Clinical trials: sponsored by Fudan University
Gastric Cancer, Chemotherapy Effect
Sintilimab Combined With Modified FLOT Regimen in the Treatment of Metastatic Gastric Cancer
This is a prospective, one-arm, single-center phase II study. The objective was to evaluate the efficacy and safety of domestic PD-1 antibody Sintilimab combined with modified FLOT regimen in the treatment of metastatic gastric…
- Conditions
- Gastric Cancer, Chemotherapy Effect, Immune Checkpoint Inhibitor
- Trial name
- NCT05982301
- Testing
- Sintilimab, paclitaxel-albumin, oxaliplatin, 5-FU
- Where
- China
- Volunteers
- 87 people
- Sponsor
- Fudan University
Ovarian Cancer
Circulating Tumor DNA Monitoring in Platinum-resistant Ovarian Cancer
This observational study is conducted to assess the utility of circulating tumor DNA in monitoring the response to pegylated liposomal doxorubicin in platinum-resistant ovarian cancer，and evaluate the consistency of circulating…
- Trial name
- NCT05976932
- Testing
- pegylated liposomal doxorubicin
- Volunteers
- 20 people
- Sponsor
- Fudan University
Esophagus Cancer, Esophageal Squamous Cell Carcinoma
Phase II Study of Postoperative Concurrent Chemoradiotherapy for Esophageal Squamous Cell Carcinoma (ESO- Shanghai 17)
The purpose of this study is to evaluate safety and 2-year local control rate for postoperative concurrent chemoradiotherapy for esophageal squamous cell carcinoma.
- Conditions
- Esophagus Cancer, Esophageal Squamous Cell Carcinoma, Chemoradiotherapy, Radiation Therapy
- Trial name
- NCT04764227
- Testing
- Paclitaxel, Carboplatin, Radiotherapy
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Fudan University
Esophageal Squamous Cell Carcinoma
Comparing 61.2 Gy Radiotherapy Dose Versus 50.4 Gy Radiotherapy Dose for Locally Advanced Esophageal Carcinoma
The purpose of this study is to determined the best definitive radiotherapy dosage for patients with locally advanced esophageal squamous cell carcinoma.
- Trial name
- NCT03790553
- Testing
- Radiotherapy
- Where
- 3 sites in China
- Volunteers
- 646 people
- Sponsor
- Fudan University
Financial Toxicity
A Longitudinal Study of the Trajectory of Financial Toxicity and Its Relationship With Symptom Burden in Breast Cancer Patients
Breast cancer has become the leading cause of global cancer incidence. With the improvement of treatment methods, some breast cancer patients have experienced different degrees of financial toxicity, which seriously affected the…
- Trial name
- NCT05964816
- Where
- 4 sites in China
- Volunteers
- 485 people
- Sponsor
- Fudan University
Metastatic Colorectal Cancer
Regorafenib Combined With TAS-102 Versus Regorafenib Monotherapy in Third or Later Line Therapy of mCRC
The purpose of this study is to evaluate the clinical benefit of regorafenib combined with TAS-102 compared with regorafenib monotherapy in patients with metastatic colorectal cancer who have failed at least two lines of…
- Trial name
- NCT05970705
- Testing
- Regorafenib, Trifluridine/Tipiracil
- Where
- China
- Volunteers
- 101 people
- Sponsor
- Fudan University
Pancreatoduodenectomy, Periampullary Carcinoma
Application of "Heidelberg Triangle" Dissection in Pancreatoduodenectomy and Distal Pancreatectomy
Aim of the study : To evaluate the effect and safety of "Heidelberg Triangle" dissection (TRIANGLE operation) combined with Pancreatoduodenectomy or Distal Pancreatectomy on the prognosis of pancreatic cancer and periampullary…
- Conditions
- Pancreatoduodenectomy, Periampullary Carcinoma, Pancreatic Cancer
- Trial name
- NCT05703581
- Testing
- TRIANGLE operation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Fudan University
Metastatic Esophageal Squamous Cell Carcinoma
A Study of IO Plus Radiotherapy in Patients With Advanced ESCC.
This study is a single-arm, prospective, phase II trial for patients with metastatic esophageal squamous cell carcinoma (ESCC) who received immunotherapy plus chemotherapy as the first-line treatment.
- Trial name
- NCT05760391
- Testing
- Radiotherapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Fudan University
Lung Adenocarcinoma, Surgical Procedure, Unspecified
Intraoperative Frozen Section Pathology to Guide Surgical Treatment for Lung Adenocarcinoma (ECTOP-1016)
This study is one of Eastern Cooperative Thoracic Oncology Projects (ECTOP-1016). The goal of this clinical trial is to confirm the concordance rate between intra-operative frozen section pathological diagnosis and post-operative…
- Conditions
- Lung Adenocarcinoma, Surgical Procedure, Unspecified, Pathology
- Trial name
- NCT05794724
- Testing
- Surgical resection
- Where
- China
- Volunteers
- 1,063 people
- Sponsor
- Fudan University
Lung Adenocarcinoma, Surgical Procedure, Unspecified
Intraoperative Frozen Section Pathology to Guide Surgical Treatment for Lung Adenocarcinoma (ECTOP-1015)
This study is one of Eastern Cooperative Thoracic Oncology Projects (ECTOP-1015). The goal of this clinical trial is to confirm the concordance rate between intra-operative frozen section pathological diagnosis and post-operative…
- Conditions
- Lung Adenocarcinoma, Surgical Procedure, Unspecified, Pathology
- Trial name
- NCT05794711
- Testing
- Surgical resection
- Where
- China
- Volunteers
- 1,063 people
- Sponsor
- Fudan University
Adenocarcinoma of Lung
Evaluation of Correlations Between Radiologic Features and Pathologic Subtypes of GGO LUAD Via WMS (ECTOP-1011)
This study is one of the Eastern Cooperative Thoracic Oncology Projects (ECTOP-1011). It aims to evaluate the correlations between radiologic features and pathologic subtypes of ground glass opacity featured lung adenocarcinoma…
- Trial name
- NCT05252676
- Where
- China
- Volunteers
- 103 people
- Sponsor
- Fudan University
Adenocarcinoma of Lung
HRCT in Prediction of Tumor Invasion in GGO Lung Adenocarcinoma (ECTOP-1008)
This study is one of Eastern Cooperative Thoracic Oncology Projects (ECTOP-1008). It aims to evaluate the correlation between radiological diagnosis based on HRCT and pathological invasiveness.Investigators observe the…
- Trial name
- NCT04165759
- Where
- 2 sites in China
- Volunteers
- 620 people
- Sponsor
- Fudan University
Carcinoma, Non-Small-Cell Lung
ELobectomy for NSCLC by VATS Versus Thoracotomy (ECTOP-1007)
This study is one of Eastern Cooperative Thoracic Oncology Projects (ECTOP-1007). The goal of this study is to determine video-assisted thoracoscopic surgery is non-inferior to thoracotomy in terms of disease-free survival for…
- Trial name
- NCT03786003
- Testing
- VATS, Thoracotomy
- Where
- China
- Volunteers
- 1,086 people, healthy volunteers welcome
- Sponsor
- Fudan University
Lung Neoplasms
Adjuvant Chemotherapy for High Risk Stage I Lung Adenocarcinoma
This is a clinical trial from Eastern Cooperative Thoracic Oncology Project (ECTOP), numbered as ECTOP-1004. Solid subtype, micropapillary subtype, vascular involvement, pleural involvement and low differentiation are high risk…
- Trial name
- ECTOP-1004 (NCT03380468)
- Testing
- cisplatin plus pemetrexed
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Fudan University
Esophageal Neoplasms
Esophagectomy:Three-field Versus Two-field Lymphadenectomy (ECTOP-2002)
This is a clinical trial from Eastern Cooperative Thoracic Oncology Project (ECTOP), numbered as ECTOP-2002. Esophageal carcinoma is an aggressive disease with a poor prognosis.
- Trial name
- NCT01807936
- Testing
- Lymphadenectomy
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Fudan University
Pulmonary Nodule, Solitary
Is Bronchoscopy Necessary in the Preoperative Workup of GGO Lung Cancer?(ECTOP-1005)
This study is one of Eastern Cooperative Thoracic Oncology Projects (ECTOP-1005). It aims to evaluate the role of flexible bronchoscopy in the pre-operative workup of ground glass opacity featured lung cancer.
- Trial name
- NCT03591445
- Testing
- Flexible Bronchoscopy
- Where
- China
- Volunteers
- 615 people
- Sponsor
- Fudan University
Esophageal Neoplasms
Esophagectomy: Sweet Versus Ivor-Lewis (ESVIL) (ECTOP-2001)
This is a clinical trial from Eastern Cooperative Thoracic Oncology Project (ECTOP), numbered as ECTOP-2001. Esophageal carcinoma is an aggressive disease with a poor prognosis.
- Trial name
- NCT01047111
- Testing
- Esophagectomy
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Fudan University
Lung Adenocarcinoma
Pemetrexed and Platinum Use in the Neoadjuvant Setting for Resectable Stage II and IIIA Lung Adenocarcinoma (ECTOP-1002)
This is a clinical trial from Eastern Cooperative Thoracic Oncology Project (ECTOP), numbered as ECTOP-1002. The study is a prospective, single-center, open-label, single-armed, phase II clinical trial.
- Trial name
- NCT02980991
- Testing
- Pemetrexed, Cisplatin
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Fudan University
Lymph Node Metastases, Non-small Cell Lung Cancer Stage I
Mediastinal Staging Accuracy of a Selective Lymphadenectomy Strategy in Early Stage NSCLC (ECTOP-1003)
This is a clinical trial from Eastern Cooperative Thoracic Oncology Project (ECTOP), numbered as ECTOP-1003. Systemic mediastinal lymphadenectomy is deemed indispensable in lung cancer surgery for accurate staging and complete…
- Trial name
- NCT03216551
- Testing
- Intra-operative frozen section
- Where
- China
- Volunteers
- 1,076 people
- Sponsor
- Fudan University
Bone Metastases
Is Bone Scintigraphy Necessary in cT1N0M0 GGO Non-Small Cell Lung Cancer? (ECTOP-1006)
This is a clinical trial from Eastern Cooperative Thoracic Oncology Project (ECTOP), numbered as ECTOP-1006. In this prospective one-arm observational study, bone scintigraphy will be performed in T1N0M0 NSCLC patients with GGO…
- Trial name
- NCT03689439
- Testing
- bone scintigraphy
- Where
- 5 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Fudan University