Clinical trials: completed, sponsored by Duke University
Ovarian Cancer, Fallopian Tube Cancer
The Treatment Preferences of Women Diagnosed With Ovarian Cancer
The primary objective of this study is to apply best-practice stated-preference methods to quantify the extent to which women with ovarian cancer accept the risks, side effects, and out-of-pocket costs associated with treatment…
- Conditions
- Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Carcinoma
- Trial name
- NCT03367260
- Testing
- Preference Elicitation
- Where
- United States
- Volunteers
- 115 people
- Sponsor
- Duke University
Prostate Cancer
Salvage Therapeutic Radiation With Enzalutamide and ADT in Men With Recurrent Prostate Cancer (STREAM)
The purpose of this study is to describe the 2 year progression-free survival in men with recurrent PSA-only disease after prostatectomy receiving combined enzalutamide and standard androgen-deprivation therapy (ADT) with salvage…
- Trial name
- STREAM (NCT02057939)
- Testing
- enzalutamide, Androgen Deprivation, Radiation Therapy
- Where
- 3 sites in United States
- Volunteers
- 38 people
- Sponsor
- Duke University
Sleep Apnea, Obstructive, Pregnancy
Obstructive Sleep Apnea in Pregnancy
Obstructive sleep apnea (OSA) is a risk factor for complications during pregnancy and current screening tools for OSA have not been shown to be reliable in pregnant women.
- Conditions
- Sleep Apnea, Obstructive, Pregnancy, Obesity, Morbid
- Trial name
- OSAinPreg (NCT02383706)
- Testing
- ApneaLink Air, Berlin Quesionnaire, Epworth Sleepiness Scale
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Duke University
Type 1 Diabetes Mellitus, Eating Disorders
iOmit: Reducing Intentional Insulin Misuse in Type 1 Diabetes
Individuals with type 1 diabetes who intentionally omit insulin to lose weight are at high risk for diabetes-related medical complications and premature death.
- Trial name
- iOmit (NCT02980627)
- Testing
- Therapy with Mobile App Enhancement
- Where
- 2 sites in United States
- Volunteers
- 27 people
- Sponsor
- Duke University
Prostate Cancer
Prospective CiRculating prOstate Cancer Predictors in HighEr Risk mCRPC studY
This study will develop a first-in-man CTC-based molecular taxonomy of CRPC in the context of novel AR-directed therapies, categorize different patterns of resistance in this disease setting, and describe their evolution over…
- Trial name
- PROPHECY (NCT02269982)
- Testing
- AR-v7 assays
- Where
- 5 sites in United States
- Volunteers
- 120 people
- Sponsor
- Duke University
Parkinson Disease
Blood Biomarker in Early Parkinson's Disease
Currently, there are no cures or disease modifying therapies for Parkinson's disease (PD). This is partially due to the inability to detect the disease before it has progressed to a stage where there are clinical manifestations.
- Trial name
- NCT03384797
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Duke University
Hip Osteoarthritis, Complications; Arthroplasty
Correlation of Spinopelvic Parameters and Acetabular Cup Orientation
In total hip arthroplasty, cup anteversion is an important factor in stability. Lewinnek's safe zone and functional anteversion are often used to assess appropriate orientation.
- Trial name
- NCT02598700
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Duke University
Healthy Gut Microbiota
Human Gut Microbiota and Prebiotic Response
This study is designed to examine the shift in gut microbiota and their metabolism after consumption of a dietary supplement (prebiotic) by healthy participants.
- Trial name
- NCT03595306
- Testing
- Prebiotic A - inulin, Prebiotic B - galactooligosaccharides(GOS), Prebiotic C - wheat dextrin
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Duke University
Metabolism
Development of Novel Therapies for NIDDM
The overarching goal of this program project grant is the development of technologies that lead to new methods for studying, detecting, and treating type 2 diabetes, and their integration with hypothesis-driven diabetes research…
- Trial name
- NCT01905722
- Testing
- 3 Tesla, 7 Tesla
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Duke University
Systemic Inflammatory Response Syndrome, Acute Kidney Injury
Platelets as Regulators of Inflammation in Cardiac Surgery
Platelets are increasingly recognized as a potent and ubiquitously present source of inflammatory activation. Importantly, antiplatelet therapy has been shown to significantly reduce major adverse events such as renal injury in…
- Trial name
- PRICS (NCT02568410)
- Testing
- coronary artery bypass grafting using cardiopulmonary bypass
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Duke University
Nonconvulsive Seizures
Nonconvulsive Seizure Identification on Quantitative EEG by Neuro ICU Nurses
This research is being conducted to determine if Neuroscience intensive care unit (ICU) nurses are able to identify seizures by reviewing quantitative EEG (qEEG) that is running at the bedside.
- Trial name
- NCT02082873
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Neisseria Gonorrhoeae Infection, Chlamydia Trachomatis Infection
Performance of Nucleic Acid Amplification Tests for the Detection of NG and CT
The purpose of this study was to use participant samples to simultaneously evaluate three nucleic acid amplification tests (NAATs) diagnostic platforms.
- Conditions
- Neisseria Gonorrhoeae Infection, Chlamydia Trachomatis Infection, Sexually Transmitted Infections
- Trial name
- pNAAT (NCT02870101)
- Testing
- Nucleic acid amplification test 1 for NG and CT, Nucleic acid amplification test 2 for NG and CT, Nucleic acid amplification test 3 for NG and CT
- Where
- 9 sites in United States
- Volunteers
- 2,767 people, healthy volunteers welcome
- Sponsor
- Duke University
Cognitive Decline
Lidocaine For Neuroprotection During Cardiac Surgery
The purpose of this study is to see if a drug called lidocaine prevents cognitive injury (a decline in mental abilities) after heart surgery.
- Trial name
- NCT00938964
- Testing
- Lidocaine
- Where
- 2 sites in United States
- Volunteers
- 550 people
- Sponsor
- Duke University
Nicotine Dependence
Combination Nicotine Patch / Lorcaserin for Smoking Cessation
This study plans to compare the efficacy of the nicotine patch / lorcaserin combination treatment vs. the nicotine patch alone in terms of leading to a reduction in smoking behavior and withdrawal symptoms.
- Trial name
- LorNic (NCT02906644)
- Testing
- lorcaserin, nicotine patch
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Duke University
Surrogate Decision Makers, Prolonged Mechanical Ventilation
Improving Decision Making for Patients With Prolonged Mechanical Ventilation
Deciding about prolonged life support for critically ill patients can be very difficult. Therefore, the investigators are doing a study to see if an internet-based decision aid can improve the quality of decision making for…
- Trial name
- NCT01751061
- Testing
- Decision aid, Usual care
- Where
- 4 sites in United States
- Volunteers
- 416 people
- Sponsor
- Duke University
Non-metastatic, Hormone naïve Prostate Cancer
EXTEND Exercise Trial
This study will examine the effect of supervised exercise training on cardiopulmonary function in men receiving the combination of enzalutamide (ENZ) and androgen deprivation therapy (ADT) for treatment of non-metastatic…
- Trial name
- NCT02256111
- Testing
- Enzalutamide, Androgen deprivation therapy, Supervised exercise training
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- Duke University
Age Related Macular Degeneration
Study on Visual Function Impairments in Dry Age-related Macular Degeneration
The study hypothesis is that patients with dry age-related macular degeneration experience visual function impairments such as defects in dark adaptation, glare intolerance, poor light transition and reading in low lighting…
- Trial name
- NCT01822873
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Duke University
Sickle Cell Disease, Quality of Life
Stigma, Self-management, & Quality of Life in SCD
Many individuals with sickle cell disease experience both a poor quality of life and stigma. Individuals with SCD often experience high levels of stigma which can be a barrier to good self-management and hinder quality of life.
- Conditions
- Sickle Cell Disease, Quality of Life, Stigma, Social, Disease Self-Management
- Trial name
- SSQ (NCT03488264)
- Where
- 2 sites in United States, Jamaica
- Volunteers
- 102 people
- Sponsor
- Duke University
Human Papilloma Virus Infection, Carcinoma in Situ of Uterine Cervix
Community-Driven Cervical Cancer Prevention in Western Kenya
There are many challenges to implementation of cervical cancer prevention in resource-limited countries, despite evidence based screening and treatment strategies.
- Trial name
- NCT02124252
- Testing
- Community-based testing with standard linkage to care, Community-based HPV testing with enhanced linkage to care
- Where
- Kenya
- Volunteers
- 7,200 people, healthy volunteers welcome
- Sponsor
- Duke University
Tinnitus
New Therapy for Patients With Severe Tinnitus
Tinnitus is a common problem for which there is no universally effective treatment. The best available estimates indicate that 10 - 15% of adults report having tinnitus symptoms, but only 20% of those who report tinnitus suffer…
- Trial name
- NCT01480193
- Testing
- Sound Based and Educational Therapies, Integrative Medicine Therapies and Sound Based Education Therapies
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Duke University