Clinical trials: completed, sponsored by Duke University
Morphea
Pilot Study Evaluating the Efficacy of a Topical PDE4 Inhibitor for Morphea
This is a pilot study to determine the safety and clinical efficacy of crisaborole 2% ointment in the treatment of morphea.
- Trial name
- NCT03351114
- Testing
- Crisaborole
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Duke University
Post-operative Pain
Genicular Nerve Block for Total Knee Arthroplasty
This study seeks to examine the analgesic efficacy of genicular nerve blocks for pain after total knee replacement.
- Trial name
- NCT03706313
- Testing
- 15mL 0.25% bupivacaine, Genicular nerve block, Saline
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Duke University
Pain, Quality of Life
FLUAD® vs. Fluzone® High-Dose Study
The overall aim of the study is to compare safety and immunogenicity of inactivated influenza vaccine (IIV), adjuvanted (FLUAD®) versus High-Dose inactivated influenza (Fluzone® High-Dose) vaccine in persons ≥65 years (20% aged…
- Conditions
- Pain, Quality of Life, Injection Site Reaction, Side Effect of Drug
- Trial name
- NCT03183908
- Testing
- FLUAD®, Fluzone® High-Dose
- Where
- 4 sites in United States
- Volunteers
- 757 people, healthy volunteers welcome
- Sponsor
- Duke University
Tobacco Use Cessation
Project Q Pilot: Smoking Cessation for Light Smokers
The purpose of this pilot study is to evaluate the feasibility, acceptability, and preliminary efficacy of an intervention to promote smoking cessation among light smokers.
- Trial name
- NCT03416621
- Testing
- Cognitive behavioral cessation counseling, Counseling and active drug intervention
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Duke University
Treatment-Resistant Hypertension
Neurocognition, Lifestyle Modification, and Treatment Resistant Hypertension
This application proposes to extend an ongoing NHLBI clinical trial (NCT02342808) examining the efficacy of a lifestyle intervention combining the Dietary Approaches to Stop Hypertension (DASH) diet with caloric restriction and…
- Trial name
- NCT03001427
- Testing
- Structured center-based lifestyle intervention, Standard education and physician advice
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Duke University
Osteoarthritis, Acetaminophen
Intravenous Versus Oral Acetaminophen in Primary Total Hip Arthroplasty
The purpose of this study is to determine if intravenous acetaminophen is superior to oral acetaminophen when used as part of a multimodal pathway for primary total hip arthroplasty.
- Conditions
- Osteoarthritis, Acetaminophen, Arthroplasty, Hip Replacement
- Trial name
- NCT02839876
- Testing
- Intravenous acetaminophen, Oral acetaminophen
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Duke University
Pain Measurement
COA-APTIC Clinician Concept Elicitation Study
This is a concept elicitation study to identify important aspects of acute pain assessment, treatment, and response to treatment in infants and young children, age 0 to 3 years old, from a clinician's perspective.
- Trial name
- NCT04380246
- Testing
- Qualitative Interview
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Duke University
Cannabis, Cannabis Use
Impact of Reduced Cannabis Use on Functional Outcomes
Nearly 20 million Americans report use of cannabis in the past month, and heavy cannabis use has increased by nearly 60% in the U.S. since 2007.
- Trial name
- NCT03681353
- Testing
- Mobile Contingency Management, active
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Duke University
Non Small Cell Lung Cancer
Evaluation of Circulating T Cells and Tumor Infiltrating Lymphocytes (TILs) During / After Pre-Surgery Chemotherapy in Non-Small Cell Lung Cancer (NSCLC)
The purpose of this study is to evaluate whether the combination of neoadjuvant chemotherapy (chemotherapy before surgery) plus ipilimumab for lung cancer increases the number of patients with detectable circulating T cells with…
- Trial name
- TOP1201 IPI (NCT01820754)
- Testing
- Ipilimumab, Paclitaxel, Cisplatin, Carboplatin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Duke University
Emotions
Emotion Regulation and Emotion Perception
The purpose of this study is to assess the impact of a brief, emotion regulation intervention on the ability to perceive other people's emotions.
- Trial name
- EREP (NCT03790878)
- Testing
- Mindful Breathing, Habituation, Control
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Duke University
Pressure Ulcer
Preventing Pressure Ulcers With Repositioning Frequency and Precipitating Factors
The purpose of this study is to determine whether repositioning frequency can be extended for nursing home (NH) residents who are low, moderate, and high risk for pressure ulcer (PrU) development.
- Trial name
- NCT02996331
- Testing
- 2 hour repositioning, 3 hour repositioning, 4 hour repositioning
- Where
- United States
- Volunteers
- 2,113 people, healthy volunteers welcome
- Sponsor
- Duke University
Cervical Dysplasia
Coherence Imaging of the Cervical Epithelium With Scanning a/LCI
The purpose of this study is to develop a low coherence interferometry (LCI) endoscopic probe that can examine the cervix for evidence of cervical dysplasia.
- Trial name
- NCT03502798
- Testing
- scanning a/LCI
- Where
- 2 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Duke University
Healthy
Using Neuroscience to Optimize Digital Health Interventions Across Adulthood
The goal of this study is to investigate the extent to which brain imaging data predict health behavior change, compared to participant self-reports.
- Trial name
- NCT03744052
- Testing
- Motivational Messages
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Duke University
Breast Cancer
A Novel Optical Spectral Imaging System for Imaging Breast Tumor Margins
The goal of this research is to further develop novel optical assay systems for intra operative assessment of tumor margins in partial mastectomy or mastectomy specimens.
- Trial name
- NCT01372631
- Testing
- miniature spectral imaging system, Bench-top optical spectrometer, High resolution microendoscope
- Where
- 2 sites in United States
- Volunteers
- 218 people
- Sponsor
- Duke University
Cancer of the Cervix, Cervical Neoplasms
Integrated Dose Escalation for Advanced, Localized Gynecologic Cancer (The IDEAL - GYN Trial)
The purpose of this study is to determine the maximum tolerated dose of integrated boost radiation therapy when given with concurrent chemotherapy (cisplatin).
- Trial name
- IDEAL (NCT01627288)
- Testing
- Boost radiation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Duke University
Treatment-Resistant Hypertension
Lifestyle Interventions in Treatment-Resistant Hypertension
This study will examine the effects of lifestyle intervention on fitness, dietary habits, and body weight in patients with resistant hypertension (RH).
- Trial name
- TRIUMPH (NCT02342808)
- Testing
- Structured center-based lifestyle intervention, Standard education and physician advice
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Duke University
Malignant Glioma, Grade 4 Malignant Glioma
Bevacizumab Beyond Progression (BBP)
Studies which have separately studied bevacizumab for recurrent gliomas and bevacizumab for newly-diagnosed glioma have shown good results and the regimens have been well-tolerated by patients.
- Conditions
- Malignant Glioma, Grade 4 Malignant Glioma, Glioblastoma, Gliosarcoma
- Trial name
- BBP (NCT01740258)
- Testing
- Radiation Therapy, Temozolomide, Bevacizumab
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Duke University
Heart Failure
Care Optimization Through Patient and Hospital Engagement Clinical Trial for Heart Failure
CONNECT-HF is a large-scale, pragmatic, cluster-randomized clinical trial to evaluate the effect of a customized, multifaceted, health system-level quality-improvement (QI) program compared with usual care on heart failure (HF)…
- Trial name
- CONNECT-HF (NCT03035474)
- Testing
- Digital Engagement, Direct Engagement
- Where
- 154 sites in United States
- Volunteers
- 5,749 people
- Sponsor
- Duke University
Cigarette Smoking
Effects of Smoking Environments on Brain Reactivity
The goal of this study is to evaluate correlations between brain reactivity (as assessed via functional magnetic resonance imaging (fMRI) following 24-h abstinence) and the amount of smoking in a specific location.
- Trial name
- CameraCue3 (NCT03421210)
- Testing
- Nicotine patch
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Duke University
Healthy Volunteers
Utilizing Gaze Training to Enhance Laparoscopic Skills Training
The purpose of this study is to test the influences of gaze training (GT) on the acquisition of laparoscopic surgical skills. For this purpose, the investigator will compare variants of GT in the second of 2 experiments.
- Trial name
- NCT03413943
- Testing
- gaze training
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Duke University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.