Clinical trials: completed, sponsored by Duke University
Posttraumatic Stress Disorder
Variable-length Cognitive Processing Therapy for Combat-Related PTSD
The primary goal of this study is to improve the overall efficacy of cognitive processing therapy-cognitive-only version (CPT-C) in a sample of 130 active-duty service members through a variable length treatment.
- Trial name
- NCT02313818
- Testing
- Cognitive Processing Therapy-Cognitive Only
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Duke University
Smokeless Tobacco Cessation
Addressing Tobacco Use Disparities Through an Innovative Mobile Phone Intervention
The purpose of this study is to evaluate the feasibility, acceptability and preliminary efficacy of a Scheduled Gradual Reduction (SGR) intervention via Short Message Service (SMS) text messaging plus SMS Support Messages in…
- Trial name
- NCT02613689
- Testing
- Scheduled Gradual Reduction (SGR), Text Messages
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Duke University
Labor Pain
Comparison of PIEB vs CEI for Labor Analgesia
The aim of this prospective, doubled-blinded randomized study is to compare two modes of epidural analgesia delivery, programmed intermittent epidural boluses (PIEB) versus continuous epidural infusion (CEI) with patient…
- Trial name
- NCT02949271
- Testing
- Programmed Intermittent Epidural Bolus, Continuous Epidural Infusion, Ropivacaine
- Where
- United States
- Volunteers
- 179 people, healthy volunteers welcome
- Sponsor
- Duke University
Weight Loss, Obesity
A High Protein Weight Loss Intervention for Sarcopenic Obesity in Women
The purpose of the trial is to assess the effects of combining regular, generous intakes of high quality protein (primarily from lean pork and other animal source proteins) with calorie restriction on functional status and lean…
- Trial name
- POWR-UP (NCT02033655)
- Testing
- Protein supplementation, Diet counseling and group education lessons
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Duke University
ANXIETY DISORDERS (or Anxiety and Phobic Neuroses)
Fast-Fail Trials in Mood and Anxiety Spectrum Disorders; Kappa Opioid Receptor Phase 2a
The available treatment for patients with mood and anxiety disorders have significant limitations (Rush, 2007; Denys and de Geus, 2005). There is a need to develop new treatments for people with these disorders.
- Trial name
- FASTMAS_Kor2 (NCT02218736)
- Testing
- CERC-501
- Where
- 6 sites in United States
- Volunteers
- 163 people
- Sponsor
- Duke University
Breast Reconstruction
Pilot Study Assessing Breast Temperature in Breast Cancer Patients
Our investigators plan to measure the skin on the breast six months after breast reconstruction. The non-reconstructed breast will be used as the control for subject with unilateral reconstruction only.
- Trial name
- NCT03376035
- Testing
- Temperature measurement of breast
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Duke University
Anesthesia
Educating Anesthesia Residents to Improve Perioperative Care for the Elderly
1. The investigators will design, test and implement a education curriculum for anesthesia residents teaching geriatric anesthesiology. 2.
- Trial name
- NCT03008863
- Testing
- Education
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Duke University
Metastatic Progressive Castration-resistant Prostate Cancer, Metastatic Progressive Breast Cancer
Isolation of Circulating Tumor Cells Using a Novel EMT-Based Capture Method
The primary objective of the preliminary lead-in study is to determine whether circulating tumor cells in patients with metastatic progressive castration-resistant prostate cancer or metastatic progressive breast cancer can be…
- Trial name
- CTC-EMT (NCT02025413)
- Testing
- Mesenchymal-marker based ferrofluid (N-cadherin or O-cadherin based)
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Duke University
Pain, Phantom, Pain, Neuropathic
Valproic Acid for the Prevention of Post-Amputation Pain
The objectives of this study are, to test the effectiveness of Valproic Acid (VPA) in the prevention of chronic neuropathic and post-amputation pain, as well as to further define the underlying inflammatory and epigenetic…
- Trial name
- NCT01928849
- Testing
- Valproic Acid, Cherry Syrup
- Where
- 2 sites in United States
- Volunteers
- 128 people
- Sponsor
- Duke University
Breast Cancer
Four Conversations RCT
The purpose of this study is to see whether patients with metastatic breast cancer, their caregivers, and their healthcare providers can improve in shared decision making (SDM) and preparedness around end of life (EOL) planning…
- Trial name
- NCT02944344
- Testing
- Four Conversations
- Where
- United States
- Volunteers
- 357 people
- Sponsor
- Duke University
Acute Kidney Injury
Understanding the Role of Patient Behavior Change in Improving AKI Outcomes
This study is looking to improve the safety of patients with acute kidney injury via education provided on a mobile tablet. This study will additionally examine if electronic tools, such as mobile tablets, can help.
- Trial name
- Change AKI (NCT03114592)
- Testing
- mHealth tool
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Duke University
Weight Loss
Measuring Eating, Activity and Strength: Understanding the Response -Using Protein
The purpose of the trial is to assess the effects of weight loss on functional status and lean muscle mass in frail, obese older adults (>/= 60) who participate in a 6 month weight reduction intervention.
- Trial name
- MEASUR-UP (NCT01715753)
- Testing
- Protein supplementation, Diet counseling and group education lessons
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Duke University
Communication Improvement Between Adolescent and Clinician
Teaching Improved Communication To Adolescents and Clinicians
The purpose of this pilot study is to evaluate the feasibility, acceptability, and preliminary efficacy of an intervention aimed at improving how adolescent patients and their clinicians communicate about behavior change.
- Trial name
- TicTac (NCT03152045)
- Testing
- Communication Intervention
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Duke University
Accidental Falls
CONNECT for Quality: A Study to Reduce Falls in Nursing Homes
Clinical trials have identified interventions that reduce adverse outcomes such as falls in nursing home (NH) residents but attempts to translate these into practice quality improvement (QI) techniques have not been successful.
- Trial name
- CONNECT (NCT00636675)
- Testing
- Falls QI, Connect
- Where
- United States
- Volunteers
- 1,726 people
- Sponsor
- Duke University
Validation of Gait Speed Device Against Existing Techniques
Gaitbox Validation Study
The purpose of this study is to validate the walking velocity measured by the Gaitbox as compared to the measures obtained by clinicians administering the timed 4 meter walk test and the Sprint System device.
- Trial name
- NCT03406806
- Testing
- Gaitbox, SprintSystem device, NIH toolbox 4 meter walk
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Duke University
Blood Loss, Hip Arthritis
TXA vs. Amicar in Total Knee and Hip Arthroplasty
The purpose of this study is to determine the relative effectiveness of two drug agents, Tranexamic acid (TXA) and aminocaproic acid (Amicar), that act through a similar mechanism of action.
- Conditions
- Blood Loss, Hip Arthritis, Knee Arthritis
- Trial name
- NCT02030821
- Testing
- Amicar, TXA
- Where
- United States
- Volunteers
- 246 people
- Sponsor
- Duke University
Attention Deficit Hyperactivity Disorder, Nicotine Dependence
Attention Deficit Hyperactivity Disorder (ADHD) Smoking Cessation Study
The overall goal of the present project is to investigate whether lisdexamphetamine (LDX; Vyvanse) is an effective adjunct to nicotine replacement therapy (NRT) to promote smoking cessation in patients with comorbid Attention…
- Trial name
- NCT00736255
- Testing
- Transdermal Nicotine Patch, Lis-dexamphetamine (Vyvanse)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Duke University
Vestibular Function in Cochlear Implant Patients
Vestibular Function After Cochlear Implantation Using Soft Surgery Techniques
This study will measure the effects of soft surgical techniques on vestibular function and quality of life in patients pre- and post-cochlear implant (CI) surgery.
- Trial name
- NCT02503592
- Testing
- Vestibular testing
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Duke University
Cervical Epithelia
Coherence Imaging of the Cervical Epithelium
The purpose of this study is to develop a multiplexed low coherence interferometry (mLCI) endoscopic probe for mapping the epithelial types of the cervix. This vaginal mLCI probe will obtain optical measurements from the cervix.
- Trial name
- NCT02903394
- Testing
- mLCI Device
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Duke University
Smoking, ADHD
Neuroimaging of Smokers With and Without Attention Deficit Hyperactivity Disorder (ADHD)
The purpose of this study is to evaluate how nicotine, withdrawal from nicotine, and methylphenidate (a drug used for the treatment of ADHD) affect the brain of smokers with and without ADHD while doing tasks in an functional…
- Trial name
- NCT01123668
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Duke University
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