Clinical trials: open to volunteers, sponsored by I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
ASA III, Elective Prosthetic Surgery
How to Prevent Post-surgery Infections
Evaluation of the effectiveness in reducing the bacterial load on the skin of bedridden opatients through the use of two different cleaning and washing systems (swash bathing gloves vs pre-soaped sponges).
- Conditions
- ASA III, Elective Prosthetic Surgery, Patient Bedridden After Surgery
- Trial name
- Bundle (NCT07848269)
- Testing
- Swab for cleaning, used as first comparator. For this group we want, during these three days and each day, measure skin pH before and after, Coltural exam before and after and time for cleaning
- Where
- Italy
- Volunteers
- 164 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Analgesia
Evaluation of Three Different Antalgic Blocks in Total Knee Prosthesis
This randomised trial examines the three main anaesthetic blocks used in knee replacement surgery, comparing them in terms of analgesic efficacy (primary outcome), range of motion and degree of flexion in the immediate…
- Trial name
- Analgesia PTG (NCT07751653)
- Testing
- Levobupivacaine
- Where
- 2 sites in Italy
- Volunteers
- 142 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
IDH Wildtype Glioblastoma, IDH Mutant Lower-Grade Gliomas
Metabolomics and Transcriptomics of Low- and High-Grade Gliomas
The goal of this observational study is to better define the molecular profile of rare brain tumors (gliomas) based on the levels of their metabolites and transcripts (the intermediate step between DNA information and proteins).
- Trial name
- GlioMeTra (NCT07832734)
- Where
- Italy
- Volunteers
- 220 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Orthopaedic Surgery
The Influence of Perioperative Strategies on the Extent of in Orthopaedic Prosthetic Surgery
To assess the extent of blood loss in prosthetic surgery, considering whether possible variables may influence, either positively or negatively, the extent of such loss.
- Trial name
- IPECO (NCT07500350)
- Where
- Italy
- Volunteers
- 1,683 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Total Knee Replacement
Femoral Component TKA: Extramedullary vs Conventional Intramedullary Guide
The study wants to evaluate the performance of this EM guide in comparison to a traditional IM guide. 75 patients will be included in the extramedullary group (to be compared with a corresponding previous group of 75 patients…
- Trial name
- EMAX (L2055) (NCT07815080)
- Where
- 3 sites in Italy
- Volunteers
- 150 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Aging, Asymmetry
Fall Risk in Adults Over 65: The Relevance of Morphological and Functional Lower Limb Asymmetries.
Falls among older adults represent a major public health burden. Approximately 30% of individuals aged 65 and older experience at least one fall each year.
- Conditions
- Aging, Asymmetry, Fall Risk Factors, Fall Prevention
- Trial name
- ASY&FALL (NCT07742397)
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Sarcopenia
Morphological and Functional Biomarkers of Skeletal Muscle Adaptations in Sarcopenia
Sarcopenia is an age-related condition characterized by progressive loss of skeletal muscle mass, muscle strength, and physical performance.
- Trial name
- EXEDOS (NCT07692308)
- Testing
- Digitally delivered home-based exercise intervention, General physical activity recommendations
- Where
- Italy
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Peripheral Arterial Disease, Aortoiliac Occlusive Disease
Predictors of Major Adverse Limb Events After Endovascular Iliac Stenting: a Real-world Cohort Study
Peripheral arterial disease involving the iliac arteries is a common manifestation of systemic atherosclerosis and a major cause of lifestyle-limiting claudication and chronic limb-threatening ischemia.
- Conditions
- Peripheral Arterial Disease, Aortoiliac Occlusive Disease, Chronic Limb-Threatening Ischemia, Intermittent Claudication
- Trial name
- PREMISE-ILIAC (NCT07672249)
- Testing
- Iliac stenting
- Where
- Italy
- Volunteers
- 98 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Environmental Sustainability in Radiology, Iodinated Contrast Agent Recovery
GREENWATER 2.0: Reducing Iodinated Contrast Agents in Hospital Wastewater
The goal of this observational study is to learn if using a dedicated urine collection device after CT scans can help reduce the amount of iodinated contrast agent released into hospital wastewater in adult outpatients undergoing…
- Trial name
- GREENWATER 2 (NCT07620093)
- Testing
- Dedicated Urine Collection Device (Toilet)
- Where
- Italy
- Volunteers
- 416 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Anterior Cruciate Ligament (ACL) Tear
Augmented Reality in Surgery
The goal of this observational study is to learn whether an artificial-intelligence software can reliably recognise the anatomical landmarks used to guide femoral bone tunnel placement on the arthroscopic monitor image during…
- Trial name
- ARS (NCT07636278)
- Testing
- Primary arthroscopic anterior cruciate ligament reconstruction
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Periodontitis, Bone Defects
The Use of Two Bone Substitutes in Adjunct to EMD for the Treatment of One- and Two-wall Intrabony Defects.
The main aim will be to evaluate the difference in PD changes at 12-month follow-up, measured from the gingival margin to the base of the pocket, comparing periodontal regeneration using two different bone substitutes, that is…
- Trial name
- OSSIXPERIO (NCT07546279)
- Testing
- EMD + collagenated DBBM, EMD + hydroxyapatite collagen matrix
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
CPPD - Calcium Pyrophosphate Deposition Disease, Gout
The Orienting Study
This study at IRCCS Galeazzi - Sant'Ambrogio Hospital involves patients with gout, CPPD, and osteoarthritis as a control group. Patients will receive routine care with regular clinical, laboratory, and imaging assessments every…
- Trial name
- ORIENTING (NCT07504146)
- Where
- Italy
- Volunteers
- 450 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Total Knee Arthroplasty\(TKA\), Osteoartrosi
Use of Cryopressotherapy in Patiens Undergoing Total Knee Replacement to Improve Clinical Outcome
The purpose of this study is to evaluate the effectiveness of cryopressotherapy in patients undergoing total knee arthroplasty by assessing clinical improvement using the KOOS at 14 days after surgery.
- Trial name
- CRYO-KNEE (NCT07456787)
- Testing
- Cryopressotherapy, Ice pack
- Where
- Italy
- Volunteers
- 78 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Scale Reliability Validity, ACL Injury
Validation and Cultural Adaptation of the KOOS-ACL Scale for the Italian Population
Submission of the KOOS ACL questionnaires in Italian for the purpose of validation and cultural adaptation of the KOOS-ACL scale for the Italian population.
- Conditions
- Scale Reliability Validity, ACL Injury, Validation and Cultural Adaptation of a Scale, PROMs
- Trial name
- VACKP (NCT07386405)
- Testing
- PROMS submition
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Coronary Artery Diease
High-risk Coronary Atherosclerosis in Subjects With Family History of Myocardial Infarction
The evidence of high-risk atherosclerosis at cardiac CT (CCT) may support aggressive primary prevention treatment, reducing the risk of future cardiovascular events.
- Trial name
- FAMILY (NCT07352111)
- Testing
- Cardiac CT
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Quantification of 25-(OH)D in Physiological Condition
Comparison of Maglumi X3 SNIBE With Other Analytical Methods in Laboratory Medicine for 25-(OH)D Quantification
The aim of this study is to assess the agreement among the results obtained using the Maglumi X3 SNIBE method and other analytical methods for the measurement of 25-(OH) vitamin D.
- Trial name
- NCT07337499
- Testing
- blood sampling
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
HIP AND KNEE OSTEOARTHRITIS
Prepare II - Predictive Model Training and External Validation
The general aim of the project is training and testing a predictive model of inpatient rehabilitation stay after hip and knee replacement for osteoarthritis.
- Trial name
- NCT07304323
- Testing
- Functional rehabilitation
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Degenrative Disc Disease
3D Biomimetic Spine Unit Model Through the Integration of Bioprinting and Transcriptomics (CDP-SUBT)
The general objective of this project is to define the transcriptional profile of primary human cells derived from the nucleus pulposus (NP), annulus fibrosus (AF), and cartilaginous endplate (CEP), and to use this information as…
- Trial name
- CDP-SUBT (NCT07250126)
- Where
- Italy
- Volunteers
- 5 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Orthopedic Disorder
Clinical and Radiological Evaluation of Total Ankle Replacement (ProtesiTT)
Numerous studies reported the efficacy of new third-generation of total ankle arthroplasties for the treatment of advanced ankle osteoarthritis and clinical results are comparable to ankle arthrodesis.
- Trial name
- ProtesiTT (NCT07168330)
- Testing
- Ankle replacement
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Bone Disease, Metabolic, Physical Activity
Metabolic Profile of Bone in Professional Athletes
Physical activity is a key stimulus for bone metabolism through both direct mechanisms (e.g., as a result of the applied load and/or impact) and indirect mechanisms (e.g., the activation of several metabolic pathways and the…
- Trial name
- SportMarkers (NCT03386981)
- Testing
- blood and saliva tests
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio