Duke University
Hematologic Malignancy
Mechanisms of Disease R/R in CAR-T for Hematologic Malignancies
The primary purpose of this IRB protocol is to perform immune profiling focusing on the measurement of Myeloid derived suppressor cells (MDSCs) over time in patients receiving Chimeric antigen receptor (CAR) T therapy and…
- Trial name
- NCT05397132
- Testing
- Blood draw
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Duke University
ASCVD
ACHIEVE Pilot Statins for Vascular Protection
ACHIEVE aims to increase statin usage among patients with ASCVD by having a pharmacist talk to patients and providers.
- Trial name
- ACHIEVE (NCT06551701)
- Testing
- Pharmacist call
- Where
- 2 sites in United States
- Volunteers
- 225 people
- Sponsor
- Duke University
Sickle Cell Disease
Gerofit Exercise Intervention for Older Adults With Sickle Cell Disease (SICKLE-FIT Study)
The purpose of this study to assess the feasibility, acceptability, and safety of a personalized exercise training program adapted from Gerofit to improve physical health and quality of life for adults with SCD
- Trial name
- SICKLE-FIT (NCT05714098)
- Testing
- Gerofit Exercise Program
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Duke University
Urinary Stones
Prevention of Urinary Stones With Hydration
A randomized clinical trial to investigate the impact of increased fluid intake and increased urine output on the recurrence rate of urinary stone disease (USD) in adults and children.
- Trial name
- PUSH (NCT03244189)
- Testing
- Fluid prescription, Financial incentive, Structured Problem Solving
- Where
- 8 sites in United States
- Volunteers
- 1,658 people
- Sponsor
- Duke University
Neurological Disorder, Autoimmune Diseases
Disease-Modifying Treatments for Myasthenia Gravis
This study is designed to address the evidence gaps in a real-world setting and help patients with MG choose treatments that are best suited to them.
- Trial name
- PROMISE-MG (NCT03490539)
- Testing
- Mycophenolate Mofetil, Azathioprine
- Where
- 19 sites in United States, Canada
- Volunteers
- 82 people
- Sponsor
- Duke University