Clinical trials: sponsored by Henan Cancer Hospital
NSCLC
Multicenter, Prospective, Real World Study of Camrelizumab in Cross-line Treatment of Non-small Cell Lung Cancer
To explore the effectiveness and safety of Camrelizumab based cross-line therapy for patients with advanced NSCLC in the real world
- Trial name
- NSCLC (NCT05547737)
- Testing
- Camrelizumab
- Volunteers
- 500 people
- Sponsor
- Henan Cancer Hospital
Breast Cancer
Pyrotinib Combined With Capecitabine in HER-2 Positive Advanced Breast Cancer and Brain Metastases (Post-PERMEATE)
This study aims to describe the different treatment time, treatment mode and clinical outcomes of pyrotinib maleate tablets combined with capecitabine in the treatment of patients with HER-2 positive advanced breast cancer with…
- Trial name
- NCT05359120
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Henan Cancer Hospital
Hepatocellular Carcinoma
Study of Donafenib Combined With Tislelizumab in the Adjuvant Treatment of Primary HCC With High Risk of Recurrence
To explore the safety and preliminary efficacy of donafenib combined with tislelizumab in adjuvant therapy after radical surgical resection of primary hepatocellular carcinoma with high risk of recurrence.
- Trial name
- NCT05545124
- Testing
- Donafenib + Tislelizumab
- Volunteers
- 32 people
- Sponsor
- Henan Cancer Hospital
Breast Cancer
Utidelone Plus Bevacizumab for Advanced Breast Cancer With Brain Metastases
This study aims to investigate the efficacy and safety of utidelone in combination with bevacizumab in the treatment of advanced breast cancer with brain metastases, and thus provides a new systemic treatment strategy for those…
- Trial name
- NCT05357417
- Testing
- utidelone, Bevacizumab
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Henan Cancer Hospital
High-Risk, Non-Muscle Invasive Bladder Urothelial Carcinoma, Perfusion; Complications
Hyperthermic Intravesical Perfusion for Muscle-invasive Bladder Urothelial Carcinoma
To evaluate the effect of hyperthermic intravesical perfusion on the risk of intraoperative implantation of muscle-invasive bladder urothelial carcinoma and its safety.
- Conditions
- High-Risk, Non-Muscle Invasive Bladder Urothelial Carcinoma, Perfusion; Complications, Intraoperative Complications
- Trial name
- NCT05276167
- Testing
- hyperthermic intravesical perfusion
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Henan Cancer Hospital
Esophageal Squamous Cell Carcinoma
Neoadjuvant Chemotherapy Versus Neoadjuvant Chemoradiotherapy for Resectable Locally Advanced Esophageal Cancer (HCHTOG1903)
Multimodal treatment combining surgery with chemotherapy and/or radiotherapy is necessary to improve the chances of survival in patients with locally advanced thoracic esophageal cancer.
- Trial name
- HCHTOG1903 (NCT04138212)
- Testing
- Paclitaxel, Cisplatin, neoadjuvant chemoradiation therapy
- Where
- China
- Volunteers
- 456 people
- Sponsor
- Henan Cancer Hospital
Bone Tumors
Application of Painting Analysis and Psychotherapy in Children With Bone Tumors
In the population suffering from cancer, children and teenagers are in the majority. For children with rapid development of body and mind, with the change of cognitive ability, they will feel anxiety and fear about the expected…
- Trial name
- NCT05475938
- Testing
- Painting therapy and psychoanalysis
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Henan Cancer Hospital
Early Gastric Cancer, Tumor Organoids
A Study on the Potential Benefit of Neoadjuvant Therapy for AGC Patients
Early gastric cancer（AGC）has no effective characteristic symptoms and signs according to clinical statistics. Neoadjuvant chemotherapy (NAC) significantly reduces the size of AGC tumors so that it has become the recommended…
- Trial name
- NCT05442138
- Volunteers
- 54 people
- Sponsor
- Henan Cancer Hospital
Solid Tumor
Camrelizumab Combined With Apatinib Mesylate
The purpose of this study is to observe the safety of camrelizumab combined with apatinib mesylate in the treatment of solid tumors
- Trial name
- NCT05380986
- Testing
- Camrelizumab combined with apatinib mesylate
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Henan Cancer Hospital
Advanced Gastric Adenocarcinoma
Camrelizumab Combined With Albumin-bound Paclitaxel and S-1 in the Treatment of Advanced Gastric Cancer
The purpose of this study is to investigate the safety and efficacy of Camrelizumab combined with paclitaxel (albumin binding type) and S-1 for first-line treatment of advanced gastric cancer, and to further explore the curative…
- Trial name
- NCT04675866
- Testing
- Camrelizumab, Albumin-bound paclitaxel, S-1
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Henan Cancer Hospital
Advanced Gastric Carcinoma, HER2-positive Gastric Cancer
RC48 Plus AK105 and Cisplatin in Advanced Gastric Cancer
To explore the safety and clinical efficacy of cisplatin combined with RC48 and anti-PD-1 antibodies AK105 in Her-2 positive advanced gastric cancer.
- Trial name
- NCT05313906
- Testing
- RC48+AK105+cisplatin
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Henan Cancer Hospital
Metastatic Colorectal Cancer
Real-World Effectiveness of Regorafenib in the Treatment of Patients With Metastatic Colorectal Cancer
Real-World Effectiveness of Regorafenib in the Treatment of Patients with Metastatic Colorectal Cancer- A Retrospective, Observational Study
- Trial name
- NCT05023720
- Testing
- nonintervention
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Henan Cancer Hospital
SCLC, Extensive Stage
Utidelone in Third-line and Above Treatment of Small Cell Lung Cancer
SCLC has a very high degree of malignancy, and 60% to 70% of patients are diagnosed as extensive stage. The median survival of patients with limited-stage disease is about 15-20 months, and the median OS of patients with…
- Trial name
- NCT05299255
- Testing
- Utidelone
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Henan Cancer Hospital
Surgery--Complications
Clinical Study on the Safety of Double and a Half Layered Esophagojejunal Anastomosis in Curative Gastrectomy
Surgical resection remain the main means for gastric cancer. With the improvement of surgical techniques and concepts, the incidence of postoperative complications gradually decreased, but esophagojejunostomy complications occur…
- Trial name
- NCT05282563
- Testing
- double and a half layered esophagojejunal anastomosis
- Where
- China
- Volunteers
- 21 people
- Sponsor
- Henan Cancer Hospital
Soft Tissue Sarcomas
Study on the Treatment of Soft Tissue Sarcoma With First-line Chemotherapy Failure by Anrotenil Hydrochloride Capsule
Soft tissue sarcoma STS is a group of malignant tumors derived from connective tissue other than bone and cartilage. It can occur in any part of the body at any age, and there is no significant gender difference.According to…
- Trial name
- NCT04223583
- Testing
- Anlotinib Hydrochloride
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Henan Cancer Hospital
Non-small Cell Lung Cancer
An Exploratory Study of Herombopag for Thrombocytopenia Induced by Chemotherapy Combined With Immunotherapy in NSCLC
The purpose of this study is to explore the safety and efficacy of herombopag olamine tablets for thrombocytopenia induced by chemotherapy combined with immunotherapy in non-small cell lung cancer
- Trial name
- NCT05252091
- Testing
- herombopag olamine tablets
- Volunteers
- 30 people
- Sponsor
- Henan Cancer Hospital
Recurrent Hepatocellular Cancer
Radiofrequency Ablation Combined With Toripalimab and Lenvatinib in the Treatment of Short-term Recurrent Hepatocellular Carcinoma.
This study is a multi-center, prospective, single-arm, open-design phase II clinical study, mainly to explore the clinical effectiveness and safety of radiofrequency ablation combined with anti-PD-1 antibody toripalimab and…
- Trial name
- NCT05162898
- Testing
- toripalimab, Lenvatinib, Radiofrequency ablation
- Volunteers
- 90 people
- Sponsor
- Henan Cancer Hospital
Gastric Cancer
Camrelizumab Combined With FOLFOX Neoadjuvant Therapy for Resectable Gastric and Gastroesophageal Junctional Adenocarcinoma
The aim of this study is to observe the efficacy, safety, postoperative pathological response rate and survival benefit of immume checkpoint inhibitor PD-1 SHR1210 combined with chemotherapy in neoadjuvant therapy of locally…
- Trial name
- NCT03939962
- Testing
- SHR1210 combined with FOLFOX
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Henan Cancer Hospital
Cholangiocarcinoma
PD-1 Inhibitor Sintilimab Combined With Capecitabine for Adjuvant Treatment After Radical Resection of Cholangiocarcinoma.
This is a single-center, single-arm, prospective phase II clinical study to evaluate the effectiveness and safety of Sintilimab combined with capecitabine in patients after radical resection of cholangiocarcinoma.
- Trial name
- SCRCA (NCT05207735)
- Testing
- Sintilimab
- Volunteers
- 73 people
- Sponsor
- Henan Cancer Hospital
Small Cell Lung Carcinoma
Camrelizumab Plus Apatinib as Maintenance Therapy in Extensive-stage Small-cell Lung Cancer
This single-arm, Phase II study was designed to evaluate the safety and efficacy of Camrelizumab (anti-programmed death-receptor 1 [PD-1] antibody) combination with Apatinib in participants with ES-SCLC who was response or stable…
- Trial name
- CAMERA (NCT04901754)
- Testing
- Camrelizumab Plus Apatinib
- Where
- China
- Volunteers
- 38 people
- Sponsor
- Henan Cancer Hospital