Clinical trials: sponsored by Federico II University
Chronic Heart Failure
Treatment of the lOw IGF-1 Syndrome aSsociated With Chronic Heart fAilure: A Randomized, Placebo-Controlled, Double-Blind Study.
The objective of the study is to determine whether treatment of the low IGF-1 syndrome in patients with CHF is able to modify some functional parameters, recognized as valid surrogate end-points of CHF progression.
- Trial name
- TOSCA2 (NCT01235273)
- Testing
- Growth Hormone
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Federico II University
Gastrointestinal Symptoms, Small Intestinal Overgrowth
Proton Pump Inhibitors and Gastrointestinal Symptoms
The aim of the study is to evaluate the potential protective effect of Lactobacillus paracasei subspecies paracasei F19 administration on bowel symptom onset in patients with gastro-esophageal reflux disease at long-term PPI…
- Trial name
- NCT02054455
- Testing
- Lactobacillus paracasei F19
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Federico II University
Multiple System Atrophy
Lithium in Multiple System Atrophy
The purpose of this study is to determine safety and tolerability of the treatment with lithium in Multiple System Atrophy. Moreover, clinical symptoms, neuronal loss, quality of life and depressive symptoms, will be considered…
- Trial name
- LAMU (NCT00997672)
- Testing
- Lithium Carbonate
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Federico II University
Dyslipidemia, Familial Hypercholesterolemia
Efficacy of a New Symbiotic Formulation in Children With Familial Hypercholesterolemia
Probiotics have been proposed for the treatment of dyslipidemia. the investigators aimed to evaluate efficacy, tolerability and safety of a new symbiotic formulation containing a combination of probiotic and prebiotics and amine…
- Trial name
- NCT02048410
- Testing
- Lactobacillus paracasei B21060, low satured diet
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Federico II University
Chronic Kidney Disease
Effect of the Synbiotic Probinul-Neutro® on Gastrointestinal Symptoms and Plasma p-Cresol Level in Chronic Renal Failure
The interest on gastrointestinal (GI) dysfunction in CKD has been growing in the last years. it is now accepted that GI dysfunction in dialyzed patients may contribute to systemic microinflammation by promoting gut dysbiosis and…
- Trial name
- NCT02008331
- Testing
- SYNBIOTIC
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Federico II University
Type 1 Diabetes
Glycaemic Load and Pre-meal Insulin Doses in Type 1 Diabetes Patients
The aim of this study is to compare the feasibility and the efficacy on short-term glucose control of pre-meal insulin doses adjustment made on the bases of the glycemic load or of the carbohydrates content of the meal in…
- Trial name
- GLUT (NCT01978704)
- Testing
- Adjustment of pre-prandial insulin doses on the bases of glycaemic load of the meal, Adjustment of pre-prandial insulin doses on the bases of carbohydrates content of the meal
- Volunteers
- 9 people
- Sponsor
- Federico II University
Pilonidal Sinus
Video Assisted Ablation of Pilonidal Sinus
The investigators supposed that the complete video assisted ablation of pilonidal sinus (VAAPS) could be an effective minimally invasive treatment of pilonidal sinus.
- Trial name
- NCT01963273
- Testing
- Video Assisted Ablation of Pilonidal Sinus
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Federico II University
Cystic Fibrosis
Probiotics on Intestinal Inflammation in Cystic Fibrosis
Cystic fibrosis (CF) is a complex systemic disease that mainly involves the respiratory and gastrointestinal (GI) tracts. The polymicrobial community composition of respiratory and GI tracts is influenced by both genetic and…
- Trial name
- NCT01961661
- Testing
- Lactobacillus rhamnosus GG
- Where
- Italy
- Volunteers
- 22 people
- Sponsor
- Federico II University
Nonmalignant Neoplasm
Alemtuzumab and Low-Dose Cyclosporine in Treating Patients With Severe Aplastic Anemia or Acquired Marrow Failure
RATIONALE: Immunosuppressive therapies, such as alemtuzumab and cyclosporine, may improve bone marrow function and increase blood cell counts.
- Trial name
- NCT00895739
- Testing
- alemtuzumab, cyclosporine
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Federico II University
Cow's Milk Allergy, Atopic Disease
Effect Of Lactobacillus GG on Atopic March
Food allergy (FA), defined as an adverse immune response to food allergens, is among the most frequent allergic disorders in childhood and it has recognized as a major paediatric health problem due to the severity of the…
- Trial name
- NCT01891916
- Testing
- Extensively hydrolyzed casein formula + LGG
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- Federico II University
Overweight
Whole Grain Polyphenol Bioavailability and Effects on Health
Whole grains (WG) contain numerous physiologically bioactive compounds, a key group being polyphenolic compounds such as ferulic acid (FA).
- Trial name
- NCT01293175
- Testing
- Whole grains
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Federico II University
Metabolic Syndrome
Effects of Dietary Polyphenols and ω-3 Fatty Acids on Cardiovascular Risk Factors in High Risk Subjects
The aim of this study is to explore if a 8-weeks dietary intervention with polyphenols and omega 3 fatty acids (alone or combined) may be effective on postprandial lipids metabolism and other cardiovascular risk factors in people…
- Trial name
- Etherpaths (NCT01154478)
- Testing
- Diet rich in omega-3 fatty acids, Diet rich in polyphenols, Control diet
- Where
- Italy
- Volunteers
- 86 people
- Sponsor
- Federico II University
Plaque-type Psoriasis, Obesity (Body Mass Index >30 kg/m2)
n-3 Polysaturated Fatty Acids-rich Diet in Psoriasis
Low-grade systemic inflammation associated with obesity may worsen the clinical course of psoriasis. Both a low-calorie diet and nutritional supplementation have been shown to have an impact on the clinical course of psoriasis…
- Trial name
- PSO (NCT01876875)
- Testing
- Energy-restricted, n-3 polysaturated fatty acids-rich diet, Usual diet
- Where
- Italy
- Volunteers
- 44 people
- Sponsor
- Federico II University
Mental Disorders
Non-invasive Brain Stimulation for the Treatment of Psychiatric Disorders
The purpose of this study is to determine whether transcranial direct current stimulation (tDCS) is effective in the treatment of psychiatric disorders in which available treatments are either ineffective or not tolerated
- Trial name
- NCT01872143
- Testing
- transcranial Direct Current Stimulation
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Federico II University
Kidney Transplantation
Diet Rich in N-3 Polyunsaturated Fatty Acids in Renal Transplant Recipients
n-3 Polyunsaturated fatty acids (PUFAs) supplementation reduces systemic inflammation and improves renal and cardiovascular prognosis in kidney transplant recipients.
- Trial name
- NCT01872455
- Testing
- n-3 rich diet, Usual diet
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Federico II University
Chronic Kidney Disease
Efficacy of the 6-point Diet
The dietary restriction of proteins and sodium is a cornerstone in the treatment of chronic kidney disease (CKD) and of its metabolic consequences. Dietary adjustments in CKD are complex and the patients' compliance is very low.
- Trial name
- PIS (NCT01865526)
- Testing
- Six point diet, Low protein diet
- Where
- Italy
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Federico II University
Inflammatory Status, P-cresol
HFR Cartridge and Inflammation
A major limitation of standard hemodialysis is that it does not clear the plasma from interleukin-6 (IL-6) and p-cresol, two uremic toxins responsible for the high cardiovascular risk in end stage renal disease (ESRD).
- Trial name
- HFR (NCT01865773)
- Testing
- HFR dialysis
- Where
- Italy
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Federico II University
Gastroesophageal Reflux, Regurgitation
Prospective, Comparative, Randomized, Controlled Trial on the Efficacy of the Treatment of Gastroesophageal Reflux Infant With Magnesium Alginate
The results on the efficacy of the formulations based on alginic acid are controversial. Corvaglia et al demonstrated a significant reduction in reflux episodes in preterm infants by evaluation with pH-impedance analysis.
- Conditions
- Gastroesophageal Reflux, Regurgitation, Vomiting, Chronic Cough
- Trial name
- NCT01858584
- Testing
- Gastrotuss, thickened milk
- Where
- Italy
- Volunteers
- 75 people
- Sponsor
- Federico II University
Chronic Heart Failure
ALERT-HF: Adherence to Guidelines in the Treatment of Patients With Chronic Heart Failure
ALERT-HF is an observational study aimed to evaluate the diagnostic criteria adopted and the adherence to the current therapeutic guidelines in a large series of patients affected with chronic heart failure.
- Trial name
- ALERT-HF (NCT01813331)
- Where
- Italy
- Volunteers
- 660 people
- Sponsor
- Federico II University
SPINOCEREBELLAR ATAXIA 2
Safety and Tolerability of Lithium in Spinocerebellar Ataxia 2 (SCA2)
The purpose of this study is to determine safety and tolerability of the treatment with lithium in Spinocerebellar Ataxia 2. Moreover, clinical symptoms, neuronal loss, quality of life and depressive symptoms, will be considered…
- Trial name
- LISCA2 (NCT00998634)
- Testing
- LITHIUM CARBONATE
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Federico II University