Clinical trials: sponsored by Federico II University
Obesity, Morbid, Rectal Cancer
Evaluation of Surgical Complications and DFS in Obese Rectal Cancer Patients
Obesity worsens treatment outcomes in rectal cancer patients: the local resective approach could in fact be more difficult in obese patients due to limited surgical visibility and it has also been reported that high visceral…
- Conditions
- Obesity, Morbid, Rectal Cancer, Surgery-Complications
- Trial name
- NCT06056726
- Testing
- BIB positioning
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Federico II University
No Condition
Joint School-Health Project of the Neapolitan Child
Unhealthy lifestyle habits during the childhood could negatively impact the health status actual and during the later stages of life.
- Trial name
- NCT05901220
- Testing
- Healthy lifestyle
- Where
- Italy
- Volunteers
- 223 people
- Sponsor
- Federico II University
Adrenalectomy; Status, Obesity, Morbid
Effect of Ketogenic Diet on Peri-operative Complications of Right Laparoscopic Adrenalectomy in Obese Patients
Ketogenic diet is often prescribed to morbid obese patients scheduled for bariatric surgery in order to reduce liver size, thus making surgery less demanding.
- Trial name
- NCT05816031
- Testing
- Ketogenic diet
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Federico II University
Acute Coronary Syndrome
Observational Registry on Acute Coronary Syndromes in Campania
This registry aims to collect data related to management of patients affected by acute coronary syndromes and hospitalized in the Campania Region of Italy
- Trial name
- Campania RESCA (NCT02650323)
- Where
- Italy
- Volunteers
- 10,000 people
- Sponsor
- Federico II University
Frail Elderly Syndrome
ICT-supported Multidimensional Approach for Frailty Screening in Community-dwelling Individuals Aged ≥ 65 Years
SUNFRAIL+ is a prospective observational cohort study aimed to carry out a multidimensional assessment of community-dwelling older adults, through an IT platform, which allows to connect the items of the SUNFRAIL frailty…
- Trial name
- SUNFRAIL+ (NCT05646472)
- Testing
- Frailty multidimensional assessment
- Where
- 8 sites in Italy
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Federico II University
Burning Mouth Syndrome
Comparison of Vortioxetine Versus Other Antidepressants With Pregabalin Augmentation in Burning Mouth Syndrome
Background: The treatment of Burning Mouth Syndrome (BMS) presents a challenge in tailoring appropriate medication for individual patients.
- Trial name
- NCT06025474
- Testing
- Vortioxetine 20Mg Tab, Paroxetine 20 Mg Oral Tablet, Sertraline 50 MG
- Where
- Italy
- Volunteers
- 203 people
- Sponsor
- Federico II University
Frailty Syndrome, Cystic Fibrosis
Cystic Fibrosis and Frailtyh What's in Common?
The goal of this observational study is to assess the main clinical and anamnestic characteristics, and frailty syndrome in an adult Cystic Fibrosis population.
- Trial name
- NCT06020547
- Where
- Italy
- Volunteers
- 139 people
- Sponsor
- Federico II University
Ulcerative Colitis
AppenDectomy Vs ANti TNF-a in Inducing Clinical and EnDoscopic Remission in Left-sided Ulcerative Colitis
Ulcerative Colitis (UC) is a chronic Inflammatory Bowel Disease (IBD) characterized by a multifactorial etiology, a variable involvement of large bowel, and a relapsing-remitting course.
- Trial name
- ADVANCED-UC (NCT05931458)
- Testing
- Appendectomy, Infliximab
- Volunteers
- 94 people
- Sponsor
- Federico II University
Periodontal Pocket, Periodontitis
PRF Therapy for Pocket Reduction
Periodontal regenerative therapy has focused on various non-surgical and surgical treatment methods. Platelet-rich fibrin (PRF) has shown to possess multiple uses, including properties that promote healing of both soft and hard…
- Trial name
- NCT05908929
- Testing
- SRP and concomitant insertion of PRF membrane, SRP
- Where
- 2 sites in Italy
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Federico II University
Labor Pain
VR Scenario for Labor Pain Control
The present study aims to evaluate Virtual Reality analgesic interventions for active labor with biofeedback-based Virtual Reality technologies synchronized to uterine activity.
- Trial name
- NCT05879848
- Testing
- VR
- Where
- Italy
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Federico II University
Type 1 Diabetes Mellitus With Artificial Pancreas Device
OCT and OCT-A Deep Learning in Diabetic Patients Wiht Artificial Pancreas Device
This study evaluates the ability of deep learning to improve the knowledge about structural and vascular retinal changes in diabetic patients undergoing artificial pancreas device, using optical coherence tomography angiography.
- Trial name
- NCT05809843
- Testing
- hybrid artificial pancreas systems (CSII)
- Where
- Italy
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Federico II University
Hepatocellular Carcinoma
Prognostic Role of HVPG and ICG-R15 in the Short- and Medium-term Results of the Surgery of HCC on Cirrhosis
AIMS To evaluate the accuracy of HVPG (direct method), ICG-R15 and LSM/SSM (non-invasive methods) in predicting the risk of PHLF and hepatic decompensation; to evaluate the correlation between hepatic functional reserve (ICG-R15)…
- Trial name
- ProHype-ICG (NCT05800561)
- Testing
- Hepatic venous-portal gradient (HVPG) measurement
- Where
- Italy
- Volunteers
- 208 people
- Sponsor
- Federico II University
Aneuploidy
A Pilot Study for Implementation of First Trimester Screening of Aneuploidies in Campania Region
The study aims to compare two different protocols for first trimester screening of aneuploidies, one based on nuchal translucency and NIPT and another one based on the integration between combined test and NIPT, in order to…
- Trial name
- PISTA (NCT05798858)
- Testing
- NIPT
- Where
- Italy
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Federico II University
Achalasia, Achalasia Cardia
Nasogastric Tube After Laparoscopic Heller-Dor Myotomy
The goal of this prospective observational study is to evaluate the role of nasogastric tube (NGT) in patients with achalasia underwent to Heller-Dor laparoscopic.
- Trial name
- NCT05729971
- Testing
- nasogastric tube
- Where
- Italy
- Volunteers
- 79 people
- Sponsor
- Federico II University
Healthy, Overweight and Obesity
Fiber-enriched Croissant Consumption and Effects on Metabolic Status, Appetite and Gut Microbiota
The aim of this study is to evaluate the effect of a daily consumption for 2 weeks of a sourdough croissant enriched with dietary fibers vs a control sourdough croissant with no fiber added on daily energy intakes, fasting…
- Trial name
- CROMA (NCT04999280)
- Testing
- Fiber Croissant (FIBCRO) Group, Control Croissant (CONCRO) Group
- Where
- Italy
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Federico II University
Diabetic Foot
Fitostimoline® Hydrogel Versus Saline Gauze Dressing in Diabetic Foot Ulcers
Diabetes Mellitus (DM) is one of the most widespread metabolic diseases and the alarming rise in its prevalence worldwide poses enormous challenges.
- Trial name
- NCT05661474
- Testing
- Fitostimoline ® hydrogel group, Saline gauze group
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Federico II University
Diabetic Retinopathy
OCTA in Epivascular Glia After Dex Implant
The aim of this prospective study was for the first time, to analyze specific morphologic features in diabetic eyes with macular oedema, such as changes of the foveal avascular zone and the presence of epivascular glia, and see…
- Trial name
- NCT05600179
- Testing
- Dexamethasone intravitreal implant
- Where
- Italy
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Federico II University
Hodgkin Lymphoma
Cell-free Tumor DNA as Minimal Residual Disease in Hodgkin Lymphoma Patients
Molecular analysis identifies residual disease by overcoming the sensitivity of imaging methods and therefore has the potential for integrating with therapy provided by FDG-PET alone.
- Trial name
- NCT05254821
- Where
- Italy
- Volunteers
- 130 people
- Sponsor
- Federico II University
Infection Cardiac, Heart Failure
Tauropace to Prevent Cardiac Implantable Device Infections in Heart Failure Patients
The main purpose of the study is to evaluate the ability of the Tauropace to reduce major cardiac implantable electronic device (CIED) infections through 12-months post-procedure following CIED in heart failure participants.
- Conditions
- Infection Cardiac, Heart Failure, Cardiac Implantable Electronic Device Infections, High Risk
- Trial name
- TRICE-HF (NCT05103267)
- Testing
- Tauropace
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- Federico II University
Diabetes Mellitus, Covid19
Individualized, Technological Interventions for Diabetes Care in the COVID-19 Ward
During the current Covid-19 pandemic, many hospitals worldwide have been overwhelmed and strategies based on new technologies have been considered to improve the outcomes in patients with diabetes and Covid-19 and to prevent…
- Trial name
- Initiator (NCT04871958)
- Testing
- Continuous glucose monitoring (CGM, Dexcom G6)
- Where
- Italy
- Volunteers
- 66 people
- Sponsor
- Federico II University