Clinical trials: completed, sponsored by Duke University
Infertility, Psychological Distress
ACT for Infertility: Case Series
In the United States, around 19% of reproductive-aged couples suffer from infertility. The psychological distress associated with infertility is well-established; those diagnosed commonly experience depression and anxiety…
- Conditions
- Infertility, Psychological Distress, Acceptance and Commitment Therapy, Psychological Flexibility
- Trial name
- NCT06388044
- Testing
- Acceptance and Commitment Therapy
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Duke University
Genetic Disease, Inborn Errors of Metabolism
Identification and Characterization of Novel Non-Coding Variants That Contribute to Genetic Disorders
The goal of this study is to identify and characterize novel non-coding and splicing variants that may contribute to genetic disorders.
- Conditions
- Genetic Disease, Inborn Errors of Metabolism, Glycogen Storage Disease, Lysosomal Storage Diseases
- Trial name
- NCT04399694
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Duke University
Parkinson Disease
Cognitive Disparities in Parkinson's Disease
This study will investigate disparities in neurocognitive impairment (NCI) among Hispanics/Latinos/as/x (henceforth Hispanics) living in the US-Mexico borderland of California or in North Carolina with Parkinson's Disease (PD)…
- Trial name
- NCT07262658
- Testing
- Will examine how Cardiovascular Disease risk, PD severity and social determinants impact neurocognitive impairment in Hispanics vs non-Hispanics Whites
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Duke University
Delirium in Old Age
REPOSE Study: Reducing Delirium by Enhancing Postoperative Sleep With Suvorexant
This research study will evaluate the effectiveness of postoperative administration of a drug called suvorexant, to improve postoperative sleep and decrease the severity of delirium (serious confusion) in adults 65 years and…
- Trial name
- REPOSE (NCT05733286)
- Testing
- Suvorexant 20 mg
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Duke University
COVID-19
RADx-UP CDCC Rapid Research Pilot Program "Culturally-relevant Community Connections (C3) to Increase COVID-19 Testing
The purpose of this study is to identify barriers and facilitators to COVID testing among members of the Black/African American community.
- Trial name
- NCT05918952
- Testing
- Covid-19 Antibody Test, Short Clip videos
- Where
- United States
- Volunteers
- 327 people, healthy volunteers welcome
- Sponsor
- Duke University
Chest Pain, Shortness of Breath
Leveraging Exercise Stress Echocardiography for Heart Failure With Preserved Ejection Fraction
The purpose of this study is to find out if additional images taken during a stress echocardiogram study and risk score calculation will help the doctor determine if shortness of breath or chest pain are caused by stiff heart…
- Trial name
- NCT06927973
- Testing
- Echocardiogram
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Duke University
Cervicogenic Upper Extremity Radiculopathy
Transforaminal Versus Lateralized Interlaminar Cervical Epidurals
The purpose of this study is to compare two methods of giving epidural steroid injections for nerve pain in the arm that comes from the neck.
- Trial name
- NCT03389620
- Testing
- dexamethasone
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Duke University
Reactions to Warnings, Hookah Smoking
Reactions to Warnings on Hookah Ads
The purpose of this study is to help us better understand what kinds of waterpipe tobacco advertisements appeal to young adults as well as to help evaluate and create health warnings that can be placed on waterpipe tobacco…
- Trial name
- NCT03723616
- Testing
- Ads Only, Ads with text-only health warning labels (HWLs), Ads with text + graphic health warning labels (HWLs)
- Where
- United States
- Volunteers
- 2,588 people, healthy volunteers welcome
- Sponsor
- Duke University
Smokeless Tobacco Cessation
A Text-based Reduction Intervention for Smokeless Tobacco Cessation- Pilot Study
All participants will receive the EnufSnuff.TXT scheduled gradual reduction (SGR) intervention for 6 weeks and, for those who do not reach the point of quit, includes getting randomized (like the flip of a coin) into either an…
- Trial name
- NCT06637358
- Testing
- Extended Scheduled Gradual Reduction (SGR), Quit Coach
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Duke University
Vaccine Hesitancy
Increasing Vaccine Uptake Among Adolescents in the Rural South
The benefits of adolescent vaccines are well known for preventing meningococcal infection and human papillomavirus (HPV)-related pre-cancerous lesions.
- Trial name
- INVEST (NCT04999267)
- Testing
- INVEST
- Where
- 2 sites in United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Duke University
Breast Cancer
mHealth Behavioral Cancer Pain Intervention for Medically Underserved Patients
The efficacy of a mobile health (mHealth) behavioral cancer pain intervention designed to decrease pain and disability for breast cancer patients in medically underserved areas has not been investigated.
- Trial name
- ICAN-NC (NCT04175639)
- Testing
- Mobile Health Pain Coping Skills Training (mPCST)
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Duke University
Resilience, Aging
Physical Resilience: Indicators and Mechanisms in the Elderly (PRIME) Collaborative Phase 2
The purpose of this study is to examine underlying physical resilience (the ability to bounce back) in response to a specific stressor (total knee replacement).
- Trial name
- PRIME-Knee (NCT04235309)
- Where
- 3 sites in United States
- Volunteers
- 297 people, healthy volunteers welcome
- Sponsor
- Duke University
New Persistent Daily Headache
NDPH Biomarker Study in Children and Adolescents
This study will recruit pediatric patients with NDPH (New Daily Persistent Headache), characterize their headache in a standard manner, and treat the NDPH with standard medications used for treatment of headaches in this…
- Trial name
- NCT06018025
- Testing
- CGRP antibody
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Duke University
Hematopoietic Steam Cell Transplantation (HCT)
ACT to Reduce Morbidity and Mortality in Hematopoietic Stem Cell Transplant (HCT) Patients
This is a research study to develop and test a novel protocol to reduce physical and psychological vulnerabilities that contribute to treatment intolerance and treatment-related morbidity and mortality among hematopoietic stem…
- Trial name
- NCT04423939
- Testing
- Acceptance and Commitment Therapy (ACT)
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Duke University
Single Level Spinal Fusion, Discetomy
Integration of Mindfulness and Acupuncture After Spine Surgery
The Integration of Mindfulness and Acupuncture for individuals undergoing Spine Surgery (I-MASS) is a novel combination of integrative treatments to improve post-surgical recovery.
- Conditions
- Single Level Spinal Fusion, Discetomy, Laminectomy
- Trial name
- I-MASS (NCT06429072)
- Testing
- Mindfulness training, Acupuncture, Enhanced education
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Duke University
Cleft Lip and Nose, Nasal Obstruction
Computational Modeling of Cleft Lip Nasal Deformity and Assessment of Nasal Function and Treatment Outcomes
The purpose of this study is to use computers to simulate airflow in 3D construction of your nasal cavity generated from cone beam CT images.
- Trial name
- NCT04150783
- Testing
- Surgical repair for nasal obstruction
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Duke University
Opioid Use, Pain, Postoperative
Optimizing Outpatient Anesthesia (OSPREy-Outpatient Surgery Pain Relief Enhancement)
The overall goal of this research is to improve perioperative pain treatment, decrease post-operative opioid consumption, diminish opioid related side effects, and reduce postop opioid prescribing (and hence opportunity for…
- Trial name
- OSPREy (NCT03726268)
- Testing
- Methadone, Fentanyl, Hydromorphone
- Where
- United States
- Volunteers
- 907 people
- Sponsor
- Duke University
Caregivers, Technology
CLARE Mobile App for Caregiver Training and Support
This pilot study will investigate the feasibility of using a digital health application, Communication, Learning, Advocacy, Resources and Expertise (CLARE), in training and support of family and friends (i.e., caregivers) of…
- Trial name
- NCT05877586
- Testing
- CLARE app
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Duke University
Chronic Neck Pain
Specific and Shared Mechanisms Associated With Treatment for Chronic Neck Pain
It is expected that different physical therapy treatments influence outcomes in many different ways. Each treatment is assumed to have a "specific" treatment mechanism, which explains how that specific treatment works.
- Trial name
- SS-MECH (NCT05940012)
- Testing
- Manual Therapy
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- Duke University
Cognitive Health, mHealth Application
Cognitive Training RCT for Older Chinese Americans
The purpose of this study is to develop and pilot test a mHealth intervention for cognitive training that is culturally and linguistically relevant to older Chinese Americans
- Conditions
- Cognitive Health, mHealth Application, Experience-based Co-design, Cognitive Training
- Trial name
- NCT05355870
- Testing
- Cognitive Training Intervention
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Duke University
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