Clinical trials: completed, sponsored by Duke University
Atrial Fibrillation
Eliminate Thromboembolism: Improving Anticoagulation in Non-valvular Atrial Fibrillation Patients
ELITE (Eliminate Thromboembolism: Improving Anticoagulation in Non-valvular Atrial Fibrillation Patients) is a two year research project to assess warfarin management issues faced by atrial fibrillation (AF) patients in…
- Trial name
- ELITE (NCT02461602)
- Where
- 21 sites in United States
- Volunteers
- 251 people
- Sponsor
- Duke University
Knee Arthritis, Hip Arthritis
Preoperative Pain Threshold and Rapid Recover Programs
To investigate the association between grip strength and preoperative pain threshold as measured by pressure algometer and validated pain outcome surveys.
- Trial name
- NCT02740738
- Testing
- Wagner Pain Algometer, Dynamometer
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- Duke University
Hepatitis C
Longitudinal Assessment of Cardiovascular and Renal Health in Patients With Hepatitis-C (CARE-Hep C)
The purpose of this study is to monitor the cardiovascular and renal health of patients who previously took BMS-986094 (an investigational medication for hepatitis C) in comparison to hepatitis C infected patients who have never…
- Trial name
- CARE-Hep C (NCT01846494)
- Where
- 13 sites in United States, Puerto Rico
- Volunteers
- 113 people
- Sponsor
- Duke University
Pain
Pain Perception With Tenaculum Placement
Randomized controlled trial that compares methods of tenaculum placement during intrauterine device insertion and their effect on pain.
- Trial name
- NCT02969421
- Testing
- Cough method for placement of tenaculum, Slow Tenaculum Placement of tenaculum
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Duke University
Palliative Care
Palliative Care For Me (PCforMe)
The purpose of this study is to test the usability of PCforMe, a web-based preparation and engagement tool about palliative care, during a pre-visit pilot trial in outpatient palliative care at the Duke Cancer Institute…
- Trial name
- NCT03874195
- Testing
- Access to PCforMe for review, Access to three nationally-recognized Palliative Care websites for review
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Duke University
Colorectal Cancer
Safety Study of Regorafenib With PF-03446962 to Treat Colorectal Cancer
The primary objective of this open-label phase Ib trial is to determine the maximum tolerated dose and the recommended phase II dose for the combination of PF-03446962 plus regorafenib in patients with metastatic colorectal…
- Trial name
- REGAL-1 (NCT02116894)
- Testing
- PF-03446962, Regorafenib
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Duke University
Resilience
Examining the Role of Expressive Writing (EW) to Improve Resilience
The purpose of this study is to determine whether a 6-week writing to heal seminar/workshop/class, Transform Your Life: Write to Heal, raises resilience scores as measured by the Connor-Davidson Resilience Scale for people who…
- Trial name
- NCT02510898
- Testing
- 6-week Writing to Heal course
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Duke University
Heart Failure, HIV
Characterizing HIV-related Diastolic Dysfunction
This is a multicenter clinical trial of a cross section of HIV+ patients with and without diastolic dysfunction. Approximately 200 HAART-treated virally suppressed HIV+ subjects (100 HIV+/DD+ \& 100 HIV+/DD-) will be enrolled.
- Conditions
- Heart Failure, HIV, Diastolic Dysfunction
- Trial name
- HFN_HIV (NCT02860156)
- Where
- 12 sites in United States
- Volunteers
- 195 people
- Sponsor
- Duke University
Nonalcoholic Steatohepatitis (NASH), Nonalcoholic Fatty Liver
Feasibility of VIIT in Adults With NASH
The purpose of this study is to determine whether patients with stage 1-3 NASH-related fibrosis are able to complete a single vigorous-intensity interval training (VIIT) session on an indoor rowing machine and provide blood…
- Conditions
- Nonalcoholic Steatohepatitis (NASH), Nonalcoholic Fatty Liver, Nonalcoholic Steatohepatitis, Liver Diseases
- Trial name
- NCT03861819
- Testing
- Vigorous-intensity interval training (VIIT)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Duke University
Chronic Kidney Disease
Providing Resources to Enhance Patients' Readiness to Make Decisions About Kidney Disease: The PREPARE NOW Study
This study evaluates the effectiveness of patient educational materials (a book and DVD) to help patients with chronic kidney disease make early, shared, and informed decisions about kidney replacement therapy.
- Trial name
- PREPARE NOW (NCT02428569)
- Testing
- PREPARED Decision Support
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Duke University
Healthy Subjects
TMS Modulation of Insula-related Brain Networks.02
The purpose of this study is to investigate the modulatory effects of repetitive transcranial magnetic stimulation (rTMS) on functional connectivity with the insula.
- Trial name
- TMSINS02 (NCT02919423)
- Testing
- transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Duke University
Musculoskeletal Pain Disorder
Integration of Musculoskeletal Physical Therapy Care in the Patient Centered Medical Home
Purpose and Objective: To determine the effectiveness of a physical therapist first versus a primary care physician first for patients entering a primary care setting with a musculoskeletal complaint on the outcomes of…
- Trial name
- IMPAC (NCT03110211)
- Testing
- Physical Therapist Evaluation, Primary Care Physician
- Where
- United States
- Volunteers
- 146 people
- Sponsor
- Duke University
Smoking, Pregnancy
BABY STEPS II: SMS Scheduled Gradual Reduction Text Messages to Help Pregnant Smokers Quit
Primary Aim: To test the efficacy of a SMS text-based scheduled gradual reduction (SGR) and counseling intervention to promote smoking cessation in the late third trimester.
- Trial name
- NCT01995097
- Testing
- Scheduled Gradual Reduction Text Messages, Support Text Messages
- Where
- United States
- Volunteers
- 331 people
- Sponsor
- Duke University
Age-Related Macular Degeneration
Brain Connectivity in Age-Related Macular Degeneration
This study is to determine how cognitive deficits (e.g.,verbal fluency deficit) in patients with Age-Related Macular Degeneration (AMD) relate to specific aspects of brain and function.
- Trial name
- NCT01996215
- Where
- United States
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Duke University
Diabetes, Hypertension
Simultaneous Risk Factor Control Using Telehealth to slOw Progression of Diabetic Kidney Disease (STOP-DKD)
Diabetic kidney disease (DKD) is associated with high rates of cardiovascular events and death. In addition, DKD is the major cause of end-stage renal disease (ESRD) in the United States.
- Conditions
- Diabetes, Hypertension, Diabetic Kidney Disease
- Trial name
- STOP-DKD (NCT01829256)
- Testing
- Pharmacist telehealth intervention
- Where
- United States
- Volunteers
- 285 people
- Sponsor
- Duke University
At Risk for HIV
PrEP for HBCUs (Study 2)
The investigators' overall goals are to target (a) pre-exposure prophylaxis (PrEP) uptake by addressing access and acceptability and (b) PrEP adherence among Historically Black Colleges and Universities (HBCU) students.
- Trial name
- PrEP for HBCUs (NCT03080597)
- Testing
- PrEP Smart app
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Duke University
Mild Cognitive Impairment, Mild to Moderate Cognitive Impairment
Novel Retinal Imaging Biomarkers in Early Alzheimer's Disease
The goal of this study is to create new retinal imaging processing software useful for the development of novel retinal biomarkers of cognitive impairment associated with Alzheimer's disease (AD).
- Trial name
- NCT01937221
- Testing
- spectral-domain optical coherence tomography (SD-OCT)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Duke University
No Applicable Condition; Study of Physiologic Monitor Alarms
Quality Improvement - Monitoring Alarm Optimization Study
This project aims to reduce the frequency of duplicate, false and clinically insignificant alarms in hospital units, and subsequent alarm fatigue resulting from excessive alarm frequency.
- Trial name
- QI-MAOS (NCT02916212)
- Testing
- Optimized alarm profiles
- Volunteers
- healthy volunteers welcome
- Sponsor
- Duke University
Sickle Cell Disease
Rejuvesol® Washed RBC in Sickle Cell Patients Requiring Frequent Transfusions
The objective of this proposal is to test the feasibility of red blood cell (RBC) rejuvenation to chronic transfusion in sickle cell disease (SCD) and the potential benefit of RBC rejuvenation in this population to determine if a…
- Trial name
- NCT02731157
- Testing
- Rejuvesol, Blood transfusion
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- Duke University
Colorectal Cancer
Pain Coping Skills for Colorectal Cancer Survivors
Colorectal cancer survivors experience long-term negative physical and psychosocial consequences of their disease. There is a critical need to develop novel behavioral interventions for improving colorectal cancer survivor…
- Trial name
- NCT02706301
- Testing
- Telephone-Based Coping Skills Training (CST)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Duke University
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