Clinical trials: sponsored by Henan Cancer Hospital
Non-small Cell Lung Cancer
AK104 With Chemotherapy as Neoadjuvant and Adjuvant Therapy for Resectable Non-small Cell Lung Cancer
AK104, a tetravalent bispecific antibody targeting PD-1 and CTLA-4, is designed to retain the efficacy benefit of combination of PD-1 and CTLA-4 and improve on the safety profile of the combination therapy.
- Trial name
- NCT05377658
- Testing
- AK104, Albumin-Bound Paclitaxel, Carboplatin
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Henan Cancer Hospital
SCLC,Extensive Stage
A Multicenter, Real-world Study of Adebrelimab in the Treatment of Extensive Stage Small Cell Lung Cancer
This study collected data on patients with extensive stage small cell lung cancer treated with Adebrelimab to investigate its safety and efficacy
- Trial name
- SCLC (NCT06267170)
- Testing
- Adebrelimab
- Volunteers
- 288 people
- Sponsor
- Henan Cancer Hospital
Acute Myeloid Leukemia, Maintenance Treatment
The Maintenance Treatment of "ITIVA" in AML Patients
We apply for this clinical study to evaluate the efficacy of "combined recombinant human interference'- α- 1b, interleukin-2, and thalidomide" regimen in obtaining MRD positive AML patients in CR,as well as the efficacy of the…
- Conditions
- Acute Myeloid Leukemia, Maintenance Treatment, Minor Residue Disease, Interferon-α-1b
- Trial name
- NCT06256627
- Testing
- recombinant human interference'- α- 1b, interleukin-2, thalidomide, Venentoclax and Azacitidine
- Where
- China
- Volunteers
- 130 people
- Sponsor
- Henan Cancer Hospital
Malignant Tumor, Chemotherapy
Application of Douyin in Patients With Bone and Soft Tissue Malignant Tumors During Perichemotherapy
A total of 90 patients with bone and soft tissue malignancies who planned to receive chemotherapy were enrolled in this study in Henan Cancer Hospital.
- Trial name
- NCT05598827
- Testing
- Tik Tok
- Volunteers
- 90 people
- Sponsor
- Henan Cancer Hospital
Sarcoma
Study on Clinical Features, Treatment Mode and Survival of Sarcoma
The clinical data of all eligible patients who received chemotherapy, radiotherapy, targeted therapy, immunotherapy, interventional therapy and surgery in Henan Tumor Hospital from June 1, 2012 to May 30, 2022 were…
- Trial name
- NCT05453409
- Testing
- No intervention
- Where
- China
- Volunteers
- 6,000 people
- Sponsor
- Henan Cancer Hospital
Soft Tissue Sarcoma
Piamprilizumab (AK105) Combined With Radiotherapy for Neoadjuvant Treatment of Soft Tissue Sarcoma
The primary objective of this study was to evaluate the safety and efficacy of paamprilimab combined with radiotherapy for neoadjuvant treatment of soft tissue sarcoma.
- Trial name
- NCT05718778
- Testing
- Piamprimab (AK105)
- Where
- China
- Volunteers
- 31 people
- Sponsor
- Henan Cancer Hospital
Malignant Tumor of Bone, Perioperative Period
Application of Douyin in Perioperative Period of Malignant Tumor Patients
Fitting into the group of 90 cases of this study was to henan tumor hospital bone prosthesis replacement of surgical treatment of bone malignant tumors patients, evaluate watch trill to be bone prosthesis replacement surgery…
- Trial name
- NCT05598229
- Testing
- Tik Tok
- Volunteers
- 90 people
- Sponsor
- Henan Cancer Hospital
Sarcoma, Cryoablation
Cryoablation for Advanced Bone and Soft Tissue Tumors
This is a single-center, open, retrospective clinical study of patients with metastatic/surgically unresectable bone and soft tissue sarcoma undergoing cryoablation of selected tumor lesions. All eligible patients were enrolled.
- Trial name
- NCT05615545
- Testing
- Cryoablation
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Henan Cancer Hospital
Soft Tissue Sarcoma
Albumin-bound Paclitaxel Plus Camrelizumab for Advanced Soft Tissue Sarcoma.
In this open, single center, one- armed clinical study, enrolled patients will receive the following treatment: 300 mg/m2 of nab-paclitaxel (Hengrui Pharmaceutical, Lianyungang, China) and 200 mg of PD-1 inhibitor (camrelizumab…
- Trial name
- NCT05189483
- Testing
- Albumin-Bound Paclitaxel, Camrelizumab
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Henan Cancer Hospital
Small Cell Lung Carcinoma
Adebrelimab and Concurrent Radiochemotherapy as First-line Treatment for Extensive-stage Small-cell Lung Cancer
Patients with extensive-stage small-cell lung cancer (ES-SCLC) have poor prognosis, with limited treatment options. Chemo-immunotherapy is the standard 1st-line therapy for patients with ES-SCLC.When 4 cycles of…
- Trial name
- NCT06236997
- Testing
- Adebrelimab, Radiation Therapy, etoposide, carboplatin(EC)
- Where
- 2 sites in China
- Volunteers
- 48 people
- Sponsor
- Henan Cancer Hospital
Gastric Cancer
Disitamab Vedotin Combined With Sintilimab and XELOX Perioperative Treatment for Resectable Gastric Caner With HER2 Overexpression
The aim of this study is to observe the efficacy, safety, postoperative pathological response rate and survival benefit of RC48 combined withSintilimab and chemotherapy in perioperative therapy of locally advanced resectable…
- Trial name
- NCT06227325
- Testing
- RC48 combined with Sintilimab and XELOX
- Where
- China
- Volunteers
- 27 people
- Sponsor
- Henan Cancer Hospital
Malignant Tumor
Application of LARS Ligament in Bone Prosthesis Replacement
This is a single-center, prospective, real-world observational study designed to enroll all patients eligible for enrollment. Basic data, treatment methods, postoperative complications and limb function were collected.
- Trial name
- NCT05616182
- Testing
- LARS ligament and bone prosthesis replacement was performed
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Henan Cancer Hospital
Limb; Fusion, Complication
Application of Antiosteoporosis Therapy in Osteolysis
To report the postoperative complications and limb function of patients with osteolysis after surgery for bone tumors of the extremities who received anti-osteoporosis therapy in Henan Cancer Hospital in the next 10 years.
- Trial name
- NCT05617846
- Testing
- Anti-osteoporosis therapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Henan Cancer Hospital
Malignant Tumor
Application of 3D Printed Prosthesis in Limb Salvage Surgery for Bone Tumors
To report the patients who underwent 3D-printed bone prosthesis replacement in Henan Cancer Hospital in the next 10 years, and collect the postoperative complications and limb function of these patients.
- Trial name
- NCT05616195
- Testing
- 3D printed bone prosthesis replacement surgery
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Henan Cancer Hospital
Non-hodgkin Lymphoma,B Cell
The Safety and Efficacy of Double-target CART-19 and 20 Cells in Non-Hodgkin's Lymphoma (NHL)
This is a study for patients who have been previously treated for NHL. The purpose of this study is to determine the safety and feasibility of double-target CART-19 and 20 cells to the patients with relapsed and refractory…
- Trial name
- NCT06160362
- Testing
- CART-19 and 20 cells, Cyclophosphamide, Fludarabine
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Henan Cancer Hospital
Early Breast Cancer
A Study of Monosialic Gangliosides to Prevent Albumin-bound Paclitaxel Neurotoxicity
Taxane-induced peripheral neuropathy (TIPN) caused by paclitaxel is a dose-limiting toxicity. The main symptoms of discomfort are numbness, tingling, and burning sensations in the glove-sock-like distribution of the limbs.
- Trial name
- NCT04222790
- Testing
- monosialic gangliosides
- Where
- China
- Volunteers
- 159 people
- Sponsor
- Henan Cancer Hospital
Malignant Tumor, Anxiety
Long-term Follow-up of Anxiety and Depression in Patients With Malignant Tumors
This study was a single-center prospective, real-world observational study with plans to enroll all eligible patients. The basic information, anxiety and depression, treatment and prognosis of these patients were collected.
- Conditions
- Malignant Tumor, Anxiety, Depression
- Trial name
- NCT05596344
- Testing
- Hospital Anxiety and Depression Scale
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Henan Cancer Hospital
Squamous Cell Carcinoma of the Skin
Camrelizumab Combined With Cisplatin in the Treatment of Advanced Cutaneous Squamous Cell Carcinoma
This study is a card Rayleigh bead single combined cisplatin treatment of advanced squamous cell carcinoma of the skin resistance of single arm phase II study, open, single center, plan in two years into the group of 20 cases…
- Trial name
- NCT05490485
- Testing
- Camrelizumab
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Henan Cancer Hospital
Desmoid
Clinical Study of Anlotinib Combined With Chemotherapy in the Treatment of Unresectable Advanced Desmoid Tumor
Thirty patients with desmoid tumors (invasive fibromatosis) will be recruited in the Department of Bone and Soft Tissue, Henan Cancer Hospital.
- Trial name
- NCT05490667
- Testing
- Anlotinib
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Henan Cancer Hospital
Advanced Melanoma
PD-1 Antibody Tislelizumab Combined With Dacarbazine in the Treatment of Advanced Melanoma
A total of 40 subjects who had not received systemic treatment or chemotherapy in the past and were allowed to receive adjuvant or neoadjuvant treatment for advanced melanoma received tirelizumab combined with dacarbazine for 4-6…
- Trial name
- NCT05466474
- Testing
- Tislelizumab Injection
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Henan Cancer Hospital