Clinical trials: sponsored by Fox Chase Cancer Center
Adult Primary Hepatocellular Carcinoma, Advanced Adult Primary Liver Cancer
PET-CT in Determining the Radioembolization Dose Delivered to Patients With Liver Metastasis, Primary Liver Cancer, or Biliary Cancer
This clinical trial studies positron emission tomography (PET)-computed tomography (CT) in determining the radiation dose delivered with radioactive spheres to patients with liver metastasis or primary liver or biliary cancer.
- Conditions
- Adult Primary Hepatocellular Carcinoma, Advanced Adult Primary Liver Cancer, Metastatic Extrahepatic Bile Duct Cancer, Recurrent Adult Primary Liver Cancer
- Trial name
- NCT02088775
- Testing
- PET scan, CT Scan, hepatic artery embolization
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Fox Chase Cancer Center
Gynecologic Cancers
Communication About Sexual Health in Gynecologic Cancer
The goal of this clinical trial is to learn if an educational video and workbook can help gynecologic cancer patients talk to their cancer providers about sexual health concerns. The main questions it aims to answer are: 1.
- Trial name
- NCT06904339
- Testing
- Starting the Conversation, Sexual Health Resources
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Fox Chase Cancer Center
Urothelial Carcinoma of the Bladder
Risk Enabled Therapy After Initiating Neoadjuvant Chemotherapy for Bladder Cancer (RETAIN)
The aim of this study is to evaluate a risk-adapted approach to the treatment of muscle invasive bladder cancer. Each baseline transuretheral resection of bladder tumor (TURBT) sample will be sequenced while proceeding with…
- Trial name
- NCT02710734
- Testing
- Methotrexate, Vinblastine, Doxorubicin
- Where
- 4 sites in United States
- Volunteers
- 78 people
- Sponsor
- Fox Chase Cancer Center
Soft Tissue Sarcoma
Phase II Trial of Ribociclib and Everolimus in Advanced Dedifferentiated Liposarcoma (DDL) and Leiomyosarcoma (LMS)
This is a two center, 2 arm, Phase II study evaluating the combination of Ribociclib and Everolimus in patients with advanced DDL and LMS who have had at least 1 prior systemic therapy.
- Trial name
- NCT03114527
- Testing
- Ribociclib, Everolimus
- Where
- 2 sites in United States
- Volunteers
- 48 people
- Sponsor
- Fox Chase Cancer Center
HER2-positive Breast Cancer
Clinical Trial of Atezolizumab With Paclitaxel, Trastuzumab, and Pertuzumab in Patients With Metastatic HER-2 Positive Breast Cancer
This is a single arm, Phase IIA clinical trial assessing the safety and efficacy of atezolizumab in combination with paclitaxel, trastuzumab, and pertuzumab in 50 patients with locally advanced, unresectable, or metastatic…
- Trial name
- NCT03125928
- Testing
- Atezolizumab, Paclitaxel, Trastuzumab
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Fox Chase Cancer Center
Renal Cell Carcinoma
Study of Nivolumab and Axitinib in Patients With Advanced Renal Cell Carcinoma
This is a Phase I/II, open-label, multi-center study of axitinib in combination with nivolumab in patients with previously treated and untreated advanced RCC.
- Trial name
- NCT03172754
- Testing
- Nivolumab, Axitinib
- Where
- 4 sites in United States
- Volunteers
- 98 people
- Sponsor
- Fox Chase Cancer Center
Renal Cell Carcinoma, Urothelial Carcinoma
Analysis of Primary and Metastatic Tumors in Patients With Renal Cell Carcinoma and Urothelial Carcinoma
This is a comparative study using resected/ biopsied tumors samples collected from renal cell carcinoma and urothelial carcinoma patients who underwent surgical removal of lesions, followed by immune checkpoint blockade (ICB)…
- Conditions
- Renal Cell Carcinoma, Urothelial Carcinoma, Bladder Cancer, Ureter Cancer
- Trial name
- NCT03291028
- Testing
- Immune checkpoint inhibitor targeting PD1
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Fox Chase Cancer Center
Non Small Cell Lung Cancer
Nivolumab Plus Ramucirumab in Patients With Recurrent, Advanced, Metastatic NSCLC
The study will enroll patients with prior IO therapy (alone or in combination with chemotherapy or in combination with other IO agents) regardless of the PD-L1 level, into a non-randomized combination trial, with primary endpoint…
- Trial name
- NCT03527108
- Testing
- Nivolumab, Ramucirumab
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Fox Chase Cancer Center
Rectal Cancer
Organ Preservation in Early Rectal Cancer Patients
This is a single arm phase II study of neoadjuvant chemotherapy followed by local excision and post-operative chemoradiotherapy in patients with early stage, low rectal adenocarcinoma.
- Trial name
- NCT03548961
- Testing
- FOLFOX regimen
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Fox Chase Cancer Center
Non-Small Cell Carcinoma of Lung, TNM Stage 4
Phase II Randomized Trial of Carboplatin+Pemetrexed+Bevacizumab+/- Atezolizumab in Stage IV NSCLC
While cigarette smoking remains the primary cause of most lung cancer cases, lung carcinoma in never smokers account for nearly 20 percent of cases.
- Trial name
- NCT03786692
- Testing
- Arm A, Arm B
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- Fox Chase Cancer Center
Soft Tissue Sarcoma
Study to Assess TOPO2A as a Biomarker for Sensitivity to Doxorubicin/Doxil in Soft Tissue Sarcoma
The primary aim of this study is to determine the utility of TOPO2A as a biomarker for sensitivity to doxorubicin or its derivatives.
- Trial name
- NCT04055753
- Testing
- Doxil, Doxorubicin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Fox Chase Cancer Center
Solid Tumor
Phase I Study in Advanced Malignancies With 5-ALA
RDT aims to take advantage of the relatively safer toxicity profiles of both lower dose radiation therapy and systemic ALA to treat non-superficial lesions in a manner similar to photodynamic therapy.
- Trial name
- NCT04381806
- Testing
- 5-ALA
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- Fox Chase Cancer Center
Pancreatic Cancer
Pulse-low-dose Rate (PLDR) Radiation in Pancreatic Cancer
Standard chemoradiation, followed by surgery are standard treatment plan for patients suffering from pancreatic adenocarcinoma. Due to damage to the surrounding healthy tissue caused by standard radiation, this study uses a new…
- Trial name
- NCT04452357
- Testing
- PLDR
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Fox Chase Cancer Center
Pancreatic Ductal Adenocarcinoma
PHL Treatment in Pancreatic Cancer
This proposal will investigate the effect of paricalcitol, hydroxychloroquine, and losartan (PHL) combination of 3 stroma-modifying drugs on pancreatic adenocarcinoma and its stroma.
- Trial name
- NCT05365893
- Testing
- Paricalcitol, Hydroxychloroquine, Losartan, Neoadjuvant therapy and surgery only (Control)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Fox Chase Cancer Center
Locally Advanced or Metastatic Melanoma
Study of CBL0137 in Combination With Ipilimumab and Nivolumab Therapy in Melanoma
Phase I, open label, dose-escalation, and safety study designed to assess the safety and biologic activity of the investigational agent CBL0137 in combination with standard of care drugs, ipilimumab and nivolumab in sequential…
- Trial name
- NCT05498792
- Testing
- CBL0137, Ipilimumab, Nivolumab
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Fox Chase Cancer Center
Oropharynx Cancer
Lymphoscintigraphy Directed Elective Neck Radiation for p16+ Favorable Risk Oropharynx Cancer
This is a prospective, phase II, stratified single arm investigation for favorable prognosis in p16+ oropharynx cancer patients with either node negative or malignant neck adenopathy with lymphoscintigraphy mapping confined to…
- Trial name
- NCT05800574
- Testing
- Radiation therapy (5 days for 7 weeks), Radiation therapy (5 days for 6 weeks), Cisplatin
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Fox Chase Cancer Center
Lung Cancer, Small-cell Lung Cancer
Dose Attenuated Chemotherapy in Compromised Patients With Lung Cancer
This is an open-label, non-randomized, single-center, phase II study to evaluate the efficacy, toxicity and, tolerability of pre-specified dose attenuated chemotherapy regimens in lung cancer patients with comorbidities.
- Conditions
- Lung Cancer, Small-cell Lung Cancer, Non Small Cell Lung Cancer
- Trial name
- NCT05800587
- Testing
- Carboplatin, Pemetrexed, Paclitaxel
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- Fox Chase Cancer Center
Anemia
Iron Replacement to Reduce Anemia During Neoadjuvant Chemotherapy
This is an open-label, single institution study evaluating the efficacy of intravenous iron sucrose monotherapy in patients with thoracic, breast, GU and GI malignancies undergoing neoadjuvant chemotherapy with the goal of…
- Trial name
- Iron-RANC (NCT05800600)
- Testing
- Venofer
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Fox Chase Cancer Center
Squamous Cell Carcinoma of Head and Neck
Neoadjuvant CADI-05 in Combination With Pembrolizumab for Surgically Resectable Locally Advanced Head and Neck Squamous Cell Carcinomas
The goal of this clinical trial is to learn if drug CADI-05, when used together with pembrolizumab (an FDA approved immunotherapy), can help treat locally advanced head and neck squamous cell carcinoma (LA-HNSCC) in adults.
- Trial name
- NCT07455032
- Testing
- intradermal injection of CADI-05, Pembrolizumab
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Fox Chase Cancer Center
Uterine Cervical Neoplasms
Evidence-Based Approach to Empower Asian American Women in Cervical Cancer Screening
This is a randomized trial to evaluate the effects of a community-based intervention on increasing cervical cancer screening rates in underserved Asian American (Korean, Vietnamese, and Chinese) women.
- Trial name
- NCT04557423
- Testing
- Community-Based Education, Navigation to Screening, HPV Self-Sampling
- Where
- United States
- Volunteers
- 797 people, healthy volunteers welcome
- Sponsor
- Fox Chase Cancer Center