Clinical trials: sponsored by Georgetown University
Hereditary Breast and Ovarian Cancer
CONTIGO - A Narrative Intervention to Enhance Genetic Counseling and Testing
This is a mixed-methods Hybrid Type 1 research design (efficacy study) in which we aim to conduct a two-arm randomized controlled trial and an Implementation Focused Process Evaluation of a culturally-targeted video and referral…
- Trial name
- NCT05130606
- Testing
- Culturally Targeted Narrative Video: "Is My Cancer Hereditary? Rosa Visits a Genetic Counselor.", FORCE Fact Sheet
- Where
- 2 sites in United States
- Volunteers
- 332 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Parenting
Connect to Baby: A Pilot Study of a Parenting and Coparenting Program
The proposed project is a randomized control trial to assess a novel 6-session parenting and coparenting intervention for low-income parents of infants.
- Trial name
- CTB (NCT06179576)
- Testing
- Connect to Baby
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Refractory Follicular Lymphoma, Relapsed Follicular Lymphoma
Ibrutinib and Venetoclax in Relapsed and Refractory Follicular Lymphoma
This is a phase I/II study in which patients will be enrolled in a standard 3+3 design. Once the maximum tolerated dose (MTD) is determined amongst patients with relapsed or refractory grade 1-3a follicular lymphoma, there will…
- Trial name
- NCT02956382
- Testing
- Ibrutinib, Venetoclax
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- Georgetown University
Locally Advanced Pancreatic Ductal Adenocarcinoma, Metastatic Pancreatic Ductal Adenocarcinoma
Eryaspase With Modified FOLFIRINOX in Advanced Pancreatic Ductal Adenocarcinoma
This will be a single-arm, multi-center, open-label phase 1 study. The standard 3+3 design will be used to determine the maximum tolerated dose (MTD) from 4 possible dose levels of Eryaspase in combination with mFOLFIRINOX.
- Trial name
- NCT04292743
- Testing
- Eryaspase, FOLFIRINOX
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Georgetown University
Distress, Psychological, Depression - Major Depressive Disorder
Relief From Stress Via Social Protection in Senegal
Despite the growing prevalence of mental health disorders in low- and middle-income countries, significant barriers to seeking and accessing mental health services persist.
- Conditions
- Distress, Psychological, Depression - Major Depressive Disorder, Generalized Anxiety Disorder (GAD)
- Trial name
- RESTORE (NCT06698471)
- Testing
- Community worker training, Referral to Health System
- Where
- Senegal
- Volunteers
- 748 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Breast Density, Breast Cancer Female
ENGAGED 2 Study: Experiences With Mammography Screening and Breast Density 2
This trial will test a decision support web based intervention for women at increased risk for breast cancer due to breast density and other risk factors (age, race/ethnicity, family history of breast cancer, history of prior…
- Trial name
- NCT03029286
- Testing
- Usual Care Arm, Personalized Web Intervention Arm
- Where
- United States
- Volunteers
- 995 people
- Sponsor
- Georgetown University
Breast Cancer Female
MEND 2: Making Treatment Decisions Using Genomic Testing
Clinical guidelines for women with early stage breast cancer integrate genomic tumor profiling tests such as the Oncotype DX Recurrence Score to refine recurrence estimates and systemic therapy selection when combined with…
- Trial name
- MEND2 (NCT03183050)
- Testing
- Question Prompt List
- Where
- 2 sites in United States
- Volunteers
- 88 people
- Sponsor
- Georgetown University
Parkinson Disease, Tremor
Istradefylline Effect Protocol on Parkinson's Disease Tremor
This is an investigator-initiated trial. In this 6-month open label, single arm, exploratory pilot study, the investigator intends to enroll a pilot sample of 25 patients with Parkinson's disease who are being started on the…
- Trial name
- NCT05885360
- Testing
- Istradefylline Pill
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Georgetown University
Pancreas Cancer
Lapatinib and Capecitabine for Second Line Treatment of Pancreas Cancer
Patients are being asked to participate in this study who have locally advanced or metastatic pancreatic cancer (cancer of the pancreas that has spread to another part of the body) that has gotten worse after first-line…
- Trial name
- NCT00881621
- Testing
- Lapatinib and Capecitabine
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Georgetown University
Antibiotic-associated Diarrhea
Mechanisms of Probiotics and Antibiotic-Associated Diarrhea
The focus of the study is to better understand the mechanisms causing antibiotic-associated diarrhea (AAD) and how probiotics may prevent some of the iatrogenic effects of antibiotic medications.
- Trial name
- OURBIOTIC (NCT04414722)
- Testing
- Amoxicillin-Clavulanate 875 Mg-125 Mg Oral Tablet, BB-12, Control Yogurt
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Antibiotic-associated Diarrhea
Efficacy and Safety of BB-12 Supplemented Strawberry Yogurt For Healthy Children on Antibiotics
Probiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. One of the most common indications for probiotic treatment is the prevention of antibiotic-associated diarrhea…
- Trial name
- PLAY ON (NCT03181516)
- Testing
- Bifidobacterium animalis subsp. lactis BB-12, Control
- Where
- United States
- Volunteers
- 255 people
- Sponsor
- Georgetown University
Cholangiocarcinoma
Study of Pembrolizumab and Olaparib in Bile Duct Cancer
The investigators propose an open label, one-arm study to assess the safety and efficacy of olaparib and pembrolizumab in patients with cholangiocarcinoma who have progressed on or cannot tolerate gemcitabine-based therapy.
- Trial name
- NCT04306367
- Testing
- Pembrolizumab, Olaparib
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Georgetown University
Ankyloglossia, Breastfeeding Support
Post-Procedural Manual Manipulation for Infant Ankyloglossia
The goal of this randomized control trial is to determine the impact of post-frenotomy manual manipulation on revision rates and breastfeeding outcomes.
- Trial name
- NCT06830148
- Testing
- Post-frenotomy manual manipulation
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Georgetown University
Hepatocellular Carcinoma
ABT-888 and Temozolomide for Liver Cancer
This study is for people with liver cancer (also called hepatocellular carcinoma, or HCC in abbreviation). The purpose of this study is to test the efficacy (effectiveness) of a new combination of drugs, ABT-888 and temozolomide…
- Trial name
- NCT01205828
- Testing
- Temozolomide, ABT-888
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Georgetown University
Metastatic Colorectal Cancer
Sunitinib and Capecitabine for First Line Colon Cancer
This study is for patients with metastatic colorectal cancer who have not been treated with chemotherapy for their cancer. The purpose of this study is to find out if Capecitabine and Sunitinib can be used together to improve…
- Trial name
- NCT00961571
- Testing
- sunitinib and capecitabine
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Georgetown University
Metastatic Breast Cancer, Human Epidermal Growth Factor 2 Negative Carcinoma of Breast
WI231696: Bosutinib, Palbocicilib and Fulvestrant for HR+HER2- Advanced Breast Cancer Refractory to a CDK4/6 Inhibitor
This is an open-label, single-arm, phase I trial. It is designed with a conservative dose escalation plan to ensure patient's safety and with a strong translational component to inform if target inhibition is achieved.
- Conditions
- Metastatic Breast Cancer, Human Epidermal Growth Factor 2 Negative Carcinoma of Breast, Hormone Receptor Positive Breast Cancer
- Trial name
- NCT03854903
- Testing
- Palbociclib, Bosutinib, Fulvestrant
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Georgetown University
Triple Negative Breast Cancer
OXEL: Immune Checkpoint or Capecitabine or Combination Therapy as Adjuvant Therapy for TNBC With Residual Disease
This pilot study will provide preliminary data regarding the role of PIS in predicting the benefit of immune checkpoint inhibition with or without chemotherapy for high risk patients with TNBC and residual disease after effective…
- Trial name
- NCT03487666
- Testing
- Nivolumab, Capecitabine
- Where
- 4 sites in United States
- Volunteers
- 45 people
- Sponsor
- Georgetown University
Breast Cancer
Pharmacokinetics and Pharmacogenomics of Ribociclib in Race-based Cohorts
The aim is to determine the pharmacological and biochemical association between ribociclib exposure and CYP3A variants in African American/Blacks and Non-Hispanic White patients.
- Trial name
- LEANORA (NCT04657679)
- Testing
- Ribociclib
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- Georgetown University
Aphasia, Stroke
ReadMap: Reading in Stroke Alexia and Typical Aging
Loss of reading ability due to stroke, called alexia, likely affects over a million Americans at any given time and causes difficulty performing many daily life functions, such as paying bills, using email/text, reading for…
- Conditions
- Aphasia, Stroke, Alexia
- Trial name
- ReadMap (NCT06700005)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Aphasia, Stroke
Brain-based Understanding of Individual Language Differences After Stroke
Strokes often cause a loss of communication ability, referred to as aphasia, as well as cognitive difficulties. Each stroke survivor has a unique pattern of strengths and weaknesses in communication and cognition, and a unique…
- Conditions
- Aphasia, Stroke, Alexia
- Trial name
- BUILD (NCT04991519)
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Georgetown University