Clinical trials: sponsored by Henan Cancer Hospital
Colorectal Cancer
Study of Apatinib Plus S-1 as the Therapy of Advanced Colorectal Cancer
The purpose of this study is to confirm the safety and efficacy of Apatinib plus S-1 as the Therapy of Advanced Colorectal Cancer.
- Trial name
- NCT03397199
- Testing
- Apatinib + S-1
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Henan Cancer Hospital
Non-small Cell Lung Cancer Metastatic
Low-dose Gemcitabine Combined With Nivolumab for Second-line and Above Line Treatment of NSCLC
In recent years, immunotherapy research has made great progress, especially the immunocheckpoint inhibitors represented by anti-pd-1 antibody have shown good efficacy in the treatment of malignant tumors, and some patients can…
- Trial name
- NCT04331626
- Testing
- Gemcitabine Injectable Product
- Volunteers
- 50 people
- Sponsor
- Henan Cancer Hospital
Advanced Cancer
Autologous Cytokine-induced Killer Cells Combined Chemotherapy in Advanced Pancreatic Cancer
The purpose of this study is to determine whether Cytokine induced killer cells combined chemotherapy is more effective in the treatment of advanced Pancreatic Cancer.
- Trial name
- NCT03002831
- Testing
- Cytokine-induced Killer Cells, Tegafur-Gimeracil-Oteracil Potassium
- Where
- China
- Volunteers
- 13 people
- Sponsor
- Henan Cancer Hospital
Esophageal Cancer TNM Staging, Magnetic Resonance Imaging
The Application of 3T MRI in Esophageal Cancer
It is very significant that assessing TN staging in esophageal cancer patients before surgery, furthermore, determining the optimize surgical strategy, predict the the efficacy of radiotherapy for patients who were not chosen to…
- Conditions
- Esophageal Cancer TNM Staging, Magnetic Resonance Imaging, Prognosis
- Trial name
- NCT03635619
- Testing
- No intervention
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Henan Cancer Hospital
Gastric Cancer Stage, CT
Study of CT and MR in the Gastric Cancer
It is very significant that assessing staging in gastric cancer patients before surgery, furthermore, determining the optimize surgical strategy ,predict the the efficacy of neoadjuvant therapy for patients.
- Conditions
- Gastric Cancer Stage, CT, MRI, Neoadjuvant Therapy
- Trial name
- NCT04028375
- Testing
- No intervention
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Henan Cancer Hospital
Diffuse Large B-cell Lymphoma
Chidamide Combined With VDDT Regimen in the Relapse and Refractory Diffuse Large B Cell Lymphoma
This is a prospective phase II clinical trial to observe the efficacy and safety of Chidamide combined with VDDT(vinorelbine，liposomal doxorubicin，dexamethasone and thalidomide) in relapsed and refractory patients with diffuse…
- Trial name
- NCT02733380
- Testing
- Chidamide, Vinorelbine, Liposomal Doxorubicin or mitoxantrone
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Henan Cancer Hospital
Lung Cancer Squamous Cell, CT
Study of CT and MR in the Lung Cancer
Lung cancer is one of the leading causes of cancer-related deaths in China. Despite advances in systemic therapy and improvement nonsurvival rates for patients with advanced lung cancer, morbidity and mortality remain high.
- Conditions
- Lung Cancer Squamous Cell, CT, Genes, Response
- Trial name
- NCT04034667
- Testing
- No intervention
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Henan Cancer Hospital
Esophageal Cancer, Lung Cancer
Thoracic Surgery Combined With Intrathoracic Hyperthermic Perfusion for Advanced Lung Cancer / Esophageal Cancer
The goal of this clinical research study is to explore whether intrathoracic hyperthermic perfusion after radical surgery could reduce local recurrence rate(13%) for advanced lung cancer / esophageal cancer.
- Conditions
- Esophageal Cancer, Lung Cancer, Hyperthermic Perfusion
- Trial name
- NCT03110939
- Testing
- hyperthermic perfusion
- Where
- China
- Sponsor
- Henan Cancer Hospital
Esophageal Squamous Cell Carcinoma
Anrotenib Plus Toripalimab Versus Toripalimab in Patients With Advanced Esophageal Squamous Cell Carcinoma
The aim of this study is to investigate the efficacy and safety of anrotenib plus toripalimab in the treatment of advanced esophageal squamous cell carcinoma.
- Trial name
- NCT04229849
- Testing
- Anrotenib plus Toripalimab, Toripalimab
- Volunteers
- 164 people
- Sponsor
- Henan Cancer Hospital
Triple-negative Breast Cancer
SHR-1210 Combined With Albumin-bound Paclitaxel and Epirubicin Neoadjuvant for Triple Negative Breast Cancer
Triple negative breast cancer (TNBC), characterized by estrogen receptor, progesterone receptor and HER2 negative, accounts for 10-20% of all breast cancers and usually occurs in young women.
- Trial name
- NCT04213898
- Testing
- SHR-1210+Albumin-bound paclitaxel + epirubicin
- Volunteers
- 39 people
- Sponsor
- Henan Cancer Hospital
NSCLC
Evaluating Combination Therapy Using Autologous Dendritic Cells Pulsed With Antigen Peptides and Nivolumab for Subjects With Advanced Non-Small Cell Lung Cancer
Study Arms: Patients receive autologous dendritic cells pulsed with antigen peptides ID on days 15, 29, 43,57,71,99,127and 155, and nivolumab IV over 60 minutes on days 15, 29, 43,57,71,85 99 and 113.
- Trial name
- NCT04199559
- Testing
- Autologous dendritic cells pulsed with antigen
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Henan Cancer Hospital
Squamous Cell Carcinoma, Esophageal Cancer
Teripalimab Plus Chemotherapy in Local Advanced Esophageal Cancer
The prognosis of locally advanced esophageal squamous cell carcinoma is poor,the role of chemotherapy as neoadjuvant therapy in locally advanced esophageal cancer has been established, which can convert some unresectable…
- Conditions
- Squamous Cell Carcinoma, Esophageal Cancer, Perioperative Period
- Trial name
- NCT03985670
- Testing
- teripalimab plus chemotherapy, chemotherapy plus teripalimab
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Henan Cancer Hospital
Mucosal Melanoma, Advanced Cancer
Apatinib Plus SHR1210 in Advanced Mucosal Melanoma
There is still no effective treatment for advanced mucosal melanoma at present. The efficacy of single-agent PD-1 inhibitors is less than 20%.
- Conditions
- Mucosal Melanoma, Advanced Cancer, Apatinib, SHR-1210
- Trial name
- NCT03986515
- Testing
- apatinib plus SHR-1210
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Henan Cancer Hospital
Advanced Gastrointestinal Tumors
Treatment of Advanced Gastrointestinal Tumors With Albumin Taxol
The purpose of this study was to evaluate the safety and efficacy of domestic injection paclitaxel (albumin binding type) in patients with advanced digestive tract tumors,and to further explore the possible predictors of…
- Trial name
- NCT03977077
- Testing
- Albumin binding taxol
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Henan Cancer Hospital
Advanced Solid Tumor
Clinical Study on the Second-line and Above Treatment of Advanced Solid Tumor With Anlotinib Combined With Pd-1 Antibody
The main objective was to evaluate the safety and efficacy of anlotinib hydrochloride combined with pd-1 antibody second-line and above in the treatment of advanced solid tumors
- Trial name
- NCT03975036
- Testing
- Anlotinib, pd-1 antibody
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Henan Cancer Hospital
Gastrointestinal Neuroendocrine Tumor
Etoposide/Cisplatin Compared With Irinotecan/Cisplatin for Advanced Gastrointestinal Neuroendocrine Tumor G3 Type
The aim of this study is to investigate the efficacy, safety, and survival benefit of etoposide plus cisplatin and irinotecan plus cisplatin in first-line therapy of non-primary pancreatic metastatic and/or unresectable…
- Trial name
- NCT03963193
- Testing
- Etoposide, Irinotecan
- Volunteers
- 112 people
- Sponsor
- Henan Cancer Hospital
Advanced Gastric Cancer
Exploratory Clinical Study of Apatinib and PD-1 in Treating Advanced Gastric Cancer
The Purpose of This Study is to Evaluate the Efficacy and Safety of Apafitini Combined With PD1 in Patients With Advanced Gastric Cancer After Second-line Treatment Failure, Thus Providing More Options for Patients With Advanced…
- Trial name
- NCT03954756
- Testing
- Apatinib and PD1
- Volunteers
- 35 people
- Sponsor
- Henan Cancer Hospital
HER2 Positive Breast Cancer
Neoadjuvant Study of Pyrotinib and Trastuzumab Plus Vinorelbine in Trastuzumab-refractory HER2-Positive Breast Cancer.
This study is a single-arm, prospective, open label clinical study for evaluating the efficacy and safety of neoadjuvant pyrotinib and trastuzumab plus Vinorelbine given as neoadjuvant treatment in Trastuzumab-refractory HER2…
- Trial name
- NCT03947242
- Testing
- Pyrotinib and Trastuzumab plus Vinorelbine
- Volunteers
- 48 people
- Sponsor
- Henan Cancer Hospital
Ovarian Cancer
Apatinib With Albumin-bound Paclitaxel in Patients With Platinum-resistant Recurrent Ovarian Cancer
The study was designed to evaluate the efficacy and safety of apatinib with albumin-bound paclitaxel in patients with platinum-resistant recurrent ovarian cancer.
- Trial name
- NCT03942068
- Testing
- albumin-bound paclitaxel, Apatinib
- Volunteers
- 35 people
- Sponsor
- Henan Cancer Hospital
B-Cell Lymphoma Stage I, Refractory
CD19/20 Bispecific Nanobody-derived CAR-T Cells in B Cell Lymphoma
Evaluation the safety and efficacy of CD19/CD20 bispecific CAR-T cells in patients with relapsed/refractory B cell lymphoma
- Conditions
- B-Cell Lymphoma Stage I, Refractory, Relapsed
- Trial name
- NCT03881761
- Testing
- CD19/CD20 bispecific CAR-T cells
- Where
- 2 sites in China
- Volunteers
- 50 people
- Sponsor
- Henan Cancer Hospital