Clinical trials: sponsored by Huashan Hospital
Skin Aging, Skin Rejuvenation
Comparative Study of a 1064-nm Fractional Picosecond Laser Versus IPL in Facial Rejuvenation
This is a single-center, prospective, randomized controlled trial conducted at Huashan Hospital, Fudan University. The purpose of this study is to compare the effectiveness and safety of two non-invasive treatment options-1064-nm…
- Conditions
- Skin Aging, Skin Rejuvenation, Photoaging
- Trial name
- NCT07122310
- Testing
- 1064-nm Fractional Picosecond Laser (PicoWay), Intense Pulsed Light Therapy (M22 IPL System)
- Where
- China
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Pneumonia
A Study on Pathogenic Surveillance and Nasopharyngeal Carriage of Children and Adolescents Based on Hospitals and Communities in Hainan Province
This study intends to screen children under the age of 10 for respiratory pathogens, Streptococcus pneumoniae, and serotyping in three representative cities in Hainan province: Haikou, Wanning, and Baisha, in order to provide a…
- Trial name
- NCT05912010
- Testing
- NP/OP swab
- Where
- 5 sites in China
- Volunteers
- 3,746 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Glioma, Patient Reported Outcome Measures
Validity and Reliability Evaluation of the PRO-CTCAE for Adult-type Diffuse Gliomas Patients in Chinese Population
Given the increasing importance of patient's perspective in adverse events reporting, Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE™) has been proposed as new PRO measures in…
- Conditions
- Glioma, Patient Reported Outcome Measures, Self Report, Adverse Effects
- Trial name
- VERONICA (NCT05486923)
- Where
- 14 sites in China
- Volunteers
- 450 people
- Sponsor
- Huashan Hospital
Gastric Cancer Patients Undergoing Minimally Invasive Gastrectomy
Application of a New Surgical Technique in Proximal Gastrectomy: a Prospective, Multicenter Randomized Controlled Study
This is a prospective study using a multicenter, randomized, controlled, open label, and efficacy validated approach.At present, there is no universally recognized optimal method for gastrointestinal reconstruction after proximal…
- Trial name
- NCT06679244
- Testing
- Totally laparoscopic proximal gastrectomy with Hao's esophagogastrostomy by fissure technique, Totally laparoscopic proximal gastrectomy with double-tract reconstruction
- Where
- 3 sites in China
- Volunteers
- 52 people
- Sponsor
- Huashan Hospital
Acute Respiratory Infections (ARIs)
RSV in Acute Respiratory Infection Surveillance Among Community-Dwelling Elderly Aged ≥50 Years in China
This is a multicenter, prospective, observational, community-based study designed to evaluate the incidence of respiratory syncytial virus (RSV) infection among community-dwelling elderly individuals in China, as well as their…
- Trial name
- RAISE (NCT07075029)
- Testing
- NP swabs
- Where
- 13 sites in China
- Volunteers
- 28,800 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Sepsis, Septic Shock
Evaluation of Droplet Digital PCR Rapid Detection Method and Precise Diagnosis and Treatment for Suspected Sepsis
Sepsis is a significant public health concern worldwide, with high morbidity and mortality. With regard to a targeted antimicrobial treatment strategy, the earliest possible pathogen detection is of crucial importance.
- Trial name
- NCT05190861
- Testing
- droplet digital PCR method, blood culture
- Where
- 9 sites in China
- Volunteers
- 1,032 people
- Sponsor
- Huashan Hospital
Cushing Disease, DVT
Postoperative Thrombosis Prevention in Patients With CD
Patients with Cushing disease was randomized to 2 groups. After surgery, the patients were managed with mechanical prevention or mechanical prevention plus anticoagulant drugs(LMWH followed by rivaroxaban), VTE was observed 24h…
- Conditions
- Cushing Disease, DVT, Pulmonary Embolism
- Trial name
- PIT-CD (NCT04486859)
- Testing
- LMWH/Rivaroxaban, IPC
- Where
- 7 sites in China
- Volunteers
- 206 people
- Sponsor
- Huashan Hospital
Cerebral Amyloid Angiopathy, Intracerebral Hemorrhage Lobar
Colchicine for the Prevention of Recurrence in Cerebral Amyloid Angiopathy RElated IntraCerebral Hemorrhage
The goal of this clinical trial is to assess the safety and tolerability of colchicine for preventing intracerebral haemorrhage (ICH) recurrence in patients with cerebral amyloid angiopathy (CAA)-ICH at high risk of recurrence.
- Trial name
- CARE-ICH (NCT07026994)
- Testing
- Colchicine 0.5mg
- Where
- 3 sites in China
- Volunteers
- 80 people
- Sponsor
- Huashan Hospital
Alzheimer Disease, Positron Emission Tomography
Establishment of the Chinese Preclinical Alzheimer's Disease Study With Multiple Neuroimaging
The goal of this observational study is to investigate neuroimage and biomarkers in the Alzheimer's continuum in Chinese population.
- Trial name
- NCT06827678
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Colorectal Cancer
Early Diagnosis and Recurrence Monitoring of Colorectal Cancer
Colorectal cancer (CRC) has an insidious onset and its survival rate is closely related to clinical stage. While the 5-year survival rate of stage I patients exceeds 90%, it drops to 14% in stage IV.
- Trial name
- NCT06991452
- Testing
- Liquid biopsy
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Myasthenia Gravis
Precision Diagnosis and Prospective Cohort Study for Myasthenia Gravis: Multicenter Analysis in China
The present study is a prospective cohort study aiming to improve the clinical capacity in the diagnosis and natural history of Chinese patients with myasthenia gravis (MG).
- Trial name
- NCT04535843
- Testing
- Biomarkers and omics data
- Where
- 4 sites in China
- Volunteers
- 500 people
- Sponsor
- Huashan Hospital
Hyperuricemia or Gout, Nephrolithiasis
Exploratory Study on the Treatment of Gout With Potassium Citrate Sustained-release Tablets
To evaluate whether alkalization has the effect of lowering uric acid and reducing gout flare and determine whether alkalization has a role in the prevention and treatment of urinary calculi in gout, the research participants…
- Trial name
- NCT06966635
- Testing
- Sodium Bicarbonate Oral Capsule, Potassium Citrate Tablets, uric-acid-lowering drug
- Where
- China
- Volunteers
- 312 people
- Sponsor
- Huashan Hospital
Gastric Cancer, Adenocarcinoma of Esophagogastric Junction
A Prospective Study on Esophagogastrostomy by an Innovative Surgical Technique
This is a single-center, open-label, Phase Ib/II study aiming to assess the perioperative safety and postoperative outcomes of a novel surgical technique in treating primary adenocarcinoma located in the upper 1/3 of the stomach…
- Trial name
- NCT06300879
- Testing
- Performing totally laparoscopic proximal gastrectomy with esophagogastrostomy by fissure technique
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Huashan Hospital
Multidrug Resistant Tuberculosis, Rifampicin Resistant Tuberculosis
Innovating(IN) Shorter(S), All- Oral, Precised(P), Individualized(I) Treatment Regimen(RE) for Rifampicin Resistant Tuberculosis(INSPIRE-TB)
The INSPIRE-TB study is a pragmatic, multicentre, randomised, controlled, non-inferiority open-label trial to evaluate the efficacy and safety of seven 9-month oral regimens compared to a 9-month standard of care (SOC) regimen in…
- Conditions
- Multidrug Resistant Tuberculosis, Rifampicin Resistant Tuberculosis, Pre-XDR-TB
- Trial name
- INSPIRE-TB (NCT05081401)
- Testing
- Bdq(Lzd)+Lfx(Mfx)+Cfz(Cs)+Pto+E+H+Z, A1, A2a
- Where
- 5 sites in China
- Volunteers
- 1,050 people
- Sponsor
- Huashan Hospital
Meige Syndrome
Bilateral Single-Electrode VO Combined With STN-DBS for Treating Meige Syndrome
Meige syndrome is a rare and debilitating movement disorder characterized by blepharospasm, oromandibular dystonia, and cervical muscle contractions, often refractory to pharmacological therapies.
- Trial name
- NCT06912282
- Testing
- deep brain stimulation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Huashan Hospital
Tuberculosis, Latent Tuberculosis Infection
Active Screening of Latent Tuberculosis Infection in School Contacts of Active Tuberculosis Patients
The goal of this observational study is to investigate the proportion of Mycobacterium tuberculosis (MTB) infection in school contacts of active tuberculosis (ATB) patients.
- Trial name
- NCT06033807
- Testing
- QuantiFERON-TB Gold (QFT) test
- Where
- 44 sites in China
- Volunteers
- 31,440 people
- Sponsor
- Huashan Hospital
Chronic Hepatitis B
Pegylated Interferon Alfa-2b in Reducing Relapse Rates After Nucleos(t)ide Analogue Withdrawal in HBeAg-negative CHB Patients with Low Level HBsAg
All enrolled patients must meet the European Guidelines for the Prevention and Treatment of Chronic Hepatitis B (EASL, 2017) recommended discontinuation criteria, that is, HBeAg-negative chronic hepatitis B patients without…
- Trial name
- NCT06900166
- Testing
- PegIFN alfa-2b, PegIFN alfa-2b and NUC
- Where
- China
- Volunteers
- 360 people
- Sponsor
- Huashan Hospital
Neuromyelitis Optica Spectrum Disorders (NMOSD)
BLAZE-Limiting Approach in NMOSD
This is an observational cohort study based on data from the hospital-based NMOSD registry (Chinese Medical Research Registration Number MR-31-22-008563; ChiCTR2000030651).
- Trial name
- NCT06888622
- Testing
- Eculizumab administration
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Huashan Hospital
Parkinson's Disease
Detection of A-synuclein Aggregate as Biomarker in Diagnosing Parkinson's Disease at Early Stage by Using Protein Misfolding Cyclic Amplification (PMCA)
The study will investigate the biomarker of a-synuclein aggregate in CSF detected by protein misfolding cyclic amplification (PMCA) and its sensitivity and specificity in diagnosing Parkinson's disease at H-Y stage I and disease…
- Trial name
- NCT04536857
- Testing
- Biomarker assay
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Huashan Hospital
Post-acute Sequelae of SARS-COV-2 Infection
Evaluating Immunomodulatory Interventions in Post-Acute Sequelae of SARS-CoV-2 InfEction
This study is a prospective, randomized controlled, basket trial. Patients diagnosed with Post-Acute Sequelae of SARS-CoV-2 Infection who meet the inclusion and exclusion criteria are recruited and divided into three symptom…
- Trial name
- RISE (NCT06597682)
- Testing
- Prednisone, Budesonide/Formoterol, Vitamin C combined with Coenzyme Q10 oral treatment
- Where
- China
- Volunteers
- 632 people
- Sponsor
- Huashan Hospital