Clinical trials: completed, sponsored by Duke University
Anencephaly, Acrania
Genetics of Spina Bifida and Anencephaly
The goal of this research study is to discover the genetic and environmental factors that contribute to the cause of neural tube defects such as spina bifida and anencephaly.
- Trial name
- NCT00636233
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Duke University
Infection Control, Surgical Site Infection
Early Recognition and Response to Increases in Surgical Site Infections Using Optimized Statistical Process Control Charts: The Early 2RIS Study
The purpose of this quality improvement study is to measure the effectiveness of surveillance using optimized statistical process control (SPC) methods and feedback on rates of surgical site infection (SSI) compared to…
- Trial name
- Early 2RIS (NCT03075813)
- Testing
- Intervention Cluster
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Duke University
Non Small Cell Lung Cancer, Small Cell Lung Cancer
Esophageal Sparing Intensity-modulated Radiation Therapy (IMRT) for Locally-Advanced Thoracic Malignancies
Hypothesis 1- Using IMRT, the radiation therapy (RT) dose can be safely escalated from 58 Gy to 74 Gy given as 6 fractions/week with concurrent chemotherapy.
- Conditions
- Non Small Cell Lung Cancer, Small Cell Lung Cancer, Thymoma, Thymus Neoplasms
- Trial name
- ESIMRT (NCT00921739)
- Testing
- Esophageal sparing IMRT
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Duke University
Prostate Cancer
Dendreon Lymph Node Biopsy in Metastatic Castrate-Resistant Prostate Cancer
This study aims to evaluate patients with metastatic castrate-resistant prostate cancer (mCRPC) undergoing treatment with sipuleucel-T for evidence of treatment-associated immune activation in lymph nodes and peripheral blood.
- Trial name
- NCT02036918
- Testing
- Sipuleucel-T, Lymph Node Biopsy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Emergency
Who Contributes to the Ordering of CT Scans in Emergency Department Patients?
The primary objectives are: 1. To investigate which healthcare workers and other individuals contribute to the decision to order computed tomography (CT) scans for emergency department (ED) patients. 2.
- Trial name
- NCT02040896
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- Duke University
Sickle Cell Disease
Disseminating NIH Evidence Based Sickle Cell Recommendations in North Carolina
This project will improve the efficiency and quality of healthcare for persons with sickle cell disease, an under-served and at risk population by implementing a co-management model of care.
- Trial name
- NCT03253211
- Where
- United States
- Volunteers
- 4,392 people
- Sponsor
- Duke University
Concussion
Mindfulness and Yoga Training for Athletes With Concussion (MYTAC)
The purpose of this study is to establish the tolerability of mindfulness and yoga therapy in the post-concussion period.
- Trial name
- (MYTAC) (NCT03304327)
- Testing
- Mindfulness and Yoga Training
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Duke University
Respiratory Depression
Predictors of Opioid-Induced Respiratory Depression (OIRD)
Purpose of the Study: (1) To classify an individual subject's ventilatory response in terms of respiratory depression to a bolus of remifentanil under normoxic and hyperoxic conditions.
- Trial name
- (OIRD) (NCT02473354)
- Testing
- Remifentanil, Oxygen, Carbon dioxide
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Duke University
Pain
Impact of Local Anesthetic Wound Infiltration on Postoperative Pain Following Cesarean Delivery
The purpose of this study is to determine if the infusion of the local anesthetic ropivacaine (a numbing medicine) and the non-steroidal anti-inflammatory drug ketorolac (a pain killer similar to ibuprofen) through a catheter…
- Trial name
- NCT02829944
- Testing
- Ropivacaine, Ketorolac
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Duke University
Nicotine Dependence
Reactions to Reduced Nicotine Cigarettes in Young Adult Low-Frequency Smokers
The purpose of this study is to evaluate reactions to, and choices to self-administer, cigarette smoke with varying nicotine content among low-frequency, non-dependent adolescent/young adult smokers between the ages of 15-25…
- Trial name
- NicRed (NCT02989038)
- Testing
- Very Low Nicotine Content Cigarettes, Intermediate Nicotine Content Cigarettes, Normal Nicotine Content Cigarettes
- Where
- United States
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Duke University
Feasibility of Best Supportive Care Delivery
PCRC Best Supportive Care (PCRC BSC)
The primary objective of this study is to formalize the delivery of BSC in advanced cancer trials. The first aim (to develop expert-derived consensus statements regarding components of supportive care in cancer clinical trials)…
- Trial name
- PCRC BSC (NCT02396641)
- Testing
- Best Supportive Care Checklist
- Volunteers
- 40 people
- Sponsor
- Duke University
Hyperlipidemia, Hypercholesterolemia
Patient and Provider Assessment of Lipid Management Registry
The purpose of the Patient and Provider Assessment of Lipid Management Registry (PALM) is to gain a better understanding of physicians' cholesterol medication prescribing practices, patient and physician attitudes and beliefs…
- Conditions
- Hyperlipidemia, Hypercholesterolemia, Cardiovascular Disease, Diabetes
- Trial name
- PALM (NCT02341664)
- Where
- 14 sites in United States
- Volunteers
- 7,658 people
- Sponsor
- Duke University
Stroke, Cerebrovascular Stroke
Addressing Real-world Anticoagulant Management Issues in Stroke
The Addressing Real-world Anticoagulant Management Issues in Stroke (ARAMIS) registry is designed to provide important and timely insight into the management of acute stroke patients who are on novel oral anticoagulants in…
- Conditions
- Stroke, Cerebrovascular Stroke, Intracerebral Hemorrhage
- Trial name
- ARAMIS (NCT02478177)
- Where
- United States
- Volunteers
- 6,000 people
- Sponsor
- Duke University
Advanced Cancer, Palliative Care
Extra Layer Of Support
The investigators aim to introduce patients with advanced cancer to supportive care resources, including specialty palliative care, through a novel app called "ELOS" (stands for "extra layer of support) in a prospective cohort…
- Trial name
- ELOS (NCT03532997)
- Testing
- ELOS
- Where
- United States
- Volunteers
- 151 people
- Sponsor
- Duke University
Smoking, Veterans
Mobile Contingency Management for Smoking Cessation in Returning US Veterans
The primary goal of the study is to evaluate the effectiveness of a combined tele-health and contingency management (CM) intervention that the investigators call mobile CM, or mCM, in promoting smoking abstinence in US Veterans.
- Trial name
- NCT02513069
- Testing
- Nicotine gum, mobile contingency management, Telephone counseling
- Where
- United States
- Volunteers
- 291 people
- Sponsor
- Duke University
Obesity
Study to Test the Feasibility, Acceptability, and Weight Change of Take Off Pounds Sensibly (TOPS) in a Safety Net Clinic
The purpose of this pilot proposal are the following: 1) to determine the feasibility and acceptability of integrating the TOPS weight loss program into underserved populations through an urban safety net clinic and 2) to gather…
- Trial name
- TOPS at DOC (NCT03202420)
- Testing
- TOPS
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Duke University
Lung Transplant Rejection
Cell-free DNA as a Biomarker After Lung Transplantation
The purpose of this investigation is to determine the association of the fraction of donor-derived cell-free DNA in plasma and lung fluid samples with acute rejection as proven by biopsy in lung transplant recipients.
- Trial name
- NCT04271267
- Testing
- No Intervention
- Volunteers
- 126 people
- Sponsor
- Duke University
Advanced Cancer, Pain
Pain Coping Skills and Meaning-Centered Intervention
The proposed study seeks to develop and test a novel psychosocial pain management intervention for patients with advanced cancer.
- Trial name
- NCT03207360
- Testing
- Pain Coping Skills
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Duke University
Cigarette Smoking, Marijuana Abuse
Mobile Contingency Management for Marijuana and Tobacco Cessation
The purpose of this pilot project is to pilot-test a combined cannabis and smoking cessation treatment. The intervention combines mobile technology with behavioral strategies, counseling, and medications.
- Trial name
- NCT02869451
- Testing
- bupropion, transdermal nicotine patch, Nicotine polacrilex
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Duke University
AOD Use, Abuse, and Dependence, Depression
Treatment for Teens With Alcohol Abuse and Depression
The investigators will recruit adolescents with alcohol or cannabis abuse and clinically significant depression. All participants will receive 12 sessions of an evidence-based treatment for alcohol abuse, Motivation Enhancement…
- Trial name
- T-TAAD (NCT02227589)
- Testing
- MET/CBT-12, CBT-D, D-TAU
- Where
- 2 sites in United States
- Volunteers
- 103 people
- Sponsor
- Duke University
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