Clinical trials: completed, sponsored by Duke University
Diabetes Mellitus, Type 2, Substance-related Disorders
Screening, Brief Intervention, and Referral to Treatment in Primary Care
This add-on study of providing tobacco, alcohol and other drug screening, brief intervention and referral for treatment to a primary care high risk diabetic population leverages the existing research resources of a funded parent…
- Trial name
- SBIRT-PC (NCT01966432)
- Testing
- Referral to Treatment, Brief Intervention
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- Duke University
Complication of Surgical Procedure, Postoperative Infection
CALYPSO Pilot Study: Machine Learning Based Predictions of Surgical Complications
This is a pilot study of surgical patients whose postoperative care will be augmented with a personalized risk prediction platform (CALYPSO app).
- Trial name
- CALYPSO (NCT02828475)
- Testing
- CALYPSO, Standard Care
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Duke University
Abdominal MRI
Single Breath Hold Abdominal MRI
The purpose of this study is to evaluate a single breath hold abdominal MRI protocol and compare the image quality of respiratory triggered 3D T1-weighted images against conventional breath hold images.
- Trial name
- NCT02434471
- Testing
- Respiratory-triggered T1w DISCO LAVA
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Duke University
Osteosarcoma
Monocyte Phenotypic and Functional Differences
The purpose of this study is to identify phenotypic (cell surface receptor expression) and functional differences in monocyte populations in humans with osteosarcoma as compared to published historical data on normal human…
- Trial name
- NCT02132182
- Testing
- Blood draw
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Duke University
Bone Metastatic Castration-Resistant Prostate Cancer
Pharmacodynamic Study of Radium-223 in Men With Bone Metastatic Castration-Resistant Prostate Cancer
This study will examine biomarkers involved in osteomimicry in bone metastases and circulating tumor cells (CTCs) of men with mCRPC before and during therapy with the bone-targeting radiopharmaceutical radium-223.
- Trial name
- NCT02204943
- Testing
- Biomarker analysis, Administration of radium-223
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Parkinson's Disease
Intraoperative Analysis of Reward and Impulsivity in the Basal Ganglia
This project studies the impulsive side effects of common treatments for Parkinson's Disease. By learning how parts of the brain involved in Parkinson's encode information related to reward and motivation, the investigators will…
- Trial name
- NCT02319694
- Volunteers
- 36 people
- Sponsor
- Duke University
Regional Anesthesia Morbidity
A Comparison of Peripheral Nerve Catheter Securement Techniques at the Insertion Site in Healthy Volunteers
Continuous peripheral nerve block catheters are used for prolonged analgesia, but are often associated with complications such as catheter failure or dislodgement.
- Trial name
- NCT03375190
- Testing
- Dressing, Dressing + adhesive, Experimental: Dressing + adhesive + strips (parallel)
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Duke University
Internal Rotation Contracture-shoulder
Glenohumeral Rotation After Throwing: RCT Comparing the Sleeper Stretch to the 90/90 Hip Lift With Balloon Blow Exercise
The primary purpose of this study is to determine if the loss of internal rotation following a throwing session is best restored through soft tissue stretching with the sleeper stretch or with scapular repositioning with the…
- Trial name
- NCT03091530
- Testing
- Sleeper Stretch, 90/90 Hip Lift with Balloon Blow Exercise
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Duke University
Congestive Heart Failure
Effective Management of Emotional Response to Generate Well-Being Post-HF Exacerbation
EMERGE is a PI-initiated feasibility study that aims to evaluate the accessibility, usability, effectiveness and relevance of an integrated psycho-behavioral intervention on heart failure patients in order to increase support…
- Trial name
- EMERGE (NCT03043261)
- Testing
- Williams LifeSkills
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Duke University
Brain Tumor, Primary
Perampanel in Seizure Patients With Primary Glial Brain Tumors
This is a Phase 2 single-arm study to assess the efficacy of perampanel as an adjunctive anti-epileptic drug (AED) in patients with primary glioma that are presenting refractory partial onset seizure activity (defined as 3 or…
- Trial name
- NCT02363933
- Testing
- Perampanel
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Duke University
Obesity, Overweight
GoalTracker: Comparing Self-Monitoring Strategies for Weight Loss
This study is a randomized controlled trial that compares 3 self-monitoring approaches for weight loss. GoalTracker is a standalone, technology-based intervention using a commercial smartphone app (MyFitnessPal) and email.
- Conditions
- Obesity, Overweight, Weight Loss
- Trial name
- NCT03254953
- Testing
- self-monitoring of body weight, self-monitoring of diet, weekly personalized feedback + lessons + action plans
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Duke University
Coronary Heart Disease, Susceptibility to, 5, Prediabetic State
Genetic Risk and Health Coaching for Type 2 Diabetes and Coronary Heart Disease
The purpose of this study is to examine whether the use of genetic test information and/or health coaching in patient risk counseling for heart disease and diabetes affect health behaviors and health outcomes in active-duty Air…
- Trial name
- NCT01884545
- Testing
- Health coaching, Genetic risk counseling, Standard risk assessment
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Duke University
Cognitive Impairment, no Dementia (CIND)
ENLIGHTEN: Exercise and NutritionaL Interventions for coGnitive and Cardiovascular HealTh ENhancement
ENLIGHTEN will examine the effects of exercise, the dietary approaches to stop hypertension diet (DASH), and a combined exercise and DASH intervention on cognitive function among adults with cardiovascular disease (CVD) risk and…
- Trial name
- ENLIGHTEN (NCT01573546)
- Testing
- Aerobic Exercise, DASH diet, Health education control
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Duke University
Soft Tissue Sarcoma, Metastatic Lung Disease
Evaluating Quality of Life in Patients With Soft Tissue Sarcoma Presenting With Metastatic Lung Disease
The purpose of this study is to evaluate the role of palliative surgery in improving Quality of Life (QoL) and symptom control for patients who present with a Soft Tissue Sarcoma (STS) and metastatic lung disease.
- Trial name
- NCT02080897
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Duke University
Diabetes Mellitus, Type 2
Diabetes Self-Management & Support LIVE
The purpose of this study is to determine whether participation in virtual environment which incorporates real-time diabetes self management and support (DSMT/S) is associated with positive changes in behavior and metabolic…
- Trial name
- NCT02040038
- Testing
- LIVE, Website
- Where
- 2 sites in United States
- Volunteers
- 212 people
- Sponsor
- Duke University
Heart Failure
Determining Optimal Dose and Duration of Diuretic Treatment in People With Acute Heart Failure (The DOSE-AHF Study)
Heart failure is a disorder in which the heart does not pump blood adequately. This can lead to several serious problems, including reduced blood flow throughout the body, congestion of blood in the veins and lungs, and fluid…
- Trial name
- NCT00577135
- Testing
- Furosemide-Q12 hour bolus, Furosemide-Continuous Infusion, Furosemide-Low Intensification
- Where
- 9 sites in United States, Canada
- Volunteers
- 308 people
- Sponsor
- Duke University
Ischemic Stroke
Comparative Effectiveness of Rehabilitation Services for Survivors of Acute Ischemic Stroke
Retrospective analysis of Get With the Guidelines-Stroke data linked with Medicare claims and the AVAIL longitudinal data sets to assess patterns, predictors, and outcomes associated with the use of rehabilitation services…
- Trial name
- NCT02284165
- Testing
- retrospective analysis
- Where
- United States
- Volunteers
- 164,246 people
- Sponsor
- Duke University
Glaucoma
The Effect of Scheduled Ripcord Removal on the Outcomes of Baerveldt 350 Implants
The purpose of this study is to compare the post-operative complication rates and surgical outcomes in patients with a Baerveldt 350 implant following scheduled rip-cord removal in clinic at post-operative week 3 versus…
- Trial name
- NCT01915706
- Testing
- Ripcord removal
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Duke University
HIV
Carolina Alcohol and Drug Resources
Substance abuse is highly prevalent among individuals with HIV and associated with negative outcomes including poorer medication adherence and HIV risk behavior.
- Trial name
- CADRE (NCT01791179)
- Testing
- Comprehensive substance abuse services
- Where
- United States
- Volunteers
- 306 people
- Sponsor
- Duke University
Stress, Psychological, Burnout, Professional
Brief Mood Enhancement Intervention
The purpose of the current study is to test the efficacy of two brief, behavioral interventions intended to improve burnout among doctoral-level graduate students (n = 102).
- Trial name
- NCT02954965
- Testing
- Reward, Approach
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Duke University
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