Clinical trials: completed, sponsored by Duke University
Breast Cancer, Breast Pain
Calming Alternatives Learned During MRI-Guided Breast Biopsy
The proposed randomized study evaluates whether a controlled breathing intervention could be efficacious for reducing pain in the MRI-guided breast biopsy setting.
- Conditions
- Breast Cancer, Breast Pain, Pain, Acute, Anxiety
- Trial name
- CALM (NCT03877146)
- Testing
- Controlled Breathing Intervention
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Duke University
Pompe Disease
Pompe Disease QMUS and EIM
Study Objectives: 1. Determine the correlation between quantitative muscle ultrasound (QMUS), electrical impedance myography (EIM) and currently accepted measures of physical function. 2.
- Trial name
- NCT02742298
- Testing
- Muscle ultrasound, Electrical Impedance Myography
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Duke University
Autoimmune Diseases, Sickle Cell Disease
Microvascular and Fibrosis Imaging Study
In this study, Laser Doppler Flowmetry (LDF), Laser Doppler Imaging (LDI), Orthogonal Polarization Spectral Imaging (OPSI), Nail fold video capillaroscopy (NVC) and Optical Coherence Tomography (OCT) will be used to assess…
- Conditions
- Autoimmune Diseases, Sickle Cell Disease, Chronic Graft Versus Host Disease
- Trial name
- NCT01758250
- Testing
- Acoustic Radiation Force Impulse (ARFI), Laser Doppler Flowmetry (LDF), Laser Doppler Perfusion Imaging (LDI)
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Duke University
Radius Fractures
Low Dose CT Distal Radius Fractures
This study is a prospective, departmental funded study examining the outcomes of Low Dose CT scans compared to Conventional Dose CT scans in patients who present to Duke University with a Distal Radius Fracture.
- Trial name
- NCT03423043
- Testing
- Low Dose CT Scan of the Wrist
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Duke University
Peer Support and Chronic Disease, Obesity
Peer Support Dyads in Churches
The purpose of this study is to explore how working with a partner can influence participation in a church wellness program. There are many different types of church wellness programs.
- Conditions
- Peer Support and Chronic Disease, Obesity, Type II Diabetes, Cardiovascular Disease
- Trial name
- NCT03463941
- Testing
- Peer Support Dyad Intervention
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Duke University
Human Papilloma Virus
SDH of HPV Vaccine Completion
The purpose of this research study is to find out which factors influence parents' ability to complete the human papillomavirus (HPV) vaccine series for their child.
- Trial name
- NCT03709602
- Where
- United States
- Volunteers
- 3,076 people
- Sponsor
- Duke University
Ventilatory Depression, Opioid Intoxication
Respiratory Control and Narcotic Effects
The aim of this study is to provide data that will assess the role of ventilatory chemosensitivity (respiratory drive) in determining postoperative respiratory depression due to opioids.
- Conditions
- Ventilatory Depression, Opioid Intoxication, Opioid Toxicity
- Trial name
- NCT04047550
- Testing
- Ventilatory chemosensitivity
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Duke University
Cancer
Digital Symptom Tracking, Patient Engagement and Quality of Life in GI Oncology Clinic Patients
A pilot study of an ePRO system in cancer patients receiving systemic therapies.
- Trial name
- NCT03459352
- Testing
- ePRO
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Duke University
Autism Spectrum Disorder
Pilot Study to Improve Access to Early Intervention for Autism in Africa
This Mentored Career Development Award will lay the foundation for a career focused on addressing two Grand Challenges in Global Mental Health priorities: 1) improving child access to evidence-based mental health care, and 2)…
- Trial name
- NCT02751957
- Testing
- Early Start Denver Model
- Where
- South Africa
- Volunteers
- 26 people
- Sponsor
- Duke University
Cancer Survivors
Expressive Writing for Cancer Survivors
The purpose of this study is to determine whether a 1-day expressive writing intervention for adult cancer survivors improves resilience scores as measured by the Connor-Davidson Resilience Scale (CD-RISC).
- Trial name
- NCT04171609
- Testing
- Expressive writing
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Duke University
Childhood Obesity, Quality of Life
Active Recreation Through Community-Healthcare Engagement Study
Current obesity treatment guidelines recommend 26 or more hours of behavior treatment, delivered over a 6-month period in a multidisciplinary weight management clinic.
- Trial name
- ARCHES (NCT03246763)
- Testing
- Integrated community-healthcare childhood obesity treatment
- Where
- 7 sites in United States
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Duke University
Cigarette Smoking
Neurobehavioral Substrates of Propranolol's Effects on Drug Cue Reactivity
The central objective of this project is to obtain proof-of-concept data demonstrating the effects of propranolol (a beta-adrenergic antagonist) on neurobiological responses to personal smoking environments and behavioral…
- Trial name
- ProCue (NCT03309943)
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Duke University
Obesity, Pregnancy Complications
NT-proBNP Levels and Obesity in Pregnancy
A screening modality to help categorize obese pregnant women as high or low probability for heart failure would be helpful in the evaluation of the obese pregnant women with dyspnea.
- Conditions
- Obesity, Pregnancy Complications, Peripartum Cardiomyopathy
- Trial name
- NCT04049136
- Testing
- NT-proBNP
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Duke University
Major Depression, Dementia
Neurocognitive Outcomes of Depression in the Elderly
Late-life depression (LLD) and cognitive impairment (CI) are significant public health problems among older adults, and their co-occurrence markedly increases disease burden and dementia risk.
- Trial name
- NCODE (NCT00570583)
- Where
- United States
- Volunteers
- 795 people, healthy volunteers welcome
- Sponsor
- Duke University
Intracranial Hypotension
Non-invasive Estimation of CSF Pressure Using MRI in Patients With Spontaneous Intracranial Hypotension
The purpose of this study is to estimate the intracranial pressure (ICP, the pressure in your head) in subjects with intracranial hypotension (a condition caused by leakage of the fluid that surrounds your brain and spine) using…
- Trial name
- NCT03041441
- Testing
- MRI algorithm, Lumbar puncture, Epidural patching
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Duke University
Literacy
Newborn Nursery Reach Out and Read
The purpose of this research study is to learn new things about how parents and others who care for babies think about sharing books with their baby and how they might respond to guidance from their doctors.
- Trial name
- NCT04147429
- Testing
- Early Literacy Intervention
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Duke University
Early Childhood Development
Evaluation of the iMBC/ECD Model in Ghana
The Duke research team will work with Catholic Relief Services (CRS) and lead the design and implementation of a cluster-randomized trial in Northern Ghana to assess the impact of the Integrated Mothers and Babies Course \& Early…
- Trial name
- NCT03665246
- Testing
- Integrated Mothers and Babies Course
- Where
- Ghana
- Volunteers
- 378 people
- Sponsor
- Duke University
Heart Failure
Abdominal Nerve Blockade in Chronic Heart Failure.
Patients with chronic heart failure and undergoing right heart catheterization will be enrolled in this study. Subjects will undergo catheterization of the heart to obtain central cardiac pressure and other cardiac hemodynamic…
- Trial name
- NCT03453151
- Testing
- splanchnic nerve anesthesia with a local anesthetic
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Duke University
Hypothermia, Rewarming
Heated Humidified Breathing Circuit Rewarming in Hypothermic Post Cardiopulmonary Bypass Patients.
Hypothermia on admission to the intensive care unit (ICU) following cardiopulmonary bypass (CPB) is common. The investigators propose that rewarming hypothermic (≤ 35 C) patients admitted to the intensive care unit following…
- Trial name
- NCT03697122
- Testing
- Heated Humidified Breathing Circuit and Forced Air Blanket
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Duke University
Radiation Exposure, Enteral Nutrition
Metoclopramide Versus Placebo for GJ Placement
The goal of this study is to determine whether use of promotility agents to stimulate gastric peristalsis can reduce fluoroscopy time and procedure time during gastrojejunostomy (GJ) tubes placement in interventional radiology…
- Trial name
- NCT03331965
- Testing
- Metoclopramide 5 MG/ML Injectable Solution, Saline
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Duke University
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