Clinical trials: completed, sponsored by Duke University
Schizophrenia, Schizoaffective Disorder
Theta Burst Stimulation for Schizophrenia
Purpose and objective Schizophrenia is a chronic debilitating illness with cognitive deficits that cause serious impairment in psychosocial recovery and with few treatments to remediate these deficits.
- Trial name
- NCT03288779
- Testing
- Theta Burst Stimulation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Duke University
ATIII Deficiency
Anti-thrombin III (ATIII) vs Placebo in Children (<7mo) Undergoing Open Congenital Cardiac Surgery
The purpose of this study is to test whether the administration of ATIII during the intra-operative period results in improved anticoagulation for cardiopulmonary bypass (CPB) and an attenuation of the activation of the…
- Trial name
- NCT02103114
- Testing
- Anti-thrombin III
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Duke University
Care Coordination in Primary Care
Feasibility of Care Coordination
The primary aim of this study is to determine feasibility of incorporating a primary care coordinator (PCC) into an integrative concierge primary care practice. Secondary aims include: 1.
- Trial name
- NCT04171596
- Testing
- Primary care coordination
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Duke University
Urethral Anesthesia
Contribution of Urethral Sensory Feedback in Voiding Efficiency
The purpose of this study is to evaluate how urethral anesthesia impacts voiding efficiency in healthy women. The investigator hypothesizes that anesthetizing the urethral with lidocaine gel will decrease voiding efficiency as…
- Trial name
- NCT03637582
- Testing
- lidocaine gel, Plain aqueous gel
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Duke University
Cocaine Use Disorders, HIV
Project IMPACT: Improving Memory Performance by Applying Cognitive Training
The purpose of this study is to examine the effects of a cognitive training program in persons with Human Immunodeficiency Virus (HIV) infection who have used cocaine.
- Trial name
- NCT02909101
- Testing
- Active Cognitive Training (ACT), Control Training (CON)
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Duke University
Fever, Malaria
Innovative Public-private Partnership to Target Subsidized Antimalarials in the Retail Sector (Aim 2)
The overall objective of this study is to evaluate the public health impact of targeted antimalarials subsidies through scale-up by determining the community-wide effects of targeting an antimalarial subsidy through a partnership…
- Trial name
- NCT02461628
- Testing
- Malaria RDT & conditional voucher for ACT from retail sector
- Where
- Kenya
- Volunteers
- 40,340 people, healthy volunteers welcome
- Sponsor
- Duke University
Pregnancy, Systemic Lupus Erythematosus
Duke Autoimmunity in Pregnancy Registry
It is difficult to predict how a women with an autoimmune disease will do during pregnancy. Some women will improve, others will worsen. Some pregnancies progress normally and others become very complicated.
- Conditions
- Pregnancy, Systemic Lupus Erythematosus, Cutaneous Lupus, Rheumatoid Arthritis
- Trial name
- DAP Registry (NCT00513591)
- Where
- United States
- Volunteers
- 513 people, healthy volunteers welcome
- Sponsor
- Duke University
Alzheimer Disease
Blood Biomarker of Alzheimer's Disease (AD)
Currently, no cures or disease modifying therapies exist for Alzheimer's disease (AD). This is partially due to the inability to detect the disease before it has progressed to a stage where there are clinical manifestations.
- Trial name
- NCT03340571
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Duke University
Sickle Cell Disease
SMART Mobile Application Technology Utilization in the Treatment of Sickle Cell Disease Post Day Hospital Discharge
The purpose of this study is to test a web-aided, mobile-based PHR (Personal Health Reporting) service to enhance SCD outpatient treatment after discharge from an acute care setting, such as Duke University Medical Center's Day…
- Trial name
- NCT02475993
- Testing
- SMART app
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Duke University
Acute Myeloid Leukemia
AML Electronic Decision Aid
The purpose of this study is to test the feasibility and preliminary efficacy of a novel electronic decision aid to improve AML patients' understanding of their illness, prognosis, and treatment options.
- Trial name
- NCT03442452
- Testing
- Electronic Decision Aid Tool
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Early Childhood Development in HIV-Exposed Children
Evaluation of an Early Childhood Development Intervention for HIV-Exposed Children in Cameroon
There is substantial evidence that early childhood development (ECD) programming can improve child health and development outcomes.
- Trial name
- NCT03195036
- Testing
- Home-based ECD services
- Where
- Cameroon
- Volunteers
- 230 people
- Sponsor
- Duke University
Families Experiencing Homelessness With Children Under 48 Months of Age
Collaboration to Promote Early Childhood Well Being in Families Experiencing Homelessness
The purpose of this study is to help us learn what are the best services to promote young children's healthy development for families who are experiencing homelessness. Participants may participate in three programs: 1.
- Trial name
- NCT03530137
- Testing
- Healthy Home, Attachment and Biobehavioral Catch-up Infant (6-24 months) and Toddler (24-48 months)., HealthySteps
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Duke University
C. Difficile, Diarrhea
Impact of Oral Antibiotic Treatment on C. Difficile
The overall aim is to characterize and to compare the extent and quantity of C. difficile stool shedding, perianal colonization and environmental contamination in patients who received oral fidaxomicin, oral metronidazole, or…
- Conditions
- C. Difficile, Diarrhea, Enterocolitis
- Trial name
- C-Diff (NCT02057198)
- Testing
- Fidaxomicin, Metronidazole, Vancomycin
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Duke University
Plasmodium Knowlesi Infection
Molecular Diagnostic Methods for Detection of Plasmodium Knowlesi
This study aims to determine the sensitivity, specificity, and practical value of two new molecular diagnostic assays compared to a more classical nested molecular diagnostic assay and the routine microscopy (both of which are…
- Trial name
- NCT03988296
- Where
- 3 sites in Malaysia
- Volunteers
- 116 people
- Sponsor
- Duke University
Heart Failure
Predischarge Initiation of Ivabradine in the Management of Heart Failure (PRIME-HF)
The PRIME-HF study is a multi-center, patient-level, randomized, open-label study of approximately 450 patients with reduced (left ventricular ejection fraction) LVEF of ≤ 35% and heart-rate ≥70 beats per minute (bpm) who are…
- Trial name
- PRIME-HF (NCT02827500)
- Testing
- ivabradine, Usual Care
- Where
- 20 sites in United States
- Volunteers
- 104 people
- Sponsor
- Duke University
Non-ST Elevation Myocardial Infarction (nSTEMI)
Risk-score Based ICU Triage
The investigators have created a new risk score that predicts whether initially stable patients with myocardial infarctions (heart attacks) will require intensive care while they are in the hospital.
- Trial name
- NCT03390270
- Testing
- Admission with NSTEMI
- Where
- United States
- Volunteers
- 462 people
- Sponsor
- Duke University
Non-small Cell Lung Carcinoma
Evaluation of Tumor and Blood Immune Biomarkers in Resected Non-small Cell Lung Cancer
The hypothesis of this study is that functional tumor infiltrating lymphocyte (TIL) isolation from resected lung cancer specimens is feasible, allowing determination of tumor antigen-specific T cell reactivities.
- Trial name
- TOP 1502 (NCT02848872)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Duke University
Sleep Apnea, Obstructive, Pregnancy
OSA in Pregnant Women With Chronic HTN
The purpose of this study is to identify whether pregnant women with chronic hypertension are at significantly higher risk of having undiagnosed OSA and should be routinely screened with home sleep tests.
- Conditions
- Sleep Apnea, Obstructive, Pregnancy, Hypertension
- Trial name
- OSA-CHTN (NCT03230110)
- Testing
- WP200U home sleep study device
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Duke University
Pregnancy, Analgesia
An Observational Study of Post-cesarean Delivery Respiratory Patterns Using a Non-invasive Minute Ventilation Monitor (Exspiron ™ System)
The purpose of this study is to evaluate the breathing patterns of women who undergo cesarean delivery with spinal or epidural morphine for post-operative pain control in the first day after surgery.
- Conditions
- Pregnancy, Analgesia, Respiratory Depression, Obstructive Sleep Apnea
- Trial name
- NCT02903173
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Duke University
Cancer
Communicating About Sexual Concerns and Dysfunction Effectively (CASCADE) Program
Patients with cancer suffer many devastating side effects; one that is understudied but vital to quality of life is the effect of cancer and its treatments on patients' sexual functioning and satisfaction.
- Trial name
- CASCADE (NCT03658161)
- Testing
- Communicating About Sexual Concerns and Dysfunction Effectively
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Duke University
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