Clinical trials: sponsored by Huashan Hospital
Glioma
The Study of Microglia/Macrophages Involved Dynamic Evolution of Glioma Microenvironment and the Function and Visualization of Targeted Molecules of Glioma
establishment of glioma microenvironment cell dynamic evolution database reveal the mechanism of GIM promoting malignant transformation of glioma cells reveal the dynamic regulation process of immune cells in the process of…
- Trial name
- NCT04781764
- Testing
- surgery
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Huashan Hospital
General Anesthetics Toxicity, Neurodevelopment
Neurodevelopment of Infants Exposed to General Anesthesia: a Multi-center Investigation
Numerous preclinical evidence has confirmed that most commonly-used general anesthetics can affect neurodevelopment of young animals adversely, causing both structural defect of brain and cognitive impairment.
- Conditions
- General Anesthetics Toxicity, Neurodevelopment, Infant
- Trial name
- GENIUS (NCT03629093)
- Testing
- General Anesthetics
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Huashan Hospital
Prone Position, Blood Volume
The Effect of High vs. Low Fluid Volume on Ocular Parameters in Prone Spine Surgery
The purpose of this trial is to compare the effect of different fluid volume infusion on ocular parameters in patients undergoing spine surgery in prone position.
- Conditions
- Prone Position, Blood Volume, Intraocular Pressure
- Trial name
- NCT03890510
- Testing
- Ringer's Lactate solution, Spine surgery under general Anesthesia in the prone position
- Where
- China
- Volunteers
- 97 people
- Sponsor
- Huashan Hospital
Supratentorial Tumors
The Therapeutic Time Window of Mannitol During Craniotomy for Optimal Brain Relaxation in Patients With Supratentorial Tumours
Although mannitol is used for brain relaxation during neurosurgery and in the treatment of raised intracranial pressure; there is not a consensus on its safe, effective dose and the duration of its administration.
- Trial name
- NCT03444519
- Testing
- Mannitol
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Huashan Hospital
Chronic Subdural Hematoma
Low Intracranial Pressure Treatment Strategies for Chronic Subdural Hematoma Patients
The proportion of the elderly population is increasing rapidly. Chronic subdural hematoma has become the most common cause of surgery in neurosurgery for elderly patients. The standard treatment for cSDH is mostly surgery.
- Trial name
- CSDH-LP (NCT04607447)
- Testing
- low intracranial pressure strategy treatment, Atorvastatin plus Dexamethasone
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Huashan Hospital
Glioma, Malignant
HSRT and IMRT Chemoradiotherapy for Newly Diagnosed GBM
This study aims to evaluate the safety and effectiveness of the combination of 30Gy/5fx HSRT and 20Gy/10fx IMRT adjuvant therapy.
- Trial name
- HSCK-010 (NCT04547621)
- Testing
- Radiation, Temozolomide
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Huashan Hospital
Glioma, Glioblastoma Multiforme
Study of DC Vaccination Against Glioblastoma
This is a Phase II study in a single center to determine the efficacy of autologous dendritic cells (DCs) loaded with autogeneic glioma stem-like cells (A2B5+) administered as a vaccination in adults with glioblastoma multiforme…
- Conditions
- Glioma, Glioblastoma Multiforme, Neoplasms
- Trial name
- NCT01567202
- Testing
- Surgery, Chemotherapy, Radiotherapy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Huashan Hospital
Cardiovascular Risk Factor, Hypertension
Cardiovascular and Renal Outcomes of Integrated Management of Blood Pressure and Other Cardiometabolic Risks in Hypertensives
this clinical trial is designed to study the cardiovascular and renal outcomes of hypertensives after an integrated management of blood pressure and other cardiometabolic risks. it is a multicenter prospective cohort study.
- Conditions
- Cardiovascular Risk Factor, Hypertension, Renal Disease
- Trial name
- NCT04531124
- Testing
- integrated management
- Where
- China
- Volunteers
- 30,000 people
- Sponsor
- Huashan Hospital
Headache, Pituitary Tumor
The TMS Treatment for Postoperative Headache in GH Tumor
Headache is a very common main complaint of patients with GH pituitary tumor, which has seriously affected the normal work and life of patients.
- Conditions
- Headache, Pituitary Tumor, Acromegaly
- Trial name
- NCT04529356
- Testing
- Transcranial magnetic stimulation, Acetaminophen
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Infertility, Female, Recurrent Implantation Failure
Short Course Rifapentine and Isoniazid for the Preventive Treatment for Latent Genital Tuberculosis
The purpose of this study is to assess the efficacy, safety and tolerability of the 1-month regimen of three times weekly rifapentine plus isoniazid in improving fertility outcome in recurrent implantation failure (RIF) patients…
- Conditions
- Infertility, Female, Recurrent Implantation Failure, Genital Tuberculoses, Female, Genital Tuberculosis, Latent
- Trial name
- SCRIPT-LGTB (NCT04528277)
- Testing
- rifapentine plus isoniazid
- Where
- China
- Volunteers
- 1,050 people
- Sponsor
- Huashan Hospital
Acromegaly, Cardiomyopathies
A Pilot Study of Empagliflozin in the Treatment of Acromegalic Cardiomyopathy
Acromegaly is a disease characterized by excess growth hormone(GH) and insulin like growth factor(IGF)-1. Pituitary GH secreting adenoma is the major cause of acromegaly.
- Trial name
- NCT04520646
- Testing
- Empagliflozin
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Huashan Hospital
Atrial Fibrillation
Screening for Atrial Fibrillation With Prolonged Continuous Single-lead ECG Devices in High-risk Patients
Atrial fibrillation(AF) can be asymptomatic and thus left unidentified in many people, but holds potential risk of lethal complications such as stroke and congestive heart failure.
- Trial name
- NCT04519190
- Testing
- Prolonged continuous single-lead ECG monitor, Intermittent ECG monitor, Routine practice
- Volunteers
- 300 people
- Sponsor
- Huashan Hospital
Multidrug Resistant Tuberculosis
MDR-TB Close Contacts Tracing in China (TCCT Study)
To investigate the incidence of etiologically confirmed or clinically diagnosed active tuberculosis in close contacts of MDR-TB patients.
- Trial name
- NCT04484129
- Where
- 8 sites in China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Silicosis, Tuberculosis
Efficacy of Weekly Rifapentine and Isoniazid for Tuberculosis Prevention
Tuberculosis (TB) remains the most important infectious disease in the world. Preventive treatment plays an important role in successful control of TB.
- Trial name
- NCT02430259
- Testing
- Weekly INH / RRT given by DOT
- Where
- China
- Volunteers
- 566 people
- Sponsor
- Huashan Hospital
Tuberculosis; Pulmonary, Confirmed, Unspecified Means
Delayed Diagnosis of Bacteriologically Positive Pulmonary Tuberculosis and Relative Optimized Suggestions in China
The purpose of the study is to collect health-seeking pathways, sociodemographic characteristics and symptoms of 400 newly diagnosed patients with bacteriologically confirmed pulmonary tuberculosis(TB).
- Trial name
- NCT04434976
- Where
- 20 sites in China
- Volunteers
- 400 people
- Sponsor
- Huashan Hospital
Klebsiella Pneumoniae Infection
WGS-guided Tracking and Infection Control Measures of CRKP
The objective of this study is to investigate the effect of the infection control measures based on the active screening of carbapenem-resistant Klebsiella pneumoniae and whole-genome based tracking and surveillance though the…
- Trial name
- NCT04413305
- Testing
- screen of CRKP and infection control measure
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Huashan Hospital
Brucelloses, Epidemic Hemorrhagic Fever
Real World Study of Classic Infectious Disease
This study aimed to collect and analyze clinical specimens of patients with classic infectious diseases in the real world. To investigate the epidemiological distribution of classic infectious diseases (brucellosis, epidemic…
- Conditions
- Brucelloses, Epidemic Hemorrhagic Fever, Kala-Azar
- Trial name
- NCT04020536
- Testing
- Antibiotics
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Huashan Hospital
COVID-19
Development and Verification of a New Coronavirus Multiplex Nucleic Acid Detection System
Our project intends to independently develop a fully enclosed rapid detection system for a total of 22 pathogens, including SARS-CoV-2, on the basis of the QIAstat-Dx fully automatic multiple PCR detection platform.
- Trial name
- NCT04311398
- Testing
- New QIAstat-Dx fully automatic multiple PCR detection platform
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Huashan Hospital
Lung Cancer, Microbiome
Study of the Correlation of Tumor Tissue Microbiome to the Pathogenesis of Lung Cancer
Lung cancer is the malignant tumor with the highest incidence, accounting for the first cause of tumor death. At present, smoking, occupational and environmental exposure, air pollution and genetic factors are considered to be…
- Trial name
- STARS (NCT04260295)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Huashan Hospital
Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Microbiome
Prospective Cohort Study of Molecular Mechanism of Lower Respiratory Tract Microbes in Patients With AECOPD
How to reduce the rapid decline of lung function in patients with AECOPD is a clinically urgent problem to be solved. Studies have suggested that there is a bacterial flora imbalance in the lower respiratory tract of COPD…
- Trial name
- REASON (NCT04259736)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Huashan Hospital