Clinical trials: sponsored by Huashan Hospital
ESRD (End Stage Renal Disease)
Research and Validation of a Big Data-Driven Intelligent Decision-Making System for Hemodialysis
Objectives and Scope:This observational study aims to leverage real-world data from Huashan Hospital to develop an AI-driven intelligent decision-making system for assessing dialysis adequacy in maintenance hemodialysis (MHD)…
- Trial name
- NCT07466329
- Where
- China
- Volunteers
- 778 people
- Sponsor
- Huashan Hospital
Glioma, Diffuse Glioma
Vorasidenib Guided by AGX PET in Recurrent/Low-grade Glioma
The goal of this prospective, single-arm, open-label clinical trial is to evaluate whether 18F-AGX PET imaging can be used to assess early treatment response and metabolic changes in adult patients with recurrent or residual WHO…
- Conditions
- Glioma, Diffuse Glioma, Recurrent Gliomas
- Trial name
- VANGUARD (NCT07469735)
- Testing
- Oral Vorasidenib administered once daily for up to 12 treatment cycles (28 days per cycle) as IDH-targeted therapy in participants with recurrent or residual IDH-mutant diffuse glioma.
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Huashan Hospital
Laser Treatment
Endocare Repair Efficacy Skincare Products in the Use of Post-laser Treatment
To Evaluate the Efficacy and Safety of Endocare Repair Efficacy Skincare Products in the Repair of Facial Skin Following Ablative Fractional Laser Treatment.
- Trial name
- NCT07442422
- Testing
- Active product contained 40% secretion of SCA
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Tuberculosis
Asymptomatic TB With Innovative Modified Short-course Regimens
This study is a randomized controlled trial among asymptomatic tuberculosis individuals aiming to assess whether the standard treatment duration can be shortened to 17 weeks without increasing the types or doses of…
- Trial name
- SWIFT (NCT06153069)
- Testing
- Four-month regimen, Three-month regimen, Standard regimen
- Where
- 5 sites in China
- Volunteers
- 426 people
- Sponsor
- Huashan Hospital
Brachial Plexus Injury, Ultrasound
Research of Brachial Plexus Anatomy
The research aims at analyzing the sonographic anatomy characteristics of the interscalene brachial plexus.
- Trial name
- Soana-ibp (NCT06901063)
- Testing
- ultrasound
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Huashan Hospital
Rectal Cancer
The Impact of Probiotic Intervention on the Gut Microbiota and Bowel Function
This study aims to propose a novel, easy-to-operate intervention strategy that effectively improves defecation function after stoma reversal and to assess its impact on the gut microbiota.The efficacy and safety of antegrade…
- Trial name
- NCT07369830
- Testing
- Clostridium butyricum (live) Tablets(Meiya)
- Where
- China
- Volunteers
- 156 people
- Sponsor
- Huashan Hospital
Primary Membranous Nephropathy
OBINOTUZUMAB Versus Cyclophosphamide + Glucocorticoids in Primary Membranous Nephropathy(Blossom Study)
This is a randomized, parallel group, active-controlled, open-label, Phase III study comparing the efficacy and safety of obinutuzumab versus cyclophosphamide combined with glucocorticoids in patients with primary membranous…
- Trial name
- NCT06781944
- Testing
- Obinutuzumab, CTX combined with Glucocorticoids
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Huashan Hospital
Multiple Sclerosis (MS), Neuromyelitis Optica Spectrum Disorders (NMOSD)
A Study of C-CAR168 in the Treatment of Central Nervous System Autoimmune Diseases Refractory to Standard Therapy
This is an investigator-initiated, single-center, open-label study of C-CAR168, an autologous bi-specific CAR-T therapy targeting CD20 and BCMA, for the treatment of adult patients with central nervous system autoimmune diseases…
- Conditions
- Multiple Sclerosis (MS), Neuromyelitis Optica Spectrum Disorders (NMOSD), Autoimmune Encephalitis, Stiff Person Syndrome
- Trial name
- NCT07341828
- Testing
- CD20/BCMA-directed CAR-T cells
- Volunteers
- 15 people
- Sponsor
- Huashan Hospital
Acute Ischemic Stroke
CHinese ischEmic Stroke Beyond 4.5 Hours With TeNecteplase Under Optimized Non-Contrast CT Selection
The CHESTNUT trial is a multicenter, open-label, blinded-endpoint, randomized, controlled, phase 3 trial. The primary objective of this study is to explore the efficacy and safety of the dose of 0.25 mg/kg tenecteplase (TNK) in…
- Trial name
- CHESTNUT (NCT06994975)
- Testing
- 0.25mg/kg TNK, Standard medical treatment
- Where
- 2 sites in China
- Volunteers
- 890 people
- Sponsor
- Huashan Hospital
Disorder of Consciousness, Temporal Interference Stimulation
Study on the Effectiveness and Safety of Temporal Interference Stimulation in Treating Patients With Severe Consciousness Disorders
Investigating the efficacy and safety of temporal interference stimulation for patients with disorders of consciousness.
- Trial name
- NCT06896279
- Testing
- TI Stimulation
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- Huashan Hospital
Chronic Hepatitis b
Long-term Outcomes of Anti-viral Therapies in Patients With Chronic Viral Hepatitis B
The goal of this observational, multicenter , real-world study is to evaluate the long-term outcomes of different antiviral therapies in adults with chronic hepatitis B (CHB).
- Trial name
- OASIS (NCT04896255)
- Testing
- peginterferon alpha based regimen, nucleos(t)ide
- Where
- China
- Volunteers
- 33,000 people
- Sponsor
- Huashan Hospital
Parkinsonian Disorders
The National Registry Study For the Real-world Patients With Parkinsonian Disorders in China
The overall goal of this project is to identify, assess and longitudinally monitor subjects who are interested in participating in this study.
- Trial name
- ForPDCN (NCT03649503)
- Testing
- No intervention
- Where
- 2 sites in China
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Myasthenia Gravis, Generalized
Safety And Efficacy Of Tofacitinib In Patients With Refractory Myasthenia Gravis: A Pilot Study
This is a 6 month study that will evaluate the efficacy of 5mg tofacitinib tablet taken twice a day in patients with refractory myasthenia gravis.
- Trial name
- NCT04431895
- Testing
- Tofacitinib 5 MG
- Where
- China
- Volunteers
- 19 people
- Sponsor
- Huashan Hospital
Primary Central Nervous System Lymphoma
New-diagnosed PCNSL Treated With Methotrexate (MTX) and Orelabrutinib-based Regimen
This study was a single-centre, retrospective study that retrospectively collected first-line PCNSL patients receiving methotrexate-based chemotherapy ± orelabrutinib at Huashan Hospital of Fudan University.
- Trial name
- NCT06115824
- Testing
- Orelabrutinib
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Huashan Hospital
Mild Cognitive Impairment, The Cognitive Normal Elderly
The Effects of Multidomain Non-pharmacological Interventions on the Elderly With or Without Mild Cognitive Impairment
The study aiming to investigate the efficacy, safety, and potential mechanism of a multimodal intervention on cognitive function in individuals with MCI or the cognitive normal elderly living in a community.
- Trial name
- NCT05483790
- Testing
- the multimodal intervention
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Head and Neck Squamous Cell Carcinoma, Patient Derived Organoid
PDO Based Drug Sensitive Test in R/M HNSCC
To evaluate the consistency of drug efficacy between the clinical systemic treatment and drug sensitive test based on patient-derived organoid in R/M HNSCC patients, using a prospective and multicenter observational study to…
- Conditions
- Head and Neck Squamous Cell Carcinoma, Patient Derived Organoid, Drug Sensitive Test in Vitro
- Trial name
- NCT06686342
- Testing
- No intervention, No Intervention: Observational Cohort
- Where
- 2 sites in China
- Volunteers
- 100 people
- Sponsor
- Huashan Hospital
Salivary Gland Cancers, Patient Derived Organoid
PDO Based Drug Sensitive Test in R/M SGC
To evaluate the consistency of drug efficacy between the clinical systemic treatment and drug sensitive test based on patient-derived organoid in R/M SGC patients, using a prospective and multicenter observational study to…
- Conditions
- Salivary Gland Cancers, Patient Derived Organoid, Drug Sensitive Test in Vitro
- Trial name
- NCT06686979
- Testing
- No Intervention: Observational Cohort
- Where
- 2 sites in China
- Volunteers
- 40 people
- Sponsor
- Huashan Hospital
Drug-resistant Tuberculosis, Pulmonary Tuberculosis
Innovating Shorter, All- Oral, Precised Treatment Regimen for Rifampicin Resistant Tuberculosis：BDLL Chinese Cohort
This is an investigational, prospective, multicenter, single-arm, open label trial. The goal of this clinical trial is to evaluate the efficacy and safety of a 6-month all-oral regimen, consisting of Bedaquiline (BDQ, B)…
- Conditions
- Drug-resistant Tuberculosis, Pulmonary Tuberculosis, Rifampin-resistant Tuberculosis
- Trial name
- INSPIRE-BDLL (NCT06649721)
- Testing
- bedaquiline, delamanid, linezolid
- Where
- 34 sites in China
- Volunteers
- 120 people
- Sponsor
- Huashan Hospital
Flow Diverter
Clinical Safety and Efficacy of Flow-diverter in the Treatment of Intracranial Aneurysms
To collect the safety and effectiveness data of flow-di in the treatment of intracranial aneurysms in real-world clinical practice, verify its classification of treatment strategies for aneurysms of different locations and…
- Trial name
- NCT06943729
- Where
- China
- Volunteers
- 523 people
- Sponsor
- Huashan Hospital
Myasthenia Gravis
Construction of A Multimodal Digital Assessment Model for Myasthenia Gravis
This research is a single-center, exploratory, observational study to be carried out in the outpatient or inpatient ward of the Neurology Department at Huashan Hospital, affiliated to Fudan University.
- Trial name
- NCT07146425
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital