Clinical trials: completed, sponsored by Duke University
Weight Loss
mHealth Messages to Sustain Recent Weight Loss - Phase 2
To assess the feasibility to translate an automated weight loss message intervention to a weight loss clinic population. Aim 1: To assess feasibility of translating the intervention in a clinic for patients who recently completed…
- Trial name
- NCT02279017
- Testing
- mHealth Texting for Weight Loss
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Duke University
Type II Diabetes
Personalized Health Planning in Shared Medical Appointments for Individuals With Type II Diabetes Pilot Study
The primary aim of this study is to examine the feasibility of implementing an evidence based patient engagement strategy, known as personalized health planning (PHP), in the context of a a shared medical appointment (SMA) for…
- Trial name
- NCT02471794
- Testing
- Personalized Health Planning Shared Medical Appointment
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Duke University
Parkinson Disease
Freezing of Gait in Parkinson's Disease
This study is designed to evaluate whether a specific visuospatial training task will change gait performance of Parkinson's disease (PD) patients in doorways, specifically freezing of gait.
- Trial name
- FOG (NCT01887054)
- Testing
- Tower of Hanoi
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Duke University
Substance-Related Disorders
Telephone Enhancement Procedure for Continuing Care - 1
The purpose of this study is to test a feasibility study of a telephone enhancement procedure (TELE) to improve participation in continuing care activities.
- Trial name
- NCT00067171
- Testing
- Behavior Therapy
- Where
- 4 sites in United States
- Volunteers
- 339 people
- Sponsor
- Duke University
Obesity
Zonisamide for Weight Reduction in Obese Adults
The primary aim of this study is to assess long-term weight loss efficacy of zonisamide relative to placebo in obese patients prescribed a dietary intervention.
- Trial name
- NCT00275834
- Testing
- Zonisamide
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Duke University
Anorexia Nervosa
Heart Rate Sensing and Response in Persons With Anorexia Nervosa
There are two major goals of this investigation. First, to develop pilot data to justify a larger randomized clinical trial of an intervention designed to train interoceptive signals (IS) and interoceptive responsivity (IR) in…
- Trial name
- NCT02579018
- Testing
- One hour supervised exercise session
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Duke University
Myopathy, Myositis
Ultrasound in Muscle Biopsy
The objective of the proposed study is to evaluate the clinical utility of muscle ultrasonography for improving the diagnostic yield and safety of core muscle biopsy.
- Conditions
- Myopathy, Myositis, Muscular Dystrophy
- Trial name
- NCT01790178
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Duke University
Healthy
Intra-Arterial Microdosing: Proof-of-Concept in Humans
The purpose of this protocol is to demonstrate that intra-arterial administration of a drug can generate information in a manner that faithfully mimics effects of systemic administration but with little or no systemic effects.
- Trial name
- IAM-POC (NCT02304211)
- Testing
- Insulin
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Duke University
Arthritis
Post-traumatic Arthritis Associated With Joint Injury
Arthritis is the nation's most common cause of disability. An estimated 50 million U.S. adults (about 1 in 5) report doctor-diagnosed arthritis. Twenty three million U.S.
- Trial name
- NCT01792791
- Testing
- Tissue sample collection at the time of surgery
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Prader Willi Syndrome, Syndromic Obesity
Prader-Willi Syndrome Macronutrient Study
The overall objective is to explore the mechanisms by which macronutrients regulate food intake and weight gain in Prader Willi Syndrome (PWS).
- Conditions
- Prader Willi Syndrome, Syndromic Obesity, Childhood Obesity
- Trial name
- NCT02011360
- Testing
- Low Carbohydrate diet, Low Fat diet
- Where
- 2 sites in United States, Canada
- Volunteers
- 10 people
- Sponsor
- Duke University
COPD, Respiratory Symptoms
Expansion of the COPD At-risk Module in 4 States BRFSS Telephone Health Surveys
This cross-sectional survey study is intended to describe the characteristics of adults in 4 US states with regards to respiratory symptoms and tobacco exposure, utilizing an existing state-administered, CDC overseen Behavioral…
- Conditions
- COPD, Respiratory Symptoms, Tobacco Use, Asthma
- Trial name
- NCT02991391
- Testing
- None, use of a questionnaire
- Volunteers
- 40,690 people, healthy volunteers welcome
- Sponsor
- Duke University
Rheumatoid Arthritis
High Intensity Interval Training and Rheumatoid Arthritis
The overall objective is to determine whether High Intensity Interval Training (HIIT) has potential to improve disease activity scores for Rheumatoid Arthritis (RA) patients.
- Trial name
- NCT02528344
- Testing
- HIIT
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Duke University
Hypertension, Atrial Fibrillation
Impact of Best Practice Alerts in Cardiology Outpatient Clinics
This quality improvement intervention seeks to implement two Best Practice Alerts (BPAs) for use in cardiology clinics while simultaneously evaluating the impact of each BPA- one for patients with uncontrolled blood pressure and…
- Trial name
- NCT02436421
- Testing
- Best Practice Alert based in the Electronic Medical Record
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- Duke University
Depression, HIV
Trial of Collaborative Depression Care Management for HIV Patients
This project will integrate a depression treatment and brief medication adherence counseling intervention into clinical care at three HIV clinics and will use a randomized controlled trial to assess whether, relative to usual…
- Trial name
- SLAM DUNC (NCT01372605)
- Testing
- Measurement-Based Care collaborative depression management, Enhanced Usual Care
- Where
- 4 sites in United States
- Volunteers
- 304 people
- Sponsor
- Duke University
Pancreatic Cancer, Malnutrition
Pancreatic Resection, Malnutrition and Readmission
The Whipple procedure is associated with increased readmission rates for infection, pancreatic leak, and failure to thrive/malnutrition.
- Trial name
- NCT01947166
- Testing
- Nestle Impact Advanced Recovery nutritional supplement
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Duke University
Health Care Quality, Access and Evaluation
Improved Patient Handoffs to Prevent Sentinel Events
The overall aim of this project is to improve the quality of the handoffs between hospitalists on the general medicine service at Durham Regional Hospital with the intent of improving transitions of care.
- Trial name
- NCT01855646
- Testing
- Structured Sign Out Form
- Where
- United States
- Volunteers
- 4,344 people
- Sponsor
- Duke University
Treatment and Prevention of Anemia After Administration of Gudness Nutrition Bar
Let's be Well Red: Efficacy of Gudness Bars in Improving the Hemoglobin and Hematocrit Levels of Anemic Subjects
To test the efficacy of Gudness Bars in improving the hemoglobin and hematocrit levels of anemic subjects longitudinally. To quantify the demographics of subjects attending anemia testing camps through LBWR and to explore…
- Trial name
- LBWR (NCT02032615)
- Testing
- Education plus Gudness Nutritional Bar, Education
- Where
- India
- Volunteers
- 358 people, healthy volunteers welcome
- Sponsor
- Duke University
Dysarthria, Down Syndrome
Intensive Dysarthria Sessions in Adults and Children With Down Syndrome
This research study is designed to investigate the feasibility and treatment effects of a behavioral speech treatment in adults and children with Down Syndrome (DS) and dysarthria.
- Trial name
- NCT01684670
- Testing
- Speech sessions
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Duke University
Diabetic Kidney Disease, Uncontrolled Hypertension
Integrated Population Program for Diabetic Kidney Disease
This study will build a population management system Simultaneous risk factor control using Telehealth to slOw Progression of Diabetic Kidney Disease STOP-DKD Application STOP-DKD APP and conduct a 6-month controlled trial to…
- Trial name
- STOP-DKD APP (NCT02418091)
- Testing
- Telehealth
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- Duke University
Diabetes Mellitus, Open Reduction External Fixation
Advancing the Standard of Care for Pin Site Care
The purpose of this study is to prospectively evaluate the effect of Active Leptospermum honey utilizing the MediHoney HCS dressing, on the occurrence of PIN site infections, and also to see if the use of MediHoney HCS reduces…
- Trial name
- NCT01965665
- Testing
- MediHoney HCS dressing
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
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