Clinical trials: sponsored by Duke University
Metastatic Renal Cell Carcinoma Treated With Cabozantinib
Development of a Cabozantinib (Cabometyx) Symptom Management Application for Use in Patients With Renal Cancer
The purpose of this study is to develop an on-line electronic symptom management application that can ultimately be used to improve clinical outcomes in patients with mRCC treated with cabozantinib.
- Trial name
- Cabo App (NCT03867045)
- Testing
- Usability of an electronic symptom management application
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Duke University
Hyperglycemia Drug Induced
A Study to Determine Safety and Efficacy of (REMD-477) in Controlling Hyperglycemia Due to Copanlisib
REMD-477 (Volagidemab) is a human anti-glucagon receptor antibody. Its proposed mechanism of action in controlling hyperglycemia is by blocking glucagon receptor (GCGR) signaling.
- Trial name
- NCT04253223
- Testing
- REMD-477
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Duke University
Anxiety, Cardiovascular Disease
Exercise and Pharmacotherapy for Anxiety in Cardiac Patients
Coronary heart disease (CHD) is the leading cause of death in the United States; more than 600,000 Americans suffer a fatal cardiac event each year.
- Trial name
- NCT02516332
- Testing
- Lexapro, Supervised Aerobic Exercise
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Duke University
A Diagnosis of Any Hematologic or Solid Malignancy
ICanSTEP : Increasing Physical Activity With Text Messaging
The proposed pilot study will develop and test feasibility and preliminary efficacy of an exercise motivation intervention using a 12-week smartphone-text messaging program tailored to physical activity data retrieved from a…
- Trial name
- NCT02627079
- Testing
- Daily SMS text messaging
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Duke University
Autophagy and Apoptosis in Human Satellite Cells
Rejuvenation of Aged Muscle Stem Cells Through Exercise
The proposed study will establish a newly-identified signaling pathway regulating both autophagy and apoptosis in human satellite cells.
- Trial name
- NCT03473288
- Testing
- Exercise, Sedentary
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Duke University
Prostate Cancer
Electronic Post-Treatment Surveillance Program for Prostate Cancer Survivors (eHealth)
The purpose of this single institution pilot study is to determine the feasibility of implementing an eHealth prostate cancer surveillance program through the eVisit electronic medical record patient portal.
- Trial name
- NCT04486846
- Testing
- eVisit
- Where
- 4 sites in United States
- Sponsor
- Duke University
Malignant Glioma
Quality of Life of Patients With Glioblastoma (GBM) Treated With Tumor-Treating Fields
This purpose of this study is to describe the effect of Tumor Treating Fields (NovoTTF) on quality of life (QOL), including exercise, sleep quality, and mood, in patients with World Health Organization (WHO) Grade IV malignant…
- Trial name
- ACTION (NCT03501134)
- Testing
- NovoTTF
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Enteral Nutrition, Brain Injuries, Traumatic
Effect of Prebiotic Fiber- Enriched (scFOS) Enteral Feeding on the Microbiome in Neurological Injury Trauma Patients (PreFEED Microbiome Trial)
This study plans to learn more about the impact of enteral nutrition on bacteria in critically ill trauma patients with brain injury.
- Conditions
- Enteral Nutrition, Brain Injuries, Traumatic, ICU Admission
- Trial name
- NCT03153397
- Testing
- Nutraflora scFOS, Osmolite
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Pharmacogenetics
Delivery of Pharmacogenetic Testing in a Community Pharmacy Setting
This study aims to compare patient use of and satisfaction with community pharmacist-delivered pharmacogenetic (PGx) testing delivered along or as part of a medication therapy management (MTM) service.
- Trial name
- NCT02937545
- Testing
- Medication Therapy Management, Pharmacogenetic testing
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Duke University
Malaria
Dynamics of Subclinical Malaria: Preliminary Study
This is a short longitudinal preliminary study that aims to describe the dynamics of low-density subclinical malaria to support the final study design of a subsequent matched cohort study.
- Trial name
- NCT03483571
- Where
- Burma
- Volunteers
- 2,970 people, healthy volunteers welcome
- Sponsor
- Duke University
Arrhythmias, Cardiac
Effect of Monitoring System Design on Response Time to Cardiac Arrhythmias
To increase the potential for timely detection and treatment of cardiac events, hospitals have implemented a number of different cardio-respiratory monitoring methods for at-risk patients.
- Trial name
- NCT02466633
- Testing
- In-hospital cardiac monitoring method
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Duke University
Carcinoma, Non Small Cell Lung (NSCLC)
Locally Advanced NSCLC Hyperfractionated RT
This is a prospective phase II study designed to evaluate an accelerated and adaptive RT approach for locally-advanced non-small cell lung cancer (NSCLC).
- Trial name
- ADAPT (NCT03128008)
- Testing
- Carboplatin, Paclitaxel, Daily hyperfractionated radiation therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Duke University
Metabolism Requirement, Energy Requirement
Longitudinal Evaluation of Energy Expenditure in ICU Patients From Admission to Discharge Using A Novel Indirect Calorimeter: LEEP-Forward Trial
The purpose of this study is to utilize the new indirect calorimetry Q-NRG device to the measurement of energy expenditure (EE) throughout your intensive care unit (ICU) stay and ultimately address fundamental questions about…
- Conditions
- Metabolism Requirement, Energy Requirement, Indirect Calorimetry
- Trial name
- NCT04132700
- Testing
- Q-NRG Metobolic Cart Device
- Where
- United States
- Sponsor
- Duke University
Cigarette Smoking, Nicotine Withdrawal
Nicotine Withdrawal and Reward Processing: Connecting Neurobiology to Real-world Behavior
This study is designed to find out how smoking affects the way the brain responds to pleasure and how this impacts smokers' behavior. Participants will complete three sessions.
- Trial name
- NicWith (NCT03840694)
- Testing
- Smoking Abstinence, Ad Lib Smoking
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Duke University
Radiation Therapy Complication, Chemotherapeutic Toxicity
System for High-Intensity Evaluation During Radiotherapy
This quality improvement project will evaluate the implementation of a previously described intervention (twice per week on-treatment clinical evaluations) in a feasible fashion using a previously described machine learning…
- Trial name
- SHIELD-RT (NCT04277650)
- Testing
- Machine learning algorithm
- Where
- United States
- Volunteers
- 311 people
- Sponsor
- Duke University
SARS-CoV-2
Pragmatic Factorial Trial of Hydroxychloroquine, Azithromycin, or Both for Treatment of Severe SARS-CoV-2 Infection
This is a pragmatic, randomized, open-label, incomplete factorial with nested randomization clinical trial evaluating the efficacy and safety of two potential treatments for hospitalized patients with confirmed SARS-CoV-2…
- Trial name
- NCT04335552
- Testing
- Standard of care, Hydroxychloroquine, Azithromycin
- Where
- 4 sites in United States
- Volunteers
- 11 people
- Sponsor
- Duke University
Smoking Cessation, Smoking Behaviors
Varenicline Light Smoking Pilot
The goal of this study is to assess varenicline vs. placebo for its effect on decreasing cue reactivity in light and intermittent smokers.
- Conditions
- Smoking Cessation, Smoking Behaviors, Smoking
- Trial name
- NCT04089982
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Duke University
Tourniquet Hypertension, Intraoperative Hypertension
Femoral Peri-arterial Local Anesthetic Injection Decreases Tourniquet Associated Ischemic Hypertension
The purpose of this prospective randomized double-blind study is to determine if the novel technique of ultrasound guided peri-arterial injection of local anesthetic around the femoral artery decreases ischemic hypertension…
- Conditions
- Tourniquet Hypertension, Intraoperative Hypertension, Total Ankle Arthroplasty, Ankle Fusion
- Trial name
- NCT03390426
- Testing
- Mepivacaine, Perifemoral Injection of Local Anesthetic, Saline
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Duke University
Ankle Osteoarthritis
Prospective Randomized Evaluation of a Two and Three Piece Total Ankle Replacement
This is a randomized study to prospectively compare and evaluate the functional outcome and patient satisfaction of total ankle replacements for tibio-talar osteoarthritis using either the STAR or Salto-Talaris prothesis.
- Trial name
- NCT01504438
- Testing
- Salto-Talaris Total Ankle Replacement, STAR Total Ankle Replacement
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Duke University
Childhood Traumatic Grief, Post Traumatic Stress
Randomized Controlled Trial of Trauma-focused CBT in Tanzania and Kenya
The primary goal is to study the effectiveness of Trauma-focused Cognitive Behavioral Therapy (TF-CBT) in treating traumatic grief and traumatic stress for orphaned children and young adolescents in two East African sites with…
- Conditions
- Childhood Traumatic Grief, Post Traumatic Stress, Post Traumatic Stress Disorder, Depressive Symptoms
- Trial name
- NCT01822366
- Testing
- Trauma-focused Cognitive Behavioral Therapy
- Where
- 3 sites in United States, Kenya and 1 more
- Volunteers
- 1,280 people
- Sponsor
- Duke University