Clinical trials: sponsored by Huashan Hospital
Diabetes Mellitus, Diabetes Mellitus, Type 1
Pharmacokinetics Study of Gamma-aminobutyric Acid
The purpose of this study is to determine upon administering GABA orally to a person how it is absorbed, distributed, as well as the drug's pharmacological effects on the body such as glucose levels, serum C-peptide and/or…
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Glucose Metabolism Disorders, Metabolic Diseases
- Trial name
- GABA-PK (NCT01917760)
- Where
- China
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Chronic Hepatitis B
Switch or Sequential Combination Therapy of Peginterferon in Hepatitis B Patients With Longterm Entecavir Therapy
This is a multicenter, prospective cohort study to evaluate the efficacy and safety of sequential combination or switch therapy of pegylated interferon alfa-2a in chronic hepatitis B patients with low HBsAg and HBeAg titers after…
- Trial name
- NCT02589652
- Testing
- Pegylated interferon alfa-2a, Pegylated interferon alfa-2a plus Entecavir, Entecavir
- Where
- 17 sites in China
- Volunteers
- 294 people
- Sponsor
- Huashan Hospital
Idiopathic Parkinson's Disease
The Effect of Pramipexole on Metabolic Network Activity Compared With Levodopa in Early Parkinson's Disease
Levodopa and non-ergot dopaminergic agonists such as pramipexole are both recommended as the first-line symptomatic treatment for early untreated Parkinson's disease (PD), previous clinical trial indicated that initial…
- Trial name
- NCT01470859
- Testing
- pramipexole, Sinemet CR
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Huashan Hospital
Diabetes
The Impact of Resistance Training on Type 2 Diabetes Patients.
The purpose of this study is to determine whether the long-term effects of high-intensity progressive resistance training could improve glucose and lipid metabolism in chinese type 2 diabetes.
- Trial name
- NCT02413060
- Testing
- Resistance training, Lifestyle counselling
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Huashan Hospital
Postoperative Nausea and Vomiting
Transcutaneous Electrical Acupoint Stimulation of P6 to Prevent Postoperation Nausea and Vomiting
The purpose of this study is to access the effect of TEAS of P6 in the prevention of PONV in women scheduled for gynecologic laparoscopic surgery with general anesthesia.
- Trial name
- TEASP6PPONV (NCT02096835)
- Testing
- Transcutaneous electrical acupoint stimulation, Tropisetron, Dexamethasone
- Where
- China
- Volunteers
- 157 people
- Sponsor
- Huashan Hospital
Central Nervous System Infections
Meropenem Penetration Across BBB in Patients With CNS Infection and Optimization of Meropenem Treatment
A prospective, open-label study investigated the pharmacokinetic profile of meropenem in patients with post-neurosurgical central nervous system (CNS) infection, especially its BBB penetration into cerebrospinal fluid (CSF).
- Trial name
- NCT02506686
- Testing
- Meropenem
- Volunteers
- 82 people
- Sponsor
- Huashan Hospital
Cushing's Disease, Corticotrophin Adenoma
Targeted Therapy With Gefitinib in Patients With USP8-mutated Cushing's Disease
The USP8 gene and its downstream target, epidermal growth factor receptor (EGFR), is a potential therapeutic target of Cushing disease.
- Trial name
- NCT02484755
- Testing
- Gefitinib
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Huashan Hospital
Glioma, Motor Pathway
Functional Monitoring for Motor Pathway in Brain Tumor Surgery Within Eloquent Area
Resection of brain tumors in eloquent areas involves the risk of postoperative motor deficits. For brain tumors within or adjacent to the eloquent area, maximizing tumor resection while preserving motor function is crucially…
- Trial name
- NCT01351337
- Testing
- diffusion tensor tractography neuronavigation and intraoperative subcortical stimulation
- Where
- China
- Volunteers
- 58 people
- Sponsor
- Huashan Hospital
Acute Pancreatitis
Relation of Glucose and Acute Pancreatitis
Acute pancreatitis (AP) is an acute inflammatory disease of the pancreas which can lead to a systemic inflammatory response syndrome with significant morbidity and mortality in 20% of patients.
- Trial name
- ROGAAP (NCT01470885)
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Huashan Hospital
Multidrug Resistant Tuberculosis
Optimization of MDR-TB Treatment Regimen Based on the Molecular Drug Susceptibility Results of Pyrazinamide
Multidrug resistant tuberculosis (MDR-TB) is difficult to treat and raises a great challenge to TB control program. That pyrazinamide can shorten the course of treatment and facilitate bacilli clearance has been proved recently.
- Trial name
- NCT02120638
- Testing
- Pyrazinamide containing regimen, Regimen without Pyrazinamide
- Where
- 11 sites in China
- Volunteers
- 100 people
- Sponsor
- Huashan Hospital
Adult-onset Craniopharyngioma, Postoperative Weight Gain
Weight Gain in Surgically Treated Adult-onset Craniopharyngioma
The aim of the study was to describe postoperative weight change in adults undergoing surgery for craniopharyngioma and identify preoperative factors associated with it.
- Trial name
- NCT01968603
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Huashan Hospital
Hypothalamic Obesity, Diabetes Mellitus
Effects of Exenatide on Obesity and/or Diabetes Mellitus Due to Hypothalamic Damage
The purpose of this study is to examine the effect of exenatide on body weight and glycemic control in subjects with obesity and/or diabetes mellitus due to hypothalamic damage.
- Trial name
- NCT01783717
- Testing
- Exenatide
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Huashan Hospital
Acromegaly, Pituitary Tumor
The Observational Study of Growth Hormone-secreting Pituitary Tumors
The major purpose of this study is to evaluate the changes of multiple organs in patients with growth hormone-secreting pituitary tumors before and after surgery.
- Trial name
- NCT01368133
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Brain Neoplasms, Surgery
Cerebral Blood Perfusion Changes After General Anesthesia for Craniotomy
Few studies look into cerebral blood flow (CBF) changes during emergence from general anesthesia for craniotomy. The purpose of this study is to demonstrate CBF changes during emergence from general anesthesia for craniotomy…
- Conditions
- Brain Neoplasms, Surgery, Hyperemia
- Trial name
- NCT01642147
- Testing
- Transcranial Doppler (TCD), jugular venous bulb catheterization, Tumor removal surgery under general anesthesia
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Huashan Hospital
Mild Cognitive Impairment
Efficacy and Safety of Cilostazol in Patients of Vascular Cognitive Impairment-no Dementia (VCIND)
Patients of vascular cognitive impairment-no dementia (VCIND) in one group is prescribed cilostazol,in the other group is prescribed aspirin. Evaluate both of them in cognitive function, MRI and other sides at given time.
- Trial name
- NCT01872858
- Testing
- Aspirin, Cilostazol
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Chronic Kidney Disease, Proteinuria
Oral Calcitriol for Reduction of Mild Proteinuria in Patients With CKD
The safety and efficacy of Caltriol on mild proteinuria (<1.0g/d) reduction in CKD patients.
- Trial name
- NCT01820832
- Testing
- Calcitriol
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Huashan Hospital
Type 1 Diabetes
Effects Of Gamma Aminobutyric Acid On The Progression Of New Onset Juvenile Type 1 Diabetes
This study is a multicenter, randomized, double-masked, placebo-controlled clinical study. All groups will receive standard intensive diabetes treatment with insulin and life style management.
- Trial name
- NCT01781884
- Testing
- Gamma Aminobutyric Acid (GABA)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Huashan Hospital
Ischemic Stroke
Efficacy Study of Huatuo Zaizao Pills in Improving of Neural Function in Acute Ischemic Stroke
The purpose of this study is to determine the efficacy of Huatuo Zaizao Pills in improving neural function and life quality in patients with acute ischemic stroke in China.
- Trial name
- HTZZP-INF (NCT01758536)
- Testing
- Huatuo Zaizao Pills
- Where
- 4 sites in China
- Volunteers
- 1,100 people
- Sponsor
- Huashan Hospital
Pituitary Adenomas
Genome-wide Association Study of Pituitary Tumors
Pituitary adenomas is a very common disease, but the cause and genetics hasn't been identified. The investigators are going to use genome-wide association study to identify genes that may be related to pituitary adenomas.
- Trial name
- NCT01442220
- Where
- China
- Volunteers
- 12,500 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Obesity
The Detection and Factors of Brown Adipose Tissue in Different Locations of Adults
Retrospective studies have combined positron-emission tomography and computed tomography (PET-CT) to identify adipose tissue with a high rate of uptake of 18F-fluorodeoxyglucose(18F-FDG) as active brown adipose tissue(BAT).
- Trial name
- NCT01387451
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Huashan Hospital