Clinical trials: sponsored by Federico II University
Prosthesis Survival
14y Prospective Study on Posterior Zirconia-based 3-unit FDPs
The main objective of the present prospective study is to evaluate the effectiveness of posterior zirconia FDPs after 14 years of function.
- Trial name
- NCT04374201
- Testing
- 2 zirconia FDPs, 1 zirconia FDP
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Federico II University
Infection Viral
Clinical Characteristics of Coronavirus Disease 2019 (COVID-19) in Pregnancy
The Novel Coronavirus (2019-nCoV), also known as Wuhan coronavirus, causes the 2019-nCoV acute respiratory disease.
- Trial name
- COVID-preg (NCT04319016)
- Testing
- pregnant women with laboratory-confirmed 2019-n-CoV
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Federico II University
Laparoscopic Right Colectomy
Surgical Stress and Intracorporeal Anastomosis
The short-term advantages of minimally invasive colon resection have been well established in several randomized trials. A major factor in the development of morbidity is the surgical stress response with subsequent increased…
- Trial name
- NCT03422588
- Testing
- Laparoscopic right colectomy
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Federico II University
Infection Viral
Clinical Characteristics of Coronavirus Disease 2019 (COVID-19) in Pregnancy: The Italian Registry on Coronavirus in Pregnancy.
The Novel Coronavirus (2019-nCoV), also known as Wuhan coronavirus, causes the 2019-nCoV acute respiratory disease. The number of patients infected by 2019-nCoV in Italy closely followed an exponential trend, and Italy reported…
- Trial name
- I-COVID (NCT04315870)
- Testing
- pregnant women with laboratory-confirmed 2019-n-CoV
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Federico II University
Coats Disease
Evaluation of Retinal and Vascular Features in Coats Disease After Intravitreal Injections of Ranibizumab
This study evaluates the retinal and vascular features in patients affected by Coats disease under the effects of Ranibizumab intravitreal injections using optical coherence tomography and optical coherence tomography angiography
- Trial name
- NCT04310631
- Testing
- Ranibizumab Injection
- Where
- Italy
- Volunteers
- 5 people
- Sponsor
- Federico II University
Hodgkin Lymphoma, High Risk
Follow Up of High Risk Hodgkin Lymphoma in First Complete Remission
Cohort study enrolled high-risk Hodgkin Lymphoma patients in first relapse after induction therapy followed after remission either with a systemic imaging-based surveillance (Imaging cohort) or with standard clinical-based…
- Conditions
- Hodgkin Lymphoma, High Risk, Relapse
- Trial name
- HOLYFU (NCT04298619)
- Testing
- Standard cohort: Clinical lab follow-up, Imaging cohort: integrated imaging follow-up
- Volunteers
- 123 people
- Sponsor
- Federico II University
Diabetes Type 2, NAFLD
Effects of a Portfolio Diet on NAFLD in Type 2 Diabetic Patients
Patients with type 2 diabetes and non-alcoholic fatty liver disease will be enrolled. According to a parallel design, the participants will be randomized to a Portfolio diet or a monounsaturated fatty acid (MUFA)-rich diet (used…
- Trial name
- MEDEA (NCT03380416)
- Testing
- Portfolio Diet, MUFA Diet
- Where
- Italy
- Volunteers
- 49 people
- Sponsor
- Federico II University
Aneuploidy
First Trimester Risk Assessment Based on Ultrasound and Cell-free DNA vs Combined Screening
There is an ongoing debate regarding how cell-free DNA (cfDNA) screening can best be incorporated into current prenatal screening algorithms for chromosomal abnormalities.
- Trial name
- NCT04077060
- Testing
- NIPT, combined screening
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Federico II University
Surgical Stress and Immune Function
Surgical Stress and Colorectal Surgery
The purpose of this study is to evaluate surgical stress and immune function after robotic versus laparoscopic colectomy.
- Trial name
- ESSIMIC (NCT02871960)
- Testing
- Robotic and Laparoscopic Colectomy
- Volunteers
- 170 people
- Sponsor
- Federico II University
Preterm Birth
Cervical Pessary for Prevention of Spontaneous Preterm Birth in Singleton Pregnancies With Arrested Preterm Labor
Preterm birth (PTB) is a major cause of perinatal morbidity and mortality. Worldwide, about 15 million babies are born too soon every year, causing 1.1 million deaths, as well as short- and long-term disability in countless…
- Trial name
- NCT03543475
- Testing
- arabin pessary, no pessary
- Where
- Italy
- Volunteers
- 61 people
- Sponsor
- Federico II University
Nausea, Vomiting
Effect of Ginger on Nausea and Vomiting During Acute Gastroenteritis in Children
The acute gastroenteritis is a very common problem in children. The frequency and duration of this condition involves a high discomfort for the child and his family, and significant costs, in connection with the purchase of…
- Trial name
- NCT02701491
- Testing
- Ginger
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Federico II University
Atelectasis
Evaluation of Thoracic Impedance Tomography During Robotic Surgery
the evaluation of distribution of mechanical ventilation during robotic surgery
- Trial name
- EIT_ROBO (NCT04194177)
- Testing
- mechanical ventilation during robotic surgery
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Federico II University
Weaning From Mechanical Ventilation
Mechanical Ventilation- Weaning and Thoracic Impedance Tomography
The aim of this multicenter, randomized controlled trial is to evaluate the weaning time from mechanical ventilation comparing non-variable PSV, variable PSV, and Smart CareTM.
- Trial name
- NCT03018483
- Testing
- Variable PSV, Conventional PSV, Automated PSV
- Where
- Italy
- Volunteers
- 342 people
- Sponsor
- Federico II University
Postprandial Hyperglycemia
Metabolic Effects of High-amylose Wheat-based Breads
The amylose-amylopectin ratio influences starch properties. A higher amylose content is associated with slower starch digestion thus reducing the postprandial plasma glucose response and improving the overall postprandial…
- Trial name
- NCT03899974
- Testing
- Test meal
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Federico II University
Peripheral Arterial Disease, Superficial Femoral Artery Stenosis
LegDeb2 Global Registry for Use of Legflow in Peripheral Arteries
LEGDEB2 is a Global Registry for the Treatment of Superficial Femoral and/or Popliteal or Below-The-Knee or Iliac Artery Lesions Using the Legflow Drug-Eluting Balloon
- Conditions
- Peripheral Arterial Disease, Superficial Femoral Artery Stenosis, Iliac Artery Stenosis, Arterial Occlusive Diseases
- Trial name
- LEGDEB2 (NCT04175197)
- Testing
- Drug Coated Balloon
- Where
- 7 sites in Italy, Mexico
- Volunteers
- 512 people
- Sponsor
- Federico II University
Exudative Age-related Macular Degeneration
Evaluation of Retinal and Vascular Features in Macular Degeneration After Intravitreal Injections of Bevacizumab
This study evaluates the retinal and vascular features in patients with macular degeneration under the effects of Bevacizumab intravitreal injections using optical coherence tomography and optical coherence tomography angiography.
- Trial name
- NCT04138420
- Testing
- Bevacizumab Injection
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- Federico II University
Obesity, Weight Loss
Effect of Liraglutide on Microbiome in Obesity
The purpose of the trial is to assess whether the beneficial effect of liraglutide on weight is mediated by changes in the composition of the intestinal Microbiome.
- Conditions
- Obesity, Weight Loss, Microbiome
- Trial name
- NCT04046822
- Testing
- Liraglutide 6 MG/ML [Saxenda]
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Federico II University
Prevention of Clinical Symptoms in Celiac Disease
Risk Factors for the Development of Celiac Disease in Genetically Predisposed Children
The study aims to identify risk factors for the development of Celiac Diseases in families with a recognized genetic risk for the presence of a confirmed proband case.
- Trial name
- NEOCEL (NCT04034303)
- Testing
- analysis of genetic and epigenetic risk factors
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Federico II University
Cardiovascular Risk Factors
Effects of LopiGLIK® on Cardiovascular Risk
The study is designed to compare the effects of two combination of nutraceuticals: Armolipid Plus® and LopiGLIK® (Akademy Pharma), a new supplement that, in addition to Berberine and Red Rice, contains Morus Alba's extract.
- Trial name
- LopiWEB (NCT02898805)
- Testing
- Prescribed Diet, LopiGLIK®, Armolipid Plus
- Where
- Italy
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Federico II University
Type 1 Diabetes
Pizza Leavening and Postprandial Glycemia in Type 1 Diabetes (LEAVEN)
The purpose of this study is to compare in patients with type 1 diabetes the postprandial glucose response to the consumption of three types of pizza, obtained with different leavening techniques.
- Trial name
- LEAVEN (NCT03619031)
- Testing
- LONG LEAVENING, SHORT LEAVENING, TRADITIONAL
- Where
- Italy
- Volunteers
- 16 people
- Sponsor
- Federico II University