Clinical trials: completed, sponsored by Duke University
Chronic Stable Angina
Effects of Ranolazine and Exercise on Daily Physical Activity Trial
The primary objective is to assess whether the increased angina threshold on ranolazine and subsequent higher training intensity will result in improved exercise tolerance and oxygen consumption; and greater than that observed…
- Trial name
- EREDA (NCT01948310)
- Testing
- Ranolazine, Aerobic Exercise
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Duke University
Diabetes
Interaction of Potassium and Genetic Risk Variants on Diabetes Risk
The investigators propose to study the association of the KCNJ11 (Potassium Voltage-Gated Channel Subfamily J Member 11) polymorphisms on diabetes risk in the Atherosclerosis Risk in Communities (ARIC) and Jackson Heart Study…
- Trial name
- NCT03367455
- Volunteers
- 11,812 people, healthy volunteers welcome
- Sponsor
- Duke University
Caregiver Wellbeing
Caregiver Outlook: An Evidence-based Intervention for the Chaplain Toolkit
This one-arm pilot study will evaluate the feasibility and acceptability of Caregiver Outlook, a manualized chaplain-led intervention to improve the well-being of caregivers of seriously ill patients.
- Trial name
- NCT01768221
- Testing
- Caregiver Intervention
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Duke University
First-degree AV-block, Pacing
Pacing in First-degree AV-block
The purpose of this study is to explore if there is a less harmful way to pace patients with first-degree AV-block to ensure that the negative effects inferred by the pacing do not outweigh the positive effects of AV-synchrony.
- Trial name
- NCT01985802
- Testing
- Pacing
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Athletes Heart
Changing the Pulse of Athletics: Applying a Standardized Cardiac Athletic Screening for NCAA Athletes
This is a study supported by Duke Sports Cardiology and Duke Sports Medicine with the intent to enhance the cardiovascular screening of collegiate athletes from a regional to nationally recognized program to understand and…
- Trial name
- NCT03150940
- Testing
- ECG, bedside cardiac ultrasound
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Duke University
Nicotine Dependence
Mechanistic Evaluations of Pre-Cessation Therapies for Smoking Cessation
The purpose of this study is to look at brain function in order to understand how different treatments work to help people quit smoking.
- Trial name
- ConNicBrain (NCT01406223)
- Testing
- Varenicline, Bupropion, Nicotine patches
- Where
- 2 sites in United States
- Volunteers
- 282 people
- Sponsor
- Duke University
Obesity
Cell Phone Intervention in Young Adults
Weight gain accelerates during early adulthood, and leads to the health consequences of obesity (high blood pressure, diabetes, heart disease, etc). Most weight loss studies enroll middle-aged adults.
- Trial name
- CITY (NCT01092364)
- Testing
- Behavioral weight loss intervention
- Where
- United States
- Volunteers
- 365 people
- Sponsor
- Duke University
Atrial Fibrillation
Clinical Trial to Improve Treatment With Blood Thinners in Patients With Atrial Fibrillation
To determine whether a comprehensive evaluation and customized multilevel educational interventions will increase the rate of use of oral anticoagulants and the adherence and persistence of use in patients with atrial…
- Trial name
- IMPACT-AF (NCT02082548)
- Testing
- Educational Intervention
- Where
- 5 sites in Argentina, Brazil and 3 more
- Volunteers
- 2,374 people
- Sponsor
- Duke University
Aging, Disease
Interval Training, Inflammation and Immune Function
PURPOSE: The purpose of this study is to investigate whether High Intensity Interval Training (HIIT)can improve the health and wellbeing of pre-diabetic elderly adults.
- Trial name
- NCT02441205
- Testing
- High Intensity Interval training
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Duke University
Aortic Valve Disease
Optimizing Health Outcomes in Patients With Symptomatic Aortic Valve Disease
Disease of the aortic heart valve is both common and progressively disabling, with no effective medical treatment. In November 2011, the United States Food and Drug Administration (U.S.
- Trial name
- PCORI-AVR (NCT02266251)
- Where
- United States
- Volunteers
- 273,365 people, healthy volunteers welcome
- Sponsor
- Duke University
Obesity, Childhood Obesity
Families on Track: A Digital Health Behavioral Intervention for Parents Seeking Treatment for Their Child With Obesity
Current models of outpatient childhood obesity treatment focus on the child's health habits, with limited efficacy. In part, this may be because childhood obesity is highly sensitive to parental lifestyle habits, who are often…
- Conditions
- Obesity, Childhood Obesity, Hypertension, Diabetes
- Trial name
- NCT02767440
- Testing
- Families on Track Intervention
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Duke University
Asthma, HIV
Determine the Prevalence and Severity of Asthma in HIV (Human Immunodeficiency Virus) Infected Patients
The purpose of this study is to determine the prevalence and severity of asthma in patients with HIV. To determine the immunological phenotype of HIV-infected patients with asthma.
- Trial name
- NCT02405026
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Duke University
Apnea of Prematurity, Premature Newborn
Effect of Feedings on Caffeine in Premature Infants
Almost all infants born <29 weeks gestational age develop apnea of prematurity and are treated with caffeine. Type of diet and disease states may be significant contributors of variability in caffeine metabolism and…
- Conditions
- Apnea of Prematurity, Premature Newborn, Caffeine
- Trial name
- NCT02293824
- Testing
- Caffeine
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Duke University
Fetal Distress, Stillbirth
Introducing Fetal Scalp Stimulation as an Adjunct to Intermittent Auscultation in Low-Resource Settings.
This study is a pilot study taking place in Moshi, Tanzania at the Kilimanjaro Christian Medical Centre (KCMC). The study aims to introduce fetal scalp stimulation into the intermittent auscultation protocols at KCMC, and to…
- Conditions
- Fetal Distress, Stillbirth, Birth Asphyxia, Acidosis
- Trial name
- NCT02862925
- Testing
- Fetal Scalp Stimulation
- Where
- Tanzania
- Volunteers
- 550 people
- Sponsor
- Duke University
Physical Activity, Cancer Survivor
Move 2 Health: A Couple-Based Physical Activity Intervention for Cancer Survivors
This pilot study will develop and test a couple-based physical activity intervention among cancer survivors and their partners. Aim 1: To determine the feasibility and acceptability of a couple-based physical activity…
- Trial name
- NCT03266718
- Testing
- Physical Activity Intervention
- Volunteers
- 40 people
- Sponsor
- Duke University
Chronic Kidney Disease
Acid-Base Compensation in Chronic Kidney Disease
The purpose of this study is to evaluate changes in urine net acid excretion, blood pressure and body chemistry that occur when the dietary acid load is lowered by using a drug/dietary supplement similar to baking soda.
- Trial name
- ABC (NCT02427594)
- Testing
- Sodium bicarbonate, Controlled diet
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Duke University
Peripheral Arterial Disease
Nitrites, Exercise, and Peripheral Arterial Disease
The hypothesis of this proposal is that in subjects with PAD, regular consumption of a high nitrate supplement which raises plasma nitrite, in conjunction with 12 weeks of supervised exercise training at the limb ischemic…
- Trial name
- NO-PAD (NCT01684930)
- Testing
- Beetroot Juice (Beet-It Stamina Shot) & Supervised Exercise Training
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Duke University
Acne Vulgaris, Isotretinoin
Identifying the Genetic Predictors of Severe Acne Vulgaris and the Outcome of Oral Isotretinoin Treatment
The goal of this study is to enroll 250 participants that have joined the MURDOCK Study Horizon 1.5 (Duke IRB Pro00011196) with a current or prior diagnosis of severe acne AND current or prior treatment with oral isotretinoin.
- Trial name
- SA (NCT01727440)
- Where
- 6 sites in United States
- Volunteers
- 123 people
- Sponsor
- Duke University
HIV Positive, Organ Transplant Recipient
Transplantation and the Use of Raltegravir in HIV-Infected Patients
Raltegravir (RAL) is a preferred option for initial antiretroviral therapy in the most recent HIV Treatment Guidelines and is emerging as a popular choice for use in the specialized population of HIV-infected patients being…
- Conditions
- HIV Positive, Organ Transplant Recipient, Active Wait Listing for Organ Transplant
- Trial name
- NCT01793467
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Duke University
Alzheimer Disease
The Cognitive Resilience Study
The purpose of this study is to test whether two new cognitive "stress tests" may help distinguish between people at lower or higher genetic risk of Alzheimer's Disease.
- Trial name
- CogRes (NCT03016702)
- Testing
- Cognitive stress tests during functional MRI, Cognitive stress tests during gait task
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Duke University
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