Clinical trials: sponsored by Hadassah Medical Organization
Head and Neck Cancer
Prospective PROM and PREM Analysis Demonstrating Specification Advantage and Language Barriers
Importance: Patient reported outcome and experience measures (PROM and PREM) constitute a cornerstone of the collective efforts to improve and personalize healthcare systems.
- Trial name
- NCT06457594
- Testing
- Questionnaire
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Hadassah Medical Organization
Surgical Site Infection
Subcutaneous Lavage in Cesarean Section
The goal of this clinical trial is to learn if antiseptic washing prior to skin closure during cesarean section reduces rates of surgical site infection.
- Trial name
- NCT06454227
- Testing
- Subcutaneous washing, no subcutaneous washing
- Where
- Israel
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Dose Escalation and Safety
NXC-201 (formerly HBI0101) Multiple Myeloma
It is a phase one study with dose escalation and safety CART in BCMA- Expressing Multiple Myeloma and AL amyloidosis Patients
- Trial name
- NCT04720313
- Testing
- NXC-201 (formerly HBI0101)
- Where
- Israel
- Volunteers
- 160 people
- Sponsor
- Hadassah Medical Organization
COVID-19, Inflammatory Response
Severe COVID-19 Infection in Children Presenting to EDs in Israel and England
Even though the COVID-19 pandemic is no longer at its peak, the threat still lingers. Engaging in prospective surveillance studies will enable us to monitor the disease and prepare for any potential resurgence.
- Trial name
- SPICE (NCT06434701)
- Testing
- Nasopharyngeal swab sampling for COVID-19
- Where
- 6 sites in Israel
- Volunteers
- 500 people
- Sponsor
- Hadassah Medical Organization
Cholangiocarcinoma
The Expression of CD24 "do-not-eat-me" Signal in Cholangiocarcinoma
The investigators found an inverse relationship between CD24 and MiR-122 levels. Then the investigators found that CD24 that goes up with MiR-122 down makes macrophages unable to engulf the tumor cells. All this in mice.
- Trial name
- CD24CCA (NCT06707025)
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Hadassah Medical Organization
Infertility
Derivation of New Human Embryonic Stem Cell Lines Lines for Clinical Use
Human embryonic stem cells (hESCs) are isolated from the early human embryo and have the capability to proliferate indefinitely in culture and to develop into nearly every cell of the human body.
- Trial name
- NCT00353197
- Where
- Israel
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Infertility
The Derivation of Human Embryonic Stem Cell Lines From PGD Embryos
Human embryonic stem cells (hESCs) are isolated from the early human embryo and have the capability to proliferate indefinitely in culture and to develop into nearly every cell of the human body.
- Trial name
- NCT00353210
- Where
- Israel
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Amyotrophic Lateral Sclerosis
Derivation of Induced Pluripotent Stem Cells From an Existing Collection of Human Somatic Cells
Induced pluripotent stem cells potentially may be useful in the future as an unlimited source of cells for transplantation. The major goal of the project is to develop human iPS cells from various types of cell cultures or lines…
- Trial name
- NCT00801333
- Where
- 2 sites in Israel
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Neurodegenerative Disorders
Development of IPS from Donated Somatic Cells of Patients with Neurological Diseases
Human fibroblasts and possibly other human somatic cells may be reprogrammed into induced pluripotent stem (iPS) cells by the forced expression of transcription factors (1-5).
- Trial name
- NCT00874783
- Where
- Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Azoospermia
Testis Needle Aspiration of Sperm in Men With Azoospermia
Needle aspiration of the epididymis causes rupture and irreversible damage to the duct. Recurring punctures and needle aspirations of fluid and tissue during Testicular Fine Needle Aspiration (TEFNA) procedure cause irreparable…
- Trial name
- NCT02418832
- Testing
- Sperm cell aspiration and TEFNA
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Hadassah Medical Organization
COVID 19
Colostrum From MERS-CoV Seropositive Camels for SARS-CoV-2 Infection - a Placebo-controlled Randomized Trial.
The study aims to study the efficacy of colostrum from MERS-CoV-positive camels applied as a nasal spray to COVID-19 patients for treatment and prevention of SARS-CoV-2 infection.
- Trial name
- NCT06857318
- Testing
- Colostrum Nasal Spray, Water for injection
- Where
- Israel
- Volunteers
- 43 people
- Sponsor
- Hadassah Medical Organization
Abdominoplasty
Fluid Therapy and Glycocalyx Shedding During Moderate Surgery
Goal-directed fluid therapy is one of the most accepted strategies in intraoperative fluid therapy, although potential fluid overload is a possible drawback.
- Trial name
- NCT05939518
- Testing
- Lactated Ringer's Fluid Bolus Response to Low Urinary Output, Post-Anesthesia Care Unit Lactated Ringer's Fluid Management Protocol
- Where
- Israel
- Volunteers
- 51 people
- Sponsor
- Hadassah Medical Organization
Malignancies
Identifying Tissue-of-origin in Transplant Patients and Patients with Malignancies.
the investigators are developing a method for diagnosing cell death in the body using blood and urine tests. The test is based on two well-known phenomena in biology.
- Trial name
- cfDNA (NCT06703853)
- Where
- Israel
- Volunteers
- 1,000 people
- Sponsor
- Hadassah Medical Organization
Healthy Older Adults, Exercise
Personalized Exercise Programs for Older Adults - a Digital User-friendly Application
Scientific Background: Despite the known health benefits of exercising during old age, older people remain highly sedentary. Official exercise guidelines aimed specifically at older people focus primarily on aerobic activity, and…
- Trial name
- NCT04181983
- Testing
- Personalized exercise program, WHO exercise guidelines
- Where
- Israel
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Pain
Bioequivalence Assessment of Cannabidiol (CBD) Administrated in Oral Formulations
The oral bio-availability of cannabidiol (CBD) is low due to poor water solubility and susceptibility to extensive first pass metabolism, resulting in relative bio-availability of 6%.This project is designed to evaluate the…
- Trial name
- NCT03877991
- Testing
- CBD-sesame oil capsule, CBD-LNL capsule, CBD powder form capsule
- Where
- Israel
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Multiple Sclerosis
Improving the Effect of Multiple Sclerosis Drugs by Chronobiology
A trial for evaluating the ability to improve the effect of dimethyl fumarate in patients with Multiple Sclerosis (MS) by chronobiology A controlled-randomization dosing regimen administered to patients with MS and provided by a…
- Trial name
- NCT06385197
- Testing
- App randomizing dosing regimen
- Where
- Israel
- Volunteers
- 8 people
- Sponsor
- Hadassah Medical Organization
Infertility Due to Nonimplantation, Infertility Secondary
Inflammation Markers in Fluid Aspirate From a Scarred Uterine vs. a Normal Uterine Cavity
A prospective study that will take place in the hydrosonography clinic, comparing patients with an intact uterus to those who had a caesarean section.
- Conditions
- Infertility Due to Nonimplantation, Infertility Secondary, Cesarean Section Complications
- Trial name
- NCT06322498
- Testing
- Uterine lavage
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Lenvatinib Treatment
Using Chronobiology to Improve Lenvatinib Efficacy
The goal of this proof-of-concept clinical trial is to assess the efficacy and safety of chronobiology implementation into lenvatinib treatment regimens of thyroid cancer patients, via a mobile application.
- Trial name
- NCT06321120
- Testing
- variability-based lenvatinib regimen
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Hadassah Medical Organization
Breast Cancer, Genitourinary Syndrome of Menopause
CO2 Laser Therapy for the Treatment of GSM in Patients With Breast Cancer
Given the need for an effective, non-hormonal treatment for Genitourinary syndrome of menopause GSM) symptoms in breast cancer survivors, the reported efficacy of fractional CO2 laser as such a treatment in retrospective studies…
- Trial name
- NCT04517370
- Testing
- Fractional/Pixel CO2 laser
- Where
- Israel
- Volunteers
- 36 people
- Sponsor
- Hadassah Medical Organization
Periodontitis
The Efficacy Of AGE On Periodontitis
The objective of this study is to assess the long-term efficacy of "AGE among on deep periodontal pockets by different doses of "AGE" for a period of 18 months.
- Trial name
- NCT06287424
- Testing
- Aged Garlic Extract
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization