Clinical trials: completed, sponsored by Duke University
Prostate Cancer
Men With Metastatic Castrate-Resistant Prostate Cancer Treated With Either Sipuleucel-T (Provenge®), Abiraterone Acetate (Zytiga®) or Enzalutamide (Xtandi®) Undergoing Cardiopulmonary EXercise Testing
This is a pilot exercise physiology and quality of life study of subjects receiving standard of care therapy for their prostate cancer using FDA-approved drugs per their labeling (abiraterone, enzalutamide, or sipuleucel-T).
- Trial name
- PEAX (NCT02353715)
- Testing
- Enzalutamide, Abiraterone acetate, Sipuleucel-T
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Duke University
Amygdala Activation
Effects of Connectivity-based rTMS and State-Dependency on Amygdala Activation
Posttraumatic stress disorder (PTSD) is a highly debilitating disease with response rates to pharmacological treatment rarely exceeding 60%.
- Trial name
- ConnecTMS (NCT03746405)
- Testing
- repetitive transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Duke University
Prostate Cancer
Abiraterone Race in Metastatic Castrate-resistant Prostate Cancer
The primary goal is to prospectively estimate the median radiographic PFS of African American and Caucasian men with mCRPC to abiraterone acetate and prednisone.
- Trial name
- NCT01940276
- Testing
- Abiraterone acetate, Prednisone
- Where
- 14 sites in United States
- Volunteers
- 100 people
- Sponsor
- Duke University
Acute Myeloid Leukemia, Myelodysplastic Syndrome
Adoptive Transfer of Haplo-identical DLI for AML and MDS
The primary hypothesis is that chemotherapy followed by donor lymphocyte infusion (DLI) from HLA-haploidentical donors is a safe procedure that will not cause Graft versus Host Disease (GVHD) or increased treatment-related…
- Trial name
- NCT02046122
- Testing
- Idarubicin, Cytarabine, DLI
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Duke University
Respiratory Tract Infections, Wheezing
A 24 Month Observational Study of Infants 3-24 Months, Who Suffer an Acute Episode of Respiratory Infection and Wheezing Illness
This study will identify infants between the age of 3 and 24 months of age who are experiencing one of their first acute respiratory infections with confirmed wheezing.
- Trial name
- BIOPA (NCT03741322)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Duke University
Malignant Glioma
Early Palliative Care Intervention in Malignant Glioma
The purpose of this research study is to determine the feasibility and acceptability of incorporating palliative care into the clinical care plans of patients newly diagnosed with malignant brain tumors.
- Trial name
- NCT03471546
- Testing
- Palliative Care
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Duke University
Fibroids, Uterine
Patient Centered Results for Uterine Fibroids
The overall goal of this project is to better enable patients with uterine fibroids (UF) to make informed decisions about treatment options by leveraging the highest possible evidence of healthcare quality.
- Trial name
- COMPARE-UF (NCT02260752)
- Testing
- hysterectomy, Uterine arterial embolization, myomectomy
- Where
- 9 sites in United States
- Volunteers
- 3,094 people
- Sponsor
- Duke University
Rotator Cuff Tear
Comparison of the Accuracy of Telehealth Examination Versus Clinical Examination in the Detection of Rotator Cuff Tears
The purpose of this study is to compare how accurately a pseudo-telehealth shoulder examination diagnoses rotator cuff tears compared to a regular clinical examination. MRI is used as the gold standard.
- Trial name
- NCT03906630
- Testing
- Telehealth clinical exam, Standard clinical exam
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- Duke University
Prostate Cancer
Molecular Mechanisms Underlying Prostate Cancer Disparities
The purpose of this study is to further elucidate the molecular mechanisms underlying prostate cancer disparities. In previous work the investigators have identified a set of differentially deregulated genes in African American…
- Trial name
- GENCADE (NCT02229565)
- Testing
- Biopsy or prostatectomy
- Where
- United States
- Volunteers
- 226 people
- Sponsor
- Duke University
Malaria, Febrile Illness
Malaria Diagnostic Testing and Conditional Subsidies to Target ACTs in the Retail Sector: the TESTsmART Trial AIM 1
The TESTsmART Trial consists of two main aims. The overall goal of the two aims is to investigate the impact of malaria rapid diagnostic test (mRDT) subsidies and conditional artemisinin combination therapy (ACT) subsidies on the…
- Trial name
- TESTsmART (NCT03810014)
- Testing
- Conditional ACT subsidy, Arm 1 levels, Conditional ACT subsidy, Arm 2 levels, Conditional ACT subsidy, Arm 3 levels
- Where
- Kenya
- Volunteers
- 842 people
- Sponsor
- Duke University
Nicotine Addiction, Serious Mental Illness
Feasibility Trial of a Tailored Smoking Cessation App for People With Serious Mental Illness
Quitting smoking has important health benefits for people with serious mental illness, more than half of whom are smokers. Smoking reductions in this population, in turn, could contribute to saving billions of dollars in…
- Trial name
- NCT03069482
- Testing
- Learn to Quit App, Nicotine patch, Nicotine lozenge
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Duke University
Asthma
A Trial Assessing the Safety and Feasibility of Respiratory Muscle Training and Exercise Training in Children and Adolescents With Persistent Asthma
The purpose of this study is to assess the safety and tolerability of a 6-week Inspiratory Muscle Training and cardiovascular exercise training program in children and adolescents with asthma.
- Trial name
- DHBS2 (NCT03911206)
- Testing
- Inspiratory muscle training (IMT), Exercise alone, IMT and Exercise
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Duke University
Diabetes Mellitus, Heart Failure
Mobile Health Behavioral Intervention in Patients With Heart Failure and Diabetes Mellitus
The overall objective of this study is to test a personalized mHealth intervention designed to increase physical activity and improve medication adherence in subjects with heart failure and diabetes mellitus.
- Trial name
- TARGET-HFDM (NCT02918175)
- Testing
- mHealth
- Where
- 6 sites in United States
- Volunteers
- 187 people
- Sponsor
- Duke University
Distress Due to COVID-19
Expressive Writing for COVID-19 Resilience
The purpose of this study is to determine the impact of a 6-week, virtually-delivered expressive writing intervention on resilience in a cohort of individuals currently navigating the COVID-19 pandemic during spring 2020.
- Trial name
- NCT04589104
- Testing
- Expressive writing
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Duke University
Cigarette Smoking, Smoking Cessation
Contingency Management, Quitting Smoking, and ADHD
The overall goal of the study is to evaluate how motivation and readiness for change are influenced in the context of a smoking cessation attempt. A total of 60 adult (i.e.
- Trial name
- ADQUIT (NCT02266784)
- Testing
- Contingency Management (CM), Transdermal nicotine skin patches (i.e. Habitrol), Supportive Counseling
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Duke University
Chronic Endometritis, in Vitro Fertilization
Chronic Endometritis and IVF
Background: Embryo quality is known to be a very important determinant to predict the implantation and pregnancy rate in IVF patients, however, the role of uterine integrity or endometrial receptivity cannot be overlooked.
- Trial name
- CEIVF (NCT02646930)
- Testing
- Endometrial biopsy
- Where
- 2 sites in United States
- Volunteers
- 57 people
- Sponsor
- Duke University
Smoking Cessation
Durham Housing Authority (DHA) Community Health Advisor (CHA) Smoking Cessation Project
Recent policy from the U.S. Department of Housing and Urban Development (HUD) mandates that all public housing units go smoke-free by August 2018.
- Trial name
- NCT04114526
- Testing
- Nicotine Replacement Therapy
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Duke University
ACL Reconstruction
Transphyseal Vs. Physeal Sparing ACL Reconstruction in Skeletally Immature Patients: Risk of Subsequent Lower Extremity Growth Deformity
To assess the risk of lower extremity angular growth deformity following anterior cruciate ligament (ACL) reconstructions in young patients who are not yet skeletally mature.
- Trial name
- NCT03081026
- Testing
- Bilateral hip to ankle x-ray, exam and strength testing.
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Duke University
Smoking, Tobacco Smoking Behavior
Novel Approaches to Reducing Tobacco Related Harm
The purpose of this study is to assess initial reactions to alternative nicotine/tobacco products among smokers living with HIV.
- Conditions
- Smoking, Tobacco Smoking Behavior, Cigarette Smoking
- Trial name
- NCT02600273
- Testing
- Usual brand cigarettes, Lower nicotine content cigarettes, Electronic cigarettes 1
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Duke University
Overactive Bladder, Insulin Resistance
Genomics and Epigenomics for New Insights in fEmale OAB (GENIE) Study
Millions of women suffer from overactive bladder, and the changes in bladder function affect their quality of life. The study team believes that it needs to be better understand why women get overactive bladder in the first place…
- Trial name
- GENIE (NCT03057158)
- Where
- United States
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- Duke University
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