Clinical trials: sponsored by Huashan Hospital
Glioblastoma
Vebreltinib Combined With Temozolomide for Glioblastoma (GBM) After Surgery
The purpose of this study is to explore the effects of Vebreltinib in primary glioblastoma patients receiving a combination therapy of chemotherapy (temozolomidel) and MET-TKI.
- Trial name
- NCT06780592
- Testing
- Vebreltinib + Temozolomide, Temozolomide
- Volunteers
- 60 people
- Sponsor
- Huashan Hospital
End-stage Renal Disease
Incremental Dialysis Decision Model Based on Expert-Guided Machine Learning
This observational prospective study combined clinical expert knowledge with machine learning to develop and validate a predictive model for incremental hemodialysis decision-making.
- Trial name
- NCT06775067
- Where
- China
- Volunteers
- 175 people
- Sponsor
- Huashan Hospital
Gastrointestinal Tumors
The Use of Propranolol in the Perioperative Period of Resectable Gastrointestinal Tumors
In this study, perioperative propranolol β-blockade was administered to patients with surgically resectable primary gastrointestinal tumors to explore the safety, efficacy, and alleviation of perioperative psychological stress.
- Trial name
- NCT06775080
- Testing
- propranolol (beta-blocker used treat high blood pressure)
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Huashan Hospital
Kidney Function Decline, Glomerular Filtration Rate
Rapid Kidney Function Decline in Older Adults
This observational study investigates whether a single set of GFR and urine albumin-to-creatinine ratio (ACR) thresholds can accurately screen for rapid kidney function decline in different elderly groups.
- Conditions
- Kidney Function Decline, Glomerular Filtration Rate, Urine Albumin-creatinine Ratio, Healthy Aging
- Trial name
- NCT06765811
- Where
- China
- Volunteers
- 1,539 people
- Sponsor
- Huashan Hospital
Disorder of Consciousness, Spinal Cord Stimulation
Efficacy and Safety of Spinal Cord Stimulation in Patients With Spinal Cord Stimulation
Investigating the efficacy and safety of spinal cord stimulation for patients with disorders of consciousness.
- Trial name
- SCORS-DOC (NCT06515132)
- Testing
- SCS Stimulation
- Where
- 3 sites in China
- Volunteers
- 50 people
- Sponsor
- Huashan Hospital
Gastric Cancer
Neoadjuvant of Sintilimab Combined Weekly Metronomic Chemotherapy (PLOF) for Resectable Locally Advanced Gastric Cancer
To evaluate efficacy and safety of Neoadjuvant of Sintilimab Combined Weekly Metronomic Chemotherapy (PLOF) in resectable locally advanced gastric cancer.
- Trial name
- NCT06054906
- Testing
- sintilimab+metronomic PLOF
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Huashan Hospital
Cavernous Malformations, Intracerebral Hemorrhage
Hemorrhagic Brainstem Cavernous Malformations Treatment With Sirolimus: aSingle Centre, Randomized, Placebo-controlled Pilot Trial
The aim of this pilot phase trial is to assess the safety and tolerability, and estimate the efficacy of sirolimus in reducing the incidence of ICH during high-risk periods for rebleeding, compared to placebo.
- Conditions
- Cavernous Malformations, Intracerebral Hemorrhage, Brainstem Stroke
- Trial name
- CALM (NCT06091332)
- Testing
- Sirolimus, Starch flake
- Where
- 2 sites in China
- Volunteers
- 75 people
- Sponsor
- Huashan Hospital
Acute Ischemic Stroke
Efficacy and Safety of Human Urinary Kallidinogenase Combined With Endovascular Therapy in Acute Ischemic Stroke With Large Vessel Occlusion
The purpose of this study is to evaluate the safety and efficacy of Human Urinary Kallidinogenase combined with endovascular therapy in acute ischemic stroke (AIS) patients with large vessel occlusion.
- Trial name
- HEAL (NCT06211712)
- Testing
- Experimental: Human Urinary Kallidinogenase
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Huashan Hospital
Multidrug Resistant Tuberculosis
Refining MDR-TB Treatment (T) Regimens (R) for Ultra(U) Short(S) Therapy(T)
The purpose of this study is to assess the efficacy, safety and tolerability of a combination of levofloxacin, linezolid, cycloserine and pyrazinamide (or clofazimine if resistant to pyrazinamide) treatments for 24 to 32 weeks…
- Trial name
- TB-TRUST (NCT03867136)
- Testing
- PZA sensitivity guided ultra-short all Oral Regimen, Standardized Shorter Regimen
- Where
- 13 sites in China
- Volunteers
- 354 people
- Sponsor
- Huashan Hospital
Multidrug Resistant Tuberculosis
Refining MDR-TB Treatment (T) Regimens (R) for Ultra(U) Short(S) Therapy(T)-PLUS
The purpose of this study is to assess the efficacy, safety and tolerability of a combination of bedaquiline, linezolid, cycloserine, clofazimine and pyrazinamide treatments guided by PZA sensitivity for 24 to 36 weeks in…
- Trial name
- TB-TRUSTplus (NCT04717908)
- Testing
- Bedaquiline, Pyrazinamide, Linezolid
- Where
- 15 sites in China
- Volunteers
- 89 people
- Sponsor
- Huashan Hospital
Pituitary Adenoma
Pre-operative Surgical Difficulty Stratification Using Predicted Tumor Perfusion and Consistency
Pituitary adenomas (PAs) are among the most prevalent lesions of the sella turcica, accounting for 10%-25% of all intracranial neoplasms. Pituitary macroadenomas (PMAs) are defined with a maximum diameter of over 1 cm.
- Trial name
- NCT06664190
- Testing
- Advanced sequences, such as arterial spin labeling (ASL) and diffusion-weighted imaging (DWI)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Huashan Hospital
Surgery, Pituitary Adenoma
Comparative Effectiveness of Different Surgical Approaches for Giant Pituitary Adenomas
The surgical treatment strategy for giant invasive pituitary adenoma is one of the current hot spots in the field of clinical research on pituitary adenoma.
- Trial name
- NCT05448690
- Testing
- Two different approaches, Non-combined approach
- Where
- 13 sites in China
- Volunteers
- 600 people
- Sponsor
- Huashan Hospital
Molar, Third, Photobiomodulation
LED Therapy for Third Molar Surgery
LED Therapy for third molar surgery
- Conditions
- Molar, Third, Photobiomodulation, Photobiomodulation Therapy, Third Molar Surgery
- Trial name
- LTTMS (NCT06640439)
- Testing
- photobiomodulation, Antibiotic
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Huashan Hospital
Cerebral Angiography
Transradial Versus Transfemoral Access for Cerebral Angiography
This study is multi-center, prospective, randomized (1:1) controlled trial designed to assess and compare the feasibility, safety and success of Transradial access (TRA) versus Transfemoral access (TFA) for diagnostic cerebral…
- Trial name
- NCT05401669
- Testing
- Trans-radial access, Trans-femoral access
- Where
- China
- Volunteers
- 748 people
- Sponsor
- Huashan Hospital
Respiratory Infectious Diseases, Artificial Intelligence
Exploring the Application Efficacy of Artificial Intelligence (AI) Diagnostic Tools in Medical Imaging (MI) of Respiratory(R) Infectious (I) Disease (D)
The early identification and severe warning of acute respiratory infectious diseases are of paramount importance. Utilizing effective means to make correct diagnoses of the source of infection at an early stage is the premise of…
- Conditions
- Respiratory Infectious Diseases, Artificial Intelligence, Medical Imaging
- Trial name
- AI-MIRID (NCT06553911)
- Testing
- Artificial Intelligence-based medical imaging interpretation
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Hepatitis B, Chronic
Improved Sensitivity Detection of Serum HBsAg and HBsAg Reversion
The goal of this observational study is to learn about the HBsAg reversion rate at 48 weeks off treatment in HBsAg-negative patients by HBsAg NEXT assay which has improved sensitivity compared to current ARCHITECT HBsAg Assay.
- Trial name
- NCT06550622
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Huashan Hospital
Cognition
A Study of the Higher Cognitive Functions of the Human Brain With Single-neuron Activity Recording
This study aims to investigate that neural activity of higher cognitve function of human brain with hyperflexible neural electrode-cortex
- Trial name
- NCT06408415
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Huashan Hospital
Positron-Emission Tomography, Neoplasms
Clinical Study of TROP-2 PET/CT for Noninvasive Diagnosis of Solid Tumors
This study will investigate the safety and preliminary diagnostic efficacy of [68Ga]Ga-NOTA-T4 or [18F]AlF-RESCA-T4 in pancreatic cancer, breast cancer, head and neck cancer, lung cancers and other types of solid tumors.
- Trial name
- NCT06203574
- Testing
- [68Ga]Ga-NOTA-T4 or [18F]AlF-RESCA-T4
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Huashan Hospital
Subdural Hematoma, Non-acute
Managing Non-acute Subdural Hematoma Using Liquid Materials：a Chinese Randomized Trial of MMA Treatment
MAGIC-MT study is multi-center, prospective, randomized (1:1) controlled trial designed to show that additional MMA embolization with Onyx in patients with non-acute symptomatic subdural hematoma(SDH) results in reduced hematoma…
- Trial name
- MAGIC-MT (NCT04700345)
- Testing
- Onyx, Burr-hole, Medical Management
- Where
- China
- Volunteers
- 722 people
- Sponsor
- Huashan Hospital
HER2-positive Breast Cancer
Study of 68Ga /131I SGMIB-ZT-199 PET Imaging Targeting HER2-positive in the Diagnosis of Metastatic Breast Cancer
To evaluate the safety, biodistribution, radiation dosimetry, and uptake in tumor lesions of patients with Her2-positive metastatic breast cancer after injection of [131I]/[68Ga]SGMIB-ZT-199.
- Trial name
- NCT05982626
- Testing
- 68Ga/131I-SGMIB-ZT-199
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Huashan Hospital