Clinical trials: sponsored by Eisai Inc.
Leukemia
Pharmacokinetic Trial of Decitabine (Dacogen) Administered as a 3-hour Infusion to Patients With Acute Myelogenous Leukemia or Myelodysplastic Syndrome
The purpose of this study is to determine the pharmacokinetics (PK) of decitabine administered to patients with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML).
- Trial name
- NCT01378416
- Testing
- Decitabine (Dacogen)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Eisai Inc.
Alzheimer's Disease, Dementia
Efficacy and Safety of Aricept in the Treatment of Severe Alzheimer's Disease
Donepezil hydrochloride (Aricept) has been approved to treat symptoms associated with mild to moderate Alzheimer's disease (AD).
- Trial name
- NCT00096473
- Testing
- Donepezil hydrochloride
- Where
- 42 sites in United States, Australia and 4 more
- Volunteers
- 229 people
- Sponsor
- Eisai Inc.
Dementia, Vascular
Donepezil Hydrochloride (E2020) in Dementia Associated With Cerebrovascular Disease
Twenty-four week, prospective, randomized, double-blind, placebo-controlled, parallel-group study.
- Trial name
- NCT00165737
- Testing
- Donepezil Hydrochloride
- Where
- 5 sites in United States
- Volunteers
- 974 people
- Sponsor
- Eisai Inc.
Alzheimer's Disease
EARTH 413: A Study of Aricept in Hispanic Patients With Mild to Moderate Alzheimer's Disease (AD)
12-week, open-label study to evaluate the effectiveness and safety of donepezil hydrochloride in Hispanic patients with mild to moderate Alzheimer's Disease (AD) in the U.S.
- Trial name
- NCT00230568
- Testing
- Aricept
- Where
- 35 sites in United States
- Volunteers
- 100 people
- Sponsor
- Eisai Inc.
Memory Loss
The Evaluation of the Efficacy and Safety of Donepezil Hydrochloride in Subjects With Mild Cognitive Impairment (MCI)
To investigate the efficacy and safety of donepezil in individuals with mild cognitive impairment on measures of cognition, global function and behavior.
- Trial name
- NCT00293176
- Testing
- Donepezil Hydrochloride
- Where
- 54 sites in United States
- Volunteers
- 821 people
- Sponsor
- Eisai Inc.
Frequent Heartburn
A Study to Investigate Use Patterns and Safety in Simulated Actual Over-the-counter (OTC) Use of Rabeprazole Sodium for the Treatment of Heartburn Symptoms
This is a multi-center, open-label, all-comers OTC actual use study in pharmacy sites where the principal investigator will be a pharmacist.
- Trial name
- NCT01286194
- Testing
- Rabeprazole sodium
- Where
- 33 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- Eisai Inc.
Ischemic Coronary Artery Disease, Coronary Artery Bypass Surgery
Comparison of AQUAVAN® Injection to DISOPRIVAN® Injectable Emulsion for Anesthesia During Coronary Artery Surgery
This is an exploratory clinical trial designed to examine the efficacy, safety and tolerability of fospropofol (AQUAVAN) Injection compared to propofol (DISOPRIVAN) Injectable Emulsion when used to preoperatively sedate, induce…
- Trial name
- NCT00209521
- Testing
- fospropofol, propofol
- Volunteers
- 16 people
- Sponsor
- Eisai Inc.
Heartburn
E3810-A001-313: Efficacy and Safety of 10 mg Rabeprazole for Treating Heartburn in Frequent Sufferers
The purpose of this study is to investigate the safety and efficacy of rabeprazole sodium 10 mg in treating frequent heartburn.
- Trial name
- NCT00236184
- Testing
- rabeprazole sodium
- Where
- United States
- Volunteers
- 629 people
- Sponsor
- Eisai Inc.
Lesions of the Liver
Study Investigating the Effect of E7337 on Tumor Like Lesions in Computed Tomography (CT) of the Liver
This is a multicenter, randomized, open-label study to investigate the superiority of the contrast enhancement effect of E7337 on tumor-like lesions in the Dynamic CT of the liver.
- Trial name
- NCT00280410
- Testing
- E7337
- Where
- 14 sites in Japan
- Volunteers
- 192 people
- Sponsor
- Eisai Inc.
Colonoscopy, Colon Polyps
A Study of AQUAVAN® Injection in the Presence of Pre-Medication in Patients Undergoing Elective Colonoscopy
This study was designed to assess the safety and efficacy of AQUAVAN® Injection in providing adequate sedation in patients undergoing colonoscopy.
- Trial name
- NCT00209534
- Testing
- fospropofol disodium
- Volunteers
- 200 people
- Sponsor
- Eisai Inc.
Gastroesophageal Reflux Disease
Treatment of Gastroesophageal Reflux Disease in 12-16 Year Old Patients With Rabeprazole
The primary objective of this study is to collect safety information on rabeprazole 10 mg and 20 mg in the treatment of gastroesophageal reflux disease (GERD) in children aged 12 to 16 years.
- Trial name
- NCT00132496
- Testing
- rabeprazole sodium
- Where
- 25 sites in United States
- Volunteers
- 111 people
- Sponsor
- Eisai Inc.
Heartburn
E3810-A001-312: Efficacy and Safety of 10 mg Rabeprazole for Treating Heartburn in Frequent Sufferers
The purpose of this study is to investigate the safety and efficacy of rabeprazole 10 mg in treating frequent heartburn.
- Trial name
- NCT00236197
- Testing
- rabeprazole sodium
- Where
- United States
- Volunteers
- 619 people
- Sponsor
- Eisai Inc.
Leukemia, Lymphocytic, Chronic
Study of ONTAK in Patients With B-Cell Chronic Lymphocytic Leukemia (CLL)
The purpose of this study is to evaluate the safety and effectiveness of ONTAK in previously treated patients with chronic lymphocytic leukemia (CLL)
- Trial name
- NCT00055146
- Testing
- ONTAK
- Where
- 14 sites in United States, Argentina and 3 more
- Volunteers
- 41 people
- Sponsor
- Eisai Inc.
Cancer
A Dose Escalation Study of E7107 Administered Intravenously on Days 1 and 8 Every 21 Days to Patients With Solid Tumors
The purpose of this study is to investigate E7107 in patients with solid tumors. This is an open label, dose-escalation study of E7107.
- Trial name
- NCT00499499
- Testing
- E7107
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Eisai Inc.
Impotence, Prostate Cancer
Evaluate the Effects of GPI 1485 on Erectile Function Following Bilateral Nerve-Sparing Prostatectomy
In this phase II study, an investigative (not approved by the FDA) drug called GPI 1485 is being assessed to see if it can help preserve erectile function after prostatectomy.
- Trial name
- NCT00090376
- Testing
- GPI 1485
- Where
- 25 sites in United States
- Volunteers
- 240 people
- Sponsor
- Eisai Inc.
Postoperative Sedation, Intubation
GPI 15715 For Sedation in the Intensive Care Unit (ICU) Setting
Patients who are in the intensive care unit after surgery and require mechanical breathing support (intubation and ventilation) usually require sedation to avoid agitation and excessive stress responses.
- Conditions
- Postoperative Sedation, Intubation, Respiration, Artificial
- Trial name
- NCT00125398
- Testing
- AQUAVAN (fospropofol disodium; GPI 15715 )
- Where
- 17 sites in United States
- Volunteers
- 60 people
- Sponsor
- Eisai Inc.
Colonoscopy, Colonic Polyps
Study of AQUAVAN® Injection (AQUAVAN; Fospropofol Disodium) for Sedation During Colonoscopy
Very often, patients receive sedative medication before a diagnostic, therapeutic, or surgical procedure to help them relax, keep them calm, and to relieve them from pain. This is called procedural sedation.
- Trial name
- NCT00125424
- Testing
- AQUAVAN® (fospropofol disodium) Injection, Midazolam HCl
- Where
- 20 sites in United States
- Volunteers
- 125 people
- Sponsor
- Eisai Inc.
Parkinson's Disease
2 Year Study to Evaluate the Effects of GPI 1485 on [123I]b-CIT/SPECTScanning and Clinical Efficacy in Patients With PD
This study was designed to assess whether GPI 1485 has the ability to delay or stop disease progression and improve symptoms in patients with Parkinson's disease (PD) that is already being treated with a dopamine agonist therapy.
- Trial name
- NCT00209508
- Testing
- GPI 1485
- Volunteers
- 200 people
- Sponsor
- Eisai Inc.
Angioplasty, Coronary Catheterization
Study to Assess Safety and Efficacy of AQUAVAN® Injection for Sedation During Cardiac Catheterization
The anticipation of pain and discomfort, a diagnosis, and other intrinsic unknowns make patients anxious both prior to and during a procedure.
- Trial name
- NCT00209547
- Testing
- fospropofol disodium
- Volunteers
- 110 people
- Sponsor
- Eisai Inc.
Colonoscopy, Colon Polyps
A Study of AQUAVAN® Injection Versus Midazolam HCl for Sedation in Patients Undergoing Elective Colonoscopy
This study was designed to demonstrate that AQUAVAN® is effective in providing adequate sedation in patients undergoing colonoscopy as well as to assess the safety profile of AQUAVAN versus that of midazolam.
- Trial name
- NCT00209573
- Testing
- fospropofol disodium
- Volunteers
- 270 people
- Sponsor
- Eisai Inc.