Clinical trials: sponsored by First Affiliated Hospital, Sun Yat-Sen University
Gastric Cancer
Safety of 250ml Preoperative Carbohydrate Drink in Gastric Cancer Patients
This study aims to assess the impact of preoperative oral carbohydrate drink on gastric emptying and PH of gastric fluid in gastric cancer patients directly.
- Trial name
- NCT02815150
- Testing
- preoperative oral carbohydrate drink
- Where
- China
- Volunteers
- 88 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Neuroendocrine Tumors, NET
A Transfer Learning Radiomics Model for Predicting Response to Initial Transarterial Embolization in Patients with Gastroenteropancreatic Neuroendocrine Tumor Liver Metastases
To develop and validate a CT-based transfer learning radiomics model for predicting response to initial TAE in GEP-NETLM patients and compare its performance with traditional radiomics and clinical models.
- Trial name
- NCT06853457
- Volunteers
- 257 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
GIST, Malignant, Liver Metastases
Comparison of Clinical Efficacy of Liver Resection, RFA, TACE, and Drug Therapy in Patients with GIST LM
The goal of this observational study is to evaluate the overall survival benefits of local treatment combined with imatinib(IM) and IM alone in patients suffering from GIST liver metastases.
- Trial name
- NCT06038552
- Testing
- imatinib (IM), hepatic resection (HR), radiofrequency ablation (RFA)
- Where
- China
- Volunteers
- 238 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Gastrointestinal Stromal Tumors
The Correlation Between Ripretinib Exposure and the Efficacy and Safety in Patients with Advanced GISTs
This is a prospective, single-center, observational study to explore the correlation between ripretinib exposure and the efficacy and safety in patients with advanced gastrointestinal stromal tumors
- Trial name
- NCT06431451
- Where
- China
- Volunteers
- 60 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Lupus Nephritis (LN)
High Quality Evidence of Guangzhou Lupus Nephritis Cohort (HOPE Cohort)
The goal of this observational study is to learn about the long-term renal and patient's survival of lupus nephritis (LN) patients in China.
- Trial name
- HOPE (NCT06682507)
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Hepatocellular Carcinoma (HCC)
Different Abbreviated MRI for Hepatocellular Carcinoma Diagnosis
Abbreviated MRI (AMRI) could improve the diagnostic performance of hepatocellular carcinoma (HCC), but it lacks analysis in different subgroups and effective validation.
- Trial name
- AMRI; LIRADS (NCT06663904)
- Where
- China
- Volunteers
- 938 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Gastrointestinal Stromal Tumor, Malignant
Correlation Between Imatinib Trough Concentration and Efficacy in Advanced GIST Patients with Different Genotypes
Imatinib (IM) has significantly enhanced the prognosis of patients (pts) with advanced gastrointestinal stromal tumors (GISTs). The clinical outcomes may correlate with IM exposure.
- Trial name
- NCT06628739
- Testing
- Imatinib
- Where
- China
- Volunteers
- 168 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Glioma
The Predictive Value of MRI for Adult-type Diffuse Gliomas
The goal of this observational study is to learn about the diagnostic value of preoperative MRI examination for adult-type diffuse gliomas.
- Trial name
- MRI; glioma; (NCT06572592)
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Glioblastoma, Meningeal Arteries
Research on the Safety and Efficacy of Blocking Dural Blood Supply in Glioblastoma Patients
Glioblastoma is the most common primary malignancy of the central nervous system with a very poor prognosis. Most of the immunotherapies that have made significant breakthroughs in the treatment of other tumors in recent years…
- Trial name
- NCT05990556
- Testing
- interventional procedure to block bilateral meningeal blood supply
- Where
- China
- Volunteers
- 20 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Newly-diagnosed Crohn's Disease
Development and Validation of a Nomogram for Predicting Surgery in Newly-diagnosed Crohn's Disease: a Retrospective Cohort Study
A majority of patients with Crohn's disease undergo surgery during the disease course. We aimed to develop an easily available nomogram to predict the risk of surgery at diagnosis.
- Trial name
- NCT06457035
- Testing
- immunosuppressant
- Volunteers
- 490 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Radiomics, Multi-omics
Neurophenotype Predicts CD Disease Progression
The goal of this observational study is aimed to develop a novel multimodal neuroimaging-based model to characterize the neurophenotype of Crohn's Disease patients and assess its ability for predicting disease progression, using…
- Trial name
- NCT06452550
- Testing
- Logistic regression (LR) prediction models
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Glioma
Intraoperative Fluorescent Staining Combined With Microsurgery for Gliomas
Through the modified formulation of sodium fluorescein and methylene blue, the surface of the suspected cut edge of the patient's glioma was stained intraoperatively, and the surgical microscope image acquisition and processing…
- Trial name
- NCT06417372
- Testing
- intraoperative fluorescent staining combined with microscopy
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Primary Membranous Nephropathy
Clinical Study of Rituximab Combined With Corticosteroids or Rituximab Monotherapy in the Treatment of Primary Membranous Nephropathy
This was a prospective, randomized, multicenter clinical trial. Seventy-eight patients with primary membranous nephropathy (PMN) were randomly divided into intervention or control group.
- Trial name
- NCT05514015
- Testing
- rituximab combined with corticosteroids, rituximab
- Where
- China
- Volunteers
- 78 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Pancreatic Neoplasms
A Deep Learning Radiomics Model for Predicting Occult Peritoneal Metastases of Pancreatic Adenocarcinoma
Occult peritoneal metastases (OPM) in patients with pancreatic ductal adenocarcinoma (PDAC) are frequently overlooked during imaging.
- Trial name
- NCT06336694
- Testing
- surgery or diagnostic staging laparoscopy
- Where
- China
- Volunteers
- 302 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Ischemic Stroke, Acute, Intracranial Atherosclerosis
Efficacy of Butylphthalide on Symptomatic Atherosclerotic Stenosis in Middle Cerebral Artery
Ischemic stroke with high incidence, mortality, disability and recurrence rate, has become the leading threat to the health worldwide.
- Trial name
- SICAS (NCT06331494)
- Testing
- Butylphthalide
- Where
- China
- Volunteers
- 140 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Otolaryngological Disease, Artificial Intelligence
To Develop and Validate a Nasoendoscopic Intelligent Diagnostic System for Nasopharyngeal Carcinoma
Nasopharyngeal carcinoma (NPC) occurs at a high frequency in southern China, northern Africa, and Alaska, with a reported incidence of 30 cases per 100 000 in Guangdong Province.
- Trial name
- NCT04547673
- Testing
- rigid nasal endoscopes
- Where
- 3 sites in China
- Volunteers
- 1,000 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Pancreatic Cancer
A CT-based Radiomics Model to Predict Survival-graded Fibrosis in PDAC
Tumor fibrosis plays an important role in chemotherapy resistance in pancreatic ductal adenocarcinoma (PDAC), however there remains a contradiction in the prognostic value of fibrosis.
- Trial name
- NCT06267690
- Testing
- surgery
- Where
- China
- Volunteers
- 295 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Pediatric Burn
Spray Skin Treats for Pediatric Burns
The treatment of burns in children remains a global challenge. At present, the clinical treatment plan is still waiting for further improvement.
- Trial name
- NCT06182345
- Testing
- spray skin, skin graft
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Breast Cancer
The Characteristics, Treatment Patterns and Prognosis of Chinese Male Breast Cancer: A Real-world Study
The goal of this observational study is to investigate the features in Chinese male breast cancer (MBC) patients. The main question it aims to answer is: The characteristics, treatment patterns and prognosis of Chinese MBC…
- Trial name
- NCT06220630
- Testing
- Breast cancer
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Healing Wound
Autologous Epidermal Cell Treat for Nonhealing Postoperative Wound
Postoperative incision healing (Postoperative incision non - ranging) occurred in the surgical incision more than 2 weeks after the operation is still not healing wounds.
- Trial name
- NCT06173908
- Testing
- cell treatment, control treatment
- Where
- China
- Volunteers
- 120 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University