Clinical trials: sponsored by Fox Chase Cancer Center
Gynecologic Cancer
Women's Health Communication Study
The central goal of this randomized, controlled pilot study is to examine the feasibility, acceptability, and preliminary effects of an educational intervention (called "Starting the Conversation"; STC) on patient communication…
- Trial name
- NCT05359952
- Testing
- Starting the Conversation, Sexual and Menopausal Health Resources Only
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Fox Chase Cancer Center
Breast Cancer
Coping Together After Breast Cancer
The objective of the proposed study is to evaluate an Intimacy Enhancement (IE) intervention in 120 female early stage breast cancer survivors reporting sexual concerns and their intimate partners (240 total participants).
- Trial name
- NCT03930797
- Testing
- Intimacy Enhancement, Living Healthy Together
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Fox Chase Cancer Center
Retroperitoneal Liposarcoma, Soft Tissue Sarcoma
Genomic Risk in Retroperitoneal Sarcoma
The protocol intends to explore the biology which may underlie recurrences of retroperitoneal liposarcoma. Surgery remains the only curative intent intervention for this disease.
- Trial name
- NCT06436846
- Testing
- Biospecimen sample collection during standard-of-care surgery
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fox Chase Cancer Center
Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis
Pacritinib w/ Talazoparib in Pts w/ Myeloproliferative Neoplasms Unresponsive to JAK2 Inhibition
This is a prospective phase I dose-escalation study, with the primary objective to access the MTD and find the RP2D of talazoparib, given in combination with standard of care dosing of pacritinib.
- Conditions
- Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis, Chronic Myelomonocytic Leukemia
- Trial name
- NCT06218628
- Testing
- Talazoparib, pacritinib
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Fox Chase Cancer Center
Mucinous Adenocarcinoma of the Rectum, Recurrent Rectal Cancer
Genetic Mutations in Blood and Tissue Samples in Predicting Response to Treatment in Patients With Locally Advanced Rectal Cancer Undergoing Chemoradiation
This research trial studies genetic mutations in blood and tissue samples to see if they can be used to predict treatment response in patients with locally advanced rectal cancer undergoing chemoradiation.
- Conditions
- Mucinous Adenocarcinoma of the Rectum, Recurrent Rectal Cancer, Signet Ring Adenocarcinoma of the Rectum, Stage IIA Rectal Cancer
- Trial name
- NCT02132858
- Testing
- cytology specimen collection procedure, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Fox Chase Cancer Center
Recurrent Fallopian Tube Cancer, Recurrent Ovarian Epithelial Cancer
Paclitaxel and Ganetespib in Treating Patients With Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
This phase I/II trial studies the side effects and best dose of ganetespib when given together with paclitaxel and to see how well they work in treating patients with recurrent ovarian, fallopian tube, or primary peritoneal…
- Conditions
- Recurrent Fallopian Tube Cancer, Recurrent Ovarian Epithelial Cancer, Recurrent Primary Peritoneal Cavity Cancer
- Trial name
- NCT01962948
- Testing
- paclitaxel, ganetespib, laboratory biomarker analysis
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Fox Chase Cancer Center
Lymphoma
HM-178: Assessing Methods for Improvement in Methotrexate Toxicity Management and Detection of Central Nervous System Involvement of Aggressive Lymphoma
This is a study to use glucarpidase prophylactically to treat methotrexate induced toxicities in lymphoma patients with cerebral involvement.
- Trial name
- NCT04668768
- Testing
- Glucarpidase
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Fox Chase Cancer Center
Major Liver Resection
Trial Using Octreotide to Enhance Liver Recovery After Hepatectomy
This will be a prospective, randomized, double blind trial enrolling patients who will undergo major liver resection. Patients will be randomized in a 1:1 ratio to receive either octreotide or placebo in the postoperative period.
- Trial name
- NCT03179995
- Testing
- Octreotide
- Where
- 2 sites in United States
- Volunteers
- 23 people
- Sponsor
- Fox Chase Cancer Center
Cancer
mychoiceTM Implementation With Medical Oncology Patients
This is a pragmatic, non-randomized mixed-methods evaluation study designed to evaluate the feasibility and acceptability of delivering the mychoiceTM tool to new Medical Oncology patients as well as to more deeply explore its…
- Trial name
- NCT06222242
- Testing
- mychoiceTM
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Fox Chase Cancer Center
Metastatic Urothelial Carcinoma
A Pilot Study of Circulating Tumor DNA Adaptive Risk Maintenance Approach for Bladder Cancer (CARMA)
Platinum-based chemotherapy remains the standard of care for advanced/metastatic unresectable bladder cancer. The JAVELIN Bladder 100 and HCRN GU14-182 trials showed that maintenance immune checkpoint inhibition(ICI) for those…
- Trial name
- CARMA (NCT06050954)
- Testing
- Pembrolizumab (200mg), Pembrolizumab (400mg), Monitoring
- Sponsor
- Fox Chase Cancer Center
Non-Small Cell Lung Cancer
Sotorasib in KRAS G12C Mutated, Resectable, Stage Ib-IIIA NSCLC
This is a single arm study, conducted at two centers, of neoadjuvant sotorasib in treatment naïve patients with stage Ib-IIIa NSCLC. The study will accrue 25 patients in all.
- Trial name
- NCT05400577
- Testing
- Sotorasib, 960 mg, oral daily dose for 4 weeks (28 days)
- Where
- United States
- Sponsor
- Fox Chase Cancer Center
Cancer-Related Pain
Buprenorphine for Cancer Pain
This study will evaluate patients on both buprenorphine and full agonist opioids (FAO) to assess for withdrawal symptoms. Patients will be evaluated by clinicians and using validated tools to assess for pain and withdrawal.
- Trial name
- NCT05910190
- Testing
- Use of buprenorphine with FAO > 30 OME, CPM Rx application use
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Fox Chase Cancer Center
Lung Cancer, Esophageal Cancer
Pulsed Low Dose Rate Radiation With Concurrent Chemotherapy for Non-Small Cell Lung Cancer and Esophageal Cancer
Phase I study with the hypothesis that Pulsed Low Dose Radiation (PLDR) radiation delivery technique can significantly decrease the rate of severe acute esophagitis in patients receiving concurrent Chemo-radiation therapy (CRT)…
- Trial name
- NCT03094884
- Testing
- Pulsed Low Dose Radiation, Carboplatin, Paclitaxel
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Fox Chase Cancer Center
Recurrent Metastatic Squamous Neck Cancer With Occult Primary, Recurrent Salivary Gland Cancer
Everolimus, Erlotinib Hydrochloride, and Radiation Therapy in Treating Patients With Recurrent Head and Neck Cancer Previously Treated With Radiation Therapy
This phase I trial studies the side effects and best dose of giving everolimus (RAD001) and erlotinib hydrochloride together with radiation therapy in treating patients with recurrent head and neck cancer previously treated with…
- Conditions
- Recurrent Metastatic Squamous Neck Cancer With Occult Primary, Recurrent Salivary Gland Cancer, Recurrent Squamous Cell Carcinoma of the Hypopharynx, Recurrent Squamous Cell Carcinoma of the Larynx
- Trial name
- NCT01332279
- Testing
- everolimus, erlotinib hydrochloride, biopsy
- Where
- United States
- Sponsor
- Fox Chase Cancer Center
Stage IA Non-small Cell Lung Cancer, Stage IB Non-small Cell Lung Cancer
Study to Evaluate NA-NOSE for Monitoring and Detecting Recurrence in Early Stage Lung Cancer
This clinical trial studies nanoscale artificial nose (NA-NOSE) in monitoring response and detecting recurrence after surgery or radiation therapy in patients with stage I or stage II non-small cell lung cancer (NSCLC).
- Conditions
- Stage IA Non-small Cell Lung Cancer, Stage IB Non-small Cell Lung Cancer, Stage IIA Non-small Cell Lung Cancer, Stage IIB Non-small Cell Lung Cancer
- Trial name
- NCT01840150
- Testing
- breath test, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Fox Chase Cancer Center
Metastatic Gastric Cancer
Improving the Approach to and Management of the Older Patient With Metastatic Gastric Cancer
The purpose of this study is to enhance the care of older metastatic gastric cancer (mGC) patients by increasing awareness among oncology providers of the unique aspects of care required for older patients.
- Trial name
- NCT04618809
- Testing
- Didactic Session, Comprehensive Geriatric Assessment, including an exploratory analysis to evaluate the use of fitness trackers for evaluation of functional status.
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Fox Chase Cancer Center
Diagnosis of Peripheral Lung Nodules
nCLE For Diagnosis Of Peripheral Lung Nodules By Robotic Navigational Bronchoscopy
Needle based confocal laser endomicroscopy (nCLE) employs a small fiber which can be passed through a biopsy needle to enable real time microscopic imaging of cells.
- Trial name
- NCT04441749
- Testing
- Images acquired by needle-based Confocal Laser Endomicroscopy (nCLE)
- Where
- 2 sites in United States, Netherlands
- Volunteers
- 25 people
- Sponsor
- Fox Chase Cancer Center
Breast Cancer
Clinician Communication About Sexual Health
The objective of this study is to adapt a previously tested brief intervention aimed at enhancing clinicians communication about sexual health (iSHARE) to a mobile web-based platform showcasing a two-part podcast and to assess…
- Trial name
- NCT04262219
- Testing
- iShare
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Fox Chase Cancer Center
Sporadic Angiomyolipomas (AMLs)
Sporadic Angiomyolipomas (AMLs) Growth Kinetics While on Everolimus
The purpose of this research study is to see if oral everolimus is tolerable and effective in the treatment of sporadic Angiomyolipomas (AMLs). AMLs are the most common non-cancerous tumor of the kidney.
- Trial name
- SAGE (NCT02539459)
- Testing
- Everolimus
- Where
- 8 sites in United States
- Volunteers
- 20 people
- Sponsor
- Fox Chase Cancer Center
Colorectal Cancer Metastatic
Local Consolidative Therapy in Colorectal Cancer
This is a Phase II randomized multisite trial to study the effect of a combination of local consolidative therapy with systemic therapy in subjects with oligometastatic colorectal cancer who have progressed on the first line of…
- Trial name
- NCT05062720
- Testing
- Local consolidative therapy
- Where
- United States
- Sponsor
- Fox Chase Cancer Center