Clinical trials: sponsored by Georgetown University
Borderline Resectable Carcinoma, Biliary Tract Cancer
Neoadjuvant Tremelimumab and Durvalumab With Gem/Cis in Intrahepatic Cholangiocarcinoma
The goal of this clinical trial is to test feasibility and safety of the combination of tremelimumab and durvalumab plus gemcitabine and cisplatin as a neoadjuvant treatment bridge patients to a curative resection in treatment…
- Trial name
- ESR-22-21719 (NCT06017297)
- Testing
- Durvalumab, Tremelimumab, Gemcitabine
- Sponsor
- Georgetown University
Transfusion Dependent Beta Thalassemia, Sickle Cell Disease
Decision-Making and Quality of Life Surrounding Hematologic Disease and Gene Therapy
Determine knowledge, attitudes, and beliefs among adult patients, and parents of pediatric patients, with transfusion dependent beta-thalassemia and sickle cell disease toward gene therapy to treat their or their child's illness…
- Trial name
- NCT06664541
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Georgetown University
Resected Pancreatic Adenocarcinoma
Study of Proton Therapy in Adjuvant Pancreatic Cancer
This trial aims to determine a safe schedule of short-course proton beam radiation therapy with adjuvant mFOLFIRINOX for patients with resected pancreatic adenocarcinoma.
- Trial name
- Proton-PANC (NCT03885284)
- Testing
- mFOLFIRINOX, Proton beam radiation
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Georgetown University
Breast Cancer
Improving Genetic Counseling for BRCA+ Mothers
Genetic counseling and testing for hereditary breast cancer may reveal that you, and possibly your blood relatives, are at increased risk for the disease across the lifespan.
- Trial name
- PCS IV (NCT04258280)
- Testing
- Education and counseling, Education
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Georgetown University
Aphasia, Primary Progressive, Anomia
Rehabilitation and Prophylaxis of Anomia in Primary Progressive Aphasia
The goal of this study is to remediate word-finding problems in patients who have Primary Progressive Aphasia (PPA) or Alzheimer's Disease and to delay the further progression of word-finding impairment.
- Conditions
- Aphasia, Primary Progressive, Anomia, Alzheimer Disease
- Trial name
- NCT02675270
- Testing
- Phonological, Orthographic, Semantic
- Where
- 2 sites in United States
- Volunteers
- 84 people
- Sponsor
- Georgetown University
Acral Lentiginous Melanoma, Mucosal Melanoma
A Biomarker Study in Advanced Mucosal or Acral Lentiginous Melanoma Receiving Nivolumab in Combination With Ipilimumab
Participants with advanced or metastatic mucosal melanoma (cohort A) and acral lentiginous melanoma (cohort B) eligible for treatment with nivolumab in combination with ipilimumab followed by nivolumab therapy will submit tissue…
- Trial name
- NCT02978443
- Testing
- Nivolumab, Ipilimumab
- Where
- 5 sites in United States
- Volunteers
- 14 people
- Sponsor
- Georgetown University
Oral Pre-exposure Prophylaxis (PrEP), Long-acting Injectable Cabotegravir for PrEP
PathToScale: An Implementation Evaluation
The purpose of this study is to evaluate the implementation and clinical outcomes of expanded pre-exposure prophylaxis delivery modalities and service delivery points offering long-acting injectable cabotegravir and oral…
- Trial name
- NCT06319105
- Testing
- Standard intervention: Offer PrEP choice
- Where
- Malawi
- Volunteers
- 9,900 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Children
Safety of BB-12 Supplemented Strawberry Yogurt For Healthy Children
The investigators believe a readily available drink containing a high dose of probiotics has the potential to improve compliance through many of these mechanisms.
- Trial name
- NCT01652287
- Testing
- BB-12 supplemented strawberry yogurt, Strawberry flavored yogurt
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Rheumatoid Arthritis
Stopping TNF Alpha Inhibitors in Rheumatoid Arthritis
Background: Rheumatoid arthritis (RA) is often treated with drugs known as tumor necrosis factor (TNF) inhibitors, that can help decrease joint pain and swelling and can even result in RA remission.
- Trial name
- STARA (NCT01793519)
- Testing
- Etanercept, Infliximab, Adalimumab
- Where
- 2 sites in United States
- Volunteers
- 290 people
- Sponsor
- Georgetown University
Metabolic Syndrome, Obesity
An Exercise RCT Targeting African-American Women With Metabolic Syndrome and High Risk for Breast Cancer
Among African-American women, in whom metabolic syndrome (MetS) is very prevalent and breast cancer mortality rates are high, it is hypothesized that intervening on MetS to improve the MetS profile may prove to be a means to…
- Trial name
- NCT02103140
- Testing
- Facility-based Exercise, Home-based Exercise
- Where
- United States
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Solid Tumor, Adult, Homologous Recombination Deficiency
Niraparib Plus Carboplatin in Patients With Homologous Recombination Deficient Advanced Solid Tumor Malignancies
This is a multi-institutional Phase I dose-escalation and dose-expansion trial for patients with advanced, solid tumor malignancies who have pre-identified deleterious germline or somatic mutations in the homologous recombination…
- Trial name
- NCT03209401
- Testing
- Niraparib, Carboplatin
- Where
- 5 sites in United States
- Volunteers
- 23 people
- Sponsor
- Georgetown University
Metastatic Colorectal Cancer, Colorectal Adenocarcinoma
Durvalumab Plus CV301 With Maintenance Chemotherapy in Metastatic Colorectal or Pancreatic Adenocarcinoma
This is a dual arm, open label phase I/II study to evaluate the safety and clinical activity of the combination of durvalumab with CV301 in combination with maintenance chemotherapy for patients with metastatic colorectal or…
- Conditions
- Metastatic Colorectal Cancer, Colorectal Adenocarcinoma, Pancreatic Adenocarcinoma, Metastatic Pancreatic Cancer
- Trial name
- NCT03376659
- Testing
- Durvalumab, CV301, Capecitabine
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Georgetown University
Prostate Cancer
Streamlined Genetic Testing in Prostate Cancer
The goal of this pilot randomized controlled trial is to evaluate the impact and efficacy of a streamlined genetic education and testing intervention for men with prostate cancer.
- Trial name
- NCT04359758
- Testing
- Proactive Streamlined Genetic Education and Testing, Usual Care
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Georgetown University
Postmenopausal, Prediabetes
Glucose-Guided Eating Pilot
This is a single center, parallel-arm randomized controlled pilot study that aims to examine the feasibility and acceptability of the glucose-guided eating (GGE) mobile app and intervention in two populations at risk of chronic…
- Conditions
- Postmenopausal, Prediabetes, Adolescent and Young Adult (AYA) Cancer Survivors
- Trial name
- GET CHARGED (NCT05998460)
- Testing
- Glucose-Guided Eating with CGM, CGM only
- Volunteers
- 100 people
- Sponsor
- Georgetown University
Smoking, Tobacco, Tobacco-Related Carcinoma
The Lung Screening, Tobacco and Health Project
The purpose of this study is to compare intensive telephone counseling (ITC) plus the nicotine patch vs. standard telephone counseling plus the nicotine patch (Usual Care; UC) among current smokers undergoing lung cancer…
- Conditions
- Smoking, Tobacco, Tobacco-Related Carcinoma, Tobacco Use, Lung Cancer Screening
- Trial name
- NCT03200236
- Testing
- Intensive Telephone Counseling (8 sessions) with nicotine replacement, Usual Care: Telephone counseling (3 sessions) with nicotine replacement
- Where
- 7 sites in United States
- Volunteers
- 1,114 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Metastatic Pancreatic Cancer
Proglumide With Gemcitabine and Nab-Paclitaxel in PatientsWith Metastatic Pancreatic Ductal Adenocarcinoma
This is a Phase I open labelled study to treat patients with metastatic pancreatic cancer with combination therapy using standard of care first line therapy with gemcitabine and nab-paclitaxel given days 1, 8, and 15 every 28…
- Trial name
- ProglumidePanc (NCT06017323)
- Testing
- Gemcitabine, Nab paclitaxel, Proglumide Dose level 1
- Where
- United States
- Sponsor
- Georgetown University
Prostate Carcinoma, Breast Neoplasm
The Genetic Education for Men Trial: Web-Based Education vs. Standard Care
The primary goal of this research is to develop and test a web-based genetic education/counseling intervention. This intervention is designed to educate men from hereditary cancer families about the personal relevance of genetic…
- Conditions
- Prostate Carcinoma, Breast Neoplasm, Pancreatic Cancer, BRCA1 Mutation
- Trial name
- GEM (NCT02957981)
- Testing
- Web-based Counseling, Standard Care
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Georgetown University
Breast Cancer, Metastatic Breast Cancer
Oral SM-88 in Patients With Metastatic HR+/HER2- Breast Cancer
This is a phase II single arm, open-label study of SM-88 used with methoxsalen, phenytoin, and sirolimus (MPS) in metastatic HR+/HER2- breast cancer.
- Conditions
- Breast Cancer, Metastatic Breast Cancer, Hormone Receptor Positive Breast Carcinoma
- Trial name
- OASIS (NCT04720664)
- Testing
- SM-88
- Where
- 5 sites in United States
- Volunteers
- 11 people
- Sponsor
- Georgetown University
Population at Risk
Educating QUitline Callers About Lung Cancer Screening
The specific aims are: 1. To evaluate the potential barriers of providing educational lung screening interventions to quitline users, the investigators will seek input from 10-20 stakeholders on the newly adapted print version of…
- Trial name
- EQUAL (NCT05046951)
- Testing
- Should I Screen website, Should I Screen print booklet
- Where
- United States
- Volunteers
- 298 people
- Sponsor
- Georgetown University
Prostate Cancer
Metabolomic Study for Localized Prostate Cancer
Prostate cancer is a common disease in men treated using surgery, radiation therapy and/or hormonal therapy. Clinical prognosis relates to stage and grade of disease.
- Trial name
- NCT01968538
- Testing
- Radiation Therapy
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Georgetown University