Clinical trials: sponsored by Huashan Hospital
Glioma, Glioblastoma
Sub-lobectomy for IDH Wild-type and TERT Promoter Mutant Glioblastoma
Glioblastoma is recognized as the most common and aggressive form of primary malignant brain tumor, with treatment options that are limited and prognosis that is extremely poor, showing median progression-free survival of 12…
- Trial name
- NCT06368934
- Testing
- sub-lobectomy, imaging total resection
- Where
- China
- Volunteers
- 326 people
- Sponsor
- Huashan Hospital
Bladder Cancer
Cryoablation Versus BCG Instillation Therapy for High-risk NMIBC
This trial plans to enroll 190 eligible patients and randomize them into two groups with a 1:1 ratio, with 95 patients in each group.
- Trial name
- NCT06324058
- Testing
- Transurethral cryoablation, Transurethral resection of bladder tumor, Bcg Intravesical
- Volunteers
- 190 people
- Sponsor
- Huashan Hospital
Positron-Emission Tomography, Colorectal Neoplasms
Clinical Study of GPA33-specific PET/CT for the Diagnosis of Colorectal Cancer
In this study, we will first investigate the imaging safety and feasibility of [68Ga]Ga-NOTA-WWH347 and [18F]F-H3RESCA-WWH347 PET/CT in patients with primary and/or metastatic colorectal cancers.
- Trial name
- NCT06203587
- Testing
- [68Ga]Ga-NOTA-WWH347 or [18F]F-H3RESCA-WWH347
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Huashan Hospital
Hepatocellular Carcinoma
A Study of [68Ga]Ga-NOTA-RG2 PET Imaging in the Diagnosis of Hepatocellular Carcinoma
The aim of this study was to establish and optimize the imaging method of [68Ga]Ga-NOTA-RG2, as well as its physiological and pathological distribution characteristics, and on this basis to evaluate the diagnostic efficacy of the…
- Trial name
- NCT06148155
- Testing
- [68Ga]Ga-NOTA-RG2 PET Imaging
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Huashan Hospital
Kidney Cancer, Lymphomas
A Study of the Clinical Application of [18F]RCCB6 and [68Ga]Ga-NOTA-RCCB6 PET/CT Imaging in the Diagnosis of CD70-expressing Multiple Tumors
The aim of this study was to establish and optimize the [18F]RCCB6 and [68Ga]Ga-NOTA-RCCB6 PET/CT imaging method, and its physiological and pathological distribution characteristics, on the basis of which the diagnostic efficacy…
- Conditions
- Kidney Cancer, Lymphomas, Positron Emission Tomography
- Trial name
- NCT06148220
- Testing
- [18F]RCCB6 and [68Ga]Ga-NOTA-RCCB6 PET/CT imaging
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Huashan Hospital
Myasthenia Gravis
Myasthenia Gravis Registry in China
Myasthenia gravis (MG) is an autoimmune disease caused by dysfunction at the neuromuscular junction, characterized by partial or generalized skeletal muscle weakness and fatigability.
- Trial name
- NCT06241521
- Where
- 16 sites in China
- Volunteers
- 1,500 people
- Sponsor
- Huashan Hospital
Parkinson's Disease
Interleaving Stimulation Improves Dyskinesia in Parkinson's Disease
This study is designed as a prospective, randomized, double-blind, controlled study to assess putative differences in the effect of interleaving stimulation and empirical stimulation with regards to post-operation dyskinesia…
- Trial name
- NCT06239454
- Testing
- interleaving stimulation, empirical stimulation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Huashan Hospital
Prostate Specific Membrane Antigen Positive Metastatic Prostate Cancer
A Study to Evaluate the Human Biodistribution and Dosimetry of the Radionuclide Labeled ZT-111 in Patients With Metastatic Prostate Cancer
This study is to evaluate the safety, biodistribution, radiation dosimetry and tumor uptake of the [131I]/[18F]/[68Ga]ZT-111 in patients with PSMA positive metastatic prostate cancer.
- Trial name
- NCT06201741
- Testing
- [131I]/[18F]/[68Ga]ZT-111
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Huashan Hospital
Malignant Glioma
Hypofractionated Stereotactic Radiotherapy With Anlotinib in Patients With Recurrent High-Grade Gliomas
A Phase II Study of Hypofractionated Stereotactic Radiotherapy (HSRT) With Anlotinib in Patients With Recurrent High-Grade Glioma. The primary endpoint is overall survival after radiotherapy.
- Trial name
- NCT04197492
- Testing
- Hypofractionated Stereotactic Radiotherapy, Anlotinib
- Where
- China
- Volunteers
- 22 people
- Sponsor
- Huashan Hospital
Progressive Supranuclear Palsy, Spinal Cord Stimulation
The Study to Evaluate the Safety and Efficacy of Spinal Cord Stimulation on Progressive Supranuclear Palsy
The study is an open-label, prospective, single-arm, unicentral (Huashan Hospital Department of Neurology/ Neurosurgery) and exploratory clinical trial.
- Trial name
- NCT04367116
- Testing
- Spinal Cord Stimulation
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Huashan Hospital
Cryptococcal Meningitis, Antifungal Agents
Amphotericin B for Non-HIV Cryptococcal Meningitis Patients
Cryptococcus neoformans and C. gatti are important causes of central nervous system (CNS) infections with significant mortality, remaining a great public health challenge worldwide.
- Trial name
- ABNCM (NCT06178627)
- Testing
- Amphotericin B 0.5 mg/kg/day i.v. combined with flucytosine four times per day orally for the first 4 weeks., Amphotericin B 0.7 mg/kg/day i.v. combined with flucytosine four times per day orally for the first 4 weeks.
- Where
- 2 sites in China
- Volunteers
- 250 people
- Sponsor
- Huashan Hospital
Pompe Disease (Late-onset)
Evaluation of the Safety, Tolerability and Efficacy of Gene Therapy Drug for Late Onset Pompe Disease (LOPD)
This is a single-center, single-arm, open-label, single-dose treatment clinical study to evaluate the safety, tolerability and efficacy of CRG003 injection in participants with late onset Pompe disease (LOPD), with a long-term…
- Trial name
- NCT06178432
- Testing
- CRG003 injection
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Huashan Hospital
Non-small Cell Lung Cancer
[68Ga]Ga-NOTA-RW102 PET Imaging in the Diagnosis of PD-L1-expressing Lung Cancer
The aim of this study was to establish and optimize the imaging method of [68Ga]Ga-NOTA-RW102, as well as its physiological and pathological distribution characteristics, on the basis of which the diagnostic efficacy of the above…
- Trial name
- NCT06165874
- Testing
- [68Ga]Ga-NOTA-RW102 PET Imaging
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Huashan Hospital
Tuberculosis, Pulmonary
Optimizing(O) RIfapentine-based(RI) Regimen and shortENing(EN) the Treatment of Drug-sensitive Tuberculosis(T)
Tuberculosis (TB) remains the most important infectious disease in the world. A major barrier to tuberculosis control is poor adherence to long-term and complex treatment regimens.
- Trial name
- ORIENT (NCT05401071)
- Testing
- Short Regimen with Rifapentine 10mg/kg, Standardized Regimen, Short Regimen with Rifapentine 15mg/kg
- Where
- 6 sites in China
- Volunteers
- 2,442 people
- Sponsor
- Huashan Hospital
Glioma
The Role of B7-H4 in Tumor Vaccine
Glioma patients have poor prognosis because of limited choices of treatment. Therapeutic cancer vaccines have been proved to improve survival in glioma, but resistance is a new challenge for vaccine treatment, and the mechanism…
- Trial name
- NCT06156150
- Testing
- tumor vaccine
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Huashan Hospital
Stroke
CHinese Acute Tissue-Based Imaging Selection for Lysis In Stroke -Tenecteplase II
To explore the efficacy and safety of tenecteplase for acute ischemic stroke patients (onset time 4.5-24h) of large vessel occlusion using early combined CT/MR imaging outcomes
- Trial name
- CHABLIS-T II (NCT04516993)
- Testing
- Tenecteplase, The best treatment selected by local doctors(Aspirin, Recombinant Tissue Plasminogen Activator, Urokinase, Thrombectomy)
- Where
- China
- Volunteers
- 224 people
- Sponsor
- Huashan Hospital
Positron Emission Tomography, Alzheimer Disease
CSF1R PET Probe [18F]CSF-23 in Alzheimer's Disease Brain Imaging
To explore the diagnostic value of [18F]CSF-23 brain imaging for CSF1R expression in Alzheimer's disease. PET imaging with this PET tracer was used to assess the role and expression of CSF1R in AD and to evaluate the level and…
- Conditions
- Positron Emission Tomography, Alzheimer Disease, Neurodegenerative Diseases
- Trial name
- NCT06148233
- Testing
- [18F]CSF-23
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Cerebral Gliosis, Positron Emission Tomography
[18F]BF3-BPA Injection for PET Imaging Study of Gliomas in the Brain
In this clinical study, we proposed to perform [18F]BF3-BPA PET imaging in subjects with gliomas, to observe the binding ability and non-specific binding of the tracer to glioma lesions in vivo, and at the same time to evaluate…
- Trial name
- NCT06148207
- Testing
- [18F]BF3-BPA Injection for PET Imaging
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Glioma, Solid Tumor
Tumor Vaccines for Solid Tumors
Glioma is the most common primary malignant intracranial tumor, characterized by limited clinical treatment options and extremely poor prognosis.
- Trial name
- NCT06102837
- Testing
- tumor vaccine, Radiotherapy, Chemotherapy
- Where
- China
- Volunteers
- 340 people
- Sponsor
- Huashan Hospital
LGMD, LGMDR2
A Multicenter Phenotype-Genotype Analysis of LGMD Patients in China
Limb-girdle muscular dystrophies (LGMD) are a series of rare progressive genetic disorders that are characterized by wasting and weakness of the voluntary proximal muscles.
- Conditions
- LGMD, LGMDR2, LGMDR1
- Trial name
- NCT04989751
- Testing
- Electromyography, IDEAL MRI
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Huashan Hospital